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5 p, 420.5 KB |
Evolocumab has no effects on heart failure with reduced ejection fraction injury biomarkers : The EVO-HF trial
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Bayés-Genís, Antoni (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Lupón, Josep (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Revuelta-López, Elena (Institut Germans Trias i Pujol) ;
Llibre, Cinta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gastelurrutia, Paloma (Institut Germans Trias i Pujol) ;
Domingo, Mar (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Cediel, Germán (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Codina, Pau (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Santiago Vacas, Evelyn (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rangel-Sousa, Diego (Hospital Universitario Virgen del Rocío (Andalusia)) ;
Fernández-Cisnal, Agustín (Fundación Investigación Clínico de Valencia-Instituto de Investigación Sanitaria) ;
Miñana, Gema (Universitat de València. Departament de Medicina) ;
Mollar, Anna (Fundación Investigación Clínico de Valencia-Instituto de Investigación Sanitaria) ;
Núñez, Julio (Universitat de València. Departament de Medicina)
Aim: Patients with heart failure with reduced ejection fraction (HFrEF) have not been shown to benefit from statins. We hypothesized that, by limiting disease progression in stable HFrEF of ischaemic etiology, the proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor evolocumab could reduce circulating troponin levels, a surrogate biomarker of myocyte injury and atherosclerosis progression. [...]
2023 -  10.1002/ejhf.2932
European Journal of Heart Failure, Vol. 25 Núm. 8 (august 2023) , p. 1439-1443
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21 p, 1.6 MB |
A Fibrosis Biomarker Early Predicts Cardiotoxicity Due to Anthracycline-Based Breast Cancer Chemotherapy
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de la Fuente, Ana (Clínica Universidad de Navarra) ;
Santisteban, Marta (Clínica Universidad de Navarra) ;
Lupón, Josep (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Aramendía, José Manuel (Clínica Universidad de Navarra) ;
Díaz, Agnes (Clínica Universidad de Navarra) ;
Santaballa, Ana (Instituto de Investigación Sanitaria La Fe) ;
Hernándiz, Amparo (Instituto de Investigación Sanitaria La Fe) ;
Sepúlveda, Pilar (Instituto de Investigación Sanitaria La Fe) ;
Cediel, Germán (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
López, Begoña (Clínica Universidad de Navarra) ;
Picazo, José María López (Clínica Universidad de Navarra) ;
Mazo, Manuel M. (Clínica Universidad de Navarra) ;
Rábago, Gregorio (Clínica Universidad de Navarra) ;
Gavira, Juan José (Clínica Universidad de Navarra) ;
García-Bolao, Ignacio (Clínica Universidad de Navarra) ;
Díez, Javier (Clínica Universidad de Navarra) ;
González, Arantxa (Clínica Universidad de Navarra) ;
Bayés-Genís, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ravassa, Susana (Clínica Universidad de Navarra) ;
Universitat Autònoma de Barcelona
Left ventricular dysfunction (LVD) induced by anthracycline-based cancer chemotherapy (ACC) is becoming an urgent healthcare concern. Myocardial fibrosis (MF) may contribute to LVD after ACC. We show that elevated circulating levels of procollagen type I C-terminal propeptide (PICP, biomarker of MF) are associated with early subclinical LVD and predict later development of cardiotoxicity in patients treated with ACC. [...]
2022 - 10.3390/cancers14122941
Cancers, Vol. 14 (june 2022)
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11 p, 1.8 MB |
Sacubitril/valsartan affects pulmonary arterial pressure in heart failure with preserved ejection fraction and pulmonary hypertension
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Codina, Pau (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Domingo, Mar (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Barceló, Elena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gastelurrutia, Paloma (Institut d'Investigació Biomèdica de Bellvitge) ;
Casquete, Daniel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Vila, Joan (Hospital del Mar (Barcelona, Catalunya)) ;
Abdul-Jawad Altisent, Omar (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Spitaleri, Giosafat (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Cediel, Germán (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Santiago Vacas, Evelyn (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Zamora, Elisabet (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ruiz-Cueto, María (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Santesmases, Javier (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
De la Espriella, Rafael (Universitat de València) ;
Pascual-Figal, Domingo A. (Centro Nacional de Investigaciones cardiovasculares (CNIC)) ;
Núñez, Julio (Universitat de València) ;
Lupón, Josep (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bayés-Genís, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Prior studies have not fully characterized the haemodynamic effects of the angiotensin receptor-neprilysin inhibitor (ARNI) sacubitril/valsartan in heart failure with preserved ejection fraction and pulmonary hypertension (HFpEF-PH). [...]
2022 - 10.1002/ehf2.13952
ESC Heart Failure, Vol. 9 (may 2022) , p. 2170-2180
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10 p, 461.9 KB |
Quality of life in patients with heart failure and improved ejection fraction : one-year changes and prognosis
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Zamora, Elisabet (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
González Fernández, Beatriz (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Lupón, Josep (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Borrellas, Andrea (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Domingo, Mar (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Santiago Vacas, Evelyn (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Cediel, Germán (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Codina, Pau (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rivas, Carmen (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pulido, Ana (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Crespo, Eva (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Velayos, Patricia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Díaz, Violeta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bayés-Genís, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
The criteria for patients with heart failure (HF) and improved ejection fraction (HFimpEF) are a baseline left ventricular ejection fraction (LVEF) ≤40%, a ≥10-point increase from baseline LVEF, and a second LVEF measurement >40%. [...]
2022 - 10.1002/ehf2.14098
ESC Heart Failure, Vol. 9 (august 2022) , p. 3804-3813
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13 p, 983.7 KB |
Fatty Acid Binding Proteins 3 and 4 Predict Both All-Cause and Cardiovascular Mortality in Subjects with Chronic Heart Failure and Type 2 Diabetes Mellitus
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Rodríguez-Calvo, Ricardo (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas) ;
Granado-Casas, Minerva (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) ;
Pérez-Montes de Oca, Alejandra (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Julián, María Teresa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Domingo, Mar (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Codina, Pau (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Santiago Vacas, Evelyn (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Cediel, Germán (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Julve i Gil, Josep (Institut d'Investigació Biomèdica Sant Pau) ;
Rossell, Joana (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas) ;
Masana, Lluís (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas) ;
Mauricio Puente, Dídac (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Lupón, Josep (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Bayés-Genís, Antoni (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Alonso Pedrol, Núria (Universitat Autònoma de Barcelona. Departament de Medicina)
Subjects with type 2 diabetes mellitus (T2D) are at increased risk for heart failure (HF). The cardiac-specific (FABP3) and adipose-tissue-specific (FABP4) types of the fatty acid binding proteins have been associated with both all-cause and cardiovascular (CV) mortality. [...]
2023 - 10.3390/antiox12030645
Antioxidants, Vol. 12 (march 2023)
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13 p, 254.3 KB |
Long-term antibiotic therapy in patients with surgery-indicated not undergoing surgery infective endocarditis
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Vallejo Camazon, Nuria (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Mateu, Lourdes (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Cediel, Germán (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Escolà-Vergé, Laura (Hospital Universitari Vall d'Hebron) ;
Fernández-Hidalgo, Nuria (Hospital Universitari Vall d'Hebron) ;
Gurguí, Mercè (Institut d'Investigació Biomèdica Sant Pau) ;
Pérez Rodriguez, María Teresa (Unidad de Enfermedades Infecciosas. Servicio de Medicina Interna. Complexo Hospitalario de Vigo) ;
Cuervo, Guillermo (Hospital Universitari de Bellvitge) ;
Núñez Aragón, Raquel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Llibre, Cinta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Sopena, Nieves (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Quesada, María Dolores (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Berastegui García, Elisabet (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Teis, Albert (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
López Ayerbe, Jorge (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Juncà Puig, Gladys (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gual, Francisoc (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ferrer Sistach, Elena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Vivero, Ainhoa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Reynaga, Esteban (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Hernández Pérez, María (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Muñoz Guijosa, Christian (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pedro-Botet, Lluïsa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bayés-Genís, Antoni (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Universitat Autònoma de Barcelona
Background: To date, there is little information regarding management of patients with infective endocarditis (IE) that did not undergo an indicated surgery. Therefore, we aimed to evaluate prognosis of these patients treated with a long-term antibiotic treatment strategy, including oral long term suppressive antibiotic treatment in five referral centres with a multidisciplinary endocarditis team. [...]
2021 - 10.5603/CJ.a2021.0054
Cardiology Journal, Vol. 28 Núm. 4 (2021) , p. 566-578
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11 p, 7.3 MB |
Lung ultrasound in outpatients with heart failure : the wet-to-dry HF study
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Domingo, Mar (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Lupón, Josep (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
Girerd, Nicolás (Centre d'Investigations Cliniques Plurithématique 1433. INSERM DCAC. CHRU de Nancy. F-CRIN INI-CRCT. Université de Lorraine) ;
Conangla, Laura (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
de Antonio Ferrer, Marta (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
Moliner, Pedro (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Santiago-Vacas, Evelyn (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Codina, Pau (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Cediel, Germán (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Spitaleri, Giosafat (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
González, Beatriz (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Díaz, Violeta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rivas Jiménez, Carmen (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Velayos, Patricia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Núñez, Julio (Universitat de València. Departament de Medicina) ;
Bayés-Genís, Antoni (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
Universitat Autònoma de Barcelona
Aims: In ambulatory patients with chronic heart failure (HF), congestion and decongestion assessment may be challenging. The aim of this study is to assess the value of lung ultrasound (LUS) in outpatients with HF in characterizing decompensation and recompensation, and in outcomes prediction. [...]
2021 - 10.1002/ehf2.13660
ESC Heart Failure, Vol. 8 Núm. 6 (december 2021) , p. 4506-4516
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8 p, 1.5 MB |
Circulating linoleic acid at the time of myocardial infarction and risk of primary ventricular fibrillation
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Oliveras, Teresa (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Lázaro, Iolanda (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Rueda, Ferran (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Cediel, Germán (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Bhatt, Deepak L. (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ;
Fitó, Montserrat (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Madrid-Gambin, Francisco (Barcelona Institute of Science and Technology (BIST)) ;
Pozo, Oscar J. (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Harris, William S. (University of South Dakota) ;
Garcia Garcia, Cosme (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Sala-Vila, Aleix (Sioux Falls (Estats Units d'Amèrica)) ;
Bayés-Genís, Antoni (Universitat Autònoma de Barcelona. Departament de Medicina)
Primary ventricular fibrillation (PVF) is a major driver of cardiac arrest in the acute phase of ST-segment elevation myocardial infarction (STEMI). Enrichment of cardiomyocyte plasma membranes with dietary polyunsaturated fatty acids (PUFA) reduces vulnerability to PVF experimentally, but clinical data are scarce. [...]
2022 - 10.1038/s41598-022-08453-0
Scientific reports, Vol. 12 (march 2022)
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10 p, 895.6 KB |
Cause of Death in Heart Failure Based on Etiology : Long-Term Cohort Study of All-Cause and Cardiovascular Mortality
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Spitaleri, Giosafat (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Zamora, Elisabet (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Cediel, Germán (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Codina, Pau (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Santiago Vacas, Evelyn (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Domingo, Mar (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Lupón, Josep (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Santesmases, Javier (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Diez-Quevedo, Crisanto (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Troya, Maria Isabel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Boldo Alcaine, Maria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Altimir Losada, Salvador (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Alonso Pedrol, Núria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
González Fernández, Beatriz (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bayés-Genís, Antoni (Universitat Autònoma de Barcelona. Departament de Medicina)
We assessed differences in long-term all-cause and cardiovascular (CV) mortality in heart failure (HF) outpatients based on the etiology of HF. Consecutive patients admitted to the HF Clinic from August 2001 to September 2019 (N = 2587) were considered for inclusion. [...]
2022 - 10.3390/jcm11030784
Journal of clinical medicine, Vol. 11 Núm. 3 (january 2022)
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