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Results overview: Found 11 records in 0.02 seconds.
Articles, 10 records found
Research literature, 1 records found
Articles 10 records found  
1.
16 p, 1.9 MB Cross-sectional evaluation of circulating hepatitis B virus RNA and DNA : Different quasispecies? / García-García, Selene (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Cortese, Maria Francesca (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Tabernero, David (Instituto de Salud Carlos II) ; Gregori i Font, Josep (Instituto de Salud Carlos II) ; Vila, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Pacín Ruiz, Beatriz (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Quer, Josep 1963- (Instituto de Salud Carlos II) ; Casillas, Rosario (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Castillo-Ribelles, Laura (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Ferrer-Costa, Roser (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Rando-Segura, Ariadna (Hospital Universitari Vall d'Hebron) ; Trejo-Zahínos, Jesús (Hospital Universitari Vall d'Hebron) ; Pumarola Suñé, Tomàs (Hospital Universitari Vall d'Hebron) ; Casis-Saez, Ernesto (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Esteban, Rafael (Instituto de Salud Carlos II) ; Riveiro Barciela, Mar (Instituto de Salud Carlos II) ; Buti, Maria (Instituto de Salud Carlos II) ; Rodríguez Frías, Francisco (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Universitat Autònoma de Barcelona
Different forms of pregenomic and other hepatitis B virus (HBV) RNA have been detected in patients' sera. These circulating HBV-RNAs may be useful for monitoring covalently closed circular DNA activity, and predicting hepatitis B e-antigen seroconversion or viral rebound after nucleos(t)ide analog cessation. [...]
2021 - 10.3748/wjg.v27.i41.7144
World Journal of Gastroenterology, Vol. 27 (november 2021) , p. 7144-7158  
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2.
17 p, 2.4 MB Quasispecies Fitness Partition to Characterize the Molecular Status of a Viral Population. Negative Effect of Early Ribavirin Discontinuation in a Chronically Infected HEV Patient / Gregori i Font, Josep (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Colomer-Castell, Sergi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Campos, Carolina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Ibañez-Lligoña, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Garcia-Cehic, D. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Rando-Segura, Ariadna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Adombie, Caroline Melanie (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Pintó, Rosa (Universitat de Barcelona) ; Guix, Susana (Universitat de Barcelona) ; Bosch, Albert (Universitat de Barcelona) ; Domingo, Esteban (Instituto de Salud Carlos III) ; Gallego, Isabel (Centro de Biología Molecular Severo Ochoa) ; Perales Viejo, Celia (Universidad Autónoma de Madrid) ; Cortese, Maria Francesca (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Tabernero, David (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Buti, Maria (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Riveiro Barciela, Mar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Esteban Mur, Juan Ignacio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Rodríguez Frías, Francisco (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Quer, Josep 1963- (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Universitat Autònoma de Barcelona
The changes occurring in viral quasispecies populations during infection have been monitored using diversity indices, nucleotide diversity, and several other indices to summarize the quasispecies structure in a single value. [...]
2022 - 10.3390/ijms232314654
International journal of molecular sciences, Vol. 23 (november 2022)  
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3.
18 p, 1.0 MB Hepatitis B Virus Variants with Multiple Insertions and/or Deletions in the X Open Reading Frame 3' End : Common Members of Viral Quasispecies in Chronic Hepatitis B Patients / García-García, Selene (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Caballero, Andrea (Hospital Universitari Vall d'Hebron) ; Tabernero, David (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ; Cortese, Maria Francesca (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ; Gregori i Font, Josep (Hospital Universitari Vall d'Hebron) ; Rodriguez-Algarra, Francisco (Queen Mary University of London) ; Quer, Josep 1963- (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Riveiro Barciela, Mar (Hospital Universitari Vall d'Hebron) ; Homs, Maria (Institut Català de la Salut) ; Rando-Segura, Ariadna (Hospital Universitari Vall d'Hebron) ; Pacín Ruiz, Beatriz (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Vila, Marta (Hospital Universitari Vall d'Hebron) ; Ferrer-Costa, Roser (Hospital Universitari Vall d'Hebron) ; Pumarola Suñé, Tomàs (Hospital Universitari Vall d'Hebron) ; Buti, Maria (Hospital Universitari Vall d'Hebron) ; Rodríguez Frías, Francisco (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Deletions in the 3' end region of the hepatitis B virus (HBV) X open reading frame (HBX) may affect the core promoter (Cp) and have been frequently associated with hepatocellular carcinoma (HCC). The aim of this study was to investigate the presence of variants with deletions and/or insertions (Indels) in this region in the quasispecies of 50 chronic hepatitis B (CHB) patients without HCC. [...]
2022 - 10.3390/biomedicines10051194
Biomedicines, Vol. 10, Issue 5 (May 2022) , art. 1194  
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4.
23 p, 2.1 MB Next-Generation Sequencing for Confronting Virus Pandemics / Quer, Josep 1963- (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Colomer-Castell, Sergi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Campos, Carolina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Andrés, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Piñana, Maria (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Cortese, Maria Francesca (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; González-Sánchez, Alejandra (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Garcia-Cehic, D. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Ibáñez, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Pumarola Suñé, Tomàs (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Rodríguez Frías, Francisco (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Antón, Andrés (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Tabernero, David (Hospital Universitari Vall d'Hebron)
Virus pandemics have happened, are happening and will happen again. In recent decades, the rate of zoonotic viral spillover into humans has accelerated, mirroring the expansion of our global footprint and travel network, including the expansion of viral vectors and the destruction of natural spaces, bringing humans closer to wild animals. [...]
2022 - 10.3390/v14030600
Viruses, Vol. 14 (march 2022)  
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5.
13 p, 1.5 MB Inspecting the Ribozyme Region of Hepatitis Delta Virus Genotype 1 : Conservation and Variability / Pacín Ruiz, Beatriz (Hospital Universitari Vall d'Hebron) ; Cortese, Maria Francesca (Hospital Universitari Vall d'Hebron) ; Tabernero, David (Hospital Universitari Vall d'Hebron) ; Sopena, Sara (Hospital Universitari Vall d'Hebron) ; Gregori i Font, Josep (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; García-García, Selene (Hospital Universitari Vall d'Hebron) ; Casillas, Rosario (Hospital Universitari Vall d'Hebron) ; Najarro-Centeno, Adrián (Hospital Universitari Vall d'Hebron) ; Aldama, Unai (Hospital Universitari Vall d'Hebron) ; Palom, Adriana (Hospital Universitari Vall d'Hebron) ; Rando-Segura, Ariadna (Hospital Universitari Vall d'Hebron) ; Galán, Anna (Hospital Universitari Vall d'Hebron) ; Vila, Marta (Hospital Universitari Vall d'Hebron) ; Riveiro Barciela, Mar (Hospital Universitari Vall d'Hebron) ; Quer, Josep 1963- (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; González-Aseguinolaza, Gloria (Univerdad de Pamplona) ; Buti, Maria (Hospital Universitari Vall d'Hebron) ; Rodríguez Frías, Francisco (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
The hepatitis delta virus (HDV) genome has an autocatalytic region called the ribozyme, which is essential for viral replication. The aim of this study was to use next-generation sequencing (NGS) to analyze the ribozyme quasispecies (QS) in order to study its evolution and identify highly conserved regions potentially suitable for a gene-silencing strategy. [...]
2022 - 10.3390/v14020215
Viruses, Vol. 14 (january 2022)  
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6.
11 p, 1.1 MB Sophisticated viral quasispecies with a genotype-related pattern of mutations in the hepatitis B X gene of HBeAg-ve chronically infected patients / Cortese, Maria Francesca (Hospital Universitari Vall d'Hebron) ; González, Carolina (Hospital Universitari Vall d'Hebron) ; Gregori i Font, Josep (Roche Diagnostics (Sant Cugat)) ; Casillas, Rosario (Hospital Universitari Vall d'Hebron) ; Carioti, Luca (University of Rome Tor Vergata) ; Guerrero Murillo, Mercedes (Hospital Universitari Vall d'Hebron) ; Riveiro Barciela, Mar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Godoy, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Sopena, Sara (Hospital Universitari Vall d'Hebron) ; Yll, Marçal (Hospital Universitari Vall d'Hebron) ; Quer, Josep 1963- (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Rando-Segura, Ariadna (Hospital Universitari Vall d'Hebron) ; Lopez-Martinez, Rosa (Hospital Universitari Vall d'Hebron) ; Pacín Ruiz, Beatriz (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; García-García, Selene (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Esteban, Rafael (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Tabernero, David (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ; Buti, Maria (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Rodríguez Frías, Francisco (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Universitat Autònoma de Barcelona
Patients with HBeAg-negative chronic infection (CI) have not been extensively studied because of low viremia. The HBx protein, encoded by HBX, has a key role in viral replication. Here, we analyzed the viral quasispecies at the 5' end of HBX in CI patients and compared it with that of patients in other clinical stages. [...]
2021 - 10.1038/s41598-021-83762-4
Scientific reports, Vol. 11 (february 2021)  
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7.
16 p, 3.5 MB Conservation and variability of hepatitis B core at different chronic hepatitis stages / Yll, Marçal (Hospital Universitari Vall d'Hebron) ; Cortese, Maria Francesca (Hospital Universitari Vall d'Hebron) ; Guerrero Murillo, Mercedes (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Orriols, Gerard (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Gregori i Font, Josep (Hospital Universitari Vall d'Hebron) ; Casillas, Rosario (Hospital Universitari Vall d'Hebron) ; González, Carolina (Hospital Universitari Vall d'Hebron) ; Sopena, Sara (Hospital Universitari Vall d'Hebron) ; Godoy, Cristina (Hospital Universitari Vall d'Hebron) ; Vila, Marta (Hospital Universitari Vall d'Hebron) ; Tabernero, David (Hospital Universitari Vall d'Hebron) ; Quer, Josep 1963- (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Rando-Segura, Ariadna (Hospital Universitari Vall d'Hebron) ; Lopez Martinez, Rosa (Hospital Universitari Vall d'Hebron) ; Esteban, Rafael (Esteban Mur) (Hospital Universitari Vall d'Hebron) ; Riveiro Barciela, Mar (Hospital Universitari Vall d'Hebron) ; Buti, Maria (Hospital Universitari Vall d'Hebron) ; Rodríguez Frías, Francisco (Hospital Universitari Vall d'Hebron) ; Universitat Autònoma de Barcelona
Since it is currently not possible to eradicate hepatitis B virus (HBV) infection with existing treatments, research continues to uncover new therapeutic strategies. HBV core protein, encoded by the HBV core gene (HBC), intervenes in both structural and functional processes, and is a key protein in the HBV life cycle. [...]
2020 - 10.3748/wjg.v26.i20.2584
World Journal of Gastroenterology, Vol. 26 (may 2020) , p. 2584-2598  
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8.
18 p, 2.2 MB Characterization of hepatitis B virus X gene quasispecies complexity in mono-infection and hepatitis delta virus superinfection / Godoy, Cristina (Hospital Universitari Vall d'Hebron) ; Tabernero, David (Hospital Universitari Vall d'Hebron) ; Sopena, Sara (Hospital Universitari Vall d'Hebron) ; Gregori i Font, Josep (Roche Diagnostics SL) ; Cortese, Maria Francesca (Hospital Universitari Vall d'Hebron) ; González, Carolina (Hospital Universitari Vall d'Hebron) ; Casillas, Rosario (Hospital Universitari Vall d'Hebron) ; Yll, Marçal (Hospital Universitari Vall d'Hebron) ; Rando-Segura, Ariadna (Hospital Universitari Vall d'Hebron) ; Lopez Martinez, Rosa (Hospital Universitari Vall d'Hebron) ; Quer, Josep 1963- (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ; González-Aseguinolaza, Gloria (Clínica Universidad de Navarra. Centro de Investigación Médica Aplicada) ; Esteban, Rafael (Esteban Mur) (Hospital Universitari Vall d'Hebron) ; Riveiro Barciela, Mar (Hospital Universitari Vall d'Hebron) ; Buti, Maria (Hospital Universitari Vall d'Hebron) ; Rodríguez Frías, Francisco (Hospital Universitari Vall d'Hebron) ; Universitat Autònoma de Barcelona
BACKGROUND Hepatitis delta virus (HDV) seems to strongly suppress hepatitis B virus (HBV) replication, although little is known about the mechanism of this interaction. Both these viruses show a dynamic distribution of mutants, resulting in viral quasispecies. [...]
2019 - 10.3748/wjg.v25.i13.1566
World Journal of Gastroenterology, Vol. 25 (april 2019) , p. 1566-1579  
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9.
14 p, 1.3 MB Detection of hyper-conserved regions in hepatitis B virus X gene potentially useful for gene therapy / González, Carolina (Hospital Universitari Vall d'Hebron) ; Tabernero, David (Hospital Universitari Vall d'Hebron) ; Cortese, Maria Francesca (Hospital Universitari Vall d'Hebron) ; Gregori i Font, Josep (Roche Diagnostics SL) ; Casillas, Rosario (Hospital Universitari Vall d'Hebron) ; Riveiro Barciela, Mar (Universitat Autònoma de Barcelona. Departament de Medicina) ; Godoy, Cristina (Hospital Universitari Vall d'Hebron) ; Sopena, Sara (Hospital Universitari Vall d'Hebron) ; Rando-Segura, Ariadna (Hospital Universitari Vall d'Hebron) ; Yll, Marçal (Hospital Universitari Vall d'Hebron) ; Lopez Martinez, Rosa (Hospital Universitari Vall d'Hebron) ; Quer, Josep 1963- (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Esteban, Rafael (Esteban Mur) (Universitat Autònoma de Barcelona. Departament de Medicina) ; Buti, Maria (Universitat Autònoma de Barcelona. Departament de Medicina) ; Rodríguez Frías, Francisco (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
To detect hyper-conserved regions in the hepatitis B virus (HBV) X gene (HBX) 5' region that could be candidates for gene therapy. The study included 27 chronic hepatitis B treatment-naive patients in various clinical stages (from chronic infection to cirrhosis and hepatocellular carcinoma, both HBeAg-negative and HBeAg-positive), and infected with HBV genotypes A-F and H. [...]
2018 - 10.3748/wjg.v24.i19.2095
World Journal of Gastroenterology, Vol. 24 (may 2018) , p. 2095-2107  
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10.
14 p, 1.3 MB Analysis of hepatitis B virus preS1 variability and prevalence of the rs2296651 polymorphism in a Spanish population / Casillas, Rosario (Hospital Universitari Vall d'Hebron) ; Tabernero, David (Hospital Universitari Vall d'Hebron) ; Gregori i Font, Josep (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Belmonte, Irene (Hospital Universitari Vall d'Hebron) ; Cortese, Maria Francesca (Hospital Universitari Vall d'Hebron) ; González, Carolina (Hospital Universitari Vall d'Hebron) ; Riveiro Barciela, Mar ; López, Rosa Maria (Hospital Universitari Vall d'Hebron) ; Quer, Josep 1963- (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Esteban, Rafael (Esteban Mur) ; Buti, Maria ; Rodríguez Frías, Francisco (Hospital Universitari Vall d'Hebron) ; Universitat Autònoma de Barcelona
To determine the variability/conservation of the domain of hepatitis B virus (HBV) preS1 region that interacts with sodium-taurocholate cotransporting polypeptide (hereafter, NTCP-interacting domain) and the prevalence of the rs2296651 polymorphism (S267F, NTCP variant) in a Spanish population. [...]
2018 - 10.3748/wjg.v24.i6.680
World Journal of Gastroenterology, Vol. 24 (february 2018) , p. 680-692  
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Research literature 1 records found  
1.
169 p, 5.4 MB Estudio de la quasiespecies del virus de la hepatitis B a través de secuenciación masiva para la identificación de dianas terapéuticas y factores pronósticos / Yll, Marçal ; Rodríguez Frías, Francisco, dir. ; Buti, Maria, dir. ; Cortese, Maria Francesca, dir.
Tot i tenir una vacuna preventiva eficaç, el virus de l'hepatitis B (VHB) és un greu problema de salut mundial degut a la seva elevada prevalença (afecta a més de 250 milions de persones a tot el món) i a la morbiditat que deriva de la seva cronicitat, ja que és el primer factor virològic de risc en el desenvolupament de carcinoma hepatocel·lular (HCC). [...]
A pesar de tener una vacuna preventiva eficaz, el virus de la hepatitis B (VHB) es un grave problema de salud mundial debido a su elevada prevalencia (afecta a más de 250 millones de personas en todo el mundo) y a la morbilidad que deriva de su cronicidad, pues es el primer factor virológico de riesgo en el desarrollo de carcinoma hepatocelular (HCC). [...]
Despite having an effective preventive vaccine, the hepatitis B virus (HBV) is a serious global health problem due to its high prevalence (it affects more than 250 million people worldwide) and the morbidity derived from its chronicity, as it is the first virological risk factor in the development of hepatocellular carcinoma (HCC). [...]
2020  
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See also: similar author names
2 Cortese, M.
1 Cortese, M.F.
1 Cortese, Maria Francesca,
10 Cortese, María Francesca
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