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24 p, 1.1 MB |
Highlights from the 2019 International Aspirin Foundation Scientific Conference, Rome, 28 June 2019 : Benefits and risks of antithrombotic therapy for cardiovascular disease prevention
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Walker, Jaqui (International Aspirin Foundation) ;
Cattaneo, Marco (Università degli studi di Milano) ;
Badimon, Lina (Institut d'Investigació Biomèdica Sant Pau) ;
Agnelli, Giancarlo (University of Perugia) ;
Chan, Andrew T. (Harvard Medical School) ;
Lanas, Angel (Universidad de Zaragoza) ;
Rocca, Bianca (Catholic University School of Medicine) ;
Rothwell, Peter (Centre for the Prevention of Stroke and Dementia) ;
Patrignani, Paola ('G.d'Annunizio' University) ;
Langley, Ruth (MRC Clinical Trials Unit at UCL) ;
Vilahur, Gemma (Institut d'Investigació Biomèdica Sant Pau) ;
Cosentino, Francesco (Karolinska University Hospital and Karolinska Institutet (Suecia)) ;
Universitat Autònoma de Barcelona
At the 2019 International Aspirin Foundation Scientific Conference 'Benefits and Risks of Antithrombotic Therapy for Cardiovascular Disease Prevention', held in Rome, Italy, international experts sought to discuss and debate the optimal antithrombotic strategy for the secondary prevention of cardiovascular disease (CVD) and to seek agreement around dosing and target populations for aspirin use in primary disease prevention. [...]
2020 -  10.3332/ECANCER.2019.998
ecancermedicalscience, Vol. 14 (13 2020) , p. 998
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8 p, 1.1 MB |
Autoimmunity and long-term safety and efficacy of alemtuzumab for multiple sclerosis : Benefit/risk following review of trial and post-marketing data
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Coles, Alasdair J. (University of Cambridge) ;
Jones, Joanne L. (University of Cambridge) ;
Vermersch, Patrick (Université de Lille) ;
Traboulsee, Anthony (University of British Columbia) ;
Bass, Ann D. (Neurology Center of San Antonio) ;
Boster, Aaron (Boster Center for Multiple Sclerosis) ;
Chan, Andrew (University of Bern) ;
Comi, Giancarlo (Vita-Salute San Raffaele University) ;
Fernández, Óscar (Hospital Regional Universitario Carlos Haya (Málaga)) ;
Giovannoni, Gavin (Queen Mary University of London) ;
Kubala Havrdova, Eva (Charles University) ;
LaGanke, Christopher (North Central Neurology Associates) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron) ;
Oreja-Guevara, Celia (Universidad Complutense de Madrid) ;
Piehl, Fredrik (Karolinska Institutet (Estocolm, Suècia)) ;
Wiendl, Heinz (University of Münster) ;
Ziemssen, Tjalf (Dresden University of Technology) ;
Universitat Autònoma de Barcelona
Does preexisting or treatment-emergent autoimmunity increase the risk of subsequent autoimmune disease in individuals with relapsing-remitting multiple sclerosis (MS) after alemtuzumab? In the extended phase 2/3 trials, 34/96 (35. [...]
2022 - 10.1177/13524585211061335
Multiple sclerosis, Vol. 28 Núm. 5 (2022) , p. 842-846
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10 p, 554.6 KB |
Early Reduction of MRI Activity During 6 Months of Treatment With Cladribine Tablets for Highly Active Relapsing Multiple Sclerosis
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De Stefano, Nicola (Hospital Universitari Vall d'Hebron) ;
Barkhof, Frederik (Hospital Universitari Vall d'Hebron) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron) ;
Achiron, Anat (Hospital Universitari Vall d'Hebron) ;
Derfuss, Tobias (Hospital Universitari Vall d'Hebron) ;
Chan, Andrew (Hospital Universitari Vall d'Hebron) ;
Hodgkinson, Suzanne (Hospital Universitari Vall d'Hebron) ;
Prat, Alexandre (Hospital Universitari Vall d'Hebron) ;
Leocani, Letizia (Hospital Universitari Vall d'Hebron) ;
Schmierer, Klaus (Hospital Universitari Vall d'Hebron) ;
Sellebjerg, Finn (Hospital Universitari Vall d'Hebron) ;
Vermersch, Patrick (Hospital Universitari Vall d'Hebron) ;
Wiendl, Heinz (Hospital Universitari Vall d'Hebron) ;
Keller, Birgit (Hospital Universitari Vall d'Hebron) ;
Roy, Sanjeev (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
The onset of action for high-efficacy immunotherapies in multiple sclerosis (MS) is an important parameter. This study (MAGNIFY-MS) evaluates the onset of action of cladribine tablets by observing changes in combined unique active (CUA) MRI lesion counts during the first 6 months of treatment in patients with highly active relapsing MS. [...]
2022 - 10.1212/NXI.0000000000001187
Neurology® neuroimmunology & neuroinflammation, Vol. 9 (june 2022)
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11 p, 760.7 KB |
Specific Patterns of Immune Cell Dynamics May Explain the Early Onset and Prolonged Efficacy of Cladribine Tablets
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Wiendl, Heinz (Hospital Universitari Vall d'Hebron) ;
Schmierer, Klaus (Hospital Universitari Vall d'Hebron) ;
Hodgkinson, Suzanne (Hospital Universitari Vall d'Hebron) ;
Derfuss, Tobias (Hospital Universitari Vall d'Hebron) ;
Chan, Andrew (Hospital Universitari Vall d'Hebron) ;
Sellebjerg, Finn (Hospital Universitari Vall d'Hebron) ;
Achiron, Anat (Hospital Universitari Vall d'Hebron) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron) ;
Prat, Alexandre (Hospital Universitari Vall d'Hebron) ;
De Stefano, Nicola (Hospital Universitari Vall d'Hebron) ;
Barkhof, Frederik (Hospital Universitari Vall d'Hebron) ;
Leocani, Letizia (Hospital Universitari Vall d'Hebron) ;
Vermersch, Patrick (Hospital Universitari Vall d'Hebron) ;
Chudecka, Anita (Hospital Universitari Vall d'Hebron) ;
Mwape, Claire (Hospital Universitari Vall d'Hebron) ;
Holmberg, Kristina H. (Hospital Universitari Vall d'Hebron) ;
Boschert, Ursula (Hospital Universitari Vall d'Hebron) ;
Roy, Sanjeev (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
Cladribine tablets cause a reduction in lymphocytes with a predominant effect on B-cell and T-cell counts. The MAGNIFY-MS substudy reports the dynamic changes on multiple peripheral blood mononuclear cell (PBMC) subtypes and immunoglobulin (Ig) levels over 12 months after the first course of cladribine tablets in patients with highly active relapsing multiple sclerosis (MS). [...]
2022 - 10.1212/NXI.0000000000200048
Neurology® neuroimmunology & neuroinflammation, Vol. 10 (november 2022)
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6 p, 201.9 KB |
Pharmacogenomic study in patients with multiple sclerosis
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Bustamante, Marta F. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Morcillo-Suarez, Carlos (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Malhotra, Sunny (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rio, Jordi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Leyva, Laura (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Fernández, Oscar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Zettl, Uwe K. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Killestein, Joep (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Brassat, David (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
García-Merino, Juan Antonio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Sánchez, Antonio J. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Urcelay, Elena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Alvarez-Lafuente, Roberto (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Villar, Lusia M. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Alvarez-Cermeño, José C (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Farré, Xavier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Lechner-Scott, Jeannette (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Vandenbroeck, Koen (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rodríguez-Antigüedad, Alfredo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Martinelli Boneschi, Filippo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Chan, Andrew (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Oksenberg, Jorge (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Navarro, Arcadi, 1969- (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Comabella, Manuel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
We aimed to investigate the association between polymorphisms located in type I interferon (IFN)-induced genes, genes belonging to the toll-like receptor (TLR) pathway, and genes encoding neurotransmitter receptors and the response to IFN-β treatment in patients with multiple sclerosis (MS). [...]
2015 - 10.1212/NXI.0000000000000154
Neurology® neuroimmunology & neuroinflammation, Vol. 2 (september 2015)
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23 p, 7.5 MB |
The Rare IL22RA2 Signal Peptide Coding Variant rs28385692 Decreases Secretion of IL-22BP Isoform-1, -2 and -3 and Is Associated with Risk for Multiple Sclerosis
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Gómez-Fernández, Paloma (University of the Basque Country) ;
Lopez de Lapuente Portilla, Aitzkoa (Lund University) ;
Astobiza, Ianire (University of the Basque Country) ;
Mena, Jorge (Instituto de Investigación Sanitaria Biocruces Bizkaia) ;
Urtasun, Andoni (University of the Basque Country) ;
Altmann, Vivian (University of Lübeck) ;
Matesanz, Fuencisla (Instituto de Parasitología y Biomedicina "López-Neyra") ;
Otaegui, David (Biodonostia Osasun Ikerketako Institutura (País Basc)) ;
Urcelay, Elena (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ;
Antigüedad, Alfredo (Hospital Universitario de Cruces (Barakaldo, País Basc)) ;
Malhotra, Sunny (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Castillo-Triviño, Tamara (Biodonostia Osasun Ikerketako Institutura (País Basc)) ;
Espino-Paisán, Laura (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ;
Aktas, Orhan (Heinrich-Heine University Düsseldorf) ;
Buttmann, Mathias (Caritas Hospital) ;
Chan, Andrew (Bern University Hospital) ;
Fontaine, Bertrand (University Hospital Pitié-Salpêtrière) ;
Gourraud, Pierre-Antoine (CHU de Nantes) ;
Hecker, Michael (University of Rostock) ;
Hoffjan, Sabine (Ruhr-University Bochum) ;
Kubisch, Christian (University Medical Center Hamburg-Eppendorf) ;
Kümpfel, Tania (Ludwig-Maximilians University) ;
Luessi, Felix (University Medical Center of the Johannes Gutenberg University Mainz) ;
Zettl, Uwe K. (University of Rostock) ;
Zipp, Frauke (University Medical Center of the Johannes Gutenberg University Mainz) ;
Alloza, Iraide (Instituto de Investigación Sanitaria Biocruces Bizkaia) ;
Comabella, Manuel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Lill, Christina M. (Imperial College) ;
Vandenbroeck, Koen (Ikerbasque) ;
Universitat Autònoma de Barcelona
The IL22RA2 locus is associated with risk for multiple sclerosis (MS) but causative variants are yet to be determined. In a single nucleotide polymorphism (SNP) screen of this locus in a Basque population, rs28385692, a rare coding variant substituting Leu for Pro at position 16 emerged significantly (p = 0. [...]
2020 - 10.3390/cells9010175
Cells, Vol. 9 (january 2020)
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7 p, 1018.1 KB |
Analysis of Plasminogen Genetic Variants in Multiple Sclerosis Patients
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Sadovnick, A. Dessa (University of British Columbia) ;
Traboulsee, Anthony L. (University of British Columbia) ;
Bernales, Cecily Q. (University of British Columbia) ;
Ross, Jay P. (University of British Columbia) ;
Forwell, Amanda L. (University of British Columbia) ;
Yee, Irene M. (University of British Columbia) ;
Guillot-Noel, Lena (Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, France) ;
Fontaine, Bertrand (Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, France) ;
Cournu-Rebeix, Isabelle (Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, France) ;
Alcina, Antonio (Instituto de Parasitología y Biomedicina "López-Neyra") ;
Fedetz, Maria (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ;
Izquierdo, Guillermo (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ;
Matesanz, Fuencisla (Instituto de Parasitología y Biomedicina "López-Neyra") ;
Hilven, Kelly (University of Leuven) ;
Dubois, Bénédicte (University Hospitals Leuven (Bèlgica)) ;
Goris, An (University of Leuven) ;
Astobiza, Ianire (Achucarro Basque Center for Neuroscience) ;
Alloza, Iraide (IKERBASQUE, Basque Foundation for Science) ;
Antigüedad, Alfredo (Hospital de Basurto (Bilbao, Biscaia)) ;
Vandenbroeck, Koen (IKERBASQUE, Basque Foundation for Science) ;
Akkad, Denis A. (Ruhr University) ;
Aktas, Orhan (Heinrich Heine University) ;
Blaschke, Paul (University of Rostock) ;
Buttmann, Mathias (University of Würzburg) ;
Chan, Andrew (Bern University Hospital) ;
Epplen, Joerg T. (Ruhr University) ;
Gerdes, Lisa-Ann (Institute for Clinical Neuroimmunology, Ludwig Maximilian University) ;
Kroner, Antje (Medical College of Wisconsin) ;
Kubisch, Christian (University Medical Center Hamburg-Eppendorf) ;
Kümpfel, Tania (Ludwig Maximilian University) ;
Lohse, Peter (Institute of Laboratory Medicine and Human Genetics) ;
Rieckmann, Peter (Sozialstiftung Bamberg Hospital) ;
Zettl, Uwe K. (University of Rostock) ;
Zipp, Frauke (University Medical Center of the Johannes Gutenberg-University Mainz) ;
Bertram, Lars (Imperial College London) ;
Lill, Christina M. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Fernández, Oscar (Instituto de Investigación Biomédica de Málaga) ;
Urbaneja, Patricia (Instituto de Investigación Biomédica de Málaga) ;
Leyva, Laura (Instituto de Investigación Biomédica de Málaga) ;
Alvarez-Cermeño, José C (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ;
Arroyo, Rafael (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ;
Garagorri, Aroa M. (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ;
García-Martínez, Angel (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ;
Villar, Luisa M. (Hospital Universitario Ramón y Cajal (Madrid)) ;
Urcelay, Elena (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ;
Malhotra, Sunny (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Comabella, Manuel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Berger, Thomas (Medical University of Innsbruck) ;
Fazekas, Franz (Medical University of Graz) ;
Reindl, Markus (Medical University of Innsbruck) ;
Schmied, Mascha C. (Medical University of Vienna) ;
Zimprich, Alexander (Medical University of Vienna) ;
Vilariño-Güell, Carles (University of British Columbia) ;
Universitat Autònoma de Barcelona
Multiple sclerosis (MS) is a prevalent neurological disease of complex etiology. Here, we describe the characterization of a multi-incident MS family that nominated a rare missense variant (p. G420D) in plasminogen (PLG) as a putative genetic risk factor for MS. [...]
2016 - 10.1534/g3.116.030841
G3, Vol. 6 (may 2016) , p. 2073-2079
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5 p, 320.8 KB |
Natalizumab-related anaphylactoid reactions in MS patients are associated with HLA class II alleles
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de la Hera, Belén (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ;
Urcelay, Elena (Hopital Purpan, Toulouse) ;
Brassat, David (Ruhr University, Bochum) ;
Chan, Andrew ;
Vidal-Jordana, Angela (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Salmen, Anke (St. Josef-Hospital) ;
Villar, Luisa Maria (Hospital Universitario Ramón y Cajal (Madrid)) ;
Alvarez-Cermeño, José C (Hospital Universitario Ramón y Cajal (Madrid)) ;
Izquierdo, Guillermo (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ;
Fernández, Oscar (Hospital Regional Universitario de Málaga) ;
Oliver, Begoña (Instituto de Investigación Biomédica de Málaga) ;
Saiz, Albert (Hospital Clínic i Provincial de Barcelona) ;
Ara, Jose Ramón (Universidad de Zaragoza) ;
Vigo, Ana G. ;
Arroyo, Rafael ;
Meca-Lallana, Virginia (Hospital Universitario de la Princesa (Madrid)) ;
Malhotra, Sunny (Hospital Universitari Vall d'Hebron) ;
Fissolo, Nicolás (Hospital Universitari Vall d'Hebron) ;
Horga, Alejandro ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron) ;
Comabella, Manuel (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
We aimed to investigate potential associations between human leukocyte antigen (HLA) class I and class II alleles and the development of anaphylactic/anaphylactoid reactions in patients with multiple sclerosis (MS) treated with natalizumab. [...]
2014 - 10.1212/NXI.0000000000000047
Neurology® neuroimmunology & neuroinflammation, Vol. 1 (december 2014)
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