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29 p, 18.3 MB |
The histone chaperone ANP32B regulates chromatin incorporation of the atypical human histone variant macroH2A
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Mandemaker, Imke K. (Hubrecht Institute) ;
Fessler, Evelyn (Gene Center and Department of Biochemistry. LMU Munich) ;
Corujo, David (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Kotthoff, Christiane (Biomedical Center (BMC). Department of Physiological Chemistry. Faculty of Medicine. LMU Munich) ;
Wegerer, Andreas (Biomedical Center (BMC). Department of Physiological Chemistry. Faculty of Medicine. LMU Munich) ;
Rouillon, Clément (Hubrecht Institute) ;
Buschbeck, Marcus (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Jae, Lucas T. (Gene Center and Department of Biochemistry. LMU Munich) ;
Mattiroli, Francesca (Hubrecht Institute) ;
Ladurner, A.G. (Eisbach Bio GmbH)
All vertebrate genomes encode for three large histone H2A variants that have an additional metabolite-binding globular macrodomain module, macroH2A. MacroH2A variants impact heterochromatin organization and transcription regulation and establish a barrier for cellular reprogramming. [...]
2023 -  10.1016/j.celrep.2023.113300
Cell reports, Vol. 42 Núm. 10 (31 2023) , p. 113300
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2.
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3.
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14 p, 4.6 MB |
Disruption of paternal circadian rhythm affects metabolic health in male offspring via nongerm cell factors
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Lassi, Maximilian (German Center for Diabetes Research (DZD)) ;
Tomar, Archana (German Center for Diabetes Research (DZD)) ;
Comas-Armangué, Gemma (German Center for Diabetes Research (DZD)) ;
Vogtmann, Rebekka (University Hospital Essen. Department of Gynecology and Obstetrics) ;
Dijkstra, Dorieke J. (University of Groningen. Department of Obstetrics and Gynecology) ;
Corujo, David (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Gerlini, Raffaelle (German Mouse Clinic. Institute of Experimental Genetics. Helmholtz Zentrum München. German Research Center for Environmental Health) ;
Darr, Jonatan (German Center for Diabetes Research (DZD)) ;
Scheid, Fabienne (German Center for Diabetes Research (DZD)) ;
Rozman, Jan (Czech Centre for Phenogenomics. Institute of Molecular Genetics of the Czech Academy of Sciences. BIOCEV) ;
Aguilar-Pimentel, Antonio (German Mouse Clinic. Institute of Experimental Genetics. Helmholtz Zentrum München. German Research Center for Environmental Health) ;
Koren, Omry (Azrieli Faculty of Medicine. Bar Ilan University) ;
Buschbeck, Marcus (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Fuchs, Helmut (German Mouse Clinic. Institute of Experimental Genetics. Helmholtz Zentrum München. German Research Center for Environmental Health) ;
Marschall, Susan (German Mouse Clinic. Institute of Experimental Genetics. Helmholtz Zentrum München. German Research Center for Environmental Health) ;
Gailus-Durner, Valerie (German Mouse Clinic. Institute of Experimental Genetics. Helmholtz Zentrum München. German Research Center for Environmental Health) ;
De Angelis, Martin Hrabe (Technische Universität München. School of Life Science Weihenstephan) ;
Plösch, Torsten (University of Groningen. Department of Obstetrics and Gynecology) ;
Gellhaus, Alexandra (Department of Gynecology and Obstetrics. University Hospital Essen) ;
Teperino, Raffaele (German Center for Diabetes Research (DZD))
Circadian rhythm synchronizes each body function with the environment and regulates physiology. Disruption of normal circadian rhythm alters organismal physiology and increases disease risk. Recent epidemiological data and studies in model organisms have shown that maternal circadian disruption is important for offspring health and adult phenotypes. [...]
2021 - 10.1126/sciadv.abg6424
Science advances, Vol. 7 Núm. 22 (may 2021) , p. eabg6424
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21 p, 4.0 MB |
MacroH2As regulate enhancer-promoter contacts affecting enhancer activity and sensitivity to inflammatory cytokines
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Corujo, David (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Malinverni, Roberto (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Carrillo-Reixach, Juan (Institut Germans Trias i Pujol) ;
Meers, Oliver (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Garcia-Jaraquemada, Arce (Institut Germans Trias i Pujol) ;
Le Pannérer, Marguerite Marie (Universitat Pompeu Fabra) ;
Valero, Vanesa (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Pérez, Ainoha (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Del Río-Álvarez, Álvaro (Institut Germans Trias i Pujol) ;
Royo, Laura (Institut Germans Trias i Pujol) ;
Pérez-González, Beatriz (Universitat Pompeu Fabra. Departament de Medicina i Ciències de la Vida) ;
Raurell Vila, Helena (Universitat Pompeu Fabra. Departament de Medicina i Ciències de la Vida) ;
Acemel, Rafael D. (Universidad Pablo de Olavide) ;
Santos-Pereira, José M. (Universidad Pablo de Olavide) ;
Garrido-Pontnou, Marta (Hospital Universitari Vall d'Hebron) ;
Gómez-Skarmeta, José Luís (Centro Andaluz de Biología del Desarrollo (CABD). CSIC-Universidad Pablo de Olavide) ;
Pasquali, Lorenzo (Universitat Pompeu Fabra. Departament de Medicina i Ciències de la Vida) ;
Manyé, Josep (Institut Germans Trias i Pujol) ;
Armengol, Carolina (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ;
Buschbeck, Marcus (Institut Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
MacroH2A histone variants have a function in gene regulation that is poorly understood at the molecular level. We report that macroH2A1. 2 and macroH2A2 modulate the transcriptional ground state of cancer cells and how they respond to inflammatory cytokines. [...]
2022 - 10.1016/j.celrep.2022.110988
Cell reports, Vol. 39 Núm. 12 (6 2022) , p. 110988
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25 p, 6.2 MB |
Poly(Adp-ribose) binding and macroh2a mediate recruitment and functions of kdm5a at dna lesions
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Kumbhar, Ramhari (University of Texas at Austin) ;
Sanchez, Anthony (University of Texas at Austin) ;
Perren, Jullian (University of Texas at Austin) ;
Gong, Fade (Baylor College of Medicine) ;
Corujo, David (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Medina, Frank (University of Texas at Austin) ;
Devanathan, Sravan K. (University of Texas at Austin) ;
Xhemalce, Blerta (University of Texas at Austin) ;
Matouschek, Andreas (University of Texas at Austin) ;
Buschbeck, Marcus (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Buck-Koehntop, Bethany A. (University of Utah) ;
Miller, Kyle M. (University of Texas at Austin) ;
Universitat Autònoma de Barcelona
The histone demethylase KDM5A erases histone H3 lysine 4 methylation, which is involved in transcription and DNA damage responses (DDRs). While DDR functions of KDM5A have been identified, how KDM5A recognizes DNA lesion sites within chromatin is unknown. [...]
2021 - 10.1083/jcb.202006149
The journal of cell biology, Vol. 220 Núm. 7 (2021) , p. e202006149
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17 p, 1.9 MB |
The Histone Variant MacroH2A1 Regulates Key Genes for Myogenic Cell Fusion in a Splice-Isoform Dependent Manner
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Hurtado-Bagès, Sarah (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Posavec Marjanovic, Melanija (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ;
Valero, Vanesa (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Malinverni, Roberto (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Corujo, David (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Bouvet, Philippe (Centre National de la Recherche Scientifique (França)) ;
Lavigne, A. C. (Center for Integrative Biology (CBI). LBME. University of Toulouse. UPS. CNRS) ;
Bystricky, K. (Center for Integrative Biology (CBI). LBME. University of Toulouse. UPS. CNRS) ;
Buschbeck, Marcus (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Universitat Autònoma de Barcelona
MacroH2A histone variants have functions in differentiation, somatic cell reprogramming and cancer. However, at present, it is not clear how macroH2As affect gene regulation to exert these functions. [...]
2020 - 10.3390/cells9051109
Cells, Vol. 9 Núm. 5 (30 2020)
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7.
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1.9 MB |
MacroH2A1.1 regulates mitochondrial respiration by limiting nuclear NAD + consumption
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Posavec Marjanović, Melanija (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ;
Hurtado-Bagès, Sarah (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Lassi, Maximilian (German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany) ;
Valero, Vanesa (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Malinverni, Roberto (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Delage, Hélène (Centre National de la Recherche Scientifique (França)) ;
Navarro, Miriam (Universitat Rovira i Virgili) ;
Corujo, David (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Guberovic, Iva (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Douet, Julien (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Gama-Pérez, Pau (Universitat de Barcelona. Departament de Ciències Fisiològiques II) ;
Garcia-Roves, Pablo M. (Universitat de Barcelona. Departament de Ciències Fisiològiques II) ;
Ahel, Ivan (Sir William Dunn School of Pathology, University of Oxford, Oxford, UK) ;
Ladurner, Andreas G. (Biomedical Center Munich (BMC) - Physiological Chemistry, Center for Integrated Protein Science Munich, Munich Cluster for Systems Neurology, Faculty of Medicine, LMU Munich, Planegg-Martinsried, Germany) ;
Yanes, Oscar (Universitat Rovira i Virgili) ;
Bouvet, Philippe (Université de Lyon, Ecole Normale Supérieure de Lyon) ;
Suelves Esteban, Mònica (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ;
Teperino, Raffaele (Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany) ;
Pospisilik, J. Andrew (Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany) ;
Buschbeck, Marcus (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Histone variants are structural components of eukaryotic chromatin that can replace replication-coupled histones in the nucleosome. The histone variant macroH2A. 1. 1 contains a macrodomain able to bind NAD + derived metabolites. [...]
2017 - 10.1038/nsmb.3481
Nature structural & molecular biology, Vol. 24 (october 2017) , p. 902-910
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