Resultados globales: 5 registros encontrados en 0.02 segundos.
Artículos, Encontrados 5 registros
Artículos Encontrados 5 registros  
1.
2 p, 188.6 KB Synthesis, in vitro profiling, and in vivo efficacy studies of a new family of multitarget antiAlzheimer compounds / Pérez-Areales, Francisco Javier (Universitat de Barcelona) ; Garrido, María (Instituto de Química Avanzada de) ; Catalunya (IQAC-CSIC) ; Aso, Ester (Universitat de Barcelona) ; Bartolini, Manuela (Department of Pharmacy and Biotechnology. Alma Mater Studiorum University of Bologna) ; De Simone, Angela (University of Bologna. Department for Life Quality Studies) ; Espargaró Colomé, Alba (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Ginex, Tiziana (Universitat de Barcelona) ; Sabate, Raimon (Universitat de Barcelona) ; Pérez, Belén (Autonomous University of Barcelona. Therapeutics and Toxicology) ; Andrisano, Vincenza (University of Bologna. Department for Life Quality Studies) ; Luque, Francisco Javier (Universitat de Barcelona) ; Ferrer, Isidro (Universitat de Barcelona. Unitat de Neuropatologia Experimental) ; Ciruela, Francisco (Universitat de Barcelona) ; Messeguer, Àngel (Instituto de Química Avanzada de) ; Catalunya (IQAC-CSIC) ; Muñoz Torrero, Diego (Universitat de Barcelona. Laboratori de Química Farmacèutica)
Simultaneous modulation of several targets or athological events with a key pathogenic role is a promising strategy to tackle thus far difficult-to-cure or incurable multifactorial diseases, such as Alzheimer's disease (AD). [...]
2019 - 10.3390/proceedings2019022071
Proceedings, Vol. 22 (2019) , p. 1-2  
2.
8 p, 1.6 MB Photomodulation of G protein-coupled adenosine receptors by a novel light-switchable ligand / Bahamonde, María Isabel (Institut de Bioenginyeria de Catalunya) ; Taura, Jaume (Universitat de Barcelona. Departament Patologia i Terapèutica Experimental) ; Paoletta, Silvia (National Institutes of Health) ; Gakh, Anadrei A. (National Institutes of Health) ; Chakraborty, Saibal (National Institutes of Health) ; Hernando Campos, Jordi (Universitat Autònoma de Barcelona. Departament de Química) ; Fernández Dueñas, Víctor (Universitat de Barcelona. Departament Patologia i Terapèutica Experimental) ; Jacobson, Kenneth A. (National Institutes of Health) ; Gorostiza, Pau (Institut de Bioenginyeria de Catalunya) ; Ciruela, Francisco (Universitat de Barcelona. Departament Patologia i Terapèutica Experimental)
The adenosinergic system operates through G protein-coupled adenosine receptors, which have become promising therapeutic targets for a wide range of pathological conditions. However, the ubiquity of adenosine receptors and the eventual lack of selectivity of adenosine-based drugs have frequently diminished their therapeutic potential. [...]
2014 - 10.1021/bc5003373
Bioconjugate chemistry, Vol. 25, Issue 10 (October 2014) , p. 1847-1854  
3.
12 p, 3.0 MB Double deficiency of Trex2 and DNase1L2 nucleases leads to accumulation of DNA in lingual cornifying keratinocytes without activating inflammatory responses / Manils, Joan (Universitat de Barcelona. Departament de Patologia i Terapèutica Experimental) ; Fischer, Heinz (Medical University of Vienna. Department of Dermatology) ; Climent, Joan (Universitat de Barcelona. Departament de Patologia i Terapèutica Experimental) ; Casas, Eduard (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; García-Martínez, Celia (Universitat de Barcelona. Departament de Patologia i Terapèutica Experimental) ; Bas, Jordi (Universitat de Barcelona. Departament de Patologia i Terapèutica Experimental) ; Sukseree, Supawadee (Medical University of Vienna. Department of Dermatology) ; Vavouri, Tanya (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Ciruela, Francisco (Universitat de Barcelona. Departament de Patologia i Terapèutica Experimental) ; de Anta, Josep Maria (Universitat de Barcelona. Departament de Patologia i Terapèutica Experimental) ; Tschachler, Erwin (Medical University of Vienna. Department of Dermatology) ; Eckhart, Leopold (Medical University of Vienna. Department of Dermatology) ; Soler, Concepció (Universitat de Barcelona. Departament de Patologia i Terapèutica Experimental) ; Universitat Autònoma de Barcelona
The cornification of keratinocytes on the surface of skin and oral epithelia is associated with the degradation of nuclear DNA. The endonuclease DNase1L2 and the exonuclease Trex2 are expressed specifically in cornifying keratinocytes. [...]
2017 - 10.1038/s41598-017-12308-4
Scientifics reports, Vol. 7 (september 2017) , p. 1-12  
4.
20 p, 2.1 MB Optical control of pain in vivo with a photoactive mGlu receptor negative allosteric modulator / Font, Joan (Universitat Autònoma de Barcelona. Institut de Neurociències) ; López-Cano, Marc (Institut d'Investigació Biomèdica de Bellvitge) ; Notartomaso, Serena (I.R.C.C.S. Neuromed, Pozzilli, Italy) ; Scarselli, Pamela (I.R.C.C.S. Neuromed, Pozzilli, Italy) ; Di Pietro, Paola (I.R.C.C.S. Neuromed, Pozzilli, Italy) ; Bresolí-Obach, Roger (Institut Químic de Sarrià, Universitat Ramon Llull) ; Battaglia, Giuseppe (I.R.C.C.S. Neuromed, Pozzilli, Italy) ; Malhaire, Fanny (Université de Montpellier) ; Rovira, Xavier (Université de Montpellier) ; Catena, Juanlo (Institut de Química Avançada de Catalunya) ; Giraldo, Jesús (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Pin, Jean-Philippe (Université de Montpellier) ; Fernández-Dueñas, Víctor (Institut d'Investigació Biomèdica de Bellvitge) ; Goudet, Cyril (Université de Montpellier) ; Nonell, Santi (Institut Químic de Sarrià, Universitat Ramon Llull) ; Nicoletti, Ferdinando (I.R.C.C.S. Neuromed, Pozzilli, Italy) ; Llebaria, Amadeu (Institut de Química Avançada de Catalunya) ; Ciruela, Francisco (Institut d'Investigació Biomèdica de Bellvitge)
Light-operated drugs constitute a major target in drug discovery, since they may provide spatiotemporal resolution for the treatment of complex diseases (i. e. chronic pain). JF-NP-26 is an inactive photocaged derivative of the metabotropic glutamate type 5 (mGlu) receptor negative allosteric modulator raseglurant. [...]
2017 - 10.7554/eLife.23545
eLife, Vol. 6 (april 2017)  
5.
11 p, 2.3 MB Illuminating phenylazopyridines to photoswitch metabotropic glutamate receptors : from the flask to the animals / Gómez-Santacana, Xavier (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Pittolo, Silvia (Institut de Bioenginyeria de Catalunya) ; Rovira, Xavier (Université de Montpellier. Institute of Functional Genomics) ; Lopez, Marc (Universitat de Barcelona. Unitat de Farmacologia) ; Zussy, Charleine (Université de Montpellier. Institute of Functional Genomics) ; Dalton, James A.R. (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Faucherre, Adèle (Université de Montpellier. Institute of Functional Genomics) ; Jopling, Chris (Université de Montpellier. Institute of Functional Genomics) ; Pin, Jean-Philippe (Université de Montpellier. Institute of Functional Genomics) ; Ciruela, Francisco (Universitat de Barcelona. Unitat de Farmacologia) ; Goudet, Cyril (Université de Montpellier. Institute of Functional Genomics) ; Giraldo, Jesús (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Gorostiza, Pau (Institut de Bioenginyeria de Catalunya) ; Llebaria, Amadeu (Instituto de Química Avanzada de Cataluña)
Phenylazopyridines are photoisomerizable compounds with high potential to control biological functions with light. We have obtained a series of phenylazopyridines with light dependent activity as negative allosteric modulators (NAM) of metabotropic glutamate receptor subtype 5 (mGlu). [...]
2017 - 10.1021/acscentsci.6b00353
ACS Central Science, Vol. 3, issue 1 (Jan. 2017) , p. 81-91  

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