Results overview: Found 7 records in 0.03 seconds.
Articles, 7 records found
Articles 7 records found  
1.
2 p, 313.7 KB Correction to : The Small GTPase RAC1/CED-10 Is Essential in Maintaining Dopaminergic Neuron Function and Survival Against α-Synuclein-Induced Toxicity / Kim, Hanna (The University of Alabama. Department of Biological Sciences) ; Calatayud, Carles (Institut d'Investigació Biomèdica de Bellvitge) ; Guha, Sanjib (Buck Institute for Age Research) ; Fernandez Carasa, Irene (Universitat de Barcelona. Institut de Biomedicina) ; Berkowitz, Laura (University of Alabama. Department of Biological Sciences) ; Carballo-Carbajal, Iria (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Ezquerra, Mario (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Fernández-Santiago, Rubén (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Kapahi, Pankaj (Buck Institute for Age Research) ; Raya, Ángel (Institució Catalana de Recerca i Estudis Avançats) ; Miranda Vizuete, Antonio (Instituto de Biomedicina de Sevilla) ; Lizcano de Vega, José Miguel (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Vila Bover, Miquel (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Caldwell, Kim A. (University of Alabama. Department of Biological Sciences) ; Caldwell, Guy A. (University of Alabama. Department of Biological Sciences) ; Consiglio, Antonella (Università degli Studi di Brescia. Dipartimento di Medicina Molecolare e Traslazionale) ; Dalfo, Esther (Universitat Autònoma de Barcelona. Institut de Neurociències)
2018 - 10.1007/s12035-018-1010-3
Molecular neurobiology, Vol. 55 (april 2018) , p. 7553-7554  
2.
4 p, 1.5 MB Intracellular crowding by age-dependent neuromelanin accumulation disrupts neuronal proteostasis and triggers Parkinson disease pathology / Vila Bover, Miquel (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Laguna, Ariadna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Carballo-Carbajal, Iria (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Universitat Autònoma de Barcelona
In Parkinson disease (PD), there is a preferential degeneration of neurons that contain the dark-brown cytoplasmic pigment neuromelanin, in particular dopaminergic neurons of the substantia nigra (SN), the loss of which leads to the typical motor symptoms of the disease and constitutes the cardinal pathological diagnostic criterion for PD. [...]
2019 - 10.1080/15548627.2019.1659621
Autophagy, Vol. 15 (september 2019) , p. 2028-2030  
3.
14 p, 1.2 MB Advances in Parkinson's Disease : 200 Years Later / Del Rey, Natalia López-González (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Quiroga-Varela, Ana (Department of Neuroscience, Centro de Investigación Médica Aplicada (CIMA), University of Navarra) ; Garbayo, Elisa (Instituto de Investigación Sanitaria de Navarra) ; Carballo-Carbajal, Iria (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Fernández-Santiago, Rubén (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Monje, Mariana H. G. (Universidad Autónoma de Madrid. Departamento de Anatomía, Histología y Neurociencia) ; Trigo-Damas, Inés (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Blanco-Prieto, María J. (Instituto de Investigación Sanitaria de Navarra) ; Blesa, Javier (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Universitat Autònoma de Barcelona
When James Parkinson described the classical symptoms of the disease he could hardly foresee the evolution of our understanding over the next two hundred years. Nowadays, Parkinson's disease is considered a complex multifactorial disease in which genetic factors, either causative or susceptibility variants, unknown environmental cues, and the potential interaction of both could ultimately trigger the pathology. [...]
2018 - 10.3389/fnana.2018.00113
Frontiers in Neuroanatomy, Vol. 12 (december 2018)  
4.
19 p, 6.1 MB Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson's disease pathogenesis / Carballo-Carbajal, Iria (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Laguna, Ariadna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Romero-Giménez, Jordi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Cuadros, Thais (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Bové, Jordi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Martinez-Vicente, M. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Parent, Annabelle (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Gonzalez-Sepulveda, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Peñuelas, Núria (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Torra, Albert (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Rodríguez-Galván, Beatriz (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Ballabio, Andrea (Telethon Institute of Genetics and Medicine (TIGEM)) ; Hasegawa, Takafumi (Department of Neurology. Tohoku University School of Medicin) ; Bortolozzi, Analía (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Gelpi, Ellen (Institute of Neurology. Medical University of Vienna) ; Vila Bover, Miquel (Institució Catalana de Recerca i Estudis Avançats) ; Universitat Autònoma de Barcelona
2019 - 10.1038/s41467-019-08858-y
Nature communications, Vol. 10 Núm. 1 (january 2019) , p. 973  
5.
20 p, 8.2 MB The small GTPase RAC1/CED-10 is essential in maintaining dopaminergic neuron function and survival against α-synuclein-induced toxicity / Kim, Hanna (University of Alabama. Department of Biological Sciences) ; Calatayud, Carles (Institut d'Investigació Biomèdica de Bellvitge) ; Guha, Sanjib (Buck Institute for Age Research) ; Fernandez Carasa, Irene (Universitat de Barcelona. Institut de Biomedicina) ; Berkowitz, Laura (University of Alabama. Department of Biological Sciences) ; Carballo-Carbajal, Iria (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Ezquerra, Mario (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Fernández-Santiago, Rubén (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Kapahi, Pankaj (Buck Institute for Age Research) ; Raya, Ángel (Institució Catalana de Recerca i Estudis Avançats) ; Miranda Vizuete, Antonio (Instituto de Biomedicina de Sevilla) ; Lizcano de Vega, José Miguel (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Vila Bover, Miquel (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Caldwell, Kim A. (University of Alabama. Department of Biological Sciences) ; Caldwell, Guy A. (University of Alabama. Department of Biological Sciences) ; Consiglio, Antonella (Università degli Studi di Brescia. Dipartimento di Medicina Molecolare e Traslazionale) ; Dalfo, Esther (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Parkinson's disease is associated with intracellular α-synuclein accumulation and ventral midbrain dopaminergic neuronal death in the Substantia Nigra of brain patients. The Rho GTPase pathway, mainly linking surface receptors to the organization of the actin and microtubule cytoskeletons, has been suggested to participate to Parkinson's disease pathogenesis. [...]
2018 - 10.1007/s12035-018-0881-7
Molecular neurobiology, Vol. 55, issue 9 (Sep. 2018) , p. 7533-7552  
6.
9 p, 2.0 MB Lack of pathogenic potential of peripheral α-synuclein aggregates from Parkinson's disease patients / Recasens, Ariadna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Carballo-Carbajal, Iria (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Parent, Annabelle (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Bové, Jordi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Gelpi, Ellen (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Tolosa, Eduardo (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Vila Bover, Miquel (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
The online version of this article (10. 1186/s40478-018-0509-1) contains supplementary material, which is available to authorized users.
2018 - 10.1186/s40478-018-0509-1
Acta neuropathologica communications, Vol. 6 (february 2018)  
7.
18 p, 2.2 MB Aberrant epigenome in -derived dopaminergic neurons from Parkinson's disease patients / Fernández-Santiago, Rubén (Universitat de Barcelona) ; Carballo-Carbajal, Iria (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Castellano, Giancarlo (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Torrent, Roger (Universitat de Barcelona. Institut de Biomedicina) ; Richaud, Yvonne (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ; Sánchez-Danés, Adriana (Universitat de Barcelona. Institut de Biomedicina) ; Vilarrasa-Blasi, Roser (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Sánchez-Pla, Alex (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Mosquera, José Luis (Universitat de Barcelona) ; Soriano, Jordi (Universitat de Barcelona) ; López-Barneo, José (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ; Canals, Josep M (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Alberch i Vié, Jordi (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Raya, Ángel (Institució Catalana de Recerca i Estudis Avançats) ; Vila Bover, Miquel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Consiglio, Antonella (University of Brescia and National Institute of Neuroscience) ; Martín-Subero, José I (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Ezquerra, Mario (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Tolosa, Eduardo (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Universitat Autònoma de Barcelona
The epigenomic landscape of Parkinson's disease () remains unknown. We performed a genomewide methylation and a transcriptome studies in induced pluripotent stem cell ()-derived dopaminergic neurons (n) generated by cell reprogramming of somatic skin cells from patients with monogenic 2-associated (L2) or sporadic (), and healthy subjects. [...]
2015 - 10.15252/emmm.201505439
EMBO Molecular Medicine, Vol. 7, Núm. 12 (October 2015) , p. 1529-1546  

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