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1.
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13 p, 1.5 MB |
Inspecting the Ribozyme Region of Hepatitis Delta Virus Genotype 1 : Conservation and Variability
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Pacin-Ruiz, Beatriz (Hospital Universitari Vall d'Hebron) ;
Cortese, Maria Francesca (Hospital Universitari Vall d'Hebron) ;
Tabernero, David (Hospital Universitari Vall d'Hebron) ;
Sopena, Sara (Hospital Universitari Vall d'Hebron) ;
Gregori i Font, Josep (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
García-García, Selene (Hospital Universitari Vall d'Hebron) ;
Casillas, Rosario (Hospital Universitari Vall d'Hebron) ;
Najarro, Adrián (Hospital Universitari Vall d'Hebron) ;
Aldama, Unai (Hospital Universitari Vall d'Hebron) ;
Palom, Adriana (Hospital Universitari Vall d'Hebron) ;
Rando-Segura, Ariadna (Hospital Universitari Vall d'Hebron) ;
Galán, Anna (Hospital Universitari Vall d'Hebron) ;
Vila, Marta (Hospital Universitari Vall d'Hebron) ;
Riveiro Barciela, Mar (Hospital Universitari Vall d'Hebron) ;
Quer, Josep (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
González-Aseguinolaza, Gloria (Univerdad de Pamplona) ;
Buti, Maria (Hospital Universitari Vall d'Hebron) ;
Rodríguez-Frías, Francisco (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
The hepatitis delta virus (HDV) genome has an autocatalytic region called the ribozyme, which is essential for viral replication. The aim of this study was to use next-generation sequencing (NGS) to analyze the ribozyme quasispecies (QS) in order to study its evolution and identify highly conserved regions potentially suitable for a gene-silencing strategy. [...]
2022 -  10.3390/v14020215
Viruses, Vol. 14 (january 2022)
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2.
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40 p, 490.3 KB |
Age-dependent impact of the major common genetic risk factor for COVID-19 on severity and mortality
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Nakanishi, Tomoko (Japan Society for the Promotion of Science, Tokyo) ;
Pigazzini, Sara (University of Milano-Bicocca, Milano) ;
Degenhardt, Frauke (University Hospital Schleswig-Holstein) ;
Cordioli, Mattia (Univerisity of Helsinki) ;
Butler-Laporte, Guillaume (McGill University, Montréal, Québec) ;
Maya-Miles, Douglas (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Nafría-Jiménez, Beatriz (Osakidetza-Servicio Vasco de Salud, Donostia) ;
Bouysran, Youssef (Université Libre de Bruxelles) ;
Niemi, Mari (Univerisity of Helsinki) ;
Palom, Adriana (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ellinghaus, David (University of Copenhagen) ;
Khan, Atlas (Columbia University, New York) ;
Martínez-Bueno, Manuel (Universidad de Granada) ;
Rolker, Selina (University Hospital Bonn (Bonn, Alemanya)) ;
Amitano, Sara (Azienda Ospedaliero-Universitaria Senese) ;
Roade, Luisa (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Fava, Francesca (University of Siena, Italy) ;
Spinner, Christoph D. (Technical University of Munich) ;
Prati, Daniele (Università degli Studi di Milano) ;
Bernardo, David (Universidad de Valladolid) ;
Garcia, Federico (Instituto de Investigación Sanitaria de Granada) ;
Darcis, Gilles (Liège University Hospital (Bèlgica)) ;
Fernandez-Cadenas, Israel (Institut d'Investigació Biomèdica Sant Pau) ;
Holter, Jan Cato (Institute of Clinical Medicine, University of Oslo, Oslo, Norway) ;
Banales, Jesus (Universidad del País Vasco) ;
Frithiof, Robert (Uppsala University, Sweden) ;
Kiryluk, Krzysztof (Columbia University, New York) ;
Duga, Stefano (IRCCS Humanitas Research Hospital, Milan) ;
Asselta, Rosanna (IRCCS Humanitas Research Hospital, Milan) ;
Pereira, Alexandre C (Universidade de São Paulo) ;
Romero-Gómez, Manuel (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Bujanda, Luis (Universidad del País Vasco) ;
Hov, Johannes R. (Oslo University Hospital (Oslo, Noruega)) ;
Migeotte, Isabelle (Fonds de la Recherche Scientifique (FNRS), Brussels) ;
Renieri, Alessandra (University of Siena, Italy) ;
Planas, Anna M. (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Ludwig, Kerstin U. (University Hospital Bonn (Bonn, Alemanya)) ;
Buti, Maria (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Rahmouni, Souad (University of Liege) ;
Alarcón-Riquelme, Marta E. (Karolinska Institutet, Solna, Sweden) ;
Schulte, Eva C. (LMU Munich University, Munich) ;
Franke, Andre (University Hospital Schleswig-Holstein, Kiel) ;
Karlsen, Tom H (Oslo University Hospital (Oslo, Noruega)) ;
Valenti, Luca (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia)) ;
Zeberg, Hugo (Max-Planck Institute for Evolutionary Anthropology, Leipzig, Germany) ;
Richards, J. Brent (King's College London, London) ;
Ganna, Andrea (Massachusetts General Hospital (Boston))
There is considerable variability in COVID-19 outcomes amongst younger adults-and some of this variation may be due to genetic predisposition. We characterized the clinical implications of the major genetic risk factor for COVID-19 severity, and its age-dependent effect, using individual-level data in a large international multi-centre consortium. [...]
2021 - 10.1101/2021.03.07.21252875
medRxiv, march 2021
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3.
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15 p, 703.1 KB |
Ultra-Deep Pyrosequencing Detects Conserved Genomic Sites and Quantifies Linkage of Drug-Resistant Amino Acid Changes in the Hepatitis B Virus Genome
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Rodriguez-Frías, Francisco (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Tabernero, David (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Quer, Josep (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Esteban, Juan I. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ortega, Israel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Domingo, Esteban (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Cubero, María Dolores (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Camós Anguila, Sílvia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ferrer, Carles (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Sánchez, Alex (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Jardí, Rosendo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Schaper, Melanie (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Homs, Maria (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Garcia-Cehic, D. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Guardia, Jaume (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Esteban, Rafael (Esteban Mur) (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Buti, Maria (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Selection of amino acid substitutions associated with resistance to nucleos(t)ide-analog (NA) therapy in the hepatitis B virus (HBV) reverse transcriptase (RT) and their combination in a single viral genome complicates treatment of chronic HBV infection and may affect the overlapping surface coding region. [...]
2012 - 10.1371/journal.pone.0037874
PloS one, Vol. 7 (may 2012)
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4.
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13 p, 974.8 KB |
Clinical Application of Estimating Hepatitis B Virus Quasispecies Complexity by Massive Sequencing : Correlation between Natural Evolution and On-Treatment Evolution
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Homs, Maria (Hospital Universitari Vall d'Hebron) ;
Caballero, Andrea (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Gregori, Josep (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Tabernero, David (Hospital Universitari Vall d'Hebron) ;
Quer, Josep (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Nieto, Leonardo (Hospital Universitari Vall d'Hebron) ;
Esteban, Rafael (Esteban Mur) (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Buti, Maria (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rodriguez-Frias, Francisco (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
To evaluate HBV quasispecies (QA) complexity in the preCore/Core regions in relation to HBeAg status, and explore QA changes under natural evolution and nucleoside analogue (NUC) treatment. Ultra-deep pyrosequencing of HBV preCore/Core regions in 30 sequential samples (baseline [diagnosis], treatment-free, and treatment-nonresponse) from 10 retrospectively selected patients grouped according to HBeAg status over time: HBeAg+ (N = 4), HBeAg- (N = 2), and fluctuating HBeAg (transient seroreversion/seroconversion pattern) (N = 4). [...]
2014 - 10.1371/journal.pone.0112306
PloS one, Vol. 9 (november 2014)
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5.
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14 p, 618.6 KB |
Evidence of an Exponential Decay Pattern of the Hepatitis Delta Virus Evolution Rate and Fluctuations in Quasispecies Complexity in Long-Term Studies of Chronic Delta Infection
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Homs, Maria (Hospital Universitari Vall d'Hebron) ;
Rodriguez-Frias, Francisco (Hospital Universitari Vall d'Hebron) ;
Gregori, Josep (Roche Diagnostics SL (Sant Cugat del Vallès, Barcelona)) ;
Ruiz, Alicia (Hospital Universitari Vall d'Hebron) ;
Reimundo, Pilar (Hospital Universitari Vall d'Hebron) ;
Casillas, Rosario (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Tabernero, David (Hospital Universitari Vall d'Hebron) ;
Godoy, Cristina (Hospital Universitari Vall d'Hebron) ;
Barakat, Salma (National Centre for Gastrointestinal and Liver disease, Khartoum, Sudan) ;
Quer, Josep (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Riveiro-Barciela, Mar (Hospital Universitari Vall d'Hebron) ;
Roggendorf, Michael (Technische Universität München/Helmholtz Zentrum München) ;
Esteban, Rafael (Esteban Mur) (Hospital Universitari Vall d'Hebron) ;
Buti, Maria (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
Chronic HDV infection can cause a severe form of viral hepatitis for which there is no specific treatment. Characterization of the hepatitis B or C viral quasispecies has provided insight into treatment failure and disease recurrence following liver transplantation, has proven useful to understand hepatitis B e antigen seroconversion, and has helped to predict whether hepatitis C infection will resolve or become chronic. [...]
2016 - 10.1371/journal.pone.0158557
PloS one, Vol. 11 (june 2016)
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6.
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15 p, 3.3 MB |
Pipeline for specific subtype amplification and drug resistance detection in hepatitis C virus
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Soria, María Eugenia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Gregori, Josep (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Chen, Qian (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Garcia-Cehic, Damir (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Llorens, Meritxell (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
de Ávila, Ana Isabel (Centro de Biología Molecular "Severo Ochoa") ;
Beach, Nathan M. (Centro de Biología Molecular "Severo Ochoa") ;
Domingo, Esteban (Centro de Biología Molecular "Severo Ochoa") ;
Rodríguez-Frías, Francisco (Universitat Autònoma de Barcelona) ;
Buti, Maria (Universitat Autònoma de Barcelona) ;
Esteban, Rafael (Esteban Mur) (Universitat Autònoma de Barcelona) ;
Esteban Mur, Juan Ignacio (Universitat Autònoma de Barcelona) ;
Quer, Josep (Universitat Autònoma de Barcelona) ;
Perales Viejo, Celia (Centro de Biología Molecular "Severo Ochoa")
Despite the high sustained virological response rates achieved with current directly-acting antiviral agents (DAAs) against hepatitis C virus (HCV), around 5-10% of treated patients do not respond to current antiviral therapies, and basal resistance to DAAs is increasingly detected among treatment-naïve infected individuals. [...]
2018 - 10.1186/s12879-018-3356-6
BMC Infectious diseases, Vol. 18 (september 2018)
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7.
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8 p, 251.6 KB |
Chronic hepatitis D associated with worse patient-reported outcomes than chronic hepatitis B
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Buti, Maria (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Stepanova, Maria (Center for Outcomes Research in Liver Disease, Washington, DC, USA) ;
Palom, Adriana (Hospital Universitari Vall d'Hebron) ;
Riveiro-Barciela, Mar (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Nader, Fatema (Center for Outcomes Research in Liver Disease, Washington) ;
Roade, Luisa (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Esteban, Rafael (Esteban Mur) (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Younossi, Zobair (Betty and Guy Beatty Center for Integrated Research) ;
Universitat Autònoma de Barcelona
Health-related quality of life (HRQoL) determined by patient-reported outcomes (PROs) is impaired in chronic hepatitis B (CHB) and C patients, but there are no data regarding patients with chronic hepatitis D (CHD). [...]
2021 - 10.1016/j.jhepr.2021.100280
JHEP Reports, Vol. 3 (march 2021)
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8.
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16 p, 3.5 MB |
Conservation and variability of hepatitis B core at different chronic hepatitis stages
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Yll, Marçal (Hospital Universitari Vall d'Hebron) ;
Cortese, Maria Francesca (Hospital Universitari Vall d'Hebron) ;
Guerrero-Murillo, Mercedes (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Orriols, Gerard (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Gregori i Font, Josep (Hospital Universitari Vall d'Hebron) ;
Casillas, Rosario (Hospital Universitari Vall d'Hebron) ;
González, Carolina (Hospital Universitari Vall d'Hebron) ;
Sopena, Sara (Hospital Universitari Vall d'Hebron) ;
Godoy, Cristina (Hospital Universitari Vall d'Hebron) ;
Vila, Marta (Hospital Universitari Vall d'Hebron) ;
Tabernero, David (Hospital Universitari Vall d'Hebron) ;
Quer, Josep (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rando-Segura, Ariadna (Hospital Universitari Vall d'Hebron) ;
Lopez Martinez, Rosa (Hospital Universitari Vall d'Hebron) ;
Esteban, Rafael (Esteban Mur) (Hospital Universitari Vall d'Hebron) ;
Riveiro Barciela, Mar (Hospital Universitari Vall d'Hebron) ;
Buti, Maria (Hospital Universitari Vall d'Hebron) ;
Rodriguez-Frias, Francisco (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
Since it is currently not possible to eradicate hepatitis B virus (HBV) infection with existing treatments, research continues to uncover new therapeutic strategies. HBV core protein, encoded by the HBV core gene (HBC), intervenes in both structural and functional processes, and is a key protein in the HBV life cycle. [...]
2020 - 10.3748/wjg.v26.i20.2584
World Journal of Gastroenterology, Vol. 26 (may 2020) , p. 2584-2598
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9.
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10 p, 1.0 MB |
Significant Improvement in Diagnosis of Hepatitis C Virus Infection by a One-Step Strategy in a Central Laboratory : an Optimal Tool for Hepatitis C Elimination?
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López-Martínez, Rosa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Arias-García, Andrea (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rodríguez-Algarra, Francisco (Queen Mary University of London) ;
Castellote, Laura (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rando-Segura, Ariadna (Hospital Universitari Vall d'Hebron) ;
Tarraso, Guillermo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Vargas-Accarino, Elena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Montserrat-Lloan, Isabel (Hospital Universitari Vall d'Hebron) ;
Blanco-Grau, Albert (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Caballero-Garralda, Andrea (Hospital Universitari Vall d'Hebron) ;
Ferrer Costa, Roser (Hospital Universitari Vall d'Hebron) ;
Pumarola Suñé, Tomàs (Universitat Autònoma de Barcelona) ;
Buti, Maria (Hospital Universitari Vall d'Hebron) ;
Esteban, Rafael (Esteban Mur) (Universitat Autònoma de Barcelona) ;
Quer, Josep (Hospital Universitari Vall d'Hebron) ;
Casis-Saez, Ernesto (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rodriguez-Frias, Francisco (Universitat Autònoma de Barcelona)
The remarkable effectivity of current antiviral therapies has led to consider the elimination of hepatitis C virus (HCV) infection. However, HCV infection is highly underdiagnosed; therefore, a global strategy for eliminating it requires improving the effectiveness of HCV diagnosis to identify hidden cases. [...]
2019 - 10.1128/JCM.01815-19
Journal of Clinical Microbiology, Vol. 58 (december 2019)
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10.
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18 p, 2.2 MB |
Characterization of hepatitis B virus X gene quasispecies complexity in mono-infection and hepatitis delta virus superinfection
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Godoy, Cristina (Hospital Universitari Vall d'Hebron) ;
Tabernero, David (Hospital Universitari Vall d'Hebron) ;
Sopena, Sara (Hospital Universitari Vall d'Hebron) ;
Gregori i Font, Josep (Roche Diagnostics SL) ;
Cortese, Maria Francesca (Hospital Universitari Vall d'Hebron) ;
González, Carolina (Hospital Universitari Vall d'Hebron) ;
Casillas, Rosario (Hospital Universitari Vall d'Hebron) ;
Yll, Marçal (Hospital Universitari Vall d'Hebron) ;
Rando-Segura, Ariadna (Hospital Universitari Vall d'Hebron) ;
Lopez Martinez, Rosa (Hospital Universitari Vall d'Hebron) ;
Quer, Josep (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
González-Aseguinolaza, Gloria (Clínica Universidad de Navarra. Centro de Investigación Médica Aplicada) ;
Esteban, Rafael (Esteban Mur) (Hospital Universitari Vall d'Hebron) ;
Riveiro Barciela, Mar (Hospital Universitari Vall d'Hebron) ;
Buti, Maria (Hospital Universitari Vall d'Hebron) ;
Rodriguez-Frias, Francisco (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
BACKGROUND Hepatitis delta virus (HDV) seems to strongly suppress hepatitis B virus (HBV) replication, although little is known about the mechanism of this interaction. Both these viruses show a dynamic distribution of mutants, resulting in viral quasispecies. [...]
2019 - 10.3748/wjg.v25.i13.1566
World Journal of Gastroenterology, Vol. 25 (april 2019) , p. 1566-1579
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