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1.
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20 p, 2.1 MB |
Sequence- and structure-based immunoreactive epitope discovery for Burkholderia pseudomallei flagellin
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Nithichanon, Arnone (Khon Kaen University. Centre for Research and Development of Medical Diagnostic Laboratories) ;
Rinchai, Darawan (Khon Kaen University. Centre for Research and Development of Medical Diagnostic Laboratories) ;
Gori, Alessandro (Consiglio Nazionale delle Ricerche. Istituto di Chimica del Riconoscimento Molecolare) ;
Lassaux, Patricia (Università degli Studi di Milano. Centro di Eccellenza Interdisciplinare Materiali e Interfacce Nanostrutturati) ;
Peri, Claudio (Consiglio Nazionale delle Ricerche. Istituto di Chimica del Riconoscimento Molecolare) ;
Conchillo-Solé, Oscar (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Ferrer Navarro, Mario (Universitat de Barcelona. Departament de Microbiologia Clínica) ;
Gourlay, Louise J. (Università degli Studi di Milano. Centro di Eccellenza Interdisciplinare Materiali e Interfacce Nanostrutturati) ;
Nardini, Marco (Università degli Studi di Milano. Centro di Eccellenza Interdisciplinare Materiali e Interfacce Nanostrutturati) ;
Vila, Jordi (Universitat de Barcelona. Departament de Microbiologia Clínica) ;
Daura i Ribera, Xavier (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Colombo, Giorgio (Consiglio Nazionale delle Ricerche. Istituto di Chimica del Riconoscimento Molecolare) ;
Bolognesi, Martino (Università degli Studi di Milano. Centro di Eccellenza Interdisciplinare Materiali e Interfacce Nanostrutturati) ;
Lertmemonkolchai, Ganjana (Khon Kaen University. Centre for Research and Development of Medical Diagnostic Laboratories)
Burkholderia pseudomallei is a Gram-negative bacterium responsible for melioidosis, a serious and often fatal infectious disease that is poorly controlled by existing treatments. Due to its inherent resistance to the major antibiotic classes and its facultative intracellular pathogenicity, an effective vaccine would be extremely desirable, along with appropriate prevention and therapeutic management. [...]
2015 -  10.1371/journal.pntd.0003917
PLoS neglected tropical diseases, Vol. 9, Issue 7 (July 2015) , e0003917
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2.
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7 p, 1.8 MB |
PrionW : a server to identify proteins containing glutamine/asparagine rich prion-like domains and their amyloid cores
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Zambrano, Rafael (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Conchillo-Solé, Óscar (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Iglesias, Valentin (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Illa, Ricard (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biomedicina Molecular) ;
Rousseau, Frederic (KU Leuven. Department for Cellular and Molecular Medicine) ;
Schymkowitz, Joost (KU Leuven. Department for Cellular and Molecular Medicine) ;
Sabate, Raimon (Universitat de Barcelona. Departament de Fisicoquímica) ;
Daura i Ribera, Xavier (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Ventura i Zamora, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular)
Prions are a particular type of amyloids with the ability to self-perpetuate and propagate in vivo. Prion-like conversion underlies important biological processes but is also connected to human disease. [...]
2015 - 10.1093/nar/gkv490
Nucleic acids research, Vol. 43 (2015) , Web Server issue W331–W337
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3.
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35 p, 1.1 MB |
Conformational and functional variants of CD44-targeted protein nanoparticles bio-produced in bacteria.
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Pesarrodona Roches, Mireia (Universitat Autònoma de Barcelona. Department de Genètica i de Microbiologia) ;
Fernández, Yolanda (CIBER de Bioingeniería, Biomateriales y Nanomedicina (Barcelona)) ;
Foradada, Laia (Hospital Vall d'Hebron. CIBBIM-Nanomedicine) ;
Sánchez Chardi, Alejandro (Universitat Autònoma de Barcelona. Servei de Microscòpia) ;
Conchillo-Solé, Oscar (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Unzueta Elorza, Ugutz (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Xu, Zhikun (CIBER de Bioingeniería, Biomateriales y Nanomedicina (Barcelona)) ;
Roldán, Mónica (Universitat Autònoma de Barcelona. Servei de Microscòpia) ;
Villegas Hernández, Sandra (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ;
Ferrer Miralles, Neus (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Schwartz, Simó (CIBER de Bioingeniería, Biomateriales y Nanomedicina (Barcelona)) ;
Rinas, Ursula (Leibniz University of Hannover. Technical Chemistry & Life Science) ;
Daura i Ribera, Xavier (Institució Catalana de Recerca i Estudis Avançats) ;
Abasolo, Ibane (CIBER de Bioingeniería, Biomateriales y Nanomedicina (Barcelona)) ;
Vázquez, Esther (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Biofabrication is attracting interest as a means to produce nanostructured functional materials because of its operational versatility and full scalability. Materials based on proteins are especially appealing, as the structure and functionality of proteins can be adapted by genetic engineering. [...]
2016
Biofabrication, Vol. 8 Núm 2 (Abril 2016) , p. 25001
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4.
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38 p, 2.7 MB |
Bottom-up instructive quality control in the biofabrication of smart protein materials
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Rueda, Fabián (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Céspedes, María Virtudes (CIBER de Bioingeniería, Biomateriales y Nanomedicina (Bellaterra)) ;
Conchillo-Solé, Óscar (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Sánchez Chardi, Alejandro (Universitat Autònoma de Barcelona. Servei de Microscòpia) ;
Seras Franzoso, Joaquin (CIBER de Bioingeniería, Biomateriales y Nanomedicina (Bellaterra)) ;
Cubarsi, Rafael (Universitat Politècnica de Catalunya. Departament de Matemàtica Aplicada IV) ;
Pesarrodona Roches, Mireia (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Ferrer Miralles, Neus (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Vázquez, Esther (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
García Fruitós, Elena (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
The impact of cell factory quality control on material properties is a neglected but critical issue in the fabrication of protein biomaterials, which are unique in merging structure and function. The molecular chaperoning of protein conformational status is revealed here as a potent molecular instructor of the macroscopic properties of self-assembling, cell-targeted protein nanoparticles, including biodistribution upon in vivo administration.
2015 - 10.1002/adma.201503676
Advanced Materials,, Vol. 27 Núm. 47 (Desembre 2015) , p. 7816-7822
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5.
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2 p, 157.4 KB |
Draft genome sequence of Stenotrophomonas maltophilia strain UV74 reveals extensive variability within its genomic group
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Conchillo-Solé, Óscar (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Yero Corona, Daniel (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Coves, Xavier (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Huedo Moreno, Pol (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Martínez-Servat, Sònia (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Daura i Ribera, Xavier (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Gibert, Isidre (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
We report the draft genome sequence of Stenotrophomonas maltophilia UV74, isolated from a vascular ulcer. This draft genome sequence shall contribute to the understanding of the evolution and pathogenicity of this species, particularly regarding isolates of clinical origin.
2015 - 10.1128/genomeA.00611-15
Genome announcements, Vol. 3, No. 3 (May/June 2015) , p. e00611-615
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6.
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2 p, 137.1 KB |
Draft genome sequence of Stenotrophomonas maltophilia strain M30, isolated from a chronic pressure ulcer in an elderly patient
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Huedo Moreno, Pol (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Conchillo-Solé, Óscar (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Yero Corona, Daniel (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Martínez-Servat, Sònia (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Daura i Ribera, Xavier (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Gibert, Isidre (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Stenotrophomonas maltophilia is an emerging opportunistic pathogen with an increasing prevalence of multidrug-resistant strains. Here, we report the draft genome sequence of S. maltophilia strain M30, isolated from a pressure ulcer in an elderly patient.
2014 - 10.1128/genomeA.00576-14
Genome announcements, Vol. 2, Issue 3 (May/June 2014) , p. e00576-14
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7.
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10 p, 1.2 MB |
Redefining the PF06864 Pfam Family Based on Burkholderia pseudomallei PilO2Bp S-SAD Crystal Structure
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Lassaux, Patricia (Università di Milano. Department of Biosciences) ;
Conchillo-Solé, Óscar (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Manjasetty, Babu A. (Grenoble Outstation. European Molecular Biology Laboratory) ;
Yero Corona, Daniel (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Perletti, Lucia (Università di Milano. Department of Biosciences) ;
Belrhali, Hassan (Grenoble Outstation. European Molecular Biology Laboratory) ;
Daura i Ribera, Xavier (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Gourlay, Louise J. (Università di Milano. Department of Biosciences) ;
Bolognesi, Martino (Università di Milano. Department of Biosciences)
Type IV pili are surface-exposed filaments and bacterial virulence factors, represented by the Tfpa and Tfpb types, which assemble via specific machineries. The Tfpb group is further divided into seven variants, linked to heterogeneity in the assembly machineries. [...]
2014 - 10.1371/journal.pone.0094981
PLoS one, Vol. 9 Issue 4 (April 2014) , p. e94981
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8.
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30 p, 8.7 MB |
In vivo architectonic stability of fully de novo designed protein-only nanoparticles
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Céspedes, María Virtudes (Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina) ;
Unzueta Elorza, Ugutz (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Tatkiewicz, Witold (Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina) ;
Sánchez Chardi, Alejandro (Universitat Autònoma de Barcelona. Servei de Microscòpia) ;
Conchillo-Solé, Óscar (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Álamo, Patricia (Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina) ;
Xu, Zhikun (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Casanova, Isolda (Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina) ;
Corchero Nieto, José Luis (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Pesarrodona Roches, Mireia (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Cedano Rodríguez, Juan Antonio (Universidad de la República (Uruguai). Laboratorio de Inmunologia) ;
Daura i Ribera, Xavier (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Ratera Bastardas, Imma (Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina) ;
Veciana i Miró, Jaume (Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina) ;
Ferrer Miralles, Neus (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Vázquez Gómez, Esther (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Mangues, Ramón (Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina)
The fully de novo design of protein building blocks for self-assembling as functional nanoparticles is a challenging task in emerging nanomedicines, which urgently demand novel, versatile, and biologically safe vehicles for imaging, drug delivery, and gene therapy. [...]
2014 - 10.1021/nn4055732
ACS nano, Vol. 8, Num. 5 (May 2014) , p. 4166-4176
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9.
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17 p, 815.0 KB |
AGGRESCAN : a server for the prediction and evaluation of "hot spots" of aggregation in polypeptides
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Conchillo-Solé, Óscar (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Sánchez de Groot, Natalia (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ;
Avilés, Francesc X. (Francesc Xavier) (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Vendrell i Roca, Josep (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Daura i Ribera, Xavier (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Ventura i Zamora, Salvador (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Background: Protein aggregation correlates with the development of several debilitating human disorders of growing incidence, such as Alzheimer's and Parkinson's diseases. On the biotechnological side, protein production is often hampered by the accumulation of recombinant proteins into aggregates. [...]
2007 - 10.1186/1471-2105-8-65
BMC Bioinformatics, Vol. 8, N. 65 (February 2007) , p. 1-17
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