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1 p, 134.6 KB Dibenzylxanthines as PPEPCK-M inhibitors for cancer therapy / Aragó, Marc (University of Barcelona. Department of Physiological Sciences, Faculty of Medicine) ; Rodríguez-Arévalo , Sergio (University of Barcelona. Institute of Biomedicine) ; Moreno, Juan (University of Barcelona. Faculty of Medicine) ; Abás, Sònia (University of Barcelona. Faculty of Pharmacy, and Institute of Biomedicine (IBUB)) ; Figueras, Agnès (Institut d'Investigació Biomèdica de Bellvitge) ; Pérez, Belén (Universitat Autònoma de Barcelona. Farmacologia Terapèutica i Toxicologia) ; Viñals, Francesc (Institut D'Investigació Biomèdica de Bellvitge (IDIBELL)) ; Carmen Escolano, María (University of Barcelona. Institute of Biomedicine(IBUB)) ; Carlos Perales, José (University of Barcelona. Faculty of Medicine)
Phosphoenolpyruvate carboxykinase (PEPCK) is the key enzyme in gluconeogenesis/glyceroneogenesis, which catalyzes the decarboxylation of oxaloacetate to phosphoenolpyruvate. In eukaryotes, there are two isozymes present either in the cytosol (PEPCKC, PCK1) or the mitochondria (PEPCK-M, PCK2). [...]
2019 - 10.3390/proceedings2019022079
Proceedings, Vol. 22 (2019) , p. 1  

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