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14 p, 1.8 MB |
The yeast Aft2 transcription factor determines selenite toxicity by controlling the low affinity phosphate transport system
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Pérez-Sampietro, Maria (Universitat de Lleida. Departament de Ciències Mèdiques Bàsiques) ;
Serra Cardona, Albert (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Canadell, David (Universitat Autònoma de Barcelona. Institut de Biotecnologia i Biomedicina) ;
Casas, Celia (Universitat de Lleida. Departament de Ciències Mèdiques Bàsiques) ;
Ariño Carmona, Joaquín (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ;
Herrero, Enrique (Universitat de Lleida. Departament de Ciències Mèdiques Bàsiques)
The yeast Saccharomyces cerevisiae is employed as a model to study the cellular mechanisms of toxicity and defense against selenite, the most frequent environmental selenium form. We show that yeast cells lacking Aft2, a transcription factor that together with Aft1 regulates iron homeostasis, are highly sensitive to selenite but, in contrast to aft1 mutants, this is not rescued by iron supplementation. [...]
2016 -  10.1038/srep32836
Scientific reports, Vol. 6 (2016) , art. 32836
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15 p, 1.1 MB |
Pemetrexed/Carboplatin/Bevacizumab followed by maintenance Pemetrexed/Bevacizumab in hispanic patients with non-squamous non-small cell lung cancer: outcomes according to Thymidylate Synthase Expression
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Cardona, Andrés Felipe (Clínica del Country (Bogotà, Colòmbia)) ;
Rojas, Leonardo (Fundación de Investigación Clínica y Molecular en Cáncer (Bogotà, Colòmbia)) ;
Wills, Beatriz (Clínica del Country (Bogotà, Colòmbia)) ;
Arrieta, Oscar (Instituto Nacional de Cancerología (Ciutat de Mèxic)) ;
Carranza, Hernán (Clínica del Country (Bogotà, Colòmbia)) ;
Vargas, Carlos (Clínica del Country (Bogotà, Colòmbia)) ;
Otero, Jorge (Clínica del Country (Bogotà, Colòmbia)) ;
Cuello, Mauricio (Hospital de Clínicas Dr. Manuel Quintela (Montevideo, Uruguay)) ;
Corrales, Luis (Hospital San Juan de Dios (San José, Costa Rica)) ;
Martín, Claudio (Instituto Alexander Fleming (Buenos Aires, Argentina)) ;
Ortiz, Carlos (Clínica del Country (Bogotà, Colòmbia)) ;
Franco, Sandra (Clínica del Country (Bogotà, Colòmbia)) ;
Rosell, Rafael (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Objective: To evaluate the efficacy and safety of pemetrexed, carboplatin and bevacizumab (PCB) followed by maintenance therapy with pemetrexed and bevacizumab (PB) in chemotherapy-naïve patients with stage IV non-squamous non-small cell lung cancer (NSCLC) through the influence of thymidylate synthase (TS) protein and mRNA expression on several outcomes. [...]
2016 - 10.1371/journal.pone.0154293
PloS one, Vol. 11 Núm. 5 (May 2016)
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20 p, 1.8 MB |
Regulation of the Na+/K+-ATPase Ena1 expression by calcineurin/Crz1 under high pH stress : a quantitative study
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Petrezsélyová, Silvia (Institute of Molecular Genetics (Vestec, República Txeca)) ;
López-Malo, María (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Canadell i Sala, David (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ;
Roque Córdova, Alicia (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ;
Serra Cardona, Albert (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ;
Marqués, M. Carmen (Instituto de Biologia Molecular y Celular de Plantas (València, Espanya)) ;
Vilaprinyó, Ester (Universitat de Lleida) ;
Alves, Rui (Universitat de Lleida) ;
Yenush, Lynne (Instituto de Biologia Molecular y Celular de Plantas (València, Espanya)) ;
Ariño Carmona, Joaquín (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular)
Regulated expression of the Ena1 Na+-ATPase is a crucial event for adaptation to high salt and/or alkaline pH stress in the budding yeast Saccharomyces cerevisiae. ENA1 expression is under the control of diverse signaling pathways, including that mediated by the calcium-regulatable protein phosphatase calcineurin and its downstream transcription factor Crz1. [...]
2016 - 10.1371/journal.pone.0158424
PloS one, Vol. 11 Num. 6 (June 2016) , p. 1-20
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12 p, 942.4 KB |
BIM and mTOR expression levels predict outcome to erlotinib in EGFR-mutant non-small-cell lung cancer
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Karachaliou, Niki (Hospital Universitari Quiron Dexeus (Barcelona, Catalunya)) ;
Codony-Servat, Jordi (Pangaea Biotech (Barcelona, Catalunya)) ;
Teixidó, Cristina (Pangaea Biotech (Barcelona, Catalunya)) ;
Pilotto, Sara (University of Verona (Itàlia)) ;
Drozdowskyj, Ana (Pivotal (Madrid)) ;
Codony-Servat, Carles (Pangaea Biotech (Barcelona, Catalunya)) ;
Giménez-Capitán, Ana (Pangaea Biotech (Barcelona, Catalunya)) ;
Molina-Vila, Miguel Ángel (Pangaea Biotech (Barcelona, Catalunya)) ;
Bertrán-Alamillo, Jordi (Pangaea Biotech (Barcelona, Catalunya)) ;
Gervais, Radj (Centre François Baclesse (Caen, França)) ;
Massuti, Bartomeu (Hospital General de Alicante) ;
Morán, Teresa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Majem, Margarita (Hospital de Sant Pau (Barcelona, Catalunya)) ;
Felip Font, Enriqueta (Hospital Vall d'Hebron (Barcelona, Catalunya)) ;
Carcereny, Enric (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
García-Campelo, Rosario (Complejo Hospitalario Universitario de A Coruña) ;
Viteri, Santiago (Hospital Universitari Quiron Dexeus (Barcelona, Catalunya)) ;
González-Cao, María (Hospital Universitari Quiron Dexeus (Barcelona, Catalunya)) ;
Morales-Espinosa, Daniela (Hospital Universitari Quiron Dexeus (Barcelona, Catalunya)) ;
Verlicchi, Alberto (Ospedale Santa Maria delle Croci (Ravenna, Itàlia)) ;
Crisetti, Elisabetta (Institute of Respiratory Diseases. University of Foggia (Itàlia)) ;
Chaib, Imane (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Santarpia, Mariacarmela (Human Pathology Department. University of Messina (Itàlia)) ;
Ramírez, José Luis (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bosch-Barrera, Joaquim (Hospital Josep Trueta, Girona. Institut Català d'Oncologia) ;
Cardona Zorrilla, Andrés Felipe (Instituto de Oncología de Clínica del Country (Bogotá, Colòmbia)) ;
De Marinis, Filippo (Istituto Europeo di Oncologia (Milà, Itàlia)) ;
López-Vivanco, Guillermo (Hospital de Cruces (Barakaldo, Biscaia)) ;
Sánchez, José Miguel (Hospital Universitario de la Princesa (Madrid)) ;
Vergnenegre, Alain (Hôpital du Cluzeau (Limoges, França)) ;
Sánchez Hernández, José Javier (Universidad Autónoma de Nuevo León (Mèxic)) ;
Sperduti, Isabella (Istituto Regina Elena Cancer Institute (Roma, Itàlia)) ;
Bria, Emilio (University of Verona (Itàlia)) ;
Rosell, Rafael (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Abstract. BIM is a proapoptotic protein that initiates apoptosis triggered by EGFR tyrosine kinase inhibitors (TKI). mTOR negatively regulates apoptosis and may influence response to EGFR TKI. We examined mRNA expression of BIM and MTOR in 57 patients with EGFR-mutant NSCLC from the EURTAC trial. [...]
2015 - 10.1038/srep17499
Scientific reports, Vol. 7 (December 2015)
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25 p, 887.3 KB |
Transient Cenozoic tectonic stages in the southern margin of the Caribbean plate : U-Th/He thermochronological constraints from Eocene plutonic rocks in the Santa Marta massif and Serranía de Jarara, northern Colombia
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Cardona, A. (Smithsonian Tropical Research Institute) ;
Valencia, V. (Washington State University. Earth and Environmental Science Department) ;
Weber, M. (Universidad Nacional de Colombia. Sede de Medellín. Escuela de Geociencias y Medio Ambiente) ;
Duque, J. (Universidad Autónoma de México. Centro de Geociencias) ;
Montes, C. (Corporación Geológica Ares) ;
Ojeda, G. (Instituto Colombiano del Petróleo-Ecopetrol) ;
Reiners, P. (University of Arizona. Department of Geosciences) ;
Domanik, K. (University of Arizona. Department of Planetary Sciences) ;
Nicolescu, S. (University of Arizona. Department of Geosciences) ;
Villagomez, D. (University of Geneva. Department of Earth Sciences)
We use U-Th/(He) zircon and apatite thermochronology and Al in hornblende geobarometry from Eocene granitoids of the Sierra Nevada de Santa Marta and Guajira uplifted massifs in northern Colombia to elucidate the exhumation history of the northern South America continental margin and its bearing to Cenozoic Caribbean– South American plate interactions. [...]
2011 - 10.1344/105.000001739
Geologica acta, Vol. 9, Núm. 3-4 (setembre-desembre 2011) , p. 445-466
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20 p, 4.4 MB |
Geochemistry and Geochronology of the Guajira Eclogites, northern Colombia : evidence of a metamorphosed primitive Cretaceous Caribbean Island-arc
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Weber, M. (Universidad Nacional de Colombia) ;
Cardona, A. (Smithsonian Tropical Research Institute) ;
Valencia, V. (The University of Arizona. Department of Geosciences) ;
Altenberger, U. (Potsdam Universität) ;
López-Martínez, M. (Centro de Investigación Científica y de Educación Superior de Ensenada (CICESE). Departamento de Geología) ;
Tobón, M. (Universidad Nacional de Colombia) ;
Zapata, S. (Universidad Nacional de Colombia) ;
Zapata, G. (Universidad Nacional de Colombia) ;
Concha, A.E. (Universidad Nacional de Colombia)
The chemical composition of eclogites, found as boulders in a Tertiary conglomerate from the Guajira Peninsula, Colombia suggests that these rocks are mainly metamorphosed basaltic andesites. They are depleted in LILE elements compared to MORB, have a negative Nb-anomaly and flat to enriched REE patterns, suggesting that their protoliths evolved in a subduction related tectonic setting. [...]
2011 - 10.1344/105.000001740
Geologica acta, Vol. 9, Núm. 3-4 (setembre-desembre 2011) , p. 425-443
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