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13 p, 4.6 MB A novel inhibitor of fatty acid synthase shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines / Puig, Teresa (Institut d'Investigació Biomèdica (Girona)) ; Aguilar, Helena (Institut Català d'Oncologia) ; Cufí, Sílvia (Institut d'Investigació Biomèdica (Girona)) ; Oliveras, Glòria (Institut d'Investigació Biomèdica (Girona)) ; Turrado, Carlos (Universidad Complutense de Madrid) ; Ortega Gutiérrez, Silvia (Universidad Complutense de Madrid) ; Benhamú, Bellinda (Universidad Complutense de Madrid) ; López-Rodríguez, María Luz (Universidad Complutense de Madrid) ; Urruticoechea, Ander (Institut Català d'Oncologia) ; Colomer Bosch, Ramón (Centro Oncológico MD Anderson (Madrid))
Introduction: Inhibiting the enzyme Fatty Acid Synthase (FASN) leads to apoptosis of breast carcinoma cells, and this is linked to human epidermal growth factor receptor 2 (HER2) signaling pathways in models of simultaneous expression of FASN and HER2. [...]
2011 - 10.1186/bcr3077
Breast cancer research, Vol. 13, N. R131 (December 2011) , p. 1-13
4 documents

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