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12 p, 653.9 KB |
HIV-1 Gag mutations alone are sufficient to reduce darunavir susceptibility during virological failure to boosted PI therapy
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Blanch Lombarte, Oscar (Institut Germans Trias i Pujol) ;
Santos, José Ramón (Institut Germans Trias i Pujol. Fundació de Lluita Contra la Sida) ;
Peña, Ruth (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Jiménez Moyano, Esther (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Clotet, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Paredes, Roger (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Prado, Julia G (Institut Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Virological failure (VF) to boosted PIs with a high genetic barrier is not usually linked to the development of resistance-associated mutations in the protease gene. From a cohort of 520 HIV-infected subjects treated with lopinavir/ritonavir or darunavir/ritonavir monotherapy, we retrospectively identified nine patients with VF. [...]
2020 -  10.1093/jac/dkaa228
Journal of Antimicrobial Chemotherapy, Vol. 75 (june 2020) , p. 2535-2546
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19 p, 2.6 MB |
Pharmacological modulation of SAMHD1 activity by CDK4/6 inhibitors improves anticancer therapy
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Castellví, Marc (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Felip, Eudald (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ezeonwumelu, Ifeanyi Jude (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Badia, Roger (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Garcia-Vidal, Edurne (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Pujantell, Maria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Gutiérrez-Chamorro, Lucía (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Teruel, Iris (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martínez Cardús, Anna (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Clotet, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Riveira-Muñoz, Eva (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Margelí, Mireia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ballana, Ester (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Universitat Autònoma de Barcelona
Sterile alpha motif and histidine-aspartic acid domain-containing protein 1 (SAMHD1) is a dNTP triphosphohydrolase involved in the regulation of the intracellular dNTP pool, linked to viral restriction, cancer development and autoimmune disorders. [...]
2020 - 10.3390/cancers12030713
Cancers, Vol. 12 Núm. 3 (march 2020) , p. 713
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12 p, 1.2 MB |
Epidemiological, clinical, diagnostic and economic features of an immigrant population of chronic schistosomiasis sufferers with long-term residence in a nonendemic country (North Metropolitan area of Barcelona, 2002-2016)
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Roure, Sílvia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Valerio, Lluís (Servei Atenció Primària, Santa Coloma de Gramenet) ;
Pérez-Quílez, Olga (Servei Atenció Primària, Santa Coloma de Gramenet) ;
Fernádez-Rivas, Gema (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martínez-Cuevas, Octavio (Servei Atenció Primària, Santa Coloma de Gramenet) ;
Alcántara-Román, Albert (Servei Atenció Primària, Santa Coloma de Gramenet) ;
Viasus, Diego (Hospital Universidad del Norte (Barranquilla)) ;
Pedro-Botet, M. Luisa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Sabrià, Miquel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Clotet, Bonaventura (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Background. Schistosomiasis, one of the neglected tropical diseases (NTD) listed by the WHO, is an acute and chronic parasitic disease caused by blood flukes (trematode worms) of the genus Schistosoma. [...]
2017 - 10.1371/journal.pone.0185245
PloS one, Vol. 12 Núm. 9 (september 2017) , p. 1-12
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14 p, 1.8 MB |
Transdermal rivastigmine for HIV-associated cognitive impairment: A randomized pilot study
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Muñoz-Moreno, Jose A. (Institut Germans Trias i Pujol. Fundació de Lluita Contra la Sida) ;
Prats, Anna (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Moltó, José (Institut Germans Trias i Pujol. Fundació de Lluita Contra la Sida) ;
Garolera, Maite (Consorci Sanitari Hospital de Terrassa. Clinical Research Group Brain, Cognition and Behavior) ;
Pérez-Álvarez, Núria (Institut Germans Trias i Pujol. Fundació de Lluita Contra la Sida) ;
Díez-Quevedo,Crisanto (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Miranda, Cristina (Institut Germans Trias i Pujol. Fundació de Lluita Contra la Sida) ;
Fumaz, Carmina R. (Institut Germans Trias i Pujol. Fundació de Lluita Contra la Sida) ;
Ferrer, Maria J. (Institut Germans Trias i Pujol. Fundació de Lluita Contra la Sida) ;
Clotet, Bonaventura (Institut Germans Trias i Pujol. Fundació de Lluita Contra la Sida) ;
TRIANT-TE Study Group
Objective. To assess the efficacy and safety of transdermal rivastigmine for the treatment of HIV-associated cognitive impairment. Methods. We recruited HIV-infected patients with cognitive impairment on stable antiretroviral therapy in a randomized controlled pilot trial with a 48-week follow-up. [...]
2017 - 10.1371/journal.pone.0182547
PloS one, Vol. 12 Núm. 8 (august 2017)
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15 p, 2.1 MB |
Proteoliposomal formulations of an HIV-1 gp41-based miniprotein elicit a lipid-dependent immunodominant response overlapping the 2F5 binding motif
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Molinos-Albert, Luis Manuel (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Bilbao, Eneritz (Universidad del País Vasco (UPV/EHU). Department of Biochemistry and Molecular Biology) ;
Agulló, Luis (Universitat de Vic. Departament de Biociències) ;
Marfil, Silvia (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
García, Elisabet (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Rodríguez de la Concepción, Maria Luisa (Institut Germans Trias i Pujol) ;
Izquierdo-Useros, Nuria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Vilaplana, Cristina (Institut Germans Trias i Pujol. Unitat de Tuberculosi Experimental) ;
Nieto-Garai, Jon A. (Universidad del País Vasco (UPV/EHU). Department of Biochemistry and Molecular Biology) ;
Contreras, F. Xabier (Universidad del País Vasco (UPV/EHU). Department of Biochemistry and Molecular Biology) ;
Floor, Martin (Universitat de Vic. Departament de Biociències) ;
Cardona, Pere J. (Institut Germans Trias i Pujol. Unitat de Tuberculosi Experimental) ;
Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Clotet, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Villà-Freixa, Jordi (Universitat de Vic. Departament de Biociències) ;
Lorizate, Maier (Universidad del País Vasco (UPV/EHU). Department of Biochemistry and Molecular Biology) ;
Carrillo, Jorge (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Blanco, Julià (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
The HIV-1 gp41 Membrane Proximal External Region (MPER) is recognized by broadly neutralizing antibodies and represents a promising vaccine target. However, MPER immunogenicity and antibody activity are influenced by membrane lipids. [...]
2017 - 10.1038/srep40800
Scientific reports, gener 2017, p. 1-15
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14 p, 954.2 KB |
Plasma HIV-1 Tropism and the Risk of Short- Term Clinical Progression to AIDS or Death
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Casadellà, Maria (Institut Germans Trias i Pujol. IrsiCaixa) ;
Cozzi-Lepri, Alessandro (Royal Free Hospital, London) ;
Phillips, Andrew (Royal Free Hospital, London) ;
Noguera-Julian, Marc (Institut Germans Trias i Pujol. IrsiCaixa) ;
Bickel, Markus (Goethe University) ;
Sedlacek, Dalibor (Charles University Hospital, Plzen, Česka ́Republika) ;
Zilmer, Kai (West-Tallinn Central Hospital, Tallinn,) ;
Clotet, Bonaventura (Institut Germans Trias i Pujol. IrsiCaixa) ;
Lundgren, Jens D. (CHIP, Department of Infectious Diseases, Rigshospitalet, University of Copenhagen) ;
Paredes, Roger (Institut Germans Trias i Pujol. IrsiCaixa) ;
EuroSIDA in EuroCOORD ;
Universitat Autònoma de Barcelona
Objective. To investigate if plasma HIV-1 tropism testing could identify subjects at higher risk for clinical progression and death in routine clinical management. Design. Nested case-control study within the EuroSIDA cohort. [...]
2017
PloS one, 2017, p. 1-14
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7 p, 628.1 KB |
Clinical and Emotional Factors Related to Erectile Dysfunction in HIV-Infected Men
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Fumaz, Carmina R. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ayestaran, Aintzane (Lluita contra la Sida Foundation- Universitat Politècnica de Catalunya, Barcelona, Spain) ;
Perez-Alvarez, Nuria (Lluita contra la Sida Foundation- Universitat Politècnica de Catalunya, Barcelona, Spain) ;
Muñoz-Moreno, Jose A. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ferrer, Maria Jose (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Negredo Puigmal, Eugènia (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Clotet, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Universitat Autònoma de Barcelona
The prevalence and associated factors of erectile dysfunction (ED) in Human Immunodeficiency Virus (HIV)-infected men remain controversial. The authors evaluated ED, clinical, and emotional variables in a group of 501 HIV-infected men in a cross-sectional 4-month observational study. [...]
2016 - 10.1177/1557988316669041
American Journal of Men's Health, Vol. 11 (september 2016) , p. 647-653
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15 p, 4.1 MB |
Lack of concordance between residual viremia and viral variants driving de novo infection of CD4 + T cells on ART
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Puertas, Maria C. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Noguera-Julian, Marc (Universitat de Vic - Universitat Central de Catalunya (UVic-UCC), Vic, Spain) ;
Massanella, Marta (Département de Microbiologie, Infectiologie et Immunologie, Centre de Recherche du CHUM et Université de Montréal) ;
Pou, Christian (Department of Cell and Molecular Biology, Karolinska Institutet, Solna, Stockholm Sweden) ;
Buzón, María José (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Clotet, Bonaventura (Universitat de Vic - Universitat Central de Catalunya (UVic-UCC), Vic, Spain) ;
Stevenson, Mario (Division of Infectious Diseases, Department of Medicine, University of Miami Miller School of Medicine, Miami, USA) ;
Paredes, Roger (Universitat de Vic - Universitat Central de Catalunya (UVic-UCC), Vic, Spain) ;
Blanco, Julià (Universitat de Vic - Universitat Central de Catalunya (UVic-UCC), Vic, Spain) ;
Martínez Picado, Francisco Javier (Institució Catalana de Recerca i Estudis Avançats (ICREA))
In most patients, current antiretroviral therapy (ART) regimens can rapidly reduce plasma viral load. However, even after years of effective treatment, a significant proportion of patients show residual plasma viremia below the clinical detection limit. [...]
2016 - 10.1186/s12977-016-0282-9
Retrovirology, Vol. 13 (august 2016)
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11 p, 635.6 KB |
P-glycoprotein (ABCB1) activity decreases raltegravir disposition in primary CD4+P-gp high cells and correlates with HIV-1 viral load
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Minuesa Dinarés, Gerard (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Arimany-Nardi, Cristina (National Biomedical Research Institute on Liver and Gastrointestinal Diseases (CIBER EHD), Instituto de Salud Carlos III) ;
Erkizia, Itziar (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Cedeño, Samandhy (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Moltó Marhuenda, José (Institut Germans Trias i Pujol. Fundació de Lluita contra la Sida) ;
Clotet, Bonaventura (Institució Catalana de Recerca i Estudis Avançats (ICREA)) ;
Pastor-Anglada, Marçal (National Biomedical Research Institute on Liver and Gastrointestinal Diseases (CIBER EHD), Instituto de Salud Carlos III) ;
Martínez Picado, Francisco Javier (Universitat de Vic, Universitat Central de Catalunya (UVic-UCC))
To evaluate the role of P-glycoprotein (P-gp) and multidrug-resistant-protein 1 (MRP1) on raltegravir intracellular drug disposition in CD4+ T cells, investigate the effect of HIV-1 infection on P-gp expression and correlate HIV-1 viraemia with P-gp activity in primary CD4+ T cell subsets. [...]
2016 - 10.1093/jac/dkw215
Journal of Antimicrobial Chemotherapy, Vol. 71 (june 2016) , p. 2782-2792
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