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Articles, 19 records found
Articles 19 records found  1 - 10next  jump to record:
1.
21 p, 2.7 MB Functionalized cerium oxide nanoparticles mitigate the oxidative stress and proinflammatory activity associated to the portal vein endothelium of cirrhotic rats / Ribera, Jordi (Hospital Clínic de Barcelona. Departament de Bioquímica i Genètica Molecular) ; Rodríguez Vita, Juan (German Cancer Research Center) ; Cordoba, Bernat (Hospital Clínic de Barcelona. Departament de Bioquímica i Genètica Molecular) ; Portolés, Irene (Hospital Clínic de Barcelona. Departament de Bioquímica i Genètica Molecular) ; Casals, Gregori (Hospital Clínic de Barcelona. Departament de Bioquímica i Genètica Molecular) ; Casals Mercadal, Eudald (Institut Català de Nanociència i Nanotecnologia) ; Jiménez, Wladimiro (Universitat de Barcelona. Departament de Biomedicina) ; Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia) ; Morales Ruiz, Manuel (Universitat de Barcelona. Departament de Biomedicina)
Background and aims- The occurrence of endothelial alterations in the liver and in the splanchnic vasculature of cirrhotic patients and experimental models of liver diseases has been demonstrated. However, the pathological role of the portal vein endothelium in this clinical context is scarcely studied and, therefore, deserves attention. [...]
2019 - 10.1371/journal.pone.0218716
PloS one, Vol. 14, Num. 6 (June 2019) , art. e0218716  
2.
15 p, 2.2 MB Shape matters : Effects of silver nanospheres and wires on human alveolar epithelial cells / Stoehr, Linda C. (University of Salzburg. Department of Molecular Biology) ; González, Edgar (Institut Català de Nanotecnologia) ; Stampfl, Andreas (Helmholtz Centre Munich) ; Casals Mercadal, Eudald (Institut Català de Nanociència i Nanotecnologia) ; Duschl, Albert (University of Salzburg. Department of Molecular Biology) ; Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia) ; Oostingh, G.J. (University of Salzburg. Department of Molecular Biology)
Background: In nanotoxicology, the exact role of particle shape, in relation to the composition, on the capacity to induce toxicity is largely unknown. We investigated the toxic and immunotoxic effects of silver wires (length: 1. [...]
2011 - 10.1186/1743-8977-8-36
Particle and fibre toxicology, Vol. 8 (December 2011) , art. 36  
3.
18 p, 2.1 MB The oxidative potential of differently charged silver and gold nanoparticles on three human lung epithelial cell types / Schlinkert, Paul (Paris Lodron-University of Salzburg. Department of Molecular Biology) ; Casals Mercadal, Eudald (Institut Català de Nanociència i Nanotecnologia) ; Boyles, Matthew S. P. (Paris Lodron-University of Salzburg. Department of Molecular Biology) ; Tischler, Ulrike (Paris Lodron-University of Salzburg. Department of Molecular Biology) ; Hornig, Eva (Paris Lodron-University of Salzburg. Department of Molecular Biology) ; Tran Thi Thanh, Ngoc (Institut Català de Nanotecnologia) ; Zhao, Jiayuan (Institute for Work and Health) ; Himly, Martin (Paris Lodron-University of Salzburg. Department of Molecular Biology) ; Riediker, Michael (Institue for Occupational Medicine) ; Oostingh, G.J. (Salzburg University of Applied Sciences) ; Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia) ; Duschl, Albert (Paris Lodron-University of Salzburg. Department of Molecular Biology)
Background: Nanoparticle (NPs) functionalization has been shown to affect their cellular toxicity. To study this, differently functionalized silver (Ag) and gold (Au) NPs were synthesised, characterised and tested using lung epithelial cell systems. [...]
2015 - 10.1186/s12951-014-0062-4
Journal of nanobiotechnology, Vol. 13 (January 2015) , art. 1  
4.
20 p, 3.7 MB Bacterial endotoxin (lipopolysaccharide) binds to the surface of gold nanoparticles, interferes with biocorona formation and induces human monocyte inflammatory activation / Li, Yang (Hebei Normal University) ; Shi, Zhenzhen (Kansas State University. Department of Anatomy and Physiology) ; Radauer-Preiml, Isabella (University of Salzburg. Department of Molecular Biology) ; Andosch, Ancuela (University of Salzburg. Department of Molecular Biology) ; Casals Mercadal, Eudald (Vall d'Hebron Institut de Recerca) ; Luetz-Meindl, Ursula (University of Salzburg. Department of Molecular Biology) ; Cobaleda-Siles, Macarena (Vall d'Hebron Institut de Recerca) ; Lin, Zhoumeng (Kansas State University. Department of Anatomy and Physiology) ; Jaberi-Douraki, Majid (Kansas State University. Department of Anatomy and Physiology) ; Italiani, Paola (National Research Council) ; Horejs-Hoeck, Jutta (University of Salzburg. Department of Molecular Biology) ; Himly, Martin (University of Salzburg. Department of Molecular Biology) ; Monteiro-Riviere, Nancy A. (Kansas State University. Department of Anatomy and Physiology) ; Duschl, Albert (University of Salzburg. Department of Molecular Biology) ; Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia) ; Boraschi, Diana (National Research Council)
Nanoparticles (NPs) are easily contaminated by bacterial endotoxin (lipopolysaccharide [LPS]). The presence of LPS can be responsible for many immune/inflammatory effects attributed to NPs. In this study, we examined the effects of LPS adsorption on the NP surface on the formation of a biocorona in biological fluids and on the subsequent inflammation-inducing activity of NPs. [...]
2017 - 10.1080/17435390.2017.1401142
Nanotoxicology, Vol. 11, Issue 9-10 (December 2017) , p. 1157-1175  
5.
1 p, 83.7 KB Corrigendum : Intrinsic and extrinsic properties affecting innate immune responses to nanoparticles: The case of cerium oxide / Casals Mercadal, Eudald (Vall d'Hebron Institut de Recerca) ; Gusta, Muriel F. (Vall d'Hebron Institut de Recerca) ; Piella, Jordi (Institut Català de Nanociència i Nanotecnologia) ; Casals, Gregori (Hospital Clínic Universitari) ; Jiménez Povedano, Wladimiro (Universitat de Barcelona. Departament de Biomedicina) ; Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia)
In the original article, we overlooked to include the FutureNanoNeeds Project financed by the European Community under the FP7 Programme under Grant Agreement No. 604602 (FP7-NMP-2013-LARGE-7, Grant Agreement No. [...]
2017 - 10.3389/fimmu.2017.01891
Frontiers in immunology, Vol. 8 (December 2017) , art. 1891  
6.
8 p, 1.2 MB Characterizing nanoparticles reactivity : structure-photocatalytic activity relationship / Piella, Jordi (Institut Català de Nanociència i Nanotecnologia) ; Gómez Bastús, Neus (Institut Català de Nanociència i Nanotecnologia) ; Casals Mercadal, Eudald (Vall d'Hebron Institut de Recerca) ; Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia)
Nanoparticles are reactive, and their final interactions with the surrounding media are ultimately determined by their reactivity, which in turns depends on the nanoparticles morphology, surface chemistry and environment in which they are embedded. [...]
2013 - 10.1088/1742-6596/429/1/012040
Journal of Physics: Conference Series, Vol. 429,conference 1 (2013) , art. 12040  
7.
7 p, 765.9 KB Intrinsic and extrinsic properties affecting innate immune responses to nanoparticles : The case of cerium oxide / Casals Mercadal, Eudald (Vall d'Hebron Institut de Recerca) ; Gusta, Muriel F. (Vall d'Hebron Institut de Recerca) ; Piella, Jordi (Institut Català de Nanociència i Nanotecnologia) ; Casals, Gregori (Hospital Clínic Universitari) ; Jiménez Povedano, Wladimiro (Universitat de Barcelona. Departament de Biomedicina) ; Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia)
We review the apparent discrepancies between studies that report anti-inflammatory effects of cerium oxide nanoparticles (CeO NPs) through their reactive oxygen specieschelating properties and immunological studies highlighting their toxicity. [...]
2017 - 10.3389/fimmu.2017.00970
Frontiers in immunology, Vol. 8 (August 2017) , art. 970  
8.
21 p, 792.0 KB Problems and challenges in the development and validation of human cell-based assays to determine nanoparticle-induced immunomodulatory effects / Oostingh, G.J. (Universität Salzburg. Fachbereich Molekulare Biologie) ; Casals Mercadal, Eudald (Institut Català de Nanotecnologia) ; Italiani, Paola (Istituto Nanoscienze Consiglio Nazionale delle Ricerche. Istituto di Tecnologie Biomediche) ; Colognato, Renato (Institute for Health and Consumer Protection (Ispra)) ; Stritzinger, René (Universität Salzburg. Fachbereich Molekulare Biologie) ; Ponti, Jessica (Institute for Health and Consumer Protection (Ispra)) ; Pfaller, Tobias (Universität Salzburg. Fachbereich Molekulare Biologie) ; Kohl, Yvonne (Fraunhofer-Institut für Biomedizinische Technik) ; Ooms, Daniëla (Centre for Advanced R&D on Alternative Methods (Bèlgica)) ; Favilli, Flavia (Istituto Nanoscienze Consiglio Nazionale delle Ricerche. Istituto di Tecnologie Biomediche) ; Leppens, Hilde (Centre for Advanced R&D on Alternative Methods (Bèlgica)) ; Lucchesi, Davide (Istituto Nanoscienze Consiglio Nazionale delle Ricerche. Istituto di Tecnologie Biomediche) ; Rossi, François (Institute for Health and Consumer Protection (Ispra)) ; Nelissen, Inge (Centre for Advanced R&D on Alternative Methods (Bèlgica)) ; Thielecke, Hagen (Fraunhofer-Institut für Biomedizinische Technik) ; Puntes, Víctor (Institució Catalana de Recerca i Estudis Avançats) ; Duschl, Albert (Universität Salzburg. Fachbereich Molekulare Biologie) ; Boraschi, Diana (Istituto Nanoscienze Consiglio Nazionale delle Ricerche. Istituto di Tecnologie Biomediche)
Background: With the increasing use of nanomaterials, the need for methods and assays to examine their immunosafety is becoming urgent, in particular for nanomaterials that are deliberately administered to human subjects (as in the case of nanomedicines). [...]
2011 - 10.1186/1743-8977-8-8
Particle and fibre toxicology, Vol. 8 (February 2011) , art. 8  
9.
19 p, 1.2 MB Cancer resistance to treatment and antiresistance tools offered by multimodal multifunctional nanoparticles / Casals Mercadal, Eudald (Vall d'Hebron Institut de Recerca) ; Gusta, Muriel F. (Vall d'Hebron Institut de Recerca) ; Cobaleda-Siles, Macarena (Vall d'Hebron Institut de Recerca) ; Garcia-Sanz, Ana (Vall d'Hebron Institut de Recerca) ; Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia)
Chemotherapeutic agents have limited efficacy and resistance to them limits today and will limit tomorrow our capabilities of cure. Resistance to treatment with anticancer drugs results from a variety of factors including individual variations in patients and somatic cell genetic differences in tumours. [...]
2017 - 10.1186/s12645-017-0030-4
Cancer Nanotechnology, Vol. 8, issue 1 (2017) , art. 7  
10.
20 p, 1.9 MB Chitosan functionalisation of gold nanoparticles encourages particle uptake and induces cytotoxicity and pro-inflammatory conditions in phagocytic cells, as well as enhancing particle interactions with serum components / Boyles, Matthew S. P. (Paris-Lodron-Universität Salzburg. Department of Molecular Biology) ; Kristl, Theresa (Paris-Lodron-Universität Salzburg. Department of Molecular Biology) ; Andosch, Ancuela (Paris-Lodron-Universität Salzburg. Department of Cell Biology) ; Zimmermann, Mirjam (Paris-Lodron-Universität Salzburg. Department of Molecular Biology) ; Tran Thi Thanh, Ngoc (Institut Català de Nanotecnologia) ; Casals Mercadal, Eudald (Institut Català de Nanotecnologia) ; Himly, Martin (Paris-Lodron-Universität Salzburg. Department of Molecular Biology) ; Puntes, Víctor (Institut Catala de Recerca i Estudis Avancats) ; Huber, Christian G. (Paris-Lodron-Universität Salzburg. Department of Molecular Biology) ; Lütz-Meindl, Ursula (Paris-Lodron-Universität Salzburg. Department of Cell Biology) ; Duschl, Albert (Paris-Lodron-Universität Salzburg. Department of Molecular Biology)
Gold nanoparticles (AuNPs) are a popular choice for use in medical and biomedical research applications. With suitable functionalisation AuNPs can be applied in drug delivery systems, or can aid in disease diagnosis. [...]
2015 - 10.1186/s12951-015-0146-9
Journal of nanobiotechnology, Vol. 13, Issue 84 (november 2015)  

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