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19 p, 5.8 MB |
Giant extinct caiman breaks constraint on the axial skeleton of extant crocodylians
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Scheyer, Torsten M. (University of Zurich. Paläontologisches Institut und Museum) ;
Hutchinson, John R. (The Royal Veterinary College (Hatfield, Regne Unit). Department of Comparative Biomedical Sciences) ;
Delfino, Massimo (Institut Català de Paleontologia Miquel Crusafont) ;
Strauss, Olivier (University of Zurich. Paläontologisches Institut und Museum) ;
Carrillo-Briceño,Jorge D. (University of Zurich. Paläontologisches Institut und Museum) ;
Sánchez, Rodolfo (Museo Paleontológico de Urumaco (Urumaco, Veneçuela)) ;
Sánchez-Villagra, Marcelo R. (University of Zurich. Paläontologisches Institut und Museum)
The number of precaudal vertebrae in all extant crocodylians is remarkably conservative, with nine cervicals, 15 dorsals and two sacrals, a pattern present also in their closest extinct relatives. The consistent vertebral count indicates a tight control of axial patterning by Hox genes during development. [...]
2019 -  10.7554/eLife.49972
eLife, 2019, art. e49972
2 documents
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15 p, 2.1 MB |
Proteoliposomal formulations of an HIV-1 gp41-based miniprotein elicit a lipid-dependent immunodominant response overlapping the 2F5 binding motif
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Molinos-Albert, Luis Manuel (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Bilbao, Eneritz (Universidad del País Vasco (UPV/EHU). Department of Biochemistry and Molecular Biology) ;
Agulló, Luis (Universitat de Vic. Departament de Biociències) ;
Marfil, Silvia (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
García, Elisabet (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Rodríguez de la Concepción, Maria Luisa (Institut Germans Trias i Pujol) ;
Izquierdo-Useros, Nuria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Vilaplana, Cristina (Institut Germans Trias i Pujol. Unitat de Tuberculosi Experimental) ;
Nieto-Garai, Jon A. (Universidad del País Vasco (UPV/EHU). Department of Biochemistry and Molecular Biology) ;
Contreras, F. Xabier (Universidad del País Vasco (UPV/EHU). Department of Biochemistry and Molecular Biology) ;
Floor, Martin (Universitat de Vic. Departament de Biociències) ;
Cardona, Pere-Joan (Institut Germans Trias i Pujol. Unitat de Tuberculosi Experimental) ;
Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Clotet, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Villà-Freixa, Jordi (Universitat de Vic. Departament de Biociències) ;
Lorizate, Maier (Universidad del País Vasco (UPV/EHU). Department of Biochemistry and Molecular Biology) ;
Carrillo, Jorge (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Blanco, Julià (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
The HIV-1 gp41 Membrane Proximal External Region (MPER) is recognized by broadly neutralizing antibodies and represents a promising vaccine target. However, MPER immunogenicity and antibody activity are influenced by membrane lipids. [...]
2017 - 10.1038/srep40800
Scientific reports, gener 2017, p. 1-15
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12 p, 2.8 MB |
Gut microbiota linked to sexual preference and HIV infection
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Noguera-Julian, Marc (Institut Germans Trias i Pujol. IrsiCaixa) ;
Rocafort, Muntsa (Institut Germans Trias i Pujol. IrsiCaixa) ;
Guillén, Yolanda (Institut Germans Trias i Pujol. IrsiCaixa) ;
Rivera, Javier (Institut Germans Trias i Pujol. IrsiCaixa) ;
Casadellà, Maria (Institut Germans Trias i Pujol. IrsiCaixa) ;
Nowak, Piotr (Karolinska Universitetssjukhuset) ;
Hildebrand, Falk (European Molecular Biology Laboratory) ;
Zeller, Georg (European Molecular Biology Laboratory) ;
Parera, Mariona (Institut Germans Trias i Pujol. IrsiCaixa) ;
Bellido, Rocío (Institut Germans Trias i Pujol. IrsiCaixa) ;
Rodríguez, Cristina (Institut Germans Trias i Pujol. IrsiCaixa) ;
Carrillo, Jorge (Institut Germans Trias i Pujol. IrsiCaixa) ;
Mothe, Beatriz (Institut Germans Trias i Pujol. IrsiCaixa) ;
Coll, Josep (Institut Germans Trias i Pujol. IrsiCaixa) ;
Bravo, Isabel (Hospital Universitari Germans Trias i Pujol) ;
Estany, Carla (Hospital Universitari Germans Trias i Pujol) ;
Herrero, Cristina (Hospital Universitari Germans Trias i Pujol) ;
Saz, Jorge (BCN Checkpoint,) ;
Sirera, Guillem (Hospital Universitari Germans Trias i Pujol) ;
Torrela, Ariadna (Hospital Universitari Vall d'Hebrón) ;
Navarro, Jordi (Hospital Universitari Vall d'Hebrón) ;
Crespo, Manel (Hospital Universitari Vall d'Hebrón) ;
Brander, Christian (Institut Germans Trias i Pujol. IrsiCaixa) ;
Negredo Puigmal, Eugènia (Universitat de Vic) ;
Blanco, Julià (Institut Germans Trias i Pujol. IrsiCaixa) ;
Guarner, Francisco (Hospital Universitari Vall d'Hebrón) ;
Calle, Maria Luz (Universitat de Vic) ;
Bork, Peer (European Molecular Biology Laboratory) ;
Sönnerborg, Anders (Karolinska Universitetssjukhuset) ;
Clotet, Bonaventura (Institut Germans Trias i Pujol. IrsiCaixa) ;
Paredes, Roger (Institut Germans Trias i Pujol. IrsiCaixa)
The precise effects of HIV-1 on the gut microbiome are unclear. Initial cross-sectional studies provided contradictory associations between microbial richness and HIV serostatus and suggested shifts from Bacteroides to Prevotella predominance following HIV-1 infection, which have not been found in animal models or in studies matched for HIV-1 transmission groups. [...]
2016 - 10.1016/j.ebiom.2016.01.032
EBioMedicine, Vol. 5 (March 2016) , p. 135-146
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16 p, 1.9 MB |
The infectious synapse formed between mature dendritic cells and CD4 + T cells is independent of the presence of the HIV-1 envelope glycoprotein
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Rodriguez-Plata, Maria T (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Puigdomènech, Isabel (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Izquierdo-Useros, Nuria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Puertas, Maria C (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Carrillo, Jorge (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Erkizia, Itziar (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Clotet, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Blanco, Julià (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Martinez-Picado, Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaix) ;
Universitat Autònoma de Barcelona
Since cell-mediated infection of human immunodeficiency virus type 1 (HIV-1) is more efficient than cell-free infection, cell-to-cell propagation plays a crucial role in the pathogenesis of HIV-1 infection. [...]
2013 - 10.1186/1742-4690-10-42
Retrovirology, Vol. 10 (april 2013) , p. 42
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11 p, 1.1 MB |
Increased ex vivo cell death of central memory CD4 T cells in treated HIV infected individuals with unsatisfactory immune recovery
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Massanella Luna, Marta, 1983- (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Gómez-Mora, Elisabet (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Carrillo, Jorge (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Curriu Martí, Marta (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ouchi, Dan (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Puig, Jordi (Institut Germans Trias i Pujol. Fundació de Lluita Contra la Sida) ;
Negredo Puigmal, Eugènia (Institut Germans Trias i Pujol. Fundació de Lluita Contra la Sida) ;
Cabrera Navarro, Cecilia (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Clotet, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Blanco Arbués, Julià (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Universitat Autònoma de Barcelona
BACKGROUND: High levels of ex vivo CD4 T-cell death and the accumulation of highly differentiated and/or immunosenescent T cells have been associated with poor CD4 T-cell recovery in treated HIV-infected individuals. [...]
2015 - 10.1186/s12967-015-0601-2
Journal of translational medicine, Vol. 13 (July 2015) , article 33
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23 p, 3.3 MB |
A human immune data-informed vaccine concept elicits strong and broad T-cell specificities associated with HIV-1 control in mice and macaques
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Mothe, Beatriz (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Hu, Xintao (National Cancer Institute at Frederick (Frederick, Estats Units d'Amèrica)) ;
Llano Montero, Anuska (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Rosati, Margherita (National Cancer Institute at Frederick (Frederick, Estats Units d'Amèrica)) ;
Olvera, Alex (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Kulkarni, Viraj (National Cancer Institute at Frederick (Frederick, Estats Units d'Amèrica)) ;
Valentin, Antonio (National Cancer Institute at Frederick (Frederick, Estats Units d'Amèrica)) ;
Alicea, Cándido (National Cancer Institute at Frederick (Frederick, Estats Units d'Amèrica)) ;
Pilkington, Guy R. (National Cancer Institute at Frederick (Frederick, Estats Units d'Amèrica)) ;
Sardesai, Niranjan Y. (Inovio Pharmaceuticals) ;
Rocafort, Muntsa (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Crespo, Manel (Hospital Universitari Vall d'Hebron) ;
Carrillo, Jorge (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Marco, Andrés (Centre Penitenciari d'Homes (Barcelona, Catalunya)) ;
Mullins, James I. (University of Washington (Estats Units d'Amèrica)) ;
Dorrell, Lucy (John Radcliffe Hospital (Oxford, Regne Unit)) ;
Hanke, Tomáš (University of Oxford (Regne Unit)) ;
Clotet, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Pavlakis, George N. (National Cancer Institute at Frederick (Frederick, Estats Units d'Amèrica)) ;
Felber, Barbara K. (National Cancer Institute at Frederick (Frederick, Estats Units d'Amèrica)) ;
Brander, Christian (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Universitat Autònoma de Barcelona
BACKGROUND: None of the HIV T-cell vaccine candidates that have reached advanced clinical testing have been able to induce protective T cell immunity. A major reason for these failures may have been suboptimal T cell immunogen designs. [...]
2015 - 10.1186/s12967-015-0392-5
Journal of translational medicine, Vol. 13 Núm. 60 (february 2015)
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18 p, 1.7 MB |
Gp120/CD4 blocking antibodies are frequently elicited in ART-naïve chronically HIV-1 infected individuals
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Carrillo, Jorge (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Molinos-Albert, Luis Manuel (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Rodríguez de la Concepción, Maria Luisa (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Marfil, Silvia (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
García, Elisabet (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Derking, Ronald (University of Amsterdam) ;
Sanders, Rogier W. (University of Amsterdam) ;
Clotet, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Blanco Arbués, Julià (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Universitat Autònoma de Barcelona
Antibodies with the ability to block the interaction of HIV-1 envelope glycoprotein (Env) gp120 with CD4, including those overlapping the CD4 binding site (CD4bs antibodies), can protect from infection by HIV-1, and their elicitation may be an interesting goal for any vaccination strategy. [...]
2015 - 10.1371/journal.pone.0120648
PloS one, Vol. 10, No. 3 (March 2015) , p. e0120648
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