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14 p, 3.2 MB |
Mutations in Hepatitis D Virus Allow It to Escape Detection by CD8 + T Cells and Evolve at the Population Level
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Karimzadeh, Hadi (Department of Internal Medicine II, University Hospital Munich-Grosshadern, Munich, Germany) ;
Kiraithe, Muthamia M. (Department of Medicine II, University Hospital Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany) ;
Oberhardt, Valerie (Faculty of Biology, University of Freiburg, Freiburg, Germany) ;
Salimi Alizei, Elahe (Faculty of Chemistry and Pharmacy, University of Freiburg, Freiburg, Germany) ;
Bockmann, Jan (German Center for Infection Research (DZIF), Sites Hamburg-Lübeck-Borstel-Riems, Hannover-Braunschweig and Munich, Germany) ;
Schulze zur Wiesch, Julian (German Center for Infection Research (DZIF), Sites Hamburg-Lübeck-Borstel-Riems, Hannover-Braunschweig and Munich, Germany) ;
Budeus, Bettina (Department of Bioinformatics, University of Duisburg-Essen, Essen, Germany) ;
Hoffmann, Daniel (Department of Bioinformatics, University of Duisburg-Essen, Essen, Germany) ;
Wedemeyer, Heiner (Department of Gastroenterology and Hepatology, University Hospital of Essen, University of Duisburg-Essen, Essen, Germany) ;
Cornberg, Markus (Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany) ;
Krawczyk, Adalbert (Department of Infectious Diseases, University Hospital of Essen, University of Duisburg-Essen, Essen, Germany) ;
Rashidi-Alavijeh, Jassin (Department of Gastroenterology and Hepatology, University Hospital of Essen, University of Duisburg-Essen, Essen, Germany) ;
Rodriguez-Frias, Francisco (Hospital Universitari Vall d'Hebron) ;
Casillas, Rosario (Hospital Universitari Vall d'Hebron) ;
Buti, Maria (Hospital Universitari Vall d'Hebron) ;
Smedile, Antonina (Department of Medical Sciences, University of Turin, Turin, Italy) ;
Alavian, Seyed Moayed (Baqiyatallah Research Center for Gastroenterology and Liver Diseases, Baqiyatallah University of Medical Sciences, Tehran, Iran) ;
Heinold, Andreas (Institute of Transfusion Medicine, University Hospital of Essen, University of Duisburg-Essen, Essen, Germany) ;
Emmerich, Florian (Institute for Transfusion Medicine and Gene Therapy, University Hospital Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany) ;
Panning, Marcus (Institute of Virology, University Hospital Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany) ;
Gostick, Emma (Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom) ;
Price, David A. (Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom) ;
Timm, Jörg (Institute of Virology, Heinrich-Heine-University, University Hospital, Duesseldorf, Germany) ;
Hofmann, Maike (Department of Medicine II, University Hospital Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany) ;
Raziorrouh, Bijan (Department of Internal Medicine II, University Hospital Munich-Grosshadern, Munich, Germany) ;
Thimme, Robert (Department of Medicine II, University Hospital Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany) ;
Protzer, Ulrike (German Center for Infection Research (DZIF), Sites Hamburg-Lübeck-Borstel-Riems, Hannover-Braunschweig and Munich, Germany) ;
Roggendorf, Michael (German Center for Infection Research (DZIF), Sites Hamburg-Lübeck-Borstel-Riems, Hannover-Braunschweig and Munich, Germany) ;
Neumann-Haefelin, Christoph (Department of Medicine II, University Hospital Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany) ;
Universitat Autònoma de Barcelona
Hepatitis D virus (HDV) superinfection in patients with hepatitis B virus (HBV) is associated with rapid progression to liver cirrhosis and hepatocellular carcinoma. Treatment options are limited, and no vaccine is available. [...]
2019 -  10.1053/j.gastro.2019.02.003
Gastroenterology, Vol. 156 (may 2019) , p. 1820-1833
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4 p, 131.8 KB |
Baseline hepatitis C virus resistance-associated substitutions present at frequencies lower than 15% may be clinically significant
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Perales, Celia (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Chen, Qian (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Soria, Maria Eugenia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Gregori, Josep (Roche Diagnostics SL, Sant Cugat del Vallès, Barcelona, Spain) ;
Garcia-Cehic, Damir (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Nieto-Aponte, Leonardo (Liver Pathology Unit, Department of Biochemistry and Microbiology, HUVH, Barcelona, Spain) ;
Castells, Lluis (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Imaz, Arkaitz (Hospital Universitari de Bellvitge) ;
Llorens-Revull, Meritxell (Hospital Universitari Vall d'Hebron) ;
Domingo, Esteban (Virology and Microbiology Department, Centro de Biología Molecular "Severo Ochoa" (CSIC-UAM), Campus de Cantoblanco, Madrid, Spain) ;
Buti, Maria (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Esteban, Juan Ignacio (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Rodriguez Frias, Francisco (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Quer, Josep (Universitat Autònoma de Barcelona. Departament de Medicina)
Controversy is ongoing about whether a minority mutant present at frequencies below 15% may be clinically relevant and should be considered to guide treatment. Resistance-associated substitution (RAS) studies were performed in patients before and at failure of antiviral treatments using Next-generation hepatitis C virus (HCV) sequencing (NGS). [...]
2018 - 10.2147/IDR.S172226
Infection and drug resistance, Vol. 11 (november 2018) , p. 2207-2210
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3.
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14 p, 1.6 MB |
Randomized prospective study evaluating tenofovir disoproxil fumarate prophylaxis against hepatitis B virus reactivation in anti- HBc-positive patients with rituximab-based regimens to treat hematologic malignancies: The Preblin study
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Buti, María (Hospital Universitari Vall d'Hebron) ;
Manzano,María L. (Hospital Universitario 12 de Octubre (Madrid)) ;
Morillas Cunill, Rosa Ma. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
García-Retortillo, Montserrat (Hospital del Mar (Barcelona, Catalunya)) ;
Martín, Leticia (Hospital de Donostia (Sant Sebastià, País Basc)) ;
Prieto, Martín (Hospital Universitario y Politécnico La Fe) ;
Gutiérrez García, María Luisa (Fundación Hospital de Alcorcón) ;
Suárez, Emilio (Hospital Nuestra Señora de Balme) ;
Gómez Rubio, Mariano (Hsopital de Getafe) ;
López,Javier (Hospital Ramón y Cajal) ;
Castillo, Pilar (Hospital La Paz) ;
Rodríguez,Manuel (Hospital Central de Asturias) ;
Zozaya, José M. (Hospital de Navarra) ;
Simón, Miguel A. (Hospital Clínico Universitario "Lozano Blesa" de Zaragoza) ;
Morano Amado, Luis Enrique (Hospital do Meixoeiro) ;
Calleja, José L. (Hospital Puerta de Hierro (Madrid)) ;
Yébenes María (Pharmacoeconomics & Outcomes Research Iberia) ;
Esteban, Rafael (Esteban Mur) (Hospital Universitari Vall d'Hebron)
Background. Hepatitis B virus (HBV) reactivation in patients with resolved HBV infection (HBsAg negative, antiHBc positive) is uncommon, but potentially fatal. The role of HBV prophylaxis in this setting is uncertain. [...]
2017 - 10.1371/journal.pone.0184550
PloS one, Vol. 12 Núm. 9 (september 2017) , p. 1-14
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14 p, 1.3 MB |
Detection of hyper-conserved regions in hepatitis B virus X gene potentially useful for gene therapy
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González, Carolina (Hospital Universitari Vall d'Hebron) ;
Tabernero, David (Hospital Universitari Vall d'Hebron) ;
Cortese, Maria Francesca (Hospital Universitari Vall d'Hebron) ;
Gregori i Font, Josep (Roche Diagnostics SL) ;
Casillas, Rosario (Hospital Universitari Vall d'Hebron) ;
Riveiro Barciela, Mar (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Godoy, Cristina (Hospital Universitari Vall d'Hebron) ;
Sopena, Sara (Hospital Universitari Vall d'Hebron) ;
Rando, Ariadna (Hospital Universitari Vall d'Hebron) ;
Yll, Marçal (Hospital Universitari Vall d'Hebron) ;
Lopez Martinez, Rosa (Hospital Universitari Vall d'Hebron) ;
Quer, Josep (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Esteban, Rafael (Esteban Mur) (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Buti, Maria (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Rodriguez-Frias, Francisco (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
To detect hyper-conserved regions in the hepatitis B virus (HBV) X gene (HBX) 5' region that could be candidates for gene therapy. The study included 27 chronic hepatitis B treatment-naive patients in various clinical stages (from chronic infection to cirrhosis and hepatocellular carcinoma, both HBeAg-negative and HBeAg-positive), and infected with HBV genotypes A-F and H. [...]
2018 - 10.3748/wjg.v24.i19.2095
World Journal of Gastroenterology, Vol. 24 (may 2018) , p. 2095-2107
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14 p, 1.3 MB |
Analysis of hepatitis B virus preS1 variability and prevalence of the rs2296651 polymorphism in a Spanish population
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Casillas, Rosario (Hospital Universitari Vall d'Hebron) ;
Tabernero, David (Hospital Universitari Vall d'Hebron) ;
Gregori, Josep (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Belmonte, Irene (Hospital Universitari Vall d'Hebron) ;
Cortese, Maria Francesca (Hospital Universitari Vall d'Hebron) ;
González, Carolina (Hospital Universitari Vall d'Hebron) ;
Riveiro-Barciela, Mar ;
López, Rosa Maria (Hospital Universitari Vall d'Hebron) ;
Quer, Josep (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Esteban, Rafael ;
Buti, Maria ;
Rodriguez-Frias, Francisco (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
To determine the variability/conservation of the domain of hepatitis B virus (HBV) preS1 region that interacts with sodium-taurocholate cotransporting polypeptide (hereafter, NTCP-interacting domain) and the prevalence of the rs2296651 polymorphism (S267F, NTCP variant) in a Spanish population. [...]
2018 - 10.3748/wjg.v24.i6.680
World Journal of Gastroenterology, Vol. 24 (february 2018) , p. 680-692
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6 p, 168.2 KB |
Assessment of a Novel Automatic Real-Time PCR Assay on the Cobas 4800 Analyzer as a Screening Platform for Hepatitis C Virus Genotyping in Clinical Practice : Comparison with Massive Sequencing
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Nieto-Aponte, Leonardo (Hospital Universitari Vall d'Hebron) ;
Quer, Josep (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ruiz-Ripa, Alicia (Hospital Universitari Vall d'Hebron) ;
Tabernero, David (Hospital Universitari Vall d'Hebron) ;
Gonzalez, Carolina (Hospital Universitari Vall d'Hebron) ;
Gregori, Josep (Hospital Universitari Vall d'Hebron) ;
Vila, Marta (Hospital Universitari Vall d'Hebron) ;
Asensio, Miriam (Hospital Universitari Vall d'Hebron) ;
Garcia-Cehic, Damir (Hospital Universitari Vall d'Hebron) ;
Ruiz, Gerardo (Hospital Universitari Vall d'Hebron) ;
Chen, Qian (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ordeig, Laura (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Llorens, Meritxell (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Saez, Montserrat (Hospital Universitari Vall d'Hebron) ;
Esteban, Juan I. (Hospital Universitari Vall d'Hebron) ;
Esteban, Rafael (Hospital Universitari Vall d'Hebron) ;
Buti, Maria (Hospital Universitari Vall d'Hebron) ;
Pumarola, Tomas (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rodriguez-Frias, Francisco (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
The unequivocal identification of hepatitis C virus (HCV) subtypes 1a/1b and genotypes 2 to 6 is required for optimizing the effectiveness of interferon-free, direct-acting antiviral therapies. We compared the performance of a new real-time HCV genotyping assay used on the Cobas 4800 system (C4800) with that of high-resolution HCV subtyping (HRCS). [...]
2017 - 10.1128/JCM.01960-16
Journal of Clinical Microbiology, Vol. 55 (january 2017) , p. 504-509
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7 p, 191.5 KB |
Paracetamol in therapeutic dosages and acute liver injury : causality assessment in a prospective case series
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Sabaté, Mònica (Hospital Universitari Vall d'Hebron) ;
Ibáñez Mora, Luisa (Hospital Universitari Vall d'Hebron) ;
Pérez, Eulàlia (Hospital Universitari Vall d'Hebron) ;
Vidal Guitart, Xavier (Hospital Universitari Vall d'Hebron) ;
Buti, Maria (Hospital Universitari Vall d'Hebron) ;
Xiol, Xavier (Hospital Universitari de Bellvitge) ;
Mas, Antoni (Hospital Clínic i Provincial de Barcelona) ;
Guarner, Carlos (Institut d'Investigació Biomèdica Sant Pau) ;
Forné, Montserrat (Hospital de Mútua (Terrassa, Catalunya)) ;
Solà Lamoglia, Ricard (Hospital del Mar (Barcelona, Catalunya)) ;
Castellote, José (Hospital Universitari de Bellvitge) ;
Rigau, Joaquim (Hospital General (Granollers, Catalunya)) ;
Laporte Rosselló, Joan-Ramón (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
Background: Acute liver injury (ALI) induced by paracetamol overdose is a well known cause of emergency hospital admission and death. However, there is debate regarding the risk of ALI after therapeutic dosages of the drug. [...]
Our results indicate that paracetamol in therapeutic dosages may be considered in the causality assessment in non-alcoholic patients with liver injury, even if the estimated incidence of ALI related to paracetamol appears to be low.
2011 - 10.1186/1471-230X-11-80
BMC Gastroenterology, Vol. 11, N. 80 (July 2011) , p. 1-7
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