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17 p, 2.0 MB Adult mice are unresponsive to AAV8-Gremlin1 gene therapy targeting the liver / Khatib Shahidi, Roxana (University of Gothenburg. Department of Molecular and Clinical Medicine) ; M. Hoffmann, Jenny (University of Gothenburg. Department of Molecular and Clinical Medicine) ; Hedjazifar, Shahram (University of Gothenburg. Department of Molecular and Clinical Medicine) ; Bonnet, Laurianne (University of Gothenburg. Department of Molecular and Clinical Medicine) ; K. Baboota, Ritesh (University of Gothenburg. Department of Molecular and Clinical Medicine) ; Heasman, Stephanie (BioPharmaceuticals R&D. Bioscience Metabolism, Research and Early Development, Cardiovascular, Renal and Metabolism) ; Church, Christopher (BioPharmaceuticals R&D. Bioscience Metabolism, Research and Early Development, Cardiovascular, Renal and Metabolism) ; Elias Puigdomenech, Ivet (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Bosch i Tubert, Fàtima (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Boucher, Jeremie (BioPharmaceuticals R&D. Bioscience Metabolism, Research and Early Development, Cardiovascular, Renal and Metabolism) ; Hammarstedt, Ann (University of Gothenburg. Department of Molecular and Clinical Medicine) ; Smith, Ulf (University of Gothenburg. Department of Molecular and Clinical Medicine)
Gremlin 1 (GREM1) is a secreted BMP2/4 inhibitor which regulates commitment and differentiation of human adipose precursor cells and prevents the browning effect of BMP4. GREM1 is an insulin antagonist and serum levels are high in type 2 diabetes (T2D). [...]
2021 - 10.1371/journal.pone.0247300
PloS one, Vol. 16 (february 2021)  
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