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13 p, 1.3 MB |
Charting a global research strategy for progressive MS-An international progressive MS Alliance proposal
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Thompson, Alan (University College London) ;
Carroll, William ;
Ciccarelli, Olga ;
Comi, Giancarlo ;
Cross, Anne H. ;
Donnelly, Alexis A. ;
Feinstein, Anthony ;
Fox, Robert J ;
Helme, Anne ;
Hohlfeld, Reinhard ;
Hyde, Robert ;
Kanellis, Pamela ;
Landsman, Douglas ;
Lubetzki, Catherine ;
Marrie, Ruth Ann ;
Morahan, Julia ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron) ;
Musch, Bruno ;
Rawlings, Sarah ;
Salvetti, Marco ;
Sellebjerg, Finn ;
Sincock, Caroline ;
Smith, Kathryn E ;
Strum, Jon ;
Zaratin, Paola ;
Coetzee, Timothy ;
Universitat Autònoma de Barcelona
Progressive forms of multiple sclerosis (MS) affect more than 1 million individuals globally. Recent approvals of ocrelizumab for primary progressive MS and siponimod for active secondary progressive MS have opened the therapeutic door, though results from early trials of neuroprotective agents have been mixed. [...]
2021 -  10.1177/13524585211059766
Multiple sclerosis, Vol. 28 (december 2021) , p. 16-28
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2.
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11 p, 844.8 KB |
Relationship between paramagnetic rim lesions and slowly expanding lesions in multiple sclerosis
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Calvi, Alberto (University College London) ;
Clarke, Margareta A. (Hospital Universitari Vall d'Hebron) ;
Prados Carrasco, Ferran (University College London) ;
Chard, Declan (University College London) ;
Ciccarelli, Olga (University College London) ;
Alberich, Manel (Hospital Universitari Vall d'Hebron) ;
Pareto, Deborah (Hospital Universitari Vall d'Hebron) ;
Rodríguez Barranco, Marta (Hospital Universitari Vall d'Hebron) ;
Sastre-Garriga, Jaume (Hospital Universitari Vall d'Hebron) ;
Tur, Carmen (Hospital Universitari Vall d'Hebron) ;
Rovira, Alex (Hospital Universitari Vall d'Hebron) ;
Barkhof, Frederik (University College London) ;
Universitat Autònoma de Barcelona
Magnetic resonance imaging (MRI) markers for chronic active lesions in MS include slowly expanding lesions (SELs) and paramagnetic rim lesions (PRLs). To identify the relationship between SELs and PRLs in MS, and their association with disability. [...]
2022 - 10.1177/13524585221141964
Multiple sclerosis, Vol. 29 (december 2022) , p. 352-362
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3.
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13 p, 1.2 MB |
Progression of regional grey matter atrophy in multiple sclerosis
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Eshaghi, Arman (University College London. Department of Computer Science) ;
Marinescu, Razvan V (University College London. Department of Computer Science) ;
Young, Alexandra L. (University College London. Department of Computer Science) ;
Firth, Nicholas C. (University College London. Department of Computer Science) ;
Prados Carrasco, Ferran (University College London. Department of Medical Physics and Bioengineering) ;
Jorge Cardoso, M. (University College London. Department of Medical Physics and Bioengineering) ;
Tur, Carmen (University College London. Faculty of Brain Sciences) ;
De Angelis, Floriana (University College London. Faculty of Brain Sciences) ;
Cawley, Niamh (University College London. Faculty of Brain Sciences) ;
Brownlee, Wallace J. (University College London. Faculty of Brain Sciences) ;
De Stefano, Nicola (University of Siena (Itàlia). Department of Medicine, Surgery and Neuroscience) ;
Laura Stromillo, M. (University of Siena (Itàlia). Department of Medicine, Surgery and Neuroscience) ;
Battaglini, Marco (University of Siena (Itàlia). Department of Medicine, Surgery and Neuroscience) ;
Ruggieri, Serena (University of Rome Sapienza. Department of Neurology and Psychiatry) ;
Gasperini, Claudio (San Camillo Forlanini Hospital) ;
Filippi, Massimo (Vita-Salute San Raffaele University (Milà, Itàlia)) ;
Rocca, Maria A. (Vita-Salute San Raffaele University (Milà, Itàlia)) ;
Rovira, Alex (Hospital Universitari Vall d'Hebron) ;
Sastre-Garriga, Jaume (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Geurts, Jeroen J. G. (Amsterdam UMC. University Medical Center) ;
Vrenken, Hugo (MS Center Amsterdam. Department of Radiology and Nuclear Medicine) ;
Wottschel, Viktor (MS Center Amsterdam. Department of Radiology and Nuclear Medicine) ;
Leurs, Cyra E. (MS Center Amsterdam. Department of Radiology and Nuclear Medicine) ;
Uitdehaag, Bernard (MS Center Amsterdam. Department of Radiology and Nuclear Medicine) ;
Pirpamer, Lukas (Medical University of Graz (Graz, Àustria)) ;
Enzinger, Christian (Medical University of Graz (Graz, Àustria)) ;
Ourselin, Sebastien (University College London Hospitals) ;
Gandini Wheeler-Kingshott, Claudia A. M (IRCCS Mondino Foundation (Pavia, Itàlia)) ;
Chard, Declan (University College London Hospitals) ;
Thompson, Alan J. (University College London. Faculty of Brain Sciences) ;
Barkhof, Frederik (MS Center Amsterdam. Department of Radiology and Nuclear Medicine) ;
Alexander, Daniel C.. (University College London. Department of Computer Science) ;
Ciccarelli, Olga (University College London Hospitals) ;
Universitat Autònoma de Barcelona
See Stankoff and Louapre (doi:) for a scientific commentary on this article. Grey matter atrophy in multiple sclerosis affects certain areas preferentially. Eshaghi et al. use a data-driven computational model to predict the order in which regions atrophy, and use this sequence to stage patients. [...]
2018 - 10.1093/brain/awy088
Brain, Vol. 141 (may 2018) , p. 1665-1677
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4.
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12 p, 3.1 MB |
Manual and automated tissue segmentation confirm the impact of thalamus atrophy on cognition in multiple sclerosis : A multicenter study
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Burggraaff, Jessica (Department of Neurology, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Location VUmc, De Boelelaan 1117, 1118, 1081 HV Amsterdam, The Netherlands) ;
Liu, Yao (Department of Radiology and Nuclear Medicine, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Location VUmc, De Boelelaan 1117, 1118, 1081 HV Amsterdam, The Netherlands) ;
Prieto, Juan C. (Harvard Medical School) ;
Simoes, Jorge (Department of Neurology, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Location VUmc, De Boelelaan 1117, 1118, 1081 HV Amsterdam, The Netherlands) ;
de Sitter, Alexandra (Department of Radiology and Nuclear Medicine, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Location VUmc, De Boelelaan 1117, 1118, 1081 HV Amsterdam, The Netherlands) ;
Ruggieri, Serena (San Camillo Forlanini Hospital) ;
Brouwer, Iman (Department of Radiology and Nuclear Medicine, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Location VUmc, De Boelelaan 1117, 1118, 1081 HV Amsterdam, The Netherlands) ;
Lissenberg-Witte, Birgit I. (Department of Epidemiology and Biostatistics, Amsterdam UMC, Location VUmc, De Boelelaan 1089a, 1081 HV Amsterdam, the Netherlands) ;
Rocca, Mara A. (Neurology Unit, San Raffaele Scientific Institute, Via Olgettina, 58, 20132 Milano MI, Italy) ;
Valsasina, Paola (Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, and Neurology Unit, San Raffaele Scientific Institute, Via Olgettina, 58, 20132 Milano MI, Italy) ;
Ropele, Stefan (Department of Neurology, Medical University of Graz, Auenbruggerplatz 22, 8036 Graz, Austria) ;
Gasperini, Claudio (San Camillo Forlanini Hospital) ;
Gallo, Antonio (Division of Neurology and 3T MRI Research Center, Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Viale Abramo Lincoln, 5, 81100 Caserta, CE, Napoli, Italy) ;
Pareto, Deborah (Hospital Universitari Vall d'Hebron) ;
Sastre-Garriga, Jaume (Hospital Universitari Vall d'Hebron) ;
Enzinger, Christian (Division of Neuroradiology, Vascular and Interventional Radiology, Department of Radiology, Medical University of Graz, Auenbruggerplatz 22, 8036 Graz, Austria) ;
Filippi, Massimo (Department of Neurological and Behavioural Sciences, University of Siena, 53100 Siena SI, Italy) ;
De Stefano, Nicola (Department of Neurological and Behavioural Sciences, University of Siena, 53100 Siena SI, Italy) ;
Ciccarelli, Olga (UCL Institute of Neurology (Regne Unit)) ;
Hulst, Hanneke E. (Amsterdam UMC. University Medical Center) ;
Wattjes, Mike P. (Department of Diagnostic and Interventional Neuroradiology, Hannover Medical School, Hannover, Carl-Neuberg-Straße, 30625 Hannover, Germany) ;
Barkhof, Frederik (Institutes of Neurology & Healthcare Engineering, UCL, 235 Euston Rd, Bloomsbury, London NW1 2BU, United Kingdom) ;
Uitdehaag, Bernard M. J. (Department of Neurology, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Location VUmc, De Boelelaan 1117, 1118, 1081 HV Amsterdam, The Netherlands) ;
Vrenken, Hugo (Department of Radiology and Nuclear Medicine, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Location VUmc, De Boelelaan 1117, 1118, 1081 HV Amsterdam, The Netherlands) ;
Guttmann, Charles R. G. (Harvard Medical School) ;
Universitat Autònoma de Barcelona
Thalamus atrophy has been linked to cognitive decline in multiple sclerosis (MS) using various segmentation methods. We investigated the consistency of the association between thalamus volume and cognition in MS for two common automated segmentation approaches, as well as fully manual outlining. [...]
2020 - 10.1016/j.nicl.2020.102549
NeuroImage, Vol. 29 (december 2020)
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5.
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12 p, 1.5 MB |
MAGNIMS consensus recommendations on the use of brain and spinal cord atrophy measures in clinical practice
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Sastre-Garriga, Jaume (Centre d'Esclerosi Mútiple de Catalunya (Cemcat)) ;
Pareto, Deborah (Hospital Universitari Vall d'Hebron) ;
Battaglini, Marco (University of Siena. Department of Medicine, Surgery and Neuroscience) ;
Rocca, Maria A. (IRCCS San Raffaele Scientific Institute (Milà, Itàlia). Institute of Experimental Neurology) ;
Ciccarelli, Olga (University College London Hospitals. National Institute for Health Research Biomedical Research Centre) ;
Enzinger, Christian (Medical University of Graz. Department of Neurology and Division of Neuroradiology, Vascular and Interventional Radiology, Department of Radiology) ;
Wuerfel, Jens (University of Basel. Medical Image Analysis Center (MIAC AG) and Department of Biomedical Engineering) ;
Sormani, Maria P. (IRCCS, Ospedale Policlinico San Martino, Genoa) ;
Barkhof, Frederik (University College London. Institutes of Neurology and Healthcare Engineering) ;
Yousry, Tarek A. (University College London Hospitals National Hospital for Neurology and Neurosurgery, University College London Institute of Neurology. Lysholm Department of Neuroradiology) ;
De Stefano, Nicola (University of Siena. Department of Medicine, Surgery and Neuroscience) ;
Tintoré, Mar (Centre d'Esclerosi Mútiple de Catalunya (Cemcat)) ;
Filippi, Massimo (Vita-Salute San Raffaele University) ;
Gasperini, Claudio (San Camillo Forlanini Hospital) ;
Kappos, Ludwig (University Hospital Basel (Basilea, Suïssa)) ;
Río, Jordi (Universitat Autònoma de Barcelona) ;
Frederiksen, Jette (University of Copenhagen) ;
Palace, Jackie (University of Oxford. Nuffield Department of Clinical Neurosciences) ;
Vrenken, Hugo (Amsterdam Neuroscience, MS Center Amsterdam, Department of Radiology and Nuclear Medicine, Amsterdam UMC) ;
Montalban, Xavier (University of Toronto. Division of Neurology, St Michael's Hospital) ;
Rovira, Alex (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona ;
Hospital Universitari Vall d'Hebron ;
Centre d'Esclerosi Mútiple de Catalunya (Cemcat)
Early evaluation of treatment response and prediction of disease evolution are key issues in the management of people with multiple sclerosis (MS). In the past 20 years, MRI has become the most useful paraclinical tool in both situations and is used clinically to assess the inflammatory component of the disease, particularly the presence and evolution of focal lesions - the pathological hallmark of MS. [...]
2020 - 10.1038/s41582-020-0314-x
Nature Reviews. Neurology, Vol. 16 (february 2020) , p. 171-182
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6.
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13 p, 3.4 MB |
Facing privacy in neuroimaging : removing facial features degrades performance of image analysis methods
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de Sitter, Alexandra (Department of Radiology and Nuclear Medicine. Amsterdam Neuroscience Amsterdam UMC. location VUmc) ;
Visser, M. (Department of Radiology and Nuclear Medicine. Amsterdam Neuroscience Amsterdam UMC. location VUmc) ;
Brouwer, Iman (Department of Radiology and Nuclear Medicine. Amsterdam Neuroscience Amsterdam UMC. location VUmc) ;
Cover, K. S. (Department of Radiology and Nuclear Medicine. Amsterdam Neuroscience Amsterdam UMC. location VUmc) ;
van Schijndel, R. A. (Department of Radiology and Nuclear Medicine. Amsterdam Neuroscience Amsterdam UMC. location VUmc) ;
Eijgelaar, R. S. (The Netherlands Cancer Institute (Amsterdam, Països Baixos)) ;
Müller, D. M. J. (Department of Neurosurgery. Amsterdam UMC. location VUmc) ;
Ropele, S. (Department of Neurology. Medical University of Graz) ;
Kappos, Ludwig (University Hospital. Kantonsspital) ;
Rovira, Alex (Hospital Universitari Vall d'Hebron) ;
Filippi, Massimo (IRCCS San Raffaele Scientific Institute. Neurorehabilitation Unit) ;
Enzinger, C. (Division of Neuroradiology. Vascular and Interventional Radiology. Department of Radiology. Medical University of Graz) ;
Frederiksen, J. (Glostrup University Hospital Copenhagen) ;
Ciccarelli, Olga (UK/NIHR UCL-UCLH Biomedical Research Centre. Institute of Neurology. UCL) ;
Guttmann, Charles R. G (Harvard Medical School) ;
Wattjes, M. P. (Hannover Medical School) ;
Witte, M. G. (The Netherlands Cancer Institute (Amsterdam, Països Baixos)) ;
de Witt Hamer, P. C. (Department of Neurosurgery. Amsterdam UMC. location VUmc) ;
Barkhof, Frederik (University College London. Institutes of Neurology & Healthcare Engineering) ;
Vrenken, Hugo (Department of Radiology and Nuclear Medicine. Amsterdam Neuroscience Amsterdam UMC. location VUmc) ;
Universitat Autònoma de Barcelona
Background: Recent studies have created awareness that facial features can be reconstructed from high-resolution MRI. Therefore, data sharing in neuroimaging requires special attention to protect participants' privacy. [...]
2020 - 10.1007/s00330-019-06459-3
European Radiology, Vol. 30 Núm. 2 (january 2020) , p. 1062-1074
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9 p, 349.5 KB |
Impact of 3 Tesla MRI on interobserver agreement in clinically isolated syndrome : A MAGNIMS multicentre study
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Hagens, M. H. J. (Department of Neurology. MS Center Amsterdam. VU University Medical Center) ;
Burggraaff, Jessica (Department of Neurology. MS Center Amsterdam. VU University Medical Center) ;
Kilsdonk, I. D. (Department of Radiology and Nuclear Medicine. Onze Lieve Vrouwen Gasthuis) ;
Ruggieri, Serena (San Camillo Forlanini Hospital) ;
Collorone, S. (NMR Research Unit. Queen Square Multiple Sclerosis Centre. UCL Institute of Neurology) ;
Cortese, R. (Department of Basic Medical Sciences. Neurosciences and Sense Organs. University of Bari) ;
Cawley, Niamh (NMR Research Unit. Queen Square Multiple Sclerosis Centre. UCL Institute of Neurology) ;
Sbardella, E. (Department of Neurology and Psychiatry. Sapienza University of Rome) ;
Andelova, M. (University Hospital Basel (Basilea, Suïssa)) ;
Amann, Michael (University Hospital Basel (Basilea, Suïssa)) ;
Lieb, J. M. (University Hospital Basel (Basilea, Suïssa)) ;
Pantano, P. (Istituto Neurologico Mediterraneo. Neuromed) ;
Lissenberg-Witte, B. I. (Department of Epidemiology and Biostatistics. VU University Medical Centre) ;
Killestein, Joep (Department of Neurology. MS Center Amsterdam. VU University Medical Center) ;
Oreja-Guevara, Celia (Hospital Clínico San Carlos (Madrid)) ;
Wuerfel, J. (University Hospital Basel (Basilea, Suïssa)) ;
Ciccarelli, Olga (NMR Research Unit. Queen Square Multiple Sclerosis Centre. UCL Institute of Neurology) ;
Gasperini, C. (San Camillo Forlanini Hospital) ;
Lukas, Cédric (Department of Diagnostic and Interventional Radiology and Nuclear Medicine. St. Josef Hospital. Ruhr University) ;
Rovira, A. (Hospital Universitari Vall d'Hebron) ;
Barkhof, Frederik (UCL Institute of Neurology (Regne Unit)) ;
Wattjes, M. P. (Department of Radiology and Nuclear Medicine. MS Center Amsterdam. VU University Medical Center) ;
Universitat Autònoma de Barcelona
Background: Compared to 1. 5 T, 3 T magnetic resonance imaging (MRI) increases signal-to-noise ratio leading to improved image quality. However, its clinical relevance in clinically isolated syndrome suggestive of multiple sclerosis remains uncertain. [...]
2019 - 10.1177/1352458517751647
Multiple sclerosis, Vol. 25 Núm. 3 (january 2019) , p. 352-360
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13 p, 862.2 KB |
Deep gray matter volume loss drives disability worsening in multiple sclerosis
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Eshaghi, Arman (University College London) ;
Prados Carrasco, Ferran (University College London Hospitals) ;
Brownlee, Wallace J. (University College London) ;
Altmann, Daniel R. (London School of Hygiene & Tropical Medicine) ;
Tur, Carmen (University College London) ;
Cardoso, M. Jorge (University College London) ;
De Angelis, Floriana (University College London) ;
van de Pavert, Steven H. (University College London) ;
Cawley, Niamh (University College London) ;
De Stefano, Nicola (University of Siena) ;
Stromillo, M. Laura (University of Siena) ;
Battaglini, Marco (University of Siena) ;
Ruggieri, Serena (University of Rome Sapienza) ;
Gasperini, Claudio (San Camillo Forlanini Hospital) ;
Filippi, Massimo (Vita-Salute San Raffaele University) ;
Rocca, Maria A. (Vita-Salute San Raffaele University) ;
Rovira, Alex (Hospital Universitari Vall d'Hebron) ;
Sastre-Garriga, Jaume (Hospital Universitari Vall d'Hebron) ;
Vrenken, Hugo (VU University Medical Centre) ;
Leurs, Cyra E. (Amsterdam UMC. University Medical Center) ;
Killestein, Joep (Amsterdam UMC. University Medical Center) ;
Pirpamer, Lukas (Medical University of Graz) ;
Enzinger, Christian (Medical University of Graz) ;
Ourselin, Sebastien (University College London Hospitals) ;
Wheeler-Kingshott, Claudia A. M. Gandini (C. Mondino National Neurological Institute) ;
Chard, Declan (University College London Hospitals) ;
Thompson, Alan J. (University College London) ;
Alexander, Daniel C.. (University College London) ;
Barkhof, Frederik (VU University Medical Centre) ;
Ciccarelli, Olga (University College London Hospitals) ;
Universitat Autònoma de Barcelona
Gray matter (GM) atrophy occurs in all multiple sclerosis (MS) phenotypes. We investigated whether there is a spatiotemporal pattern of GM atrophy that is associated with faster disability accumulation in MS. [...]
2018 - 10.1002/ana.25145
Annals of neurology, Vol. 83, Issue 2 (February 2018) , p. 210-222
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25 p, 1.2 MB |
MRI criteria for the diagnosis of multiple sclerosis : magnims consensus guidelines
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Filippi, Massimo (IRCCS San Raffaele Scientific Institute. Neurorehabilitation Unit) ;
Rocca, M. A. (IRCCS San Raffaele Scientific Institute (Milà, Itàlia)) ;
Ciccarelli, Olga (National Institute for Health Research (NIHR), UCL/UCLH Biomedical Research Centre (BRC)) ;
De Stefano, Nicola (Department of Medicine, Surgery and Neuroscience, University of Siena) ;
Evangelou, Nikos (University of Nottingham) ;
Kappos, Ludwig (Department of Neurology, University of Basel) ;
Rovira, A. (Hospital Universitari Vall d'Hebron) ;
Sastre-Garriga, Jaume (Hospital Universitari Vall d'Hebron) ;
Tintorè, M. (Hospital Universitari Vall d'Hebron) ;
Frederiksen, J. L. (Glostrup University Hospital Copenhagen) ;
Gasperini, C. (San Camillo Forlanini Hospital) ;
Palace, J. (Department of Clinical Neurology, University of Oxford Hospitals Trust, Oxford, UK) ;
Reich, D. S. (National Institute of Neurological Disorders and Stroke (Bethesda, Estats Units d'Amèrica)) ;
Banwell, B. (Children's Hospital of Philadelphia (Pennsilvània)) ;
Montalban, X. (Hospital Universitari Vall d'Hebron) ;
Barkhof, Frederik (Amsterdam Universitair Medische Centra (Amsterdam, Països Baixos)) ;
Universitat Autònoma de Barcelona
In patients presenting with a clinically isolated syndrome (CIS), magnetic resonance imaging (MRI) can support and substitute clinical information for multiple sclerosis (MS) diagnosis demonstrating disease dissemination in space (DIS) and time (DIT) and helping to rule out other conditions that can mimic MS. [...]
2016 - 10.1016/S1474-4422(15)00393-2
The Lancet neurology, Vol. 15 (january 2016) , p. 292-303
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11 p, 2.4 MB |
Spatial variability and changes of metabolite concentrations in the cortico-spinal tract in multiple sclerosis using coronal CSI
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Tur, Carmen (Hospital Universitari Vall d'Hebron) ;
Wheeler-Kingshott, Claudia A. M. (UCL Institute of Neurology (Regne Unit). Department of Neuroinflammation) ;
Altmann, Daniel R. (Medical Statistics Unit, London School of Hygiene and Tropical Medicine) ;
Miller, David H. (UCL Institute of Neurology (Regne Unit). Department of Neuroinflammation) ;
Thompson, Alan J. (UCL Institute of Neurology (Regne Unit)) ;
Ciccarelli, Olga (UCL Institute of Neurology (Regne Unit)) ;
Universitat Autònoma de Barcelona
We characterized metabolic changes along the cortico-spinal tract (CST) in multiple sclerosis (MS) patients using a novel application of chemical shift imaging (CSI) and considering the spatial variation of metabolite levels. [...]
2012 - 10.1002/hbm.22229
Human brain mapping, Vol. 35 (december 2012) , p. 993-1003
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