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19 p, 3.9 MB Increasing polarity in tacrine and huprine derivatives : Potent anticholinesterase agents for the treatment of myasthenia gravis / Galdeano, Carles (Universitat de Barcelona. Laboratori de Química Farmaceutica) ; Coquelle, Nicolas (Large-Scale Structures Group. Institut Laue-Langevin) ; Cieslikiewicz-Bouet, Monika (Laboratory COBRA (UMR 6014). Normandie Université. UNIROUEN. Institut National des Sciences Appliquées (INSA) Rouen. CNRS) ; Bartolini, Manuela (Department of Pharmacy and Biotechnology. Alma Mater Studiorum University of Bologna) ; Pérez, Belen (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Clos, Victòria (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Silman, Israel (Department of Neurobiology. Weizmann Institute of Science) ; Jean, Ludovic (Laboratory COBRA (UMR 6014). Normandie Université. UNIROUEN. Institut National des Sciences Appliquées (INSA) Rouen. CNRS) ; Colletier, Jacques Phillippe (Institut de Biologie Structurale. Université Grenoble Alpes. Centre National de la Recherche Scientifique (CNRS). Commissariat à l'Énergie Atomique (CEA) (UMR 5075)) ; Renard, Pierre Yves (Laboratory COBRA (UMR 6014). Normandie Université. UNIROUEN. Institut National des Sciences Appliquées (INSA) Rouen. CNRS) ; Muñoz Torrero, Diego (Universitat de Barcelona. Laboratori de Química Farmaceutica)
Symptomatic treatment of myasthenia gravis is based on the use of peripherally-acting acetylcholinesterase (AChE) inhibitors that, in some cases, must be discontinued due to the occurrence of a number of side-effects. [...]
2018 - 10.3390/molecules23030634
Molecules, Vol. 23 Núm. 3 (2018) , p. 634  

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