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9 p, 1.3 MB Phase 1b study of the BET protein inhibitor RO6870810 with venetoclax and rituximab in patients with diffuse large B-cell lymphoma / Dickinson, Michael (University of Melbourne. Sir Peter MacCallum Department of Oncology) ; Briones Meijide, Javier (Institut d'Investigació Biomèdica Sant Pau) ; Herrera, Álex F. (Department of Hematology and Hematopoietic Cell Transplantation. City of Hope National Medical Center) ; Gonzalez-Barca, Eva (Institut d'Investigació Biomèdica de Bellvitge) ; Ghosh, Nilanjan (Department of Hematologic Oncology and Blood Disorders. Levine Cancer Institute. Atrium Health) ; Cordoba, Raul (Hospital Universitario Fundación Jiménez Díaz) ; Rutherford, Sarah C. (Meyer Cancer Center. Division of Hematology and Medical Oncology. Weill Department of Medicine. New York-Presbyterian Hospital. Weill Cornell Medicine) ; Bournazou, Eirini (Roche Innovation Center New York. Roche Pharma Research and Early Development) ; Labriola-Tompkins, Emily (Roche Innovation Center New York. Roche Pharma Research and Early Development) ; Franjkovic, Izolda (Roche Innovation Center Munich. Roche Pharma Research and Early Development) ; Chesne, Evelyne (Roche Innovation Center Basel. Roche Pharma Research and Early Development) ; Brouwer-Visser, Jurriaan (Roche Innovation Center New York. Roche Pharma Research and Early Development) ; Lechner, Katharina (Roche Innovation Center Munich. Roche Pharma Research and Early Development) ; Brennan, Barbara (Roche Innovation Center New York. Roche Pharma Research and Early Development) ; Nüesch, Eveline (Roche Innovation Center Basel. Roche Pharma Research and Early Development) ; DeMario, Mark (Roche Innovation Center New York. Roche Pharma Research and Early Development) ; Rüttinger, Dominik (Roche Innovation Center Munich. Roche Pharma Research and Early Development) ; Kornacker, Martin (Roche Innovation Center Basel. Roche Pharma Research and Early Development) ; Hutchings, Martin (Rigshospitalet. Copenhagen University Hospital) ; Universitat Autònoma de Barcelona
Bromodomain and extraterminal (BET) proteins are transcriptional activators for multiple oncogenic processes in diffuse large B-cell lymphoma (DLBCL), including MYC, BCL2, E2F, and toll-like receptor signaling. [...]
2021 - 10.1182/bloodadvances.2021004619
Blood advances, Vol. 5 Núm. 22 (November 2021) , p. 4762-4770  
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1 Chesne, Evelyne
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