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16 p, 657.0 KB |
Perspectives for systems biology in the management of tuberculosis
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Kontsevaya, Irina (University of Lübeck) ;
Lange, Christoph (University of Lübeck) ;
Comella-del-Barrio, Patricia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Coarfa, Cristian (Baylor College of Medicine) ;
DiNardo, Andrew R. (The Baylor College of Medicine) ;
Gillespie, Stephen H. (University of St Andrew) ;
Hauptmann, Matthias (Hamburg-Lübeck-Borstel-Riems) ;
Leschczyk, Christoph (Hamburg-Lübeck-Borstel-Riems) ;
Mandalakas, Anna M. (Baylor College of Medicine) ;
Martinecz, Antal (Arctic University of Norway) ;
Merker, Matthias (Hamburg-Lübeck-Borstel-Riems) ;
Niemann, Stefan (Hamburg-Lübeck-Borstel-Riems) ;
Reimann, Maja (University of Lübeck) ;
Rzhepishevska, Olena (Umeå University (Suècia)) ;
Schaible, Ulrich E. (Hamburg-Lübeck-Borstel-Riems) ;
Scheu, Katrin M. (Research Center Borstel) ;
Schurr, Erwin (Research Institute of the McGill University Health Centre (Montréal, Canada)) ;
Abel zur Wiesch, Pia (Pennsylvania State University (Estats Units d'Amèrica)) ;
Heyckendorf, Jan (University of Lübeck) ;
Universitat Autònoma de Barcelona
Standardised management of tuberculosis may soon be replaced by individualised, precision medicine-guided therapies informed with knowledge provided by the field of systems biology. Systems biology is a rapidly expanding field of computational and mathematical analysis and modelling of complex biological systems that can provide insights into mechanisms underlying tuberculosis, identify novel biomarkers, and help to optimise prevention, diagnosis and treatment of disease. [...]
2021 -  10.1183/16000617.0377-2020
European Respiratory Review, Vol. 30 (may 2021)
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12 p, 995.8 KB |
Tobacco Smoking and Second-Hand Smoke Exposure Impact on Tuberculosis in Children
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Altet, Neus (Unitat Clínica de Tractament Directament Observat de la Tuberculosi (Barcelona)) ;
Latorre, Irene (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Jiménez-Fuentes, María Ángeles (Hospital Universitari Vall d'Hebron) ;
Soriano-Arandes, Antoni (Hospital Universitari Vall d'Hebron) ;
Villar-Hernández, Raquel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Milà, Celia (Hospital Universitari Vall d'Hebron) ;
Rodríguez-Fernández, Pablo (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Muriel-Moreno, Beatriz (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Comella-del-Barrio, Patricia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Godoy, Pere (Institut de Recerca Biomèdica de Lleida) ;
Millet, Joan-Pau (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
De Souza Galvão, Maria Luiza (Hospital Universitari Vall d'Hebron) ;
Jiménez-Ruiz, Carlos A. (Comunidad Autónoma de Madrid. Unidad de Tabaquismo) ;
Domínguez, José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Little is known about whether second-hand smoke (SHS) exposure affects tuberculosis (TB). Here, we investigate the association of cigarette smoke exposure with active TB and latent TB infection (LTBI) in children, analyzing Interferon-Gamma Release Assays' (IGRAs) performance and cytokine immune responses. [...]
2022 - 10.3390/jcm11072000
Journal of clinical medicine, Vol. 11 (april 2022)
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3.
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11 p, 1.7 MB |
Urine NMR-based TB metabolic fingerprinting for the diagnosis of TB in children
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Comella-del-Barrio, Patricia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Izquierdo-Garcia, José Luis (Basque Research and Technology Alliance) ;
Gautier, Jacqueline (Hôpital Saint-Damien (Haití)) ;
Doresca, Mariette Jean Coute (Hôpital Saint-Damien (Haití)) ;
Campos-Olivas, Ramón (Centro Nacional de Investigaciones Oncológicas (Madrid)) ;
Santiveri, Clara M. (Centro Nacional de Investigaciones Oncológicas (Madrid)) ;
Muriel-Moreno, Beatriz (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prat i Aymerich, Cristina (University Medical Center Utrecht) ;
Abellana, Rosa (Universitat de Barcelona. Facultat de Medicina i Ciències de la Salut) ;
Pérez-Porcuna, Tomás M. (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Cuevas, Luis E.. (Liverpool School of Tropical Medicine. Department of Clinical Sciences) ;
Ruiz-Cabello, Jesús (IKERBASQUE, Basque Foundation for Science) ;
Domínguez, José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Tuberculosis (TB) is a major cause of morbidity and mortality in children, and early diagnosis and treatment are crucial to reduce long-term morbidity and mortality. In this study, we explore whether urine nuclear magnetic resonance (NMR)-based metabolomics could be used to identify differences in the metabolic response of children with different diagnostic certainty of TB. [...]
2021 - 10.1038/s41598-021-91545-0
Scientific reports, Vol. 11 (june 2021)
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8 p, 268.4 KB |
Diagnostic Performance of the Fujifilm SILVAMP TB-LAM in Children with Presumptive Tuberculosis
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Comella-del-Barrio, Patricia (Institut Germans Trias i Pujol) ;
Molina-Moya, Barbara (Institut Germans Trias i Pujol) ;
Gautier, Jacqueline (Hôpital Saint-Damien) ;
Villar-Hernández, Raquel (Institut Germans Trias i Pujol) ;
Doresca, Mariette Jean Coute (Hôpital Saint-Damien) ;
Sallés-Mingels, Beatriz (Institut Català de la Salut) ;
Canales-Aliaga, Lydia (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Narcisse, Margareth (Department of Pediatrics, Division of Tuberculosis, Hôpital Saint-Damien, Nos Petits-Frères et Sœurs, Port-au-Prince 6112, Haiti; (J.G.); (M.J.C.D.); (M.N.)) ;
Pérez-Porcuna, Tomás M. (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Creswell, Jacob (Stop TB Partnership (Suïssa)) ;
Cuevas, Luis E.. (Liverpool School of Tropical Medicine) ;
Domínguez, José (Institut Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Current diagnostics for tuberculosis (TB) only manage to confirm a small proportion of children with TB and require respiratory samples, which are difficult to obtain. There is a need for non-invasive biomarker-based tests as an alternative to sputum testing. [...]
2021 - 10.3390/jcm10091914
Journal of clinical medicine, Vol. 10 (april 2021)
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5.
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13 p, 2.4 MB |
Discovery and validation of an NMR-based metabolomic profile in urine as TB biomarker
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Izquierdo-Garcia, José Luis (Universidad Complutense de Madrid) ;
Comella-del-Barrio, Patricia (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Campos-Olivas, Ramón (Centro Nacional de Investigaciones Oncológicas) ;
Villar-Hernández, Raquel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prat i Aymerich, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
De Souza Galvão, Maria Luiza (Hospital Universitari Vall d'Hebron) ;
Jiménez-Fuentes, Maria Angeles (Hospital Universitari Vall d'Hebron) ;
Ruiz-Manzano, Juan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Stojanovic, Zoran (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
González, Adela (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Serra-Vidal, Mar (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
García-García, Esther (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Muriel-Moreno, Beatriz (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Millet, Joan-Pau (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
Molina-Pinargote, Israel (Unitat Clínica de Tractament Directament Observat de la Tuberculosi (Barcelona)) ;
Casas, Xavier (Unitat Clínica de Tractament Directament Observat de la Tuberculosi (Barcelona)) ;
Santiago, Javier (Unitat Clínica de Tractament Directament Observat de la Tuberculosi (Barcelona)) ;
Sabriá, Fina (Hospital de Sant Joan Despí Moisès Broggi) ;
Martos, Carmen (Hospital de Sant Joan Despí Moisès Broggi) ;
Herzmann, Christian (Research Center Borstel. Center for Clinical Studies, Germany) ;
Ruiz-Cabello, Jesús (IKERBASQUE, Basque Foundation for Science) ;
Domínguez, José (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Despite efforts to improve tuberculosis (TB) detection, limitations in access, quality and timeliness of diagnostic services in low- and middle-income countries are challenging for current TB diagnostics. [...]
2020 - 10.1038/s41598-020-78999-4
Scientific reports, Vol. 10 (december 2020)
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9 p, 376.9 KB |
Fujifilm silvamp tb-lam for the diagnosis of tuberculosis in nigerian adults
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Comella-del-Barrio, Patricia (Institut Germans Trias i Pujol) ;
Bimba, John (Bingham University. Zankli Research Centre and Department of Community Medicine) ;
Adelakun, Ramota (Liverpool School of Tropical Medicine. Department of Clinical Sciences) ;
Kontogianni, Konstantina (Liverpool School of Tropical Medicine. Department of Clinical Sciences) ;
Molina-Moya, Barbara (Institut Germans Trias i Pujol) ;
Osazuwa, Okoedoh (Bingham University. Zankli Research Centre and Department of Community Medicine) ;
Creswell, Jacob (TB REACH. Stop TB Partnership) ;
Cuevas, Luis E.. (Liverpool School of Tropical Medicine. Department of Clinical Sciences.) ;
Domínguez, José (Institut Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona.
Departament de Genètica i de Microbiologia
There is a need for diagnostics for tuberculosis (TB) that are easy to use, able to screen non-sputum samples, and able to provide rapid results for the management of both immunocompromised and immunocompetent individuals. [...]
2021 - 10.3390/jcm10112514
Journal of clinical medicine, Vol. 10 Núm. 11 (june 2021) , p. 2514
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15 p, 638.1 KB |
A model based on the combination of ifn-γ, ip-10, ferritin and 25-hydroxyvitamin d for discriminating latent from active tuberculosis in children
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Comella-del-Barrio, Patricia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Abellana, Rosa (Universitat de Barcelona. Facultat de Medicina i Ciències de la Salut) ;
Villar-Hernández, Raquel (Institut Germans Trias i Pujol) ;
Coute, M. D. J. (Saint-Damien Pediatric Hospital) ;
Mingels, B. S. (Radiology and Imaging Diagnose Department. Manso Primary Care Center) ;
Canales-Aliaga, Lydia (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Narcisse, M. (Saint-Damien Pediatric Hospital) ;
Gautier, Jacqueline (Saint-Damien Pediatric Hospital) ;
Ascaso, C. (Universitat de Barcelona. Facultat de Medicina i Ciències de la Salut) ;
Latorre, Irene (Institut Germans Trias i Pujol) ;
Domínguez, J.. (Institut Germans Trias i Pujol) ;
Pérez-Porcuna, Tomás M. (Universitat de Barcelona. Hospital Mútua de Terrassa) ;
Universitat Autònoma de Barcelona
In recent years, pediatric research on tuberculosis (TB) has focused on addressing new biomarkers with the potential to be used as immunological non-sputum-based methods for the diagnosis of TB in children. [...]
2019 - 10.3389/fmicb.2019.01855
Frontiers in microbiology, Vol. 10 Núm. AUG (2019) , p. 1855
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