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Self-assembling as regular nanoparticles dramatically minimizes photobleaching of tumour-targeted GFP
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Unzueta Elorza, Ugutz (Institut d'Investigació Biomèdica Sant Pau) ;
Roldán, Mònica (Institut de Recerca Sant Joan de Déu) ;
Pesarrodona Roches, Mireia (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Benitez, Raul (Institut de Recerca Sant Joan de Déu) ;
Sánchez Chardi, Alejandro (Universitat de Barcelona. Departament de Biologia Evolutiva, Ecologia i Ciències Ambientals) ;
Conchillo-Solé, Oscar (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Mangues, Ramon (Institut d'Investigació Biomèdica Sant Pau) ;
Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Vázquez Gómez, Esther (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Fluorescent proteins are useful imaging and theranostic agents, but their potential superiority over alternative dyes is weakened by substantial photobleaching under irradiation. Enhancing protein photostability has been attempted through diverse strategies, with irregular results and limited applicability. [...]
2020 -  10.1016/j.actbio.2019.12.003
Acta Biomaterialia, Vol. 103 (Feb. 2020) , p. 272-280
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16 p, 406.6 KB |
Assembly of histidine-rich protein materials controlled through divalent cations
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López-Laguna, Hèctor (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Unzueta Elorza, Ugutz. (Institut d'Investigació Biomèdica Sant Pau) ;
Conchillo-Solé, Oscar (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Sánchez Chardi, Alejandro (Universitat Autònoma de Barcelona. Servei de Microscòpia) ;
Pesarrodona Roches, Mireia (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Cano-Garrido, Olivia (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Voltà-Durán, Eric (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Sánchez, Laura (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Serna, Naroa (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Saccardo, Paolo (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Mangues, Ramon (Institut d'Investigació Biomèdica Sant Pau) ;
Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Vázquez Gómez, Esther (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Nanostructured protein materials show exciting biomedical applications, since both structure and function can be genetically programmed. In particular, self-assembling histidine-rich proteins benefit from functional plasticity that allows the generation of protein-only nanoparticles for cell targeted drug delivery. [...]
2019 - 10.1016/j.actbio.2018.10.030
Acta Biomaterialia, Vol. 83 (Jan. 2019) , p. 257-264
8 documents
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3.
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13 p, 1.9 MB |
Recombinant protein-based nanoparticles : elucidating their inflammatory effects in vivo and their potential as a new therapeutic format
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Gifre-Renom, Laia (Institut de Recerca i Tecnologia Agroalimentàries) ;
Ugarte-Berzal, Estefanía (Katholieke Universiteit Leuven. Department of Microbiology, Immunology and Transplantation) ;
Martens, Erik (Katholieke Universiteit Leuven. Department of Microbiology, Immunology and Transplantation) ;
Boon, Lise (Katholieke Universiteit Leuven. Department of Microbiology, Immunology and Transplantation) ;
Cano-Garrido, Olivia (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Martínez-Núñez, Esther (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Luque, Teresa (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Roca-Pinilla, Ramon (Institut de Recerca i Tecnologia Agroalimentàries) ;
Conchillo-Solé, Oscar (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Ferrer Miralles, Neus (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Opdenakker, Ghislain (Katholieke Universiteit Leuven. Department of Microbiology, Immunology and Transplantation) ;
García Fruitós, Elena (Institut de Recerca i Tecnologia Agroalimentàries) ;
Arís i Giralt, Anna (Institut de Recerca i Tecnologia Agroalimentàries)
Bacterial inclusion bodies (IBs) are protein-based nanoparticles of a few hundred nanometers formed during recombinant protein production processes in different bacterial hosts. IBs contain active protein in a mechanically stable nanostructured format that has been broadly characterized, showing promising potential in different fields such as tissue engineering, protein replacement therapies, cancer, and biotechnology. [...]
2020 - 10.3390/pharmaceutics12050450
Pharmaceutics, Vol. 12, issue 5 (2020) , art. 450
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4.
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4 p, 2.2 MB |
The fusogenic peptide HA2 impairs selectivity of CXCR4-targeted protein nanoparticles
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Sánchez García, Laura (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Serna Romero, Naroa (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Mattanovich, M. (University of Natural Resources and Life Sciences. Department of Biotechnology) ;
Cazzanelli, P. (University of Natural Resources and Life Sciences. Department of Biotechnology) ;
Sánchez Chardi, Alejandro (Universitat Autònoma de Barcelona. Servei de Microscòpia) ;
Conchillo-Solé, Oscar (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Cortés, Fran (Universitat Autònoma de Barcelona. Servei de Cultius Cel·lulars, Producció d'Anticossos i Citometria) ;
Daura i Ribera, Xavier (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Unzueta Elorza, Ugutz (Institut d'Investigació Biomèdica Sant Pau) ;
Mangues, Ramon (Institut d'Investigació Biomèdica Sant Pau) ;
Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Vázquez Gómez, Esther (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Universitat Autònoma de Barcelona
We demonstrate here that the genetic incorporation of the fusogenic peptide HA2 into a CXCR4-targeted protein nanoparticle dramatically reduces the specificity of the interaction between nanoparticles and cell receptors, a factor to be considered when designing tumor-homing drug vehicles displaying endosomal-escape agents. [...]
2017 - 10.1039/c6cc09900a
Chemical communications, Vol. 53, issue 33 (April 2017) , p. 4565-4568
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45 p, 777.6 KB |
Aggregation-prone peptides modulate activity of bovine interferon gamma released from naturally occurring protein nanoparticles
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Carratalá, José Vicente (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Cano-Garrido, Olivia (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Sánchez, Julieta María (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Membrado, Cristina (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Pérez, Eudald (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Conchillo-Solé, Oscar (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Daura i Ribera, Xavier (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Sánchez Chardi, Alejandro (Universitat Autònoma de Barcelona. Servei de Microscòpia) ;
Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Arís i Giralt, Anna (Institut de Recerca i Tecnologia Agroalimentàries) ;
García Fruitós, Elena (Institut de Recerca i Tecnologia Agroalimentàries) ;
Ferrer Miralles, Neus (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Efficient protocols for the production of recombinant proteins are indispensable for the development of the biopharmaceutical sector. Accumulation of recombinant proteins in naturally-occurring protein aggregates is detrimental to biopharmaceutical development. [...]
2020 - 10.1016/j.nbt.2020.02.001
New Biotechnolgy, Vol. 57 (July 2020) , p. 11-19
2 documents
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7.
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14 p, 7.6 MB |
BPSL1626 : reverse and structural vaccinology reveal a novel candidate for vaccine design against Burkholderia pseudomallei
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Capelli, Riccardo (Center for Complexity and Biosystems and Dipartimento di Fisica, Università degli Studi di Milano) ;
Peri, Claudio (Consiglio Nazionale delle Ricerche. Istituto di Chimica del Riconoscimento Molecolare) ;
Villa, Riccardo (Department of Biosciences, Università degli Studi di Milano) ;
Nithichanon, Arnone (Khon Kaen University. Centre for Research and Development of Medical Diagnostic Laboratories) ;
Conchillo-Solé, Oscar (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Yero Corona, Daniel (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Gagni, Paola (Istituto di Chimica del Riconoscimento Molecolare, Consiglio Nazionale delle Ricerche) ;
Chiari, Marcella (Istituto di Chimica del Riconoscimento Molecolare, Consiglio Nazionale delle Ricerche) ;
Lertmemongkolchai, Ganjana (Center for Research and Development of Medical Diagnostic Laboratories (CMDL), Faculty of Associated Medical Sciences, Khon Kaen University) ;
Cretich, Marina (Istituto di Chimica del Riconoscimento Molecolare, Consiglio Nazionale delle Ricerche) ;
Daura i Ribera, Xavier (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Bolognesi, Martino (Università degli Studi di Milano. Centro di Eccellenza Interdisciplinare Materiali e Interfacce Nanostrutturati) ;
Colombo, Giorgio (Consiglio Nazionale delle Ricerche. Istituto di Chimica del Riconoscimento Molecolare) ;
Gourlay, Louise J. (Università degli Studi di Milano. Centro di Eccellenza Interdisciplinare Materiali e Interfacce Nanostrutturati)
Due to significant advances in computational biology, protein prediction, together with antigen and epitope design, have rapidly moved from conventional methods, based on experimental approaches, to in silico-based bioinformatics methods. [...]
2018 - 10.3390/antib7030026
Antibodies, Vol. 7 (2018) , p. 1-14
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20 p, 2.1 MB |
Sequence- and structure-based immunoreactive epitope discovery for Burkholderia pseudomallei flagellin
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Nithichanon, Arnone (Khon Kaen University. Centre for Research and Development of Medical Diagnostic Laboratories) ;
Rinchai, Darawan (Khon Kaen University. Centre for Research and Development of Medical Diagnostic Laboratories) ;
Gori, Alessandro (Consiglio Nazionale delle Ricerche. Istituto di Chimica del Riconoscimento Molecolare) ;
Lassaux, Patricia (Università degli Studi di Milano. Centro di Eccellenza Interdisciplinare Materiali e Interfacce Nanostrutturati) ;
Peri, Claudio (Consiglio Nazionale delle Ricerche. Istituto di Chimica del Riconoscimento Molecolare) ;
Conchillo-Solé, Oscar (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Ferrer Navarro, Mario (Universitat de Barcelona. Departament de Microbiologia Clínica) ;
Gourlay, Louise J. (Università degli Studi di Milano. Centro di Eccellenza Interdisciplinare Materiali e Interfacce Nanostrutturati) ;
Nardini, Marco (Università degli Studi di Milano. Centro di Eccellenza Interdisciplinare Materiali e Interfacce Nanostrutturati) ;
Vila, Jordi (Universitat de Barcelona. Departament de Microbiologia Clínica) ;
Daura i Ribera, Xavier (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Colombo, Giorgio (Consiglio Nazionale delle Ricerche. Istituto di Chimica del Riconoscimento Molecolare) ;
Bolognesi, Martino (Università degli Studi di Milano. Centro di Eccellenza Interdisciplinare Materiali e Interfacce Nanostrutturati) ;
Lertmemonkolchai, Ganjana (Khon Kaen University. Centre for Research and Development of Medical Diagnostic Laboratories)
Burkholderia pseudomallei is a Gram-negative bacterium responsible for melioidosis, a serious and often fatal infectious disease that is poorly controlled by existing treatments. Due to its inherent resistance to the major antibiotic classes and its facultative intracellular pathogenicity, an effective vaccine would be extremely desirable, along with appropriate prevention and therapeutic management. [...]
2015 - 10.1371/journal.pntd.0003917
PLoS neglected tropical diseases, Vol. 9, Issue 7 (July 2015) , e0003917
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7 p, 1.8 MB |
PrionW : a server to identify proteins containing glutamine/asparagine rich prion-like domains and their amyloid cores
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Zambrano, Rafael (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Conchillo-Solé, Oscar (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Iglesias, Valentin (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Illa, Ricard (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Rousseau, Frederic (KU Leuven. Department for Cellular and Molecular Medicine) ;
Schymkowitz, Joost (KU Leuven. Department for Cellular and Molecular Medicine) ;
Sabate, Raimon (Universitat de Barcelona. Departament de Fisicoquímica) ;
Daura i Ribera, Xavier (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular)
Prions are a particular type of amyloids with the ability to self-perpetuate and propagate in vivo. Prion-like conversion underlies important biological processes but is also connected to human disease. [...]
2015 - 10.1093/nar/gkv490
Nucleic acids research, Vol. 43 (2015) , Web Server issue W331-W337
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10.
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35 p, 1.1 MB |
Conformational and functional variants of CD44-targeted protein nanoparticles bio-produced in bacteria
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Pesarrodona Roches, Mireia (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Fernández, Yolanda (CIBER de Bioingeniería, Biomateriales y Nanomedicina (Barcelona)) ;
Foradada, Laia (Hospital Vall d'Hebron. CIBBIM-Nanomedicine) ;
Sánchez Chardi, Alejandro (Universitat Autònoma de Barcelona. Servei de Microscòpia) ;
Conchillo-Solé, Oscar (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Unzueta Elorza, Ugutz (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Xu, Zhikun (CIBER de Bioingeniería, Biomateriales y Nanomedicina (Barcelona)) ;
Roldán, Mónica (Universitat Autònoma de Barcelona. Servei de Microscòpia) ;
Villegas Hernández, Sandra (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ;
Ferrer Miralles, Neus (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Schwartz, Simó (CIBER de Bioingeniería, Biomateriales y Nanomedicina (Barcelona)) ;
Rinas, Ursula (Leibniz University of Hannover. Technical Chemistry & Life Science) ;
Daura i Ribera, Xavier (Institució Catalana de Recerca i Estudis Avançats) ;
Abasolo, Ibane (CIBER de Bioingeniería, Biomateriales y Nanomedicina (Barcelona)) ;
Vázquez Gómez, Esther (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Biofabrication is attracting interest as a means to produce nanostructured functional materials because of its operational versatility and full scalability. Materials based on proteins are especially appealing, as the structure and functionality of proteins can be adapted by genetic engineering. [...]
2016 - 10.1088/1758-5090/8/2/025001
Biofabrication, Vol. 8 Núm 2 (Abril 2016) , p. 25001
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