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11 p, 2.5 MB |
Modulation of the autophagic pathway inhibits HIV-1 infection in human lymphoid tissue cultured ex vivo
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Pedreño López, Sònia (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
García Rodríguez, Elisabet (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Guerrero, Dolores (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gomez, Elisabet (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Molina Mateu, Laura (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Orera Pérez, Fernando (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Senserrich, Jordi (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Clotet Sala, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Cabrera Navarro, Cecilia (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Universitat Autònoma de Barcelona.
Departament de Cirurgia
A complex link exists between HIV-1 and autophagy, and discordant results have been reported in different in vitro models regarding the way HIV and autophagy modulate each other. Despite this, there is very limited knowledge about the interplay between HIV and autophagy in vivo in lymphoid tissue, due in part by the lack of cell models that recapitulate the in vivo setting. [...]
2022 -  10.1038/s41598-022-11181-0
Scientific reports, Vol. 12 (may 2022)
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21 p, 9.6 MB |
Women for science and science for women : Gaps, challenges and opportunities towards optimizing pre-exposure prophylaxis for HIV-1 prevention
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Karim, Quarraisha Abdool (Department of Epidemiology, Mailman School of Public Health, Columbia University) ;
Archary, Derseree (Department of Medical Microbiology, School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal) ;
Barré-Sinoussi, Françoise (Institut Pasteur) ;
Broliden, Kristina (Karolinska Institutet (Estocolm, Suècia)) ;
Cabrera Navarro, Cecilia (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Chiodi, Francesca (Karolinska Institutet (Estocolm, Suècia)) ;
Fidler, Sarah J. (Imperial College London) ;
Gengiah, Tanuja N. (Centre for the AIDS Programme of Research in South Africa (CAPRISA)) ;
Herrera, Carolina (Imperial College London) ;
Kharsany, Ayesha B. M. (University of KwaZulu-Natal) ;
Liebenberg, Lenine J. P. (University of KwaZulu-Natal) ;
Mahomed, Sharana (University of KwaZulu-Natal) ;
Menu, Elisabeth (Institut Pasteur) ;
Moog, Christiane (Université de Strasbourg) ;
Scarlatti, Gabriella (IRCCS Ospedale San Raffaele) ;
Seddiki, Nabila (Université Paris-Saclay) ;
Sivro, Aida (Public Health Agency of Canada) ;
Cavarelli, Mariangela (Université Paris-Saclay) ;
Universitat Autònoma de Barcelona
Preventing new HIV infections remains a global challenge. Young women continue to bear a disproportionate burden of infection. Oral pre-exposure prophylaxis (PrEP), offers a novel women-initiated prevention technology and PrEP trials completed to date underscore the importance of their inclusion early in trials evaluating new HIV PrEP technologies. [...]
2022 - 10.3389/fimmu.2022.1055042
Frontiers in immunology, Vol. 13 (december 2022)
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1 p, 662.8 KB |
Author Correction : Modulation of the autophagic pathway inhibits HIV-1 infection in human lymphoid tissue cultured ex vivo
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Pedreño‑López, Sònia (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
García Rodríguez, Elisabet (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Guerrero, Dolores (Institut Germans Trias i Pujol) ;
Gómez‑Mora, Elisabet (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Mateu, Laura Molina (Institut Germans Trias i Pujol) ;
Pérez, Fernando Orera (Institut Germans Trias i Pujol) ;
Senserrich, Jordi (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Clotet Sala, Bonaventura (Universitat de Vic - Universitat Central de Catalunya) ;
Cabrera Navarro, Cecilia (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
2023 - 10.1038/s41598-023-30114-z
Scientific reports, Vol. 13 (february 2023)
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4.
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16 p, 7.2 MB |
Remodeling the bladder tumor immune microenvironment by mycobacterial species with changes in their cell envelope composition
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Senserrich, Jordi (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Guallar Garrido, Sandra (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Gomez-Mora, Elisabet (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Urrea, Víctor (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Clotet Sala, Bonaventura (Centro de Investigación Biomédica en Red de Enfermedades Infecciosas) ;
Julián Gómez, Esther (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Cabrera Navarro, Cecilia (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
Intravesical BCG instillation after bladder tumor resection is the standard treatment for non-muscle invasive bladder cancer; however, it is not always effective and frequently has undesirable side effects. [...]
2022 - 10.3389/fimmu.2022.993401
Frontiers in immunology, Vol. 13 (october 2022)
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5.
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0 p, 3.1 MB |
Mycobacterial surface characters remodeled by growth conditions drive different tumor-infiltrating cells and systemic IFN-γ/IL-17 release in bladder cancer treatment
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Guallar Garrido, Sandra (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Campo Pérez, Víctor (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Pérez-Trujillo, Míriam (Universitat Autònoma de Barcelona. Departament de Química) ;
Cabrera Navarro, Cecilia (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Senserrich, Jordi (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Sánchez Chardi, Alejandro (Universitat Autònoma de Barcelona. Servei de Microscòpia) ;
Rabanal Prados, Rosa Ma (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ;
Gomez, Elisabet (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Noguera-Ortega, Estela (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Luquín Fernández, M. (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Julián Gómez, Esther (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
The mechanism of action of intravesical Mycobacterium bovis BCG immunotherapy treatment for bladder cancer is not completely known, leading to misinterpretation of BCG-unresponsive patients, who have scarce further therapeutic options. [...]
2022 - 10.1080/2162402X.2022.2051845
Oncoimmunology, Vol. 11, Issue 1 (March 2022) , art. e2051845
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6.
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15 p, 2.9 MB |
Susceptibility of Human Lymphoid Tissue Cultured ex vivo to Xenotropic Murine Leukemia Virus-Related Virus (XMRV) Infection
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Curriu Martí, Marta (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Carrillo, Jorge (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Massanella, Marta (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
García Rodríguez, Elisabet (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Cunyat, Francesc (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Peña, Ruth (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Wienberg, Peter (Hospital Sant Joan de Déu (Barcelona, Catalunya)) ;
Carrato, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Areal, Joan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bofill, Margarita (Institució Catalana de Recerca i Estudis Avançats) ;
Clotet Sala, Bonaventura (Institut Germans Trias i Pujol. Fundació de Lluita Contra la Sida) ;
Blanco, Julià (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Cabrera Navarro, Cecilia (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Universitat Autònoma de Barcelona
Xenotropic murine leukemia virus-related virus (XMRV) was generated after a recombination event between two endogenous murine leukemia viruses during the production of a prostate cancer cell line. Although the associations of the XMRV infection with human diseases appear unlikely, the XMRV is a retrovirus of undefined pathogenic potential, able to replicate in human cells in vitro. [...]
2012 - 10.1371/journal.pone.0037415
PloS one, Vol. 7 (may 2012)
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11 p, 946.6 KB |
Viremic HIV Infected Individuals with High CD4 T Cells and Functional Envelope Proteins Show Anti-gp41 Antibodies with Unique Specificity and Function
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Curriu Martí, Marta (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Fausther-Bovendo, Hughes (Université Paris-6, France) ;
Pernas, María (Centro Nacional de Microbiología (Espanya)) ;
Massanella, Marta (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Carrillo, Jorge (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Cabrera Navarro, Cecilia (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
López-Galíndez, Cecilio (Centro Nacional de Microbiología (Espanya)) ;
Clotet Sala, Bonaventura (Institut Germans Trias i Pujol. Fundació de Lluita Contra la Sida) ;
Debré, Patrice (Université Paris-6, France) ;
Vieillard, Vincent (Université Paris-6, France) ;
Blanco, Julià (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Universitat Autònoma de Barcelona
CD4 T-cell decay is variable among HIV-infected individuals. In exceptional cases, CD4 T-cell counts remain stable despite high plasma viremia. HIV envelope glycoprotein (Env) properties, namely tropism, fusion or the ability to induce the NK ligand NKp44L, or host factors that modulate Env cytopathic mechanisms may be modified in such situation. [...]
2012 - 10.1371/journal.pone.0030330
PloS one, Vol. 7 (february 2012)
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12 p, 630.4 KB |
HIV-1 Tropism Testing in Subjects Achieving Undetectable HIV-1 RNA : Diagnostic Accuracy, Viral Evolution and Compartmentalization
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Pou, Christian (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Codoñer, Francisco M. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Thielen, Alexander (Max-Planck-Institut für Informatik, Saarbücken, Germany) ;
Bellido, Rocío (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Pérez-Álvarez, Susana (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Cabrera Navarro, Cecilia (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Dalmau, Judith (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Curriu Martí, Marta (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Lie, Yolanda (Monogram Biosciences Inc., South San Francisco, California, United States of America) ;
Noguera-Julian, Marc (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Puig, Jordi (Institut Germans Trias i Pujol. Fundació de Lluita Contra la Sida) ;
Martínez-Picado, Javier (Institució Catalana de Recerca i Estudis Avançats) ;
Blanco, Julià (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Coakley, Eoin (Monogram Biosciences Inc., South San Francisco, California, United States of America) ;
Däumer, Martin (Institut für Immunologie und Genetik, Kaiserlautern, Germany) ;
Clotet Sala, Bonaventura (Institut Germans Trias i Pujol. Fundació de Lluita Contra la Sida) ;
Paredes, Roger (Institut Germans Trias i Pujol. Fundació de Lluita Contra la Sida) ;
Universitat Autònoma de Barcelona
Technically, HIV-1 tropism can be evaluated in plasma or peripheral blood mononuclear cells (PBMCs). However, only tropism testing of plasma HIV-1 has been validated as a tool to predict virological response to CCR5 antagonists in clinical trials. [...]
2013 - 10.1371/journal.pone.0067085
PloS one, Vol. 8 (august 2013)
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13 p, 1.3 MB |
Functional Analyses Reveal Extensive RRE Plasticity in Primary HIV-1 Sequences Selected under Selective Pressure
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Cunyat, Francesc (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Beerens, Nancy (Aarhus University, Aarhus, Denmark) ;
García Rodríguez, Elisabet (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Clotet Sala, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Kjems, Jørgen (Aarhus University, Aarhus, Denmark) ;
Cabrera Navarro, Cecilia (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Universitat Autònoma de Barcelona
HIV-1 Rev response element (RRE) is a functional region of viral RNA lying immediately downstream to the junction of gp120 and gp41 in the env coding sequence. The RRE is essential for HIV replication and binds with the Rev protein to facilitate the export of viral mRNA from nucleus to cytoplasm. [...]
2014 - 10.1371/journal.pone.0106299
PloS one, Vol. 9 (august 2014)
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17 p, 9.8 MB |
Elevated humoral response to cytomegalovirus in HIV-infected individuals with poor CD4 + T-cell immune recovery
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Gomez, Elisabet (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Massanella, Marta (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
García Rodríguez, Elisabet (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Giles, David (Biokit, Lliçà d'Amunt) ;
Bernadó, Marta (Biokit, Lliçà d'Amunt) ;
Urrea, Victor (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Carrillo, Jorge (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ouchi, Dan (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Puig, Jordi (Institut Germans Trias i Pujol. Fundació de Lluita Contra la Sida) ;
Negredo Puigmal, Eugènia (Institut Germans Trias i Pujol. Fundació de Lluita Contra la Sida) ;
Clotet Sala, Bonaventura (Institut Germans Trias i Pujol. Fundació de Lluita Contra la Sida) ;
Blanco, Julià (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Cabrera Navarro, Cecilia (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Some HIV-infected c-ART-suppressed individuals show incomplete CD4 + T-cell recovery, abnormal T-cell activation and higher mortality. One potential source of immune activation could be coinfection with cytomegalovirus (CMV). [...]
2017 - 10.1371/journal.pone.0184433
PloS one, Vol. 12 (september 2017)
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