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14 p, 928.6 KB |
Incidence and characteristics of adverse drug reactions in a cohort of patients treated with PD-1/PD-L1 inhibitors in real-world practice
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Sabaté, Mònica (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Pérez, Eulàlia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Garcia Doladé, Núria (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Vidal Guitart, Xavier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Carreras Soler, Maria Josep (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Farriols Danés, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Felip, Enriqueta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Braña, Irene (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Carles, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Morales-Barrera, Rafael (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Muñoz Couselo, Eva (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Agustí Escasany, M. Antònia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Data related to adverse drug reactions (ADRs), specifically immune-related adverse events (irAEs), in long-term treatment with immunotherapy in real-world practice is scarce, as is general information regarding the management of ADRs. [...]
2022 -  10.3389/fmed.2022.891179
Frontiers in Medicine, Vol. 9 (august 2022)
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8 p, 440.5 KB |
Standardizing Definitions of Hematopoietic Recovery, Graft Rejection, Graft Failure, Poor Graft Function, and Donor Chimerism in Allogeneic Hematopoietic Cell Transplantation : A Report on Behalf of the American Society for Transplantation and Cellular Therapy
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Kharfan-Dabaja, Mohamed A. (Mayo Clinic. Division of Hematology-Oncology and Blood and Marrow Transplantation and Cellular Therapies Program) ;
Kumar, Ambuj (Program for Comparative Effectiveness Research. Morsani College of Medicine. University of South Florida) ;
Ayala, Ernesto (Division of Hematology-Oncology and Blood and Marrow Transplantation and Cellular Therapies Program. Mayo Clinic) ;
Aljurf, Mahmoud (Department of Adult Hematology and Stem Cell Transplantation. King Faisal Specialist Hospital and Research Centre) ;
Nishihori, Taiga (Department of Blood and Marrow Transplantation and Cellular Immunotherapy. Moffitt Cancer Center) ;
Marsh, Rebecca (Cincinnati Children's Hospital Medical Center) ;
Burroughs, Laura M. (Fred Hutchinson Cancer Research Center) ;
Majhail, Navneet (Blood and Marrow Transplant Program. Taussig Cancer Institute. Cleveland Clinic) ;
Al-Homsi, Ahmad Samer (NYU Langone Health) ;
Al-Kadhimi, Zaid S. (Division of Oncology and Hematology. Department of Internal Medicine. University of Nebraska Medical Center) ;
Bar, Merav (Fred Hutchinson Cancer Research Center) ;
Bertaina, Alice (Division of Stem Cell Transplant and Regenerative Medicine. Department of Pediatrics. Stanford University) ;
Boelens, Jaap Jan (Stem Cell Transplantation and Cellular Therapies Program. Department Pediatrics. Memorial Sloan Kettering Cancer Center) ;
Champlin, Richard (Department of Stem Cell Transplantation and Cellular Therapy. The University of Texas MD Anderson Cancer Center) ;
Chaudhury, Sonali (Ann and Robert H. Lurie Children's Hospital of Chicago) ;
DeFilipp, Zachariah (Department of Hematology-Oncology and Hematopoietic Cell Transplant and Cellular Therapy Program. Massachusetts General Hospital) ;
Dholaria, Bhagirathbhai (Vanderbilt University Medical Center) ;
El-Jawahri, Areej (Department of Hematology-Oncology and Hematopoietic Cell Transplant and Cellular Therapy Program. Massachusetts General Hospital) ;
Fanning, Suzanne (Blood and Marrow Transplant Program. University of South Carolina School of Medicine) ;
Fraint, Ellen (Stem Cell Transplantation and Cellular Therapies Program. Department Pediatrics. Memorial Sloan Kettering Cancer Center) ;
Gergis, Usama (Bone Marrow Transplant and Immune Cellular Therapy. Thomas Jefferson University Hospital) ;
Giralt, Sergio (Department of Medicine. Division of Hematologic Malignancies. Memorial Sloan Kettering Cancer Center Weill Cornell Medical College) ;
Hamilton, Betty K. (Blood and Marrow Transplant Program. Taussig Cancer Institute. Cleveland Clinic) ;
Hashmi, Shahrukh K (Department of Medicine. Sheikh Shakhbout Medical City) ;
Horn, Biljana (Department of Pediatrics. Division of Hematology/Oncology. University of Florida. UF Health Shands Children's Hospital) ;
Inamoto, Yoshihiro (National Cancer Center Hospital) ;
Jacobsohn, David A. (Children's National Medical Center) ;
Jain, Tania (Johns Hopkins University School of Medicine) ;
Johnston, Laura (Stanford University School of Medicine) ;
Kanate, Abraham S. (West Virginia University) ;
Kansagra, Ankit (UT Southwestern Medical Center) ;
Kassim, Adetola (Vanderbilt University Medical Center) ;
Kean, Leslie S. (Boston Children's Hospital. Dana-Farber Cancer Institute) ;
Kitko, Carrie L. (Vanderbilt University Medical Center) ;
Knight-Perry, Jessica (University of Colorado School of Medicine) ;
Kurtzberg, Joanne (Duke University School of Medicine) ;
Liu, Hien (Moffitt Cancer Center) ;
MacMillan, Margaret L (University of Minnesota Medical School) ;
Mahmoudjafari, Zahra (University of Kansas Cancer Center) ;
Mielcarek, Marco (Fred Hutchinson Cancer Research Center) ;
Mohty, Mohamad (Sorbonne Université. INSERM. Centre de Recherche Saint-Antoine and Hôpital Saint-Antoine. Service d'Hématologie Clinique et Thérapie Cellulaire) ;
Nagler, Arnon (Chaim Sheba Medical Center (Israel)) ;
Nemecek, Eneida (Oregon Health & Science University) ;
Olson, Timothy S. (Children's Hospital of Philadelphia (Pennsilvània)) ;
Oran, Betul (The University of Texas MD Anderson Cancer Center) ;
Perales, Miguel Angel (Memorial Sloan Kettering Cancer Center Weill Cornell Medical College) ;
Prockop, Susan E. (Stem Cell Transplantation and Cellular Therapies Program. Department Pediatrics. Memorial Sloan Kettering Cancer Center) ;
Pulsipher, Michael A. (Children's Hospital Los Angeles Cancer and Blood Disease Institute. USC Keck School of Medicine) ;
Pusic, Iskra (Washington University School of Medicine) ;
Riches, Marcie L. (University of North Carolina at Chapel Hill) ;
Rodriguez, Cesar (Wake Forest University School of Medicine) ;
Romee, Rizwan (Dana-Farber Cancer Institute (Boston, Estats Units d'Amèrica)) ;
Rondon, Gabriela (The University of Texas MD Anderson Cancer Center) ;
Saad, Ayman (The Ohio State University. Division of Hematology) ;
Shah, Nina (University of California San Francisco. Department of Medicine) ;
Shaw, Peter J. (The Children's Hospital at Westmead) ;
Shenoy, Shalini (Washington University School of Medicine) ;
Sierra, Jorge (Institut d'Investigació Biomèdica Sant Pau) ;
Talano, Julie (Children's Hospital of Wisconsin) ;
Verneris, Michael R. (University of Colorado School of Medicine) ;
Veys, Paul (University College London. Great Ormond Street Hospital.) ;
Wagner, John E. (University of Minnesota Medical School) ;
Savani, Bipin N. (Vanderbilt University Medical Center) ;
Hamadani, Mehdi (Medical College of Wisconsin) ;
Carpenter, Paul A. (Fred Hutchinson Cancer Research Center) ;
Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Allogeneic hematopoietic cell transplantation (allo-HCT) is potentially curative for certain hematologic malignancies and nonmalignant diseases. The field of allo-HCT has witnessed significant advances, including broadening indications for transplantation, availability of alternative donor sources, less toxic preparative regimens, new cell manipulation techniques, and novel GVHD prevention methods, all of which have expanded the applicability of the procedure. [...]
2021 - 10.1016/j.jtct.2021.04.007
Transplantation and Cellular Therapy, Vol. 27 Núm. 8 (august 2021) , p. 642-649
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12 p, 3.6 MB |
Combining microfluidics with machine learning algorithms for RBC classification in rare hereditary hemolytic anemia
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Rizzuto, Valeria (Universitat de Barcelona. Departament de Medicina) ;
Mencattini, Arianna (University of Rome Tor Vergata) ;
Álvarez-González, Begoña (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Di Giuseppe, Davide (University of Rome Tor Vergata) ;
Beneitez Pastor, David (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Mañú Pereira, María del Mar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Lopez-Martinez, Maria José (Universitat de Barcelona. Departament d'Enginyeria Electrònica i Biomèdica) ;
Samitier, Josep (Universitat de Barcelona. Departament d'Enginyeria Electrònica i Biomèdica) ;
Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras
Combining microfluidics technology with machine learning represents an innovative approach to conduct massive quantitative cell behavior study and implement smart decision-making systems in support of clinical diagnostics. [...]
2021 - 10.1038/s41598-021-92747-2
Scientific reports, Vol. 11 Núm. 1 (december 2021) , p. 13553
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15 p, 1.0 MB |
Relevance of infections on the outcomes of patients with myelodysplastic syndromes, chronic myelomonocytic leukemia, and acute myeloid leukemia treated with hypomethylating agents : a cohort study from the GESMD
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Vilorio-Marqués, Laura (Instituto de Investigación Sanitaria del Principado de Asturias) ;
Castañón Fernández, Christelle (Instituto de Investigación Sanitaria del Principado de Asturias) ;
Mora, Elvira (Hospital Universitari i Politècnic La Fe (València)) ;
Gutiérrez, Lorena (Hospital Universitario de Canarias (La Laguna)) ;
Rey Bua, Beatriz (Hospital Clínico Universitario) ;
Jiménez Lorenzo, Maria José (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Díaz-Beyá, Marina (Hospital Clínic i Provincial de Barcelona) ;
Vara Pampliega, Miriam (Hospital Universitario de Cruces (Barakaldo, País Basc)) ;
Molero, Antonieta (Hospital Universitari Vall d'Hebron) ;
Sánchez-García, Joaquín (Hospital Universitario Reina Sofía (Còrdova, Espanya)) ;
Calabuig, Marisa (Hospital Clínic Universitari (València)) ;
Cedena, María Teresa (Hospital Universitario 12 de Octubre (Madrid)) ;
Chen-Liang, Tzu (Hospital General Universitario Morales Meseguer (Múrcia)) ;
Díaz Santa, Johana Alejandra (Institut Catalá de Oncología) ;
Padilla, Irene (Complejo Asistencial Universitario de León) ;
Hernández, Francisca (Hospital Universitario Virgen de las Nieves (Granada)) ;
Díez, Rosana (Hospital Universitario Miguel Servet (Saragossa)) ;
Asensi, Pedro (Hospital Universitari i Politècnic La Fe (València)) ;
Xicoy, Blanca (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Sanz, Guillermo (Hospital Universitari i Politècnic La Fe (València)) ;
Valcárcel, David (Hospital Universitari Vall d'Hebron) ;
Diez-Campelo, María (Hospital Clínico Universitario (Salamanca)) ;
Bernal, Teresa (Hospital Universitario Central de Asturias. Instituto de Investigación Sanitaria del Principado de Asturias) ;
Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras ;
Universitat Autònoma de Barcelona
Background: The consequences of infectious toxicity of hypomethylating agents (HMAs) on overall survival (OS) of patients diagnosed with high-risk myeloid neoplasms have not been thoroughly investigated. [...]
2022 - 10.1177/20406207221127547
Therapeutic Advances in Hematology, Vol. 13 (2022)
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9 p, 1.4 MB |
Usefulness of NGS for Diagnosis of Dominant Beta-Thalassemia and Unstable Hemoglobinopathies in Five Clinical Cases
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Rizzuto, Valeria (Universitat de Barcelona. Departament de Medicina) ;
Koopmann, Tamara T. (Leiden University Medical Center) ;
Blanco, Adoración (Hospital Universitari Vall d'Hebron) ;
Tazón-Vega, Bárbara (Hospital Universitari Vall d'Hebron) ;
Idrizovic, Amira (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Díaz de Heredia, Cristina (Hospital Universitari Vall d'Hebron) ;
Del Orbe Barreto, Rafael Andrés (Hospital Universitario de Cruces (Barakaldo, País Basc)) ;
Pampliega, Miriam Vara (Hospital Universitario de Cruces (Barakaldo, País Basc)) ;
Velasco, Pablo (Hospital Universitari Vall d'Hebron) ;
Beneitez Pastor, David (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Santen, Gijs Santen W.E. (Leiden University Medical Center) ;
Waisfisz, Quinten (VU Medical Center) ;
Elting, Mariet (VU Medical Center) ;
Smiers, Frans J.W. (Leiden University Medical Center) ;
de Pagter, Anne J. (Leiden University Medical Center) ;
Kerkhoffs, Jean Louis H. (AGA City Hospital) ;
Harteveld, Cornelis L. (Leiden University Medical Center) ;
Mañú Pereira, María del Mar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras
Unstable hemoglobinopathies (UHs) are rare anemia disorders (RADs) characterized by abnormal hemoglobin (Hb) variants with decreased stability. UHs are therefore easily precipitating, causing hemolysis and, in some cases, leading to dominant beta-thalassemia (dBTHAL). [...]
2021 - 10.3389/fphys.2021.628236
Frontiers in physiology, Vol. 12 (may 2021) , p. 628236
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13 p, 2.4 MB |
The Diphtheria Toxin Translocation Domain Impairs Receptor Selectivity in Cancer Cell-Targeted Protein Nanoparticles
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Voltà-Durán, Eric (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Sanchez, Julieta M. (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Parladé Molist, Eloi (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Serna, Naroa (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Vázquez Gómez, Esther (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Unzueta Elorza, Ugutz (Institut d'Investigació Biomèdica Sant Pau) ;
Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras
Protein-based materials intended as nanostructured drugs or drug carriers are progressively gaining interest in nanomedicine, since their structure, assembly and cellular interactivity can be tailored by recruiting functional domains. [...]
2022 - 10.3390/pharmaceutics14122644
Pharmaceutics, Vol. 14, Issue 12 (December 2022) , art. 2644
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12 p, 2.0 MB |
The Poly-Histidine Tag H6 Mediates Structural and Functional Properties of Disintegrating, Protein-Releasing Inclusion Bodies
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Sánchez, Julieta María (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Carratalá, José Vicente (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Serna, Naroa (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Unzueta Elorza, Ugutz (Institut d'Investigació Biomèdica Sant Pau) ;
Nolan, Verónica (Universidad Nacional de Córdoba. Departamento de Química) ;
Sánchez Chardi, Alejandro (Universitat Autònoma de Barcelona. Servei de Microscòpia) ;
Voltà-Durán, Eric (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
López-Laguna, Hèctor (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Ferrer-Miralles, Neus (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Vázquez Gómez, Esther (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras
The coordination between histidine-rich peptides and divalent cations supports the formation of nano- and micro-scale protein biomaterials, including toxic and non-toxic functional amyloids, which can be adapted as drug delivery systems. [...]
2022 - 10.3390/pharmaceutics14030602
Pharmaceutics, Vol. 14, Issue 3 (March 2022) , art. 602
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14 p, 1.9 MB |
Polymer-enhanced stability of inorganic perovskite nanocrystals and their application in color conversion LEDs
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Meyns, Michaela (Institut de Recerca en Energia de Catalunya) ;
Perálvarez, Mariano (Institut de Recerca en Energia de Catalunya) ;
Heuer-Jungemann, Amelie (University of Southampton. Physics and Astronomy) ;
Hertog, Wim (Institut de Recerca en Energia de Catalunya) ;
Ibáñez, Maria (ETH Zürich. Institute of Inorganic Chemistry) ;
Nafria, Raquel (Institut de Recerca en Energia de Catalunya) ;
Genç, Aziz (Institut Català de Nanociència i Nanotecnologia) ;
Arbiol i Cobos, Jordi (Institut Català de Nanociència i Nanotecnologia) ;
Kovalenko, Maksym V. (ETH Zürich. Institute of Inorganic Chemistry) ;
Carreras, Josep (Institut de Recerca en Energia de Catalunya) ;
Cabot, Andreu (Institut de Recerca en Energia de Catalunya) ;
Kanaras, Antonios G. (University of Southampton. Physics and Astronomy)
Cesium lead halide (CsPbX₃, X = Cl, Br, I) nanocrystals (NCs) offer exceptional optical properties for several potential applications but their implementation is hindered by a low chemical and structural stability and limited processability. [...]
2016 - 10.1021/acsami.6b02529
ACS applied materials & interfaces, Vol. 8, Issue 30 (August 2016) , p. 19579-19586
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13 p, 944.0 KB |
El artesano de La Canal dels Avellaners (Edad del Bronce, Barcelona) : análisis de huellas dactilares
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Míguez Marcos, Virginia (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia) ;
Ibáñez-Gimeno, Pere (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia) ;
Carreras, Josep (Societat d'Arqueologia del Berguedà) ;
Liria, Josep (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia) ;
Malgosa Morera, Assumpció (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia)
Trabajos recientes han descrito la existencia de diferencias sexuales y de edad en la anchura de las crestas epidérmicas en huellas dactilares humanas. El potencial forense de esta característica es muy amplio y se ha empezado a utilizar para obtener información a partir de las huellas encontradas tanto en el lugar del crimen como en objetos cerámicos antiguos. [...]
Several studies have reported sex and age differences in epidermal ridge breadth in human fingerprints and analyzed its variability in different populations. In recent years, some investigations have explored the forensic application of this feature for inferring information from fingerprints found at a crime scene or on ancient ceramic artifacts. [...]
2016 - 10.3989/tp.2016.12168
Trabajos de prehistoria, Vol. 73, núm. 1 (2016) , p. 147-159
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