Results overview: Found 6 records in 0.01 seconds.
Articles, 5 records found
Research literature, 1 records found
Articles 5 records found  
1.
20 p, 858.8 KB Adaptation and Conservation throughout the Drosophila melanogaster Life-Cycle / Coronado-Zamora, Marta (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Salvador-Martínez, Irepan (University College London. Department of Genetics, Evolution and Environment) ; Castellano Esteve, David (Aarhus University. Bioinformatics Research Center) ; Barbadilla Prados, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Salazar Ciudad, Isaac (Centre de Recerca Matemàtica)
Previous studies of the evolution of genes expressed at different life-cycle stages of Drosophila melanogaster have not been able to disentangle adaptive from nonadaptive substitutions when using nonsynonymous sites. [...]
2019 - 10.1093/gbe/evz086
Genome biology and evolution, Vol. 11, Num. 5 (May 2019) , p. 1463-1482  
2.
28 p, 2.6 MB Functional impact and evolution of a novel human polymorphic inversion that disrupts a gene and creates a fusion transcript / Puig Font, Marta (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Castellano Esteve, David (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Pantano, Lorena (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Giner-Delgado, Carla (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Izquierdo Fontanills, David (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Gayà Vidal, Magdalena (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Lucas Lledó, José Ignacio (Universitat de València. Institut Cavanilles de Biodiversitat i Biologia Evolutiva) ; Esko, Tõnu (Estonian Genome Center) ; Terao, Chikashi (Kyoto University Graduate School of Medicine) ; Matsuda, Fumihiko (Center for Genomic Medicine. Kyoto University Graduate School of Medicine) ; Cáceres Aguilar, Mario (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Despite many years of study into inversions, very little is known about their functional consequences, especially in humans. A common hypothesis is that the selective value of inversions stems in part from their effects on nearby genes, although evidence of this in natural populations is almost nonexistent. [...]
2015 - 10.1371/journal.pgen.1005495
PLoS Genetics, Vol. 11, issue 10 (2015) , art. e1005495  
3.
6 p, 807.2 KB The Drosophila melanogaster Genetic Reference Panel / MacKay, Trudy F. C. (Department of Genetics. North Carolina State University) ; Richards, Stephen (Human Genome Sequencing Center. Baylor College of Medicine) ; Stone, Eric A. (Department of Genetics. North Carolina State University) ; Barbadilla Prados, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Ayroles, Julien F. (Harvard University) ; Zhu, Dianhui (Human Genome Sequencing Center. Baylor College of Medicine) ; Casillas Viladerrams, Sònia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Han, Yi (Human Genome Sequencing Center. Baylor College of Medicine) ; Magwire, Michael M. (Department of Genetics. North Carolina State University) ; Cridland, Julie M. (Department of Ecology and Evolutionary Biology. University of California-Irvine) ; Richardson, Mark F. (Faculty of Life Sciences. University of Manchester) ; Anholt, Robert R. H. (Department of Biology. North Carolina State University) ; Barrón Aduriz, Maite Garazi (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Bess, Crystal (Human Genome Sequencing Center. Baylor College of Medicine) ; Blankenburg, Kerstin Petra (Human Genome Sequencing Center. Baylor College of Medicine) ; Carbone, Mary Anna (Department of Genetics. North Carolina State University) ; Castellano Esteve, David (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Chaboub, Lesley (Human Genome Sequencing Center. Baylor College of Medicine) ; Duncan, Laura (Department of Genetics. North Carolina State University) ; Harris, Zeke (Department of Genetics. North Carolina State University) ; Javaid, Mehwish (Human Genome Sequencing Center. Baylor College of Medicine) ; Jayaseelan, Joy Christina (Human Genome Sequencing Center. Baylor College of Medicine) ; Jhangiani, Shalini N. (Human Genome Sequencing Center. Baylor College of Medicine) ; Jordan, Katherine W. (Department of Genetics. North Carolina State University) ; Lara, Fremiet (Human Genome Sequencing Center. Baylor College of Medicine) ; Lawrence, Faye (Department of Genetics. North Carolina State University) ; Lee, Sandra L. (Human Genome Sequencing Center. Baylor College of Medicine) ; Librado, Pablo (Universitat de Barcelona. Departament de Genètica) ; Linheiro, Raquel S. (Faculty of Life Sciences. University of Manchester) ; Lyman, Richard F. (Department of Genetics. North Carolina State University) ; MacKey, Aaron J. (Center for Public Health Genomics. University of Virginia) ; Munidasa, Mala (Human Genome Sequencing Center. Baylor College of Medicine) ; Muzny, Donna Marie (Human Genome Sequencing Center. Baylor College of Medicine) ; Nazareth, Lynne (Human Genome Sequencing Center. Baylor College of Medicine) ; Newsham, Irene (Human Genome Sequencing Center. Baylor College of Medicine) ; Perales, Lora (Human Genome Sequencing Center. Baylor College of Medicine) ; Pu, Ling-Ling (Human Genome Sequencing Center. Baylor College of Medicine) ; Qu, Carson (Human Genome Sequencing Center. Baylor College of Medicine) ; Ràmia Jesús, Miquel (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Reid, Jeffrey G. (Human Genome Sequencing Center. Baylor College of Medicine) ; Rollmann, Stephanie M. (Department of Biological Sciences. University of Cincinnati) ; Rozas, Julio (Universitat de Barcelona. Departament de Genètica) ; Saada, Nehad (Human Genome Sequencing Center. Baylor College of Medicine) ; Turlapati, Lavanya (Department of Genetics. North Carolina State University) ; Worley, Kim C. (Human Genome Sequencing Center. Baylor College of Medicine) ; Wu, Yuan-Qing (Human Genome Sequencing Center. Baylor College of Medicine) ; Yamamoto, Akihiko (Department of Genetics. North Carolina State University) ; Zhu, Yiming (Human Genome Sequencing Center. Baylor College of Medicine) ; Bergman, Casey M. (Faculty of Life Sciences. University of Manchester) ; Thornton, Kevin R. (Department of Ecology and Evolutionary Biology. University of California-Irvine) ; Mittelman, David (Virginia Bioinformatics Institute. Department of Biological Sciences. Virginia Tech) ; Gibbs, Richard A. (Human Genome Sequencing Center. Baylor College of Medicine)
A major challenge of biology is understanding the relationship between molecular genetic variation and variation in quantitative traits, including fitness. This relationship determines our ability to predict phenotypes from genotypes and to understand how evolutionary forces shape variation within and between species. [...]
2012 - 10.1038/nature10811
Nature, Vol. 482, issue 7384 (Feb. 2012) , p. 173-178  
4.
14 p, 1.8 MB Evolutionary and functional impact of common polymorphic inversions in the human genome / Giner-Delgado, Carla (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Villatoro, Sergi (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Lerga Jaso, Jon (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Gayà Vidal, Magdalena (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Oliva Pavia, Meritxell (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Castellano Esteve, David (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Pantano, Lorena (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Bitarello, Bárbara D. (Max-Planck-Institut für Evolutionäre Anthropologie) ; Izquierdo Fontanills, David (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Noguera, Isaac (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Olalde, Iñigo (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ; Delprat Obeaga, Alejandra (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Blancher, Antoine (Centre de Physiopathologie Toulouse-Purpan) ; Lalueza-Fox, Carles (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ; Esko, Tõnu (Estonian Genome Center) ; O'Reilly, Paul F. (King's College London. Institute of Psychiatry, Psychology & Neuroscience) ; Andrés, Aida M. (Max-Planck-Institut für Evolutionäre Anthropologie) ; Ferretti, Luca (University of Oxford. Big Data Institute) ; Puig Font, Marta (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Cáceres Aguilar, Mario (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Inversions are one type of structural variants linked to phenotypic differences and adaptation in multiple organisms. However, there is still very little information about polymorphic inversions in the human genome due to the difficulty of their detection. [...]
2019 - 10.1038/s41467-019-12173-x
Nature communications, Vol. 10 (2019) , art. 4222  
5.
14 p, 652.3 KB Adaptive evolution is substantially impeded by Hill-Robertson interference in Drosophila / Castellano Esteve, David (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Coronado-Zamora, Marta (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Campos, Jose L. (University of Edinburgh. Institute of Evolutionary Biology, School of Biological Sciences) ; Barbadilla Prados, Antonio (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Eyre-Walker, Adam (University of Sussex. Centre for the Study of Evolution, School of Life Sciences) ; Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia
Hill-Robertson interference (HRi) is expected to reduce the efficiency of natural selection when two or more linked selected sites do not segregate freely, but no attempt has been done so far to quantify the overall impact of HRi on the rate of adaptive evolution for any given genome. [...]
2015 - 10.1093/molbev/msv236
Molecular biology and evolution, Vol. 33, Núm. 2 (October 2015) , p. 442-455  

Research literature 1 records found  
1.
267 p, 6.3 MB Estimación de la huella de la selección natural y el efecto Hill-Robertson a lo largo del genoma de Drosophila melanogaster / Castellano Esteve, David ; Barbadilla Prados, Antonio, dir. ; Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia
La presente tesis es un estudio exhaustivo de genómica de poblaciones en la especie modelo Drosophila melanogaster la cual combina aproximaciones bioinformáticas y teórico-estadísticas. El objetivo de este estudio es doble, queremos estimar la importancia relativa de distintos regímenes de selección natural y el impacto del efecto Hill-Robertson a lo largo del genoma de D. [...]
The present thesis is a comprehensive population genomic study in the model species Drosophila melanogaster which combines bioinformatic and theoretical-statistical approaches. The purpose of this study is two-fold, we want to estimate the relative importance of different regimes of natural selection and the impact of the Hill-Robertson effect along the genome of D. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2016  

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