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The long-term outcomes of CIS patients in the Barcelona inception cohort : Looking back to recognize aggressive MS
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Tintore, Mar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Arrambide, Georgina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Otero-Romero, Susana (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Carbonell-Mirabent, Pere (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Río, Jordi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Tur, Carmen (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Comabella, Manuel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Nos, Carlos (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Arévalo, María Jesús (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Anglada, Elisenda (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Menendez, Rebeca (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Midaglia, Luciana (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Galán, Ingrid (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Vidal-Jordana, Angela (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Castilló, Joaquin (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Mulero, Patricia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Zabalza, Ana (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rodríguez-Acevedo, Breogan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rodriguez, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Espejo, Carmen (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Sequeira, Joao (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Mitjana, Raquel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
de Barros, Andrea (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Pareto, Deborah (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Auger, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Pérez-Hoyos, Santiago (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Sastre-Garriga, Jaume (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rovira, Alex (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
To explore the long-term outcomes of patients with clinically isolated syndromes from the Barcelona cohort. We selected patients with a follow-up longer than 10 years to (1) estimate the risks of multiple sclerosis (MS) and disability accumulation according to the baseline number of T2 lesions and to compare treated versus untreated patients and early versus delayed treatment, and (2) to study baseline features of patients with aggressive MS (Expanded Disability Status Scale (EDSS) ⩾6. [...]
2019 -  10.1177/1352458519877810
Multiple Sclerosis (Houndmills, Basingstoke, England), Vol. 26 (october 2019) , p. 1658-1669
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2 p, 577.9 KB |
Una nova variant de risc per a l'Esclerosi Múltiple està associada a l'expansió de les cèl·lules T reguladores circulatòries CXCR5 +
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Comabella, Manuel (Universitat Autònoma de Barcelona. Departament de Medicina)
Conèixer més variants genètiques lligades a l'expressió de l'Esclerosi Múltiple (EM) permetria identificar els efectes que aquestes desencadenen i precisar el focus d'anàlisi per desemmascarar les causes que provoquen la malaltia. [...]
Conocer más variantes genéticas ligadas a la expresión de la Esclerosis Múltiple (EM) permitiría identificar los efectos que estas desencadenan y precisar el foco de análisis para desenmascarar las causas que provocan la enfermedad. [...]
Knowing more genetic variants linked to the expression of Multiple Sclerosis (MS) would help to identify the effects that these trigger and to define the focus of analysis in order to unmask the causes that provoke the disease. [...]
2020
UAB divulga, Octubre 2020
3 documents
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3 p, 420.0 KB |
La reseqüenciació dirigida revela variants rares enriquides en gens susceptibles d'Esclerosi Múltiple
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Comabella, Manuel (Universitat Autònoma de Barcelona. Departament de Medicina)
Per tal d'eixamplar el mapa de les variants genètiques implicades amb la malaltia de l'Esclerosi Múltiple (EM) i així explorar l'origen d'aquesta, el grup del Servei de Neurologia- Neuroimmunologia del Centre d'Esclerosi Múltiple de Catalunya (Cemcat) i de l'Institut de Recerca Vall d'Hebron (VHIR) de l'Hospital Universitari Vall d'Hebron ha estudiat el paper de les variants rarament associades a contreure EM, específicament ubicades a 4 dels 14 gens analitzats i vinculats amb EM. [...]
Con el fin de ampliar el mapa de las variantes genéticas implicadas con enfermedad de la Esclerosis Múltiple (EM) y así explorar el origen de ésta, el grupo del Servicio de Neurologia- Neuroinmunología del Centro de Esclerosis Múltiple de Cataluña (Cemcat) y del Instituto de Investigación Vall d'Hebron (VHIR) del Hospital Universitario Vall d'Hebron ha estudiado el papel de las variantes raramente asociadas a contraer EM, específicamente ubicadas en 4 de los 14 genes analizados y vinculados con EM. [...]
In order to broaden the map of the genetic variants involved in Multiple Sclerosis (MS) disease and thus explore its origin, the group of the Neurology-Neuroimmunology Service from the Multiple Sclerosis Center of Catalonia (Cemcat) and from the Research Institute Vall d'Hebron (VHIR) of the University Hospital Vall d'Hebron has studied the role of the variants rarely associated with contracting MS, specifically located in 4 of the 14 genes analyzed and linked to MS. [...]
2020
UAB divulga, Setembre 2020
3 documents
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10 p, 237.0 KB |
Native ancestry is associated with optic neuritis and age of onset in hispanics with multiple sclerosis
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Amezcua, Lilyana (University of Southern California) ;
Beecham, Ashley H. (University of Miami. Miller School of Medicine) ;
Delgado, Silvia R. (University of Miami. Miller School of Medicine) ;
Chinea, Angel (San Juan Multiple Sclerosis Center (Puerto Rico)) ;
Burnett, Margaret (University of Southern California) ;
Manrique, Clara Patricia (University of Miami. Miller School of Medicine) ;
Gomez, Refujia (University of Southern California) ;
Comabella, Manuel (University of San Francisco School of Medicine) ;
Montalban, Xavier (University of San Francisco School of Medicine) ;
Ortega, Melissa (University of Miami. Miller School of Medicine) ;
Tornes, Leticia (University of Miami. Miller School of Medicine) ;
Lund, Brett T. (University of Southern California) ;
Islam, Talat (Institut de Recerca Vall d'Hebron) ;
Conti, David (Institut de Recerca Vall d'Hebron) ;
Oksenberg, Jorge R. (University of Southern California) ;
McCauley, Jacob L. (University of Miami. Miller School of Medicine) ;
Universitat Autònoma de Barcelona
Hispanics with multiple sclerosis (MS) present younger and more often with optic neuritis (ON) as compared to Whites in the western United States. Regional differences related to Hispanic genetic admixture could be responsible. [...]
2018 - 10.1002/acn3.646
Annals of Clinical and Translational Neurology, Vol. 5, Issue 11 (November 2018) , p. 1362-1371
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6 p, 152.3 KB |
Lesion topographies in multiple sclerosis diagnosis
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Arrambide, Georgina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Tintoré, Mar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Auger, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Río, Jordi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Castilló, Joaquín (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Vidal-Jordana, Angela (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Galán, Ingrid (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Nos, Carlos (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Comabella, Manuel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Mitjana, Raquel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Mulero, Patricia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
de Barros, Andrea (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rodríguez-Acevedo, Breogán (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Midaglia, Luciana (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Sastre-Garriga, Jaume (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rovira, Alex (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron. Institut de Recerca)
To assess the contributions of cortico-juxtacortical and corpus callosum lesions to multiple sclerosis diagnosis and to compare the value of ≥1 vs ≥3 periventricular lesions in clinically isolated syndromes (CIS). [...]
2017 - 10.1212/WNL.0000000000004715
Neurology, Vol. 89 (december 2017) , p. 2351-2356
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16 p, 688.9 KB |
Consensus guidelines for lumbar puncture in patients with neurological diseases
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Engelborghs, Sebastiaan (Department of Neurology and Memory Clinic, Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken, Antwerp, Belgium) ;
Niemantsverdriet, Ellis (Reference Center for Biological Markers of Dementia (BIODEM), Department of Biomedical Sciences, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium) ;
Struyfs, Hanne (Reference Center for Biological Markers of Dementia (BIODEM), Department of Biomedical Sciences, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium) ;
Blennow, Kaj (Clinical Neurochemistry Laboratory, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden) ;
Brouns, Raf (Department of Neurology, Universitair Ziekenhuis Brussel (UZ Brussel), Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Brussels, Belgium) ;
Comabella, Manuel (Hospital Universitari Vall d'Hebron) ;
Dujmovic, Irena (Clinic of Neurology, Clinical Centre of Serbia, Department of Neurology, Faculty of Medicine, University of Belgrade School of Medicine, Belgrade, Serbia) ;
van der Flier, Wiesje (Alzheimer center and Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands) ;
Frölich, Lutz (Department of Geriatric Psychiatry, Central Institute of Mental Health, Medical Faculty, Mannheim/Heidelberg University, Mannheim, Germany) ;
Galimberti, Daniela (Neurology Unit, Department of Pathophysiology and Transplantation, University of Milan, Fondazione Ca' Granda, IRCCS Ospedale Policlinico, Milan, Italy) ;
Gnanapavan, Sharmilee (Department of Neuroscience and Trauma, Blizard Institute, Queen Mary University of London, London, United Kingdom) ;
Hemmer, Bernhard (Munich Cluster for Systems Neurology (SyNergy), Munich, Germany) ;
Hoff, Erik (Department of Neurology, Atrium Medisch Centrum Parkstad, Heerlen, The Netherlands) ;
Hort, Jakub (International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic) ;
Iacobaeus, Ellen (Department of Clinical Neuroscience, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden) ;
Ingelsson, Martin (Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden) ;
Jan de Jong, Frank (Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands) ;
Jonsson, Michael (Memory Clinic, Department of Neuropsychiatry, Sahlgrenska University Hospital, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden) ;
Khalil, Michael (Department of Neurology, Medical University Graz, Graz, Austria) ;
Kuhle, Jens (Department of Neurology, University Hospital Basel, Basel, Switzerland) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
de Mendonça, Alexandre (Laboratory of Neurosciences, Department of Molecular Medicine and Faculty of Medicine, University of Lisbon, Lisbon, Portugal) ;
Molinuevo, José Luis (Alzheimer's disease and other cognitive disorders unit, Neurology Service, Hospital Clinic i Universitari, IDIBAPS, Barcelona, Spain) ;
Nagels, Guy (National MS Center Melsbroek, Brussels, Belgium) ;
Paquet, Claire (Research Memory Center Lariboisière Hospital University Paris Diderot INSERMU942, Paris, France) ;
Parnetti, Lucilla (Section of Neurology, Centre for Memory Disturbances, Department of Medicine, University of Perugia, Perugia, Italy) ;
Roks, Gerwin (Department of Neurology, St Elisabeth Ziekenhuis, Tilburg, The Netherlands) ;
Rosa-Neto, Pedro (Departments of Psychiatry, McGill Centre for Studies in Aging, Douglas Hospital Research Center, McGill University, Montreal, Canada) ;
Scheltens, Philip (Alzheimer center and Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands) ;
Skårsgard, Constance (Department of Geriatrics, Kalmar County Hospital, Kalmar, Sweden) ;
Stomrud, Erik (Clinical Memory Research Unit, Department of Clinical Sciences, Lund University, Lund, Sweden) ;
Tumani, Hayrettin (CSF Laboratory and Multiple Sclerosis Outpatient Unit, Department of Neurology, University of Ulm, Ulm, Germany) ;
Visser, Pieter Jelle (Alzheimer Centre Limburg, School for Mental Health and Neuroscience, Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, The Netherlands) ;
Wallin, Anders (Memory Clinic, Department of Neuropsychiatry, Sahlgrenska University Hospital, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden) ;
Winblad, Bengt (Karolinska Institutet, Department of Neurobiology, Care Sciences and Society (NVS), Center for Alzheimer Research, Division for Neurogeriatrics, Huddinge, Sweden) ;
Zetterberg, Henrik (UCL Institute of Neurology, Department of Molecular Neuroscience, London, United Kingdom) ;
Duits, Flora (Alzheimer center and Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands) ;
Teunissen, Charlotte E. (Neurochemistry Laboratory and Biobank, Department of Clinical Chemistry, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands) ;
Universitat Autònoma de Barcelona
Cerebrospinal fluid collection by lumbar puncture (LP) is performed in the diagnostic workup of several neurological brain diseases. Reluctance to perform the procedure is among others due to a lack of standards and guidelines to minimize the risk of complications, such as post-LP headache or back pain. [...]
2017 - 10.1016/j.dadm.2017.04.007
Alzheimer's & dementia, Vol. 8 (may 2017) , p. 111-126
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9 p, 405.7 KB |
Neurofilament light chain level is a weak risk factor for the development of MS
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Arrambide, Georgina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Espejo, Carmen (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Eixarch, Herena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Villar, Luisa M. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Alvarez-Cermeño, José C. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Picón, Carmen (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Kuhle, Jens (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Disanto, Giulio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Kappos, Ludwig (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Sastre-Garriga, Jaume (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Pareto, Deborah (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Simon, Eva (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Comabella, Manuel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Río, Jordi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Nos, Carlos (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Tur, Carmen (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Castilló, Joaquín (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Vidal-Jordana, Angela (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Galán, Ingrid (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Arévalo, Maria J. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Auger, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rovira, Alex (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Tintoré, Mar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
To determine the prognostic value of selected biomarkers in clinically isolated syndromes (CIS) for conversion to multiple sclerosis (MS) and disability accrual. Data were acquired from 2 CIS cohorts. [...]
2016 - 10.1212/WNL.0000000000003085
Neurology, Vol. 87 (september 2016) , p. 1076-1084
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Analysis of Plasminogen Genetic Variants in Multiple Sclerosis Patients
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Sadovnick, A. Dessa (Division of Neurology, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada) ;
Traboulsee, Anthony L. (Division of Neurology, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada) ;
Bernales, Cecily Q. (Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada) ;
Ross, Jay P. (Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada) ;
Forwell, Amanda L. (Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada) ;
Yee, Irene M. (Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada) ;
Guillot-Noel, Lena (Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, France) ;
Fontaine, Bertrand (Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, France) ;
Cournu-Rebeix, Isabelle (Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, France) ;
Alcina, Antonio (Department of Cell Biology and Immunology, Instituto de Parasitología y Biomedicina López Neyra (IPBLN), CSIC, 18100 Granada, Spain) ;
Fedetz, Maria (Unidad de Esclerosis Múltiple, Hospital Universitario Virgen Macarena, 41071 Sevilla, Spain) ;
Izquierdo, Guillermo (Unidad de Esclerosis Múltiple, Hospital Universitario Virgen Macarena, 41071 Sevilla, Spain) ;
Matesanz, Fuencisla (Department of Cell Biology and Immunology, Instituto de Parasitología y Biomedicina López Neyra (IPBLN), CSIC, 18100 Granada, Spain) ;
Hilven, Kelly (Laboratory for Neuroimmunology, Neurosciences, University of Leuven, 1022, Belgium) ;
Dubois, Bénédicte (Department of Neurology, University Hospitals Leuven, University of Leuven, Belgium) ;
Goris, An (Laboratory for Neuroimmunology, Neurosciences, University of Leuven, 1022, Belgium) ;
Astobiza, Ianire (Achucarro Basque Center for Neuroscience, 48170 Spain) ;
Alloza, Iraide (IKERBASQUE, Basque Foundation for Science, 48011 Spain) ;
Antigüedad, Alfredo (Servicio de Neurología, Hospital Universitario Basurto-Osakidetza, 48940 Bilbao, Spain) ;
Vandenbroeck, Koen (IKERBASQUE, Basque Foundation for Science, 48011 Spain) ;
Akkad, Denis A. (Department of Human Genetics, Ruhr University, 44801 Bochum, Germany) ;
Aktas, Orhan (Department of Neurology, Medical Faculty, Heinrich Heine University, 40225 Düsseldorf, Germany) ;
Blaschke, Paul (Department of Neurology, University of Rostock, 18059 Germany) ;
Buttmann, Mathias (Department of Neurology, University of Würzburg, 97080 Würzburg, Germany) ;
Chan, Andrew (Department of Neurology, University Hospital Bern and University of Bern, 3010 Bern, Switzerland) ;
Epplen, Joerg T. (Department of Human Genetics, Ruhr University, 44801 Bochum, Germany) ;
Gerdes, Lisa-Ann (Institute for Clinical Neuroimmunology, Ludwig Maximilian University, 80539 Munich, Germany) ;
Kroner, Antje (Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI 53226) ;
Kubisch, Christian (Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany) ;
Kümpfel, Tania (Institute for Clinical Neuroimmunology, Ludwig Maximilian University, 80539 Munich, Germany) ;
Lohse, Peter (Institute of Laboratory Medicine and Human Genetics, 78224 Singen, Germany) ;
Rieckmann, Peter (Department of Neurology, Sozialstiftung Bamberg Hospital, 96049 Germany) ;
Zettl, Uwe K. (Department of Neurology, University of Rostock, 18059 Germany) ;
Zipp, Frauke (Department of Neurology, Focus Program Translational Neuroscience, University Medical Center of the Johannes Gutenberg-University Mainz, 55122 Germany) ;
Bertram, Lars (School of Public Health, Medicine, Imperial College London, SW7 2AZ, UK) ;
Lill, Christina M (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Fernandez, Oscar (Department of Neurology, UGC Neurociencias Clínicas. IBIMA-Hospital Regional Universitario de Málaga, 29010 Spain) ;
Urbaneja, Patricia (Department of Neurology, UGC Neurociencias Clínicas. IBIMA-Hospital Regional Universitario de Málaga, 29010 Spain) ;
Leyva, Laura (Research Laboratory, UGC Neurociencias Clínicas. IBIMA-Hospital Regional Universitario de Málaga, 29010 Spain) ;
Alvarez-Cermeño, Jose Carlos (Immunology and Neurology Service, Multiple Sclerosis Unit, Ramón y Cajal University Hospital-IRYCIS, 28034 Madrid, Spain) ;
Arroyo, Rafael (Department of Neurology, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos-IdISSC, 28040 Madrid, Spain) ;
Garagorri, Aroa M. (Department of Immunology, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos-IdISSC, Madrid, Spain) ;
García-Martínez, Angel (Department of Immunology, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos-IdISSC, Madrid, Spain) ;
Villar, Luisa M. (Immunology and Neurology Service, Multiple Sclerosis Unit, Ramón y Cajal University Hospital-IRYCIS, 28034 Madrid, Spain) ;
Urcelay, Elena (Department of Immunology, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos-IdISSC, Madrid, Spain) ;
Malhotra, Sunny (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Comabella, Manuel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Berger, Thomas (Department of Clinical Neurology, Medical University of Innsbruck, 6020 Austria) ;
Fazekas, Franz (Department of Neurology, Medical University of Graz, 8010 Austria) ;
Reindl, Markus (Department of Clinical Neurology, Medical University of Innsbruck, 6020 Austria) ;
Schmied, Mascha C. (Department of Neurology, Medical University of Vienna, 1090 Austria) ;
Zimprich, Alexander (Department of Neurology, Medical University of Vienna, 1090 Austria) ;
Vilariño-Güell, Carles (Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada) ;
Universitat Autònoma de Barcelona
Multiple sclerosis (MS) is a prevalent neurological disease of complex etiology. Here, we describe the characterization of a multi-incident MS family that nominated a rare missense variant (p. G420D) in plasminogen (PLG) as a putative genetic risk factor for MS. [...]
2016 - 10.1534/g3.116.030841
G3, enomes
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Multicentre comparison of a diagnostic assay : aquaporin-4 antibodies in neuromyelitis optica
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Waters, Patrick (University of Oxford) ;
Reindl, Markus (Medical University of Innsbruck) ;
Saiz, Albert (Neuroimmunology Program, Hospital Clinic and Institut d'Investigació Biomèdica August Pi i Sunyer (IDIBAPS), Universitat de Barcelona) ;
Schanda, Kathrin (Medical University of Innsbruck) ;
Tuller, Friederike (Medical University of Innsbruck) ;
Kral, Vlastimil (Zdravotni ustav se sidlem v Usti nad Labem, Centrum imunologie a mikrobiologie) ;
Nytrova, Petra (Center of Clinical Neuroscience First Faculty of Medicine, General University Hospital and First Faculty of Medicine, Charles University in Prague) ;
Sobek, Ondrej (Topelex Ltd) ;
Nielsen, Helle Hvilsted (Odense University Hospital) ;
Barington, Torben (Odense University Hospital) ;
Lillevang, Søren T (Odense University Hospital) ;
Illes, Zsolt (University of Pécs) ;
Rentzsch, Kristin (Euroimmun AG) ;
Berthele, Achim (Klinikum rechts der Isar der TU München, Klinik für Neurologie) ;
Berki, Tímea (University of Pécs) ;
Granieri, Letizia (Neuroscience Institute Cavalieri Ottolenghi (NICO), University Hospital San Luigi Gonzaga, Regional Referring Multiple Sclerosis Centre) ;
Bertolotto, Antonio (Neuroscience Institute Cavalieri Ottolenghi (NICO), University Hospital San Luigi Gonzaga, Regional Referring Multiple Sclerosis Centre) ;
Giometto, Bruno (Azienda ULSS 9 Treviso) ;
Zuliani, Luigi (Azienda ULSS 9 Treviso) ;
Hamann, Dörte (Sanquin Diagnostic Services, Department of Immunopathology and Blood Coagulation, Amsterdam) ;
van Pelt, E Daniëlle (MS Centre ErasMS, Erasmus MC) ;
Hintzen, Rogier (MS Centre ErasMS, Erasmus MC) ;
Höftberger, Romana (Medical University of Vienna. Institute of Neurology) ;
Costa, Carme (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Comabella, Manuel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Tintoré, Mar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Siva, Aksel (Istanbul University, Cerrahpasa Medical School) ;
Altintas, Ayse (Istanbul University, Cerrahpasa Medical School) ;
Deniz, Günnur (Istanbul University, Institute of Experimental Medicine) ;
Woodhall, Mark (University of Oxford) ;
Palace, Jacqueline (University of Oxford) ;
Paul, Friedemann (NeuroCure Clinical Research Center (NCRC), Charité Universitätsmedizin Berlin) ;
Hartung, Hans-Peter (Heinrich-Heine-University Düsseldorf) ;
Aktas, Orhan (Heinrich-Heine-University Düsseldorf) ;
Jarius, Sven (University of Heidelberg) ;
Wildemann, Brigitte (University of Heidelberg) ;
Vedeler, Christian (Haukeland University Hospital) ;
Ruiz, Anne (Lyon Neurosciences Research Centre, Neuro-inflammation and Neuro-oncology Team) ;
Leite, M Isabel (University of Oxford) ;
Trillenberg, Peter (University Hospital of Schleswig-Holstein, Campus Lübeck) ;
Probst, Monika (Institute for Quality Assurance) ;
Saschenbrecker, Sandra (Euroimmun AG) ;
Vincent, Angela (University of Oxford) ;
Marignier, Romain (Lyon Neurosciences Research Centre, Neuro-inflammation and Neuro-oncology Team) ;
Universitat Autònoma de Barcelona
Antibodies to cell surface central nervous system proteins help to diagnose conditions which often respond to immunotherapies. The assessment of antibody assays needs to reflect their clinical utility. [...]
2016 - 10.1136/jnnp-2015-312601
Journal of Neurology, Neurosurgery, and Psychiatry, Vol. 87 (april 2016) , p. 1005-1015
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Role of high mobility group box protein 1 (HMGB1) in peripheral blood from patients with multiple sclerosis
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Malhotra, Sunny (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Fissolo, Nicolas (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Tintoré, Mar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Wing, Ana Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Castilló, Joaquin (SHospital Universitari Vall d'Hebron. Institut de Recerca) ;
Vidal-Jordana, Angela (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Comabella, Manuel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
High mobility group box protein 1 (HMGB1) is a transcriptional regulator that is receiving increasing attention in autoimmune disorders including multiple sclerosis (MS). Here, we investigated the role of HMGB1 in the peripheral blood compartment from MS patients. [...]
2015 - 10.1186/s12974-015-0269-9
Journal of neuroinflammation, Vol. 12 (march 2015)
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