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1.
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10 p, 2.5 MB |
Myo5b knockout mice as a model of microvillus inclusion disease
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Cartón-Garcia, Fernando (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Overeem, Arend W. (University Medical Center Groningen) ;
Nieto Raya, Rocio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Bazzocco, Sarah (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Dopeso, Higinio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Macaya, Irati (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Bilic Zimmermann, Josipa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Landolfi, Stefania (Hospital Universitari Vall d'Hebron) ;
Hernandez-Losa, Javier (Hospital Universitari Vall d'Hebron) ;
Schwartz, Simo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ramon y Cajal, Santiago (Hospital Universitari Vall d'Hebron) ;
van Ijzendoorn, Sven C. D. (University Medical Center Groningen) ;
Arango, Diego (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Inherited MYO5B mutations have recently been associated with microvillus inclusion disease (MVID), an autosomal recessive syndrome characterized by intractable, life-threatening, watery diarrhea appearing shortly after birth. [...]
2015 -  10.1038/srep12312
Scientific reports, Vol. 5 (07 2015)
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2.
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12 p, 2.3 MB |
Loss of the EPH receptor B6 contributes to colorectal cancer metastasis
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Mateo-Lozano, Silvia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Bazzocco, Sarah (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rodrigues, Paulo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Mazzolini, Rocco (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Andretta, Elena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Dopeso, Higinio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Fernández Caparrós, Yolanda (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
del Llano, Edgar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Bilic Zimmermann, Josipa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Suárez-López, Lucía (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Macaya, Irati (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Cartón-Garcia, Fernando (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Nieto Raya, Rocio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Jimenez-Flores, Lizbeth M. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
de Marcondes, Priscila Guimarães (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Nuñez, Yaiza (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Afonso, Elsa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Cacci, Karina (Hospital Universitari Vall d'Hebron) ;
Hernandez-Losa, Javier (Hospital Universitari Vall d'Hebron) ;
Landolfi, Stefania (Hospital Universitari Vall d'Hebron) ;
Abasolo, Ibane (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ramón y Cajal, Santiago (Hospital Universitari Vall d'Hebron) ;
Mariadason, John M. (La Trobe University) ;
Schwartz, Simo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Matsui, Toshimitsu (Kobe University Graduate School of Medicine) ;
Arango, Diego (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Although deregulation of EPHB signaling has been shown to be an important step in colorectal tumorigenesis, the role of EPHB6 in this process has not been investigated. We found here that manipulation of EPHB6 levels in colon cancer cell lines has no effect on their motility and growth on a solid substrate, soft agar or in a xenograft mouse model. [...]
2017 - 10.1038/srep43702
Scientific reports, Vol. 7 (03 2017)
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3.
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14 p, 2.1 MB |
Investigation of the role of tyrosine kinase receptor EPHA3 in colorectal cancer
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Andretta, Elena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Cartón-Garcia, Fernando (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Martínez-Barriocanal, Águeda (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
de Marcondes, Priscila Guimarães (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Jimenez-Flores, Lizbeth M. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Macaya, Irati (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Bazzocco, Sarah (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Bilic Zimmermann, Josipa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rodrigues, Paulo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Nieto Raya, Rocio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Landolfi, Stefania (Hospital Universitari Vall d'Hebron) ;
Ramon y Cajal, Santiago (Hospital Universitari Vall d'Hebron) ;
Schwartz, Simo (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Brown, Arthur (Robarts Research Institute) ;
Dopeso, Higinio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Arango, Diego (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
EPH signaling deregulation has been shown to be important for colorectal carcinogenesis and genome-wide sequencing efforts have identified EPHA3 as one of the most frequently mutated genes in these tumors. [...]
2017 - 10.1038/srep41576
Scientific reports, Vol. 7 (02 2017)
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4.
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17 p, 2.5 MB |
A Molecular Mechanism Underlying Genotype-Specific Intrahepatic Cholestasis Resulting From MYO5B Mutations
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Overeem, Arend W. (University Medical Center Groningen) ;
Li, Qinghong (University Medical Center Groningen) ;
Qiu, Yi-Ling (Children's Hospital of Fudan University, Shanghai) ;
Cartón-Garcia, Fernando (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Leng, Changsen (University Medical Center Groningen) ;
Klappe, Karin (University Medical Center Groningen) ;
Dronkers, Just (University Medical Center Groningen) ;
Hsiao, Nai-Hua (University Medical Center Groningen) ;
Wang, Jian-She (Children's Hospital of Fudan University, Shanghai) ;
Arango, Diego (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
van Ijzendoorn, Sven C. D. (University Medical Center Groningen) ;
Universitat Autònoma de Barcelona
Progressive familial intrahepatic cholestasis (PFIC) 6 has been associated with missense but not biallelic nonsense or frameshift mutations in MYO5B, encoding the motor protein myosin Vb (myoVb). This genotype-phenotype correlation and the mechanism through which MYO5B mutations give rise to PFIC are not understood. [...]
2020 - 10.1002/hep.31002
Hepatology, Vol. 72 (april 2020) , p. 213-229
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5.
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29 p, 6.1 MB |
Loss of MYO5B expression deregulates late endosome size which hinders mitotic spindle orientation
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Leng, Changsen (Department of Biomedical Sciences of Cells and Systems, section Molecular Cell Biology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands) ;
Overeem, Arend W. (Department of Biomedical Sciences of Cells and Systems, section Molecular Cell Biology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands) ;
Cartón-Garcia, Fernando (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Li, Qinghong (Department of Biomedical Sciences of Cells and Systems, section Molecular Cell Biology, University of Groningen, University Medical Center Groningen) ;
Klappe, Karin (Department of Biomedical Sciences of Cells and Systems, section Molecular Cell Biology, University of Groningen, University Medical Center Groningen) ;
Kuipers, Jeroen (Department of Biomedical Sciences of Cells and Systems, section Molecular Cell Biology, University of Groningen, University Medical Center Groningen) ;
Cui, Yingying (Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen) ;
Zuhorn, Inge S. (Department of Biomedical Engineering, University of Groningen, University Medical Center Groningen) ;
Arango, Diego (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
van IJzendoorn, Sven C. D. (Department of Biomedical Sciences of Cells and Systems, section Molecular Cell Biology, University of Groningen, University Medical Center Groningen) ;
Universitat Autònoma de Barcelona
Recycling endosomes regulate plasma membrane recycling. Recently, recycling endosome-associated proteins have been implicated in the positioning and orientation of the mitotic spindle and cytokinesis. [...]
2019 - 10.1371/journal.pbio.3000531
PLoS biology, Vol. 17 (november 2019)
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6.
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11 p, 1.5 MB |
Mechanisms of inactivation of the tumour suppressor gene RHOA in colorectal cancer
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Dopeso, Higinio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rodrigues, Paulo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Bilic Zimmermann, Josipa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Bazzocco, Sarah (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Cartón-Garcia, Fernando (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Macaya, Irati (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
de Marcondes, Priscila Guimarães (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Anguita, Estefanía (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Masanas, Marc (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Jiménez-Flores, Lizbeth M. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Martínez-Barriocanal, Águeda (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Nieto Raya, Rocio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Segura, Miguel F. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Schwartz Jr, Simo (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Mariadason, John M. (La Trobe University School of Cancer Medicine, Olivia Newton-John Cancer Research Institute) ;
Arango, Diego (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Reduced RHOA signalling has been shown to increase the growth/metastatic potential of colorectal tumours. However, the mechanisms of inactivation of RHOA signalling in colon cancer have not been characterised. [...]
2017 - 10.1038/bjc.2017.420
British Journal of Cancer, Vol. 118 (december 2017) , p. 106-116
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