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Safety, efficacy, and pharmacokinetics of gremubamab (MEDI3902), an anti-Pseudomonas aeruginosa bispecific human monoclonal antibody, in P. aeruginosa-colonised, mechanically ventilated intensive care unit patients : a randomised controlled trial
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Chastre, Jean (Service de Médecine Intensive Réanimation. Institut de Cardiologie. Groupe Hospitalier Pitié-Salpêtrière. Assistance Publique-Hôpitaux de Paris. Sorbonne University) ;
François, Bruno (Réanimation Polyvalente and Inserm CIC 1435 & UMR 1092. CHU) ;
Bourgeois, Marc (AZ Sint-Jan Brugge-Oostende AV) ;
Komnos, Apostolos (General Hospital of Larissa) ;
Ferrer, Ricard (Hospital Universitari Vall d'Hebron) ;
Rahav, Galia (Chaim Sheba Medical Center. Sackler School of Medicine. Tel Aviv University) ;
De Schryver, Nicolas (Clinique Saint-Pierre) ;
Lepape, Alain (Hospices Civils de Lyon Hôpital Lyon Sud) ;
Koksal, Iftihar (Faculty of Medicine. Trabzon and Acibadem University Faculty of Medicine. Karadeniz Technical University) ;
Luyt, Charles-Edouard (Service de Médecine Intensive Réanimation. Institut de Cardiologie. Groupe Hospitalier Pitié-Salpêtrière. Assistance Publique-Hôpitaux de Paris. Sorbonne University) ;
Sánchez-García, Miguel (Hospital Clínico San Carlos. Unidad de Cuidados Intensivos) ;
Torres, Antoni (Hospital Clínic i Provincial de Barcelona. Servei de Pneumologia) ;
Eggimann, Philippe (Department of Locomotor Apparatus. Centre Hospitalier Universitaire Vaudois CHUV) ;
Koulenti, Despoina (2nd Critical Care Department. Attikon University Hospital. National and Kapodistrian. University of Athens) ;
Holland, Thomas L. (Duke Clinical Research Institute) ;
Ali, Omar (Clinical Research and Development. Vaccines and Immune Therapies. BioPharmaceuticals R&D. AstraZeneca Biopharmaceuticals) ;
Shoemaker, Kathryn (Respiratory and Immunology. BioPharmaceuticals R&D. AstraZeneca) ;
Ren, Pin (Respiratory and Immunology. BioPharmaceuticals R&D. AstraZeneca) ;
Sauser, Julien (Infection Control Program. Faculty of Medicine. Geneva University Hospitals) ;
Ruzin, Alexey (Clinical Research and Development. Vaccines and Immune Therapies. BioPharmaceuticals R&D. AstraZeneca Biopharmaceuticals) ;
Tabor, David E. (Clinical Research and Development. Vaccines and Immune Therapies. BioPharmaceuticals R&D. AstraZeneca Biopharmaceuticals) ;
Akhgar, Ahmad (Clinical Pharmacology and Quantitative Pharmacology. Clinical Pharmacology and Safety Sciences. BioPharmaceuticals R&D. AstraZeneca) ;
Wu, Yuling (Clinical Pharmacology and Quantitative Pharmacology. Clinical Pharmacology and Safety Sciences. BioPharmaceuticals R&D. AstraZeneca) ;
Jiang, Yu (Clinical Pharmacology and Quantitative Pharmacology. Clinical Pharmacology and Safety Sciences. BioPharmaceuticals R&D. AstraZeneca) ;
DiGiandomenico, Antonio (Clinical Research and Development. Vaccines and Immune Therapies. BioPharmaceuticals R&D. AstraZeneca Biopharmaceuticals) ;
Colbert, Susan (Oncology. US SM&M. AstraZeneca) ;
Vandamme, Drieke (Inserm CIC 1435. CHU) ;
Coenjaerts, Frank (University Medical Center Utrecht) ;
Malhotra-Kumar, Surbhi (University of Antwerp. Laboratory of Medical Microbiology) ;
Timbermont, Leen (University of Antwerp. Laboratory of Medical Microbiology) ;
Oliver, Antonio (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ;
Barraud, Olivier (INSERM U1092. Centre Hospitalier Universitaire de Limoges. Université Limoges) ;
Bellamy, Terramika (Clinical Research and Development. Vaccines and Immune Therapies. BioPharmaceuticals R&D. AstraZeneca Biopharmaceuticals) ;
Bonten, Marc (Julius Center for Health Science and Primary Care. University Medical Center Utrecht. Utrecht University) ;
Goossens, Herman (Laboratory of Medical Microbiology. Vaccine and Infectious Disease Institute. University of Antwerp) ;
Reisner, Colin (DevPro Biopharma) ;
Esser, Mark T. (Clinical Research and Development. Vaccines and Immune Therapies. BioPharmaceuticals R&D. AstraZeneca Biopharmaceuticals) ;
Jafri, Hasan S. (Late-Stage Development. Respiratory and Immunology. BioPharmaceuticals R&D. AstraZeneca) ;
Joannidis, Michael ;
Klimscha, Walter ;
De Waele, Elisabeth ;
Devriendt, Jacques ;
Huberlant, Vincent ;
Depuydt, Pieter ;
Van Boxstael, Sam ;
Peric, Mladen ;
Kopic, Jasminka ;
Hanauer, Michal ;
Hruby, Tomas ;
Sramek, Vladimir ;
Svoboda, Petr ;
Vymazal, Tomas ;
Novacek, Martin ;
Annane, Djillali ;
Mira, Jean-Paul ;
Souweine, Bertrand ;
Dequin, Pierre-François ;
Meziani, Ferhat ;
Stephan, François ;
Nseir, Saad ;
Gibot, Sebastien ;
Schwebel, Carole ;
Plantefeve, Gaetan ;
Diehl, Jean-Luc ;
Richard, Christian ;
Lamer, Christian ;
Klouche, Kada ;
Jaber, Samir ;
Zakynthinos, Epaminondas ;
Filntisis, Georgios ;
Zakynthinos, Spyros ;
Koutsoukou, Antonia ;
Saroglou, Georgios ;
Nikolaou, Charikleia ;
Vlachogianni, Glykeria ;
Pnevmatikos, Ioannis ;
Mandragos, Konstantinos ;
Kremer, Ildiko ;
Rozgonyi, Zsolt Dezso ;
Marjanek, Zsuzsa ;
Martin-Loeches, Ignacio ;
Singer, Pierre ;
Van Heerden, Vernon ;
Carmeli, Yehuda ;
Povoa, Pedro ;
AlvarezSeoane, Antonio ;
Moura, Pedro ;
Gonzalez, Filipe ;
Ramirez, Paula ;
Torres Marti, Antonio ;
Ferrer Roca, Ricard ;
Oteiza, Lorena ;
Escudero, Dolores ;
Piacentini, Enrique ;
Vera-Artazcoz, Paula (Institut d'Investigació Biomèdica Sant Pau) ;
Tamayo, Luis ;
Gonzalez Gallego, Miguel Angel ;
Suberviola Canas, Borja ;
Figueira, Iglesias ;
Leon, Rafael ;
Korten, Volkan ;
Akova, Murat ;
Wyncoll, Duncan ;
Whitehouse, Tony ;
Hopkins, Phil ;
Sim, Malcolm ;
Golan, Yoav ;
Zervos, Marcus ;
Vazquez, Jose ;
Cherabuddi, Kartikeya ;
Smulian, George ;
Rouphael, Nadine ;
Welker, James ;
Sims, Mathew ;
Van Duin, David ;
McCarthy, Todd ;
Polk, Christopher
Background: Ventilator-associated pneumonia caused by Pseudomonas aeruginosa (PA) in hospitalised patients is associated with high mortality. The effectiveness of the bivalent, bispecific mAb MEDI3902 (gremubamab) in preventing PA nosocomial pneumonia was assessed in PA-colonised mechanically ventilated subjects. [...]
2022 -  10.1186/s13054-022-04204-9
Critical Care, Vol. 26 Núm. 1 (december 2022) , p. 355
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5 p, 732.0 KB |
Intensive care unit patients with lower respiratory tract nosocomial infections : the ENIRRIs project
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De Pascale, Gennaro (Università Cattolica del Sacro Cuore) ;
Ranzani, Otavio T. (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Nseir, Saad (CHU Lille) ;
Chastre, Jean (Groupe Hospitalier Pitié-Salpêtrière) ;
Welte, Tobias (Hannover Medical School) ;
Antonelli, Massimo (Università Cattolica del Sacro Cuore) ;
Navalesi, Paolo (Università della Magna Graecia) ;
Garofalo, Eugenio (Università della Magna Graecia) ;
Bruni, Andrea (Università della Magna Graecia) ;
Coelho, Luis (New University of Lisbon) ;
Skoczynski, Szymon (Medical University of Silesia) ;
Longhini, Federico (Sant'Andrea Hospital) ;
Taccone, Fabio Silvio (Université Libre de Bruxelles) ;
Grimaldi, David (Université Libre de Bruxelles) ;
Salzer, Helmut J. F. (University of Lübeck) ;
Lange, Christoph (University of Lübeck) ;
Froes, Filipe (Hospital Pulido Valente) ;
Artigas Raventós, Antoni (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Díaz-Aparicio, Efren (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Vallés, Jordi (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Rodríguez, Alejandro (Hospital Universitari Joan XXIII de Tarragona) ;
Panigada, Mauro (Ospedale Maggiore Policlinico) ;
Comellini, Vittoria (Alma Mater University) ;
Fasano, Luca (Alma Mater University) ;
Soave, Paolo M. (Università Cattolica del Sacro Cuore) ;
Spinazzola, Giorgia (Università Cattolica del Sacro Cuore) ;
Luyt, Charles-Edouard (Groupe Hospitalier Pitié-Salpêtrière) ;
Álvarez Lerma, Francisco (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Marin, Judith (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Masclans, Joan R (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Chiumello, Davide (Università degli Studi di Milano) ;
Pezzi, Angelo (Università degli Studi di Milano) ;
Schultz, Marcus (Mahidol University) ;
Mohamed, Hafiz (St. James's Hospital (Irlanda)) ;
Van Der Eerden, Menno (Erasmus MC (Rotterdam)) ;
Hoek, Roger A. S. (Erasmus MC (Rotterdam)) ;
Gommers, D. A. M. P. J. (Erasmus MC (Rotterdam)) ;
Pasquale, Marta Di (IRCCS Fondazione Cà Granda Ospedale Maggiore Policlinico) ;
Civljak, Rok (University of Zagreb School of Medicine) ;
Kutleša, Marko (University of Zagreb School of Medicine) ;
Bassetti, Matteo (Medicine University of Udine and Santa aria Misericordia Hospital) ;
Dimopoulos, George (University General Hospital Attikon (Haidari, Grècia)) ;
Nava, Stefano (Alma Mater University) ;
Rios, Fernando (Hospital Nacional Profesor A Posadas (Argentina)) ;
Zampieri, Fernando G. (Hospital do Coração (Brasil)) ;
Povoa, Pedro (New University of Lisbon) ;
Bos, Lieuwe D.. (Academic Medical Center (Holanda)) ;
Aliberti, Stefano (IRCCS Fondazione Cà Granda Ospedale Maggiore Policlinico) ;
Torres, Antoni (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Martín-Loeches, Ignacio (St. James's Hospital (Irlanda)) ;
Universitat Autònoma de Barcelona
The clinical course of intensive care unit (ICU) patients may be complicated by a large spectrum of lower respiratory tract infections (LRTI), defined by specific epidemiological, clinical and microbiological aspects. [...]
2017 - 10.1183/23120541.00092-2017
ERJ Open Research, Vol. 3 (november 2017)
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