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1 p, 682.3 KB |
Erratum to : Detoxifying Escherichia coli for endotoxin-free production of recombinant proteins
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Mamat, Uwe (Leibniz-Center for Medicine and Biosciences. Division of Structural Biochemistry) ;
Wilke, Kathleen (Leibniz-Center for Medicine and Biosciences. Division of Structural Biochemistry) ;
Bramhill, David (Bramhill Biological Consulting. East Moonstone Drive) ;
Schromm, Andra Beate (Leibniz-Center for Medicine and Biosciences. Division of Structural Biochemistry) ;
Lindner, Buko (Leibniz-Center for Medicine and Biosciences. Division of Structural Biochemistry) ;
Kohl, Thomas Andreas (Leibniz-Center for Medicine and Biosciences. Division of Structural Biochemistry) ;
Corchero, José Luis (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Villaverde Corrales, Antonio (CIBER de Bioingeniería, Biomateriales y Nanomedicina (Barcelona)) ;
Schaffer, Lana (The Scripps Research Institute. NGS and Microarray Core Facility) ;
Head, Steven Robert (The Scripps Research Institute. NGS and Microarray Core Facility) ;
Souvignier, Chad (Research Corporation Technologies (Tucson)) ;
Meredith, Timothy Charles (Pennsylvania State University. Department of Biochemistry and Molecular Biology) ;
Woodard, Ronald Wesley (University of Michigan. Department of Medicinal Chemistry)
2015 -  10.1186/s12934-015-0265-x
Microbial cell factories, Vol. 14, Issue 57 (2015)
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12 p, 5.7 MB |
Intracellular CXCR4 + cell targeting with T22-empowered protein-only nanoparticles
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Unzueta Elorza, Ugutz (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Céspedes, María Virtudes (CIBER de Bioingeniería, Biomateriales y Nanomedicina (Barcelona)) ;
Ferrer Miralles, Neus (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Casanova, Isolda (CIBER de Bioingeniería, Biomateriales y Nanomedicina (Barcelona)) ;
Cedano, Juan (Laboratory of Immunology, Regional Norte, Universidad de la Republica, Salto, Uruguay) ;
Corchero, José Luis (CIBER en Bioingeniería, Biomateriales y Nanomedicina, Bellaterra, Barcelona) ;
Domingo-Espín, Joan (CIBER en Bioingeniería, Biomateriales y Nanomedicina, Bellaterra, Barcelona) ;
Villaverde, Antonio (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Mangues, Ramón (CIBER en Bioingeniería, Biomateriales y Nanomedicina, Bellaterra, Barcelona) ;
Vázquez Gómez, Esther (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Universitat Autònoma de Barcelona.
Departament de Genètica i de Microbiologia
Cell-targeting peptides or proteins are appealing tools in nanomedicine and innovative medicines because they increase the local drug concentration and reduce potential side effects. CXC chemokine receptor 4 (CXCR4) is a cell surface marker associated with several severe human pathologies, including colorectal cancer, for which intracellular targeting agents are currently missing. [...]
2012 - 10.2147/IJN.S34450
International Journal of Nanomedicine, Vol. 7 (august 2012) , p. 4533-4544
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5 p, 470.7 KB |
Packaging protein drugs as bacterial inclusion bodies for therapeutic applications
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Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
García Fruitós, Elena (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Rinas, Ursula (Helmholtz-Zentrum für Infektionsforschung) ;
Seras Franzoso, Joaquin (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Kosoy, Ana (Janus Development SL) ;
Corchero Nieto, José Luis (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Vázquez Gómez, Esther (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Institut de Biotecnologia i de Biomedicina
A growing number of insights on the biology of bacterial inclusion bodies (IBs) have revealed intriguing utilities of these protein particles. Since they combine mechanical stability and protein functionality, IBs have been already exploited in biocatalysis and explored for bottom-up topographical modification in tissue engineering. [...]
2012 - 10.1186/1475-2859-11-76
Microbial cell factories, Vol. 11 (June 2012) , art. 76
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5 p, 243.9 KB |
Biological activities of histidine-rich peptides; merging biotechnology and nanomedicine
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Ferrer Miralles, Neus (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Corchero Nieto, José Luis (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Kumar, Pradeep (CSIR-Institute of Genomics and Integrative Biology) ;
Cedano Rodríguez, Juan Antonio (Universidad de la República (Uruguay).) ;
Gupta, Kailash C (CSIR-Indian Institute of Toxicology Research) ;
Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Vázquez Gómez, Esther (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Histidine-rich peptides are commonly used in recombinant protein production as purification tags, allowing the one-step affinity separation of the His-tagged proteins from the extracellular media or cell extracts. [...]
2011 - 10.1186/1475-2859-10-101
Microbial cell factories, Vol. 10 (2011) , art. 101
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10 p, 1.7 MB |
Bacterial mimetics of endocrine secretory granules as immobilized in vivo depots for functional protein drugs
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Céspedes, María Virtudes (Institut d'Investigacions Biomèdiques Sant Pau) ;
Fernández, Yolanda (CIBER de Bioingeniería, Biomateriales y Nanomedicina (Barcelona)) ;
Unzueta Elorza, Ugutz (Institut d'Investigacions Biomèdiques Sant Pau) ;
Mendoza, Rosa (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Seras Franzoso, Joaquin (CIBER de Bioingeniería, Biomateriales y Nanomedicina (Barcelona)) ;
Sánchez Chardi, Alejandro (Universitat Autònoma de Barcelona. Servei de Microscòpia) ;
Álamo, Patricia (Institut d'Investigacions Biomèdiques Sant Pau) ;
Toledo-Rubio, Verónica (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Ferrer Miralles, Neus (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Vázquez Gómez, Esther (Institut d'Investigacions Biomèdiques Sant Pau) ;
Schwartz Jr, Simó (CIBER de Bioingeniería, Biomateriales y Nanomedicina (Barcelona)) ;
Abasolo, Ibane (CIBER de Bioingeniería, Biomateriales y Nanomedicina (Barcelona)) ;
Corchero Nieto, José Luis (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Mangues, Ramon (Institut d'Investigacions Biomèdiques Sant Pau) ;
Villaverde Corrales, Antonio, (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
In the human endocrine system many protein hormones including urotensin, glucagon, obestatin, bombesin and secretin, among others, are supplied from amyloidal secretory granules. These granules form part of the so called functional amyloids, which within the whole aggregome appear to be more abundant than formerly believed. [...]
2016 - 10.1038/srep35765
Scientific Reports, Vol. 6 Núm. 35765 (October 2016) , p. 1-10
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47 p, 816.8 KB |
Highly versatile polyelectrolyte complexes for improving the enzyme replacement therapy of lysosomal storage disorders.
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Giannotti, MI (Universitat de Barcelona. Departament de Química física) ;
Abasolo, Ibane (Universitat Autònoma de Barcelona. Vall d'Hebron Institut de Recerca) ;
Oliva, Mireia (Universitat de Barcelona. Departament de Farmàcia i Tecnologia Farmacèutica, i Fisicoquímica) ;
Andrade, Fernanda (Universitat de Barcelona. Departament de Farmàcia i Tecnologia Farmacèutica, i Fisicoquímica) ;
García-Aranda, Natalia (Universitat Autònoma de Barcelona. Vall d'Hebron Institut de Recerca) ;
Melgarejo, Marta (Combinatorial Chemistry Unit, Barcelona Science Park (Baldiri Reixac)) ;
Pulido, Daniel (Combinatorial Chemistry Unit, Barcelona Science Park (Baldiri Reixac)) ;
Corchero Nieto, José Luis (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Fernández, Yolanda (Universitat Autònoma de Barcelona. Vall d'Hebron Institut de Recerca) ;
Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Royo, Miriam (Combinatorial Chemistry Unit, Barcelona Science Park (Baldiri Reixac)) ;
Garcia-Parajo, Maria F. (Institut de Ciencies Fotoniques, The Barcelona Institute of Science and Technology) ;
Sanz, Fausto (Combinatorial Chemistry Unit, Barcelona Science Park (Baldiri Reixac)) ;
Simó Schwartz Jr (Universitat Autònoma de Barcelona. Vall d'Hebron Institut de Recerca)
Lysosomal storage disorders are currently treated by enzyme replacement therapy (ERT) through the direct administration of the unprotected recombinant protein to the patients. Herein we present an ionically crosslinked polyelectrolyte complex (PEC) composed of trimethyl chitosan (TMC) and -galactosidase A (GLA), the defective enzyme in Fabry disease, with the capability of directly targeting endothelial cells by incorporating peptide ligands containing the RGD sequence. [...]
2016 - 10.1021/acsami.6b08356
ACS applied materials & interfaces, Vol. 8 Núm 39 (Octubre 2016) , p. 25741-25752
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56 p, 354.6 KB |
Engineering protein self-assembling in protein-based nanomedicines for drug delivery and gene therapy
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Ferrer Miralles, Neus (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Rodríguez-Carmona, Escarlata (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Corchero Nieto, José Luis (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
García Fruitós, Elena (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Vázquez, Esther (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Lack of targeting and improper biodistribution are major flaws in current drug-based therapies that prevent reaching high local concentrations of the therapeutic agent. Such weaknesses impose the administration of high drug doses, resulting in undesired side effects, limited efficacy and enhanced production costs. [...]
2015 - 10.3109/07388551.2013.833163
Critical reviews in biotechnology, Vol. 35 (2015)
6 documents
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20 p, 248.7 KB |
A novel bio-functional material based on mammalian cell aggresomes
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Rodríguez-Carmona, Escarlata (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Mendoza, Rosa (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Ruiz Cánovas, Eugènia (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Ferrer Miralles, Neus (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Abasolo, Ibane (CIBER de Bioingeniería, Biomateriales y Nanomedicina (Barcelona)) ;
Schwartz Jr, Simó (CIBER de Bioingeniería, Biomateriales y Nanomedicina (Barcelona)) ;
Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Corchero Nieto, José Luis (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Aggresomes are protein aggregates found in mammalian cells when the intracellular protein degradation machinery is over-titered. Despite that they abound in cells producing recombinant proteins of biomedical and biotechnological interest, the physiological roles of these protein clusters and the functional status of the embedded proteins remain basically unexplored. [...]
2015 - 10.1007/s00253-015-6684-0
Applied microbiology and biotechnology, Vol. 99 Issue 17, p. 7079–7088 (Setembre 2015)
8 documents
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