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15 p, 4.7 MB |
Is Age the Most Important Risk Factor in COVID-19 Patients? The Relevance of Comorbidity Burden : A Retrospective Analysis of 10,551 Hospitalizations
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Valero-Bover, Damià (Institut d'Investigació Biomèdica de Bellvitge) ;
Monterde, David (Institut d'Investigació Biomèdica de Bellvitge) ;
Carot-Sans, Gerard (Institut d'Investigació Biomèdica de Bellvitge) ;
Cainzos-Achirica, Miguel (Johns Hopkins Medical Institutions) ;
Comín-Colet, Josep (Institut d'Investigació Biomèdica de Bellvitge) ;
Vela, Emili (Institut d'Investigació Biomèdica de Bellvitge) ;
Cleries, Montserrat (Institut d'Investigació Biomèdica de Bellvitge) ;
Folguera, Júlia (Institut d'Investigació Biomèdica de Bellvitge) ;
Abilleira i Castells, Sònia (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
Arrufat, Miquel (Institut Català de la Salut) ;
Lejardi, Yolanda (Institut Català de la Salut) ;
Solans, Òscar (Institut d'Investigació Biomèdica de Bellvitge) ;
Dedeu, Toni (WHO European Centre for Primary Health Care) ;
Coca, Marc (Institut d'Investigació Biomèdica de Bellvitge) ;
Pérez-Sust, Pol (Institut Català de la Salut) ;
Pontes García, Caridad (Institut d'Investigació Biomèdica de Bellvitge) ;
Piera-Jiménez, Jordi (Institut d'Investigació Biomèdica de Bellvitge) ;
Universitat Autònoma de Barcelona
To assess the contribution of age and comorbidity to the risk of critical illness in hospitalized COVID-19 patients using increasingly exhaustive tools for measuring comorbidity burden. We assessed the effect of age and comorbidity burden in a retrospective, multicenter cohort of patients hospitalized due to COVID-19 in Catalonia (North-East Spain) between March 1, 2020, and January 31, 2022. [...]
2023 -  10.2147/CLEP.S408510
Clinical Epidemiology, Vol. 15 (june 2023) , p. 811-825
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2.
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14 p, 535.9 KB |
Clinical Determinants and Prognosis of Left Ventricular Reverse Remodelling in Non-Ischemic Dilated Cardiomyopathy
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Díez-López, Carles (Universitat de Barcelona. Departament de Medicina) ;
Salazar-Mendiguchía, Joel (Hospital Universitari de Bellvitge. Servei de Cardiologia) ;
García-Romero, Elena (Institut d'Investigació Biomèdica de Bellvitge) ;
Fuentes, Lara (Institut d'Investigació Biomèdica de Bellvitge) ;
Lupón, Josep (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
Bayés-Genís, Antoni (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
Manito, Nicolás (Hospital Universitari de Bellvitge. Servei de Cardiologia) ;
de Antonio Ferrer, Marta (Institut d'Investigació Biomèdica Sant Pau) ;
Moliner, Pedro (Programa d'insuficiència cardíaca comunitària. Hospital Universitari de Bellvitge. Servei de Cardiologia) ;
Zamora, Elisabet (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
Catalá-Ruiz, Pablo (Institut d'Investigació Biomèdica de Bellvitge) ;
Cainzos-Achirica, Miguel (RTI Health Solutions. Pharmacoepidemiology and Risk Management) ;
Comín-Colet, Josep (Programa d'insuficiència cardíaca comunitària. Hospital Universitari de Bellvitge. Servei de Cardiologia) ;
González-Costello, José (Universitat de Barcelona. Departament de Medicina)
Aims: Non-ischaemic dilated cardiomyopathy (NIDCM) is characterized by left ventricular (LV) chamber enlargement and systolic dysfunction in the absence of coronary artery disease. Left ventricular reverse remodelling (LVRR) is the ability of a dilated ventricle to restore its normal size, shape and function. [...]
2022 - 10.3390/jcdd9010020
Journal of Cardiovascular Development and Disease, Vol. 9 Núm. 1 (january 2022) , p. 20
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3.
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13 p, 720.0 KB |
Real world heart failure epidemiology and outcome : A population-based analysis of 88,195 patients
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Farré, Núria (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Vela, Emili (Institut Català de la Salut) ;
Cleries, Montserrat (Institut Català de la Salut) ;
Bustins, Montse (Institut Català de la Salut) ;
Cainzos-Achirica, Miguel (Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, Maryland, United States of America) ;
Enjuanes, Cristina (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Moliner, Pedro (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Ruiz, Sonia (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Verdú-Rotellar, José María (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Comín-Colet, Josep (Institut d'Investigació Biomèdica de Bellvitge)
Heart failure (HF) is frequent and its prevalence is increasing. We aimed to evaluate the epidemiologic features of HF patients, the 1-year follow-up outcomes and the independent predictors of those outcomes at a population level. [...]
2017 - 10.1371/journal.pone.0172745
PloS one, Vol. 12 (february 2017)
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4.
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14 p, 672.9 KB |
Validation of the Spanish version of the questionnaire on Patient Empowerment in Long-Term Conditions
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Garcimartin, Paloma (Parc de Salut MAR de Barcelona) ;
Comín-Colet, Josep (Universitat de Barcelona. Departament de Ciències Clíniques) ;
Pardo Cladellas, Yolanda (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Badosa, Neus (Parc de Salut MAR de Barcelona) ;
Linas, Anna (Parc de Salut MAR de Barcelona) ;
Rosenfeld, Laia (Hospital Universitari de Bellvitge) ;
Faraudo, Merçe (Hospital de Sant Joan Despí Moisès Broggi) ;
Valero, Oliver (Universitat Autònoma de Barcelona. Departament de Matemàtiques) ;
Hidalgo, Encarnación (Hospital Universitari de Bellvitge) ;
Cainzos-Achirica, Miguel (Hospital Universitari de Bellvitge) ;
Ruiz, Sonia (Institut Parc de Salut MAR de Barcelona) ;
Delgado-Hito, Pilar (Universitat de Barcelona)
Patient empowerment is a key factor in improving health outcomes. To evaluate the psychometric properties of the Spanish version of the questionnaire on Patient Empowerment in Long-Term Conditions (PELC) that evaluates the degree of empowerment of patients with chronic diseases. [...]
2020 - 10.1371/journal.pone.0233338
PloS one, Vol. 15 (june 2020)
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5.
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10 p, 429.3 KB |
Association Between Norepinephrine Levels and Abnormal Iron Status in Patients With Chronic Heart Failure : Is Iron Deficiency More Than a Comorbidity?
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Moliner, Pedro (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Enjuanes, Cristina (Hospital Universitari de Bellvitge) ;
Tajes, Marta (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Cainzos-Achirica, Miguel (Hospital Universitari de Bellvitge) ;
Lupón, Josep (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Garay, Alberto (Hospital Universitari de Bellvitge) ;
Jimenez-Marrero, Santiago (Institut d'Investigació Biomèdica de Bellvitge) ;
Yun, Sergi (Institut d'Investigació Biomèdica de Bellvitge) ;
Farré, Núria (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Cladellas Capdevila, Mercè (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Díez, Carles (Institut d'Investigació Biomèdica de Bellvitge) ;
Gonzalez-Costello, Jose (Institut d'Investigació Biomèdica de Bellvitge) ;
Comín-Colet, Josep (Hospital Universitari de Bellvitge)
Mechanisms underlying iron homeostasis dysregulation in patients with chronic heart failure remain unsettled. In cardiomyocyte models, norepinephrine may lead to intracellular iron depletion, but the potential association between catecholamines (sympathetic activation markers) and iron metabolism biomarkers in chronic heart failure is unknown. [...]
2019 - 10.1161/JAHA.118.010887
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol. 8 (february 2019)
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11 p, 2.8 MB |
Management of Heart Failure with Reduced Ejection Fraction after ESC 2016 Heart Failure Guidelines : The Linx Registry
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De Frutos, Fernando (Hospital Universitari de Bellvitge) ;
Mirabet Pérez, Sonia (Institut d'Investigació Biomèdica Sant Pau) ;
Ortega-Paz, Luis (Hospital Clínic i Provincial de Barcelona) ;
Buera Surribas, Irene (Hospital de Viladecans) ;
Darnés, Sara (Hospital de Figueres) ;
Farré, Núria (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Perez, Bernardo (Hospital General de Granollers) ;
Adeliño, Raquel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bascompte, Ramón (Hospital Arnau de Vilanova (Lleida, Catalunya)) ;
Pérez-Rodón, Jordi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Aparicio, Xavier (Hospital de Mataró. Consorci Sanitari del Maresme) ;
Sutil-Vega, Mario (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Soto, Adriana (Hospital de Martorell) ;
Faraudo, Mercedes (Hospital de Sant Joan Despí Moisès Broggi) ;
Cainzos-Achirica, Miguel (Hospital Universitari de Bellvitge) ;
Manito, Nicolás (Hospital Universitari de Bellvitge) ;
Universitat Autònoma de Barcelona
In May 2016, a new version of the European Society of Cardiology (ESC) Guidelines for the management of heart failure (HF) was released. The aim of this study was to describe the management of HF with reduced ejection fraction after the publication of ESC Guidelines. [...]
2020 - 10.1002/ehf2.12567
ESC Heart Failure, Vol. 7 (january 2020) , p. 25-35
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11 p, 1.2 MB |
Antidepressant use in Denmark, Germany, Spain, and Sweden between 2009 and 2014 : Incidence and comorbidities of antidepressant initiators
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Forns, Joan (RTI Health Solutions. Epidemiology) ;
Pottegård, Anton (Clinical Pharmacology and Pharmacy. Department of Public Health. University of Southern Denmark) ;
Reinders, Tammo (Leibniz Institute for Prevention Research and Epidemiology-BIPS) ;
Poblador-Plou, Beatriz (Instituto de Investigación Sanitaria de Aragón) ;
Morros, Rosa (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Brandt, Lena (Centre for Pharmacoepidemiology. Department of Medicine. Solna. Karolinska Institutet. Karolinska University Hospital) ;
Cainzos-Achirica, Miguel (Epidemiology. RTI Health Solutions) ;
Hellfritzsch, Maja (Clinical Pharmacology and Pharmacy. Department of Public Health. University of Southern Denmark) ;
Schink, Tania (Leibniz Institute for Prevention Research and Epidemiology-BIPS) ;
Prados-Torres, Alexandra (Instituto de Investigación Sanitaria de Aragón) ;
Giner-Soriano, Maria (Institut Català de la Salut) ;
Hägg, David (Centre for Pharmacoepidemiology. Department of Medicine. Solna. Karolinska Institutet. Karolinska University Hospital) ;
Hallas, Jesper (Clinical Pharmacology and Pharmacy. Department of Public Health. University of Southern Denmark) ;
Cortés, Jordi (Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa) ;
Jacquot, Emmanuelle (Pharmacoepidemiology Department. Les Laboratoires Servier) ;
Deltour, Nicolas (Pharmacoepidemiology Department. Les Laboratoires Servier) ;
Perez-Gutthann, S. (Epidemiology. RTI Health Solutions) ;
Pladevall-Vila, Manel (Epidemiology. RTI Health Solutions) ;
Reutfors, Johan (Centre for Pharmacoepidemiology. Department of Medicine. Solna. Karolinska Institutet. Karolinska University Hospital)
Background: We aimed to describe patterns of use and characteristics of 10 commonly used antidepressants for the period 2009-2014 in Denmark, Germany, Spain, and Sweden. Methods: Adult initiators from 2009 to 2014 of each study antidepressant were identified in four countries using five data sources: the Danish National registers, GePaRD (Germany), EpiChron (Aragon, Spain), SIDIAP (Catalonia, Spain), and the Swedish National Registers. [...]
2019 - 10.1016/j.jad.2019.02.010
Journal of Affective Disorders, Vol. 249 (April 2019) , p. 242-252
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8.
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13 p, 786.0 KB |
Risk of Acute Liver Injury in Agomelatine and Other Antidepressant Users in Four European Countries : A Cohort and Nested Case-Control Study Using Automated Health Data Sources
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Pladevall-Vila, Manel (Epidemiology. RTI Health Solutions) ;
Pottegård, Anton (Clinical Pharmacology and Pharmacy. Department of Public Health. University of Southern Denmark) ;
Schink, Tania (Leibniz Institute for Prevention Research and Epidemiology-BIPS) ;
Reutfors, Johan (Centre for Pharmacoepidemiology. Department of Medicine. Solna. Karolinska Institutet. Karolinska University Hospital) ;
Morros, Rosa. (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Poblador-Plou, Beatriz (Instituto de Investigación Sanitaria de Aragón) ;
Timmer, Antje (Division of Epidemiology and Biometry. Medical Faculty. Carl von Ossietzky University) ;
Forns, Joan (Epidemiology. RTI Health Solutions) ;
Hellfritzsch, Maja (Clinical Pharmacology and Pharmacy. Department of Public Health. University of Southern Denmark) ;
Reinders, Tammo (Leibniz Institute for Prevention Research and Epidemiology-BIPS) ;
Hägg, David (Centre for Pharmacoepidemiology. Department of Medicine. Solna. Karolinska Institutet. Karolinska University Hospital) ;
Giner-Soriano, Maria (Institut Català de la Salut) ;
Prados-Torres, Alexandra (Instituto de Investigación Sanitaria de Aragón) ;
Cainzos-Achirica, Miguel (Epidemiology. RTI Health Solutions) ;
Hallas, Jesper (Clinical Pharmacology and Pharmacy. Department of Public Health. University of Southern Denmark) ;
Brandt, Lena (Centre for Pharmacoepidemiology. Department of Medicine. Solna. Karolinska Institutet. Karolinska University Hospital) ;
Cortés, Jordi (Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa) ;
Aguado, Jaume (Epidemiology. RTI Health Solutions) ;
Perlemuter, Gabriel (INSERM U996) ;
Falissard, Bruno (CESP INSERM U1018. Université Paris-Saclay. Université Paris-Sud. UVSQ. APHP) ;
Castellsague, Jordi (Epidemiology. RTI Health Solutions) ;
Jacquot, Emmanuelle (Pharmacoepidemiology Department. Servier) ;
Deltour, Nicolas (Pharmacoepidemiology Department. Servier) ;
Perez-Gutthann, S. (Epidemiology. RTI Health Solutions)
Background: Agomelatine is a melatonin receptor agonist and serotonin 5-HT receptor antagonist indicated for depression in adults. Hepatotoxic reactions like acute liver injury (ALI) are an identified risk in the European risk management plan for agomelatine. [...]
2019 - 10.1007/s40263-019-00611-9
CNS Drugs, Vol. 33 Núm. 4 (april 2019) , p. 383-395
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9.
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11 p, 536.7 KB |
Validity of ICD-9 and ICD-10 codes used to identify acute liver injury : A study in three European data sources
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Forns, Joan (RTI Health Solutions) ;
Cainzos-Achirica, Miguel (RTI Health Solutions) ;
Hellfritzsch, Maja (Clinical Pharmacology and Pharmacy. Department of Public Health. University of Southern Denmark) ;
Morros, Rosa (Universitat Autònoma de Barcelona) ;
Poblador-Plou, Beatriz (Instituto de Investigación Sanitaria de Aragón) ;
Hallas, Jesper (Clinical Pharmacology and Pharmacy. Department of Public Health. University of Southern Denmark) ;
Giner-Soriano, Maria (Universitat Autònoma de Barcelona) ;
Prados-Torres, Alexandra (Instituto de Investigación Sanitaria de Aragón) ;
Pottegård, Anton (Clinical Pharmacology and Pharmacy. Department of Public Health. University of Southern Denmark) ;
Cortés, Jordi (Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa) ;
Castellsague, Jordi (RTI Health Solutions) ;
Jacquot, Emmanuelle (Pharmacoepidemiology Department. Les Laboratoires Servier) ;
Deltour, Nicolas (Pharmacoepidemiology Department. Les Laboratoires Servier) ;
Perez-Gutthann, S. (RTI Health Solutions) ;
Pladevall-Vila, Manel (RTI Health Solutions)
Purpose: Validating cases of acute liver injury (ALI) in health care data sources is challenging. Previous validation studies reported low positive predictive values (PPVs). Methods: Case validation was undertaken in a study conducted from 2009 to 2014 assessing the risk of ALI in antidepressants users in databases in Spain (EpiChron and SIDIAP) and the Danish National Health Registers. [...]
2019 - 10.1002/pds.4803
Pharmacoepidemiology and Drug Safety, Vol. 28 Núm. 7 (july 2019) , p. 965-975
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