Results overview: Found 6 records in 0.02 seconds.
Articles, 5 records found
Research literature, 1 records found
Articles 5 records found  
1.
5 p, 584.6 KB Immunotherapy with Tolerogenic Dendritic Cells Alone or in Combination with Rapamycin Does Not Reverse Diabetes in NOD Mice / Pujol-Autonell, Irma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Ampudia, Rosa M. (Institut Germans Trias i Pujol) ; Monge, Pau (Institut Germans Trias i Pujol) ; Lucas, Anna M. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Carrascal, Jorge (Universitat de Lleida) ; Verdaguer, Joan (Universitat de Lleida) ; Vives Pi, Marta (Institut Germans Trias i Pujol) ; Universitat Autònoma de Barcelona
Type 1 diabetes is a metabolic disease caused by autoimmunity towards β -cells. Different strategies have been developed to restore β -cell function and to reestablish immune tolerance to prevent and cure the disease. [...]
2013 - 10.1155/2013/346987
ISRN Endocrinology, Vol. 2013 (march 2013)  
2.
11 p, 5.0 MB B-Lymphocyte Phenotype Determines T-Lymphocyte Subset Differentiation in Autoimmune Diabetes / Egia-Mendikute, Leire (Institut de Recerca Biomèdica de Lleida) ; Arpa, Berta (Institut de Recerca Biomèdica de Lleida) ; Rosell-Mases, Estela (Institut de Recerca Biomèdica de Lleida) ; Corral-Pujol, Marta (Institut de Recerca Biomèdica de Lleida) ; Carrascal, Jorge (Institut de Recerca Biomèdica de Lleida) ; Carrillo, Jorge (Institut de Recerca Biomèdica de Lleida) ; Mora, Conchi (Institut de Recerca Biomèdica de Lleida) ; Chapman, Harold (Jackson Laboratory) ; Panosa, Anaïs (Institut de Recerca Biomèdica de Lleida) ; Vives Pi, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Stratmann, Thomas (Universitat de Barcelona. Departament de Biologia Cel·lular, Fisiologia i Immunologia) ; Serreze, David (Jackson Laboratory) ; Verdaguer, Joan (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas)
Previous studies indicate that B-lymphocytes play a key role activating diabetogenic T-lymphocytes during the development of autoimmune diabetes. Recently, two transgenic NOD mouse models were generated: the NOD-PerIg and the 116C-NOD mice. [...]
2019 - 10.3389/fimmu.2019.01732
Frontiers in immunology, Vol. 10 (2019) , p. 1732  
3.
5 p, 584.6 KB Immunotherapy with Tolerogenic Dendritic Cells Alone or in Combination with Rapamycin Does Not Reverse Diabetes in NOD Mice / Pujol-Autonell, Irma (Institut Germans Trias i Pujol. Banc de Sang i Teixits) ; Ampudia, Rosa Maria (Institut Germans Trias i Pujol. Banc de Sang i Teixits) ; Monge, Pau (Institut Germans Trias i Pujol. Banc de Sang i Teixits) ; Lucas, Anna M. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Carrascal, Jorge (Institut de Recerca Biomèdica de Lleida) ; Verdaguer, Joan (Institut de Recerca Biomèdica de Lleida) ; Vives Pi, Marta (Institut Germans Trias i Pujol. Banc de Sang i Teixits)
Type 1 diabetes is a metabolic disease caused by autoimmunity towards β -cells. Different strategies have been developed to restore β -cell function and to reestablish immune tolerance to prevent and cure the disease. [...]
2013
ISRN Endocrinology, Vol. 2013 (march 2013)  
4.
22 p, 1.1 MB Type 1 diabetes prevention in NOD mice by targeting DPPIV/CD26 is associated with changes in CD8+T effector memory subset / Alonso Pedrol, Núria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Julián, María Teresa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Carrascal, Jorge (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Colobrán Oriol, Roger (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Pujol-Autonell, Irma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Rodriguez Fernandez, Silvia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Teniente Serra, Aina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Fernández Sanmartin, Marco Antonio (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Miñarro Alonso, Antoni (Universitat de Barcelona. Departament d'Estadística) ; Ruiz de Villa, María del Carmen (Universitat de Barcelona. Departament d'Estadística) ; Vives Pi, Marta (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Puig Domingo, Manuel Luis (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Universitat Autònoma de Barcelona. Departament de Medicina
CD26 is a T cell activation marker consisting in a type II transmembrane glycoprotein with dipeptidyl peptidase IV (DPPIV) activity in its extracellular domain. It has been described that DPPIV inhibition delays the onset of type 1 diabetes and reverses the disease in non-obese diabetic (NOD) mice. [...]
2015 - 10.1371/journal.pone.0142186
PloS one, Vol. 10, Issue 11 (Novembre 2015) , p. e0142186  
5.
10 p, 893.6 KB Efferocytosis Promotes Suppressive Effects on Dendritic Cells through Prostaglandin E2 Production in the Context of Autoimmunity / Pujol-Autonell, Irma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Ampudia, Rosa Maria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Planas, Raquel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Marin-Gallen, Silvia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Carrascal, Jorge (Universitat de Lleida. Departament de Ciències Bàsiques) ; Sanchez, Alex (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Marin, Ana (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Puig Domingo, Manuel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Pujol-Borrell, Ricardo (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Verdaguer, Joan (Universitat de Lleida. Departament de Ciències Bàsiques) ; Vives Pi, Marta (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Introduction: Efferocytosis is a crucial process by which apoptotic cells are cleared by phagocytes, maintaining immune tolerance to self in the absence of inflammation. Peripheral tolerance, lost in autoimmune processes, may be restored by the administration of autologous dendritic cells loaded with islet apoptotic cells in experimental type 1 diabetes. [...]
2013 - 10.1371/journal.pone.0063296
PloS one, Vol. 8 Issue 5 (May 2013) , p. e63296  

Research literature 1 records found  
1.
113 p, 2.3 MB Caracterización fenotípica del ratón transgénico 116-NOD, y aproximación a la identificación del antígeno reconocido por el anticuerpo monoclonal H116 / Carrascal Sánchez, Jorge ; Verdaguer Antonell, Joan, dir. ; Vives Pi, Marta, dir. (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular i de Fisiologia
Los modelos animales están sirviendo para el estudio de un gran número de procesos patológicos como es la diabetes autoinmunitaria (T1D). La utilización de ratones transgénicos basados en modelos de enfermedad ya establecidos, como por ejemplo ratones NOD transgénicos, donde se pueden analizar variables muy concretas de la enfermedad, están aportando una gran fuente de conocimiento de los mecanismos inmunopatogénicos que ocurren durante el desarrollo de la T1D. [...]
Animal models are being used for the study of a large number of pathological processes such as autoimmune diabetes (T1D). The use of transgenic mice based on established disease models such as transgenic NOD mice, which can analyze very specific variables of the disease, are providing a great source of knowledge of the immunopathogenic mechanisms that occur during the development of T1D . [...]

Bellaterra : Universitat Autònoma de Barcelona, 2012  

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