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16 p, 3.1 MB Neuroprotective effects of the multitarget agent AVCRI104P3 in brain of middle-aged mice / Relat, J. (Department of Pharmacology. Therapeutic and Toxicology. Autonomous University of Barcelona) ; Come, J. (Department of Pharmacology. Therapeutic and Toxicology. Autonomous University of Barcelona) ; Perez, B. (Department of Pharmacology. Therapeutic and Toxicology. Autonomous University of Barcelona) ; Camps, P. (Laboratory of Pharmaceutical Chemistry (CSIC Associated Unit). Faculty of Pharmacy and Food Sciences. Institute of Biomedicine (IBUB). University of Barcelona) ; Muñoz-Torrero, D. (Laboratory of Pharmaceutical Chemistry (CSIC Associated Unit). Faculty of Pharmacy and Food Sciences. Institute of Biomedicine (IBUB). University of Barcelona) ; Badia Sancho, A. (Albert) (Department of Pharmacology. Therapeutic and Toxicology. Autonomous University of Barcelona) ; Gimenez-Llort, L. (Department of Psychiatry and Forensic Medicine. Autonomous University of Barcelona) ; Clos, M.V. (Department of Pharmacology. Therapeutic and Toxicology. Autonomous University of Barcelona)
Molecular factors involved in neuroprotection are key in the design of novel multitarget drugs in aging and neurodegeneration. AVCRI104P3 is a huprine derivative that exhibits potent inhibitory effects on human AChE, BuChE, and BACE-1 activities, as well as on AChE-induced and self-induced Aβ aggregation. [...]
2018 - 10.3390/ijms19092615
International Journal of Molecular Sciences, Vol. 19 Núm. 9 (april 2018) , p. 2615  

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