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21 p, 3.4 MB NAADP mediates ATP-induced Ca2+ signals in astrocytes / Barceló Torns, Miquel (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Lewis, Alexander M. ((University of Oxford)) ; Gubern Burset, Albert (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Barneda, David (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Bloor-Young, Duncan ((University of Oxford)) ; Picatoste Ramón, Fernando (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Churchill Grant C. ((University of Oxford)) ; Claro Izaguirre, Enrique (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Masgrau Juanola, Roser (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular)
Intracellular Ca2+ signals provide astrocytes with a specific form of excitability that enables them to regulate synaptic transmission. In this study, we demonstrate that NAADP-AM, a membrane-permeant analogue of the new second messenger nicotinic acid-adenine dinucleotide phosphate (NAADP), mobilizes Ca2+ in astrocytes and that the response is blocked by Ned-19, an antagonist of NAADP signalling. [...]
2011 - 10.1016/j.febslet.2011.05.062
FEBS letters, Vol. 585, Num. 14 (2011) , p. 2300-2306  

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