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27 p, 2.8 MB |
Tumor Cell-Intrinsic Immunometabolism and Precision Nutrition in Cancer Immunotherapy
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Cuyàs, Elisabet (Institut d'Investigació Biomèdica de Girona) ;
Verdura, Sara (Institut d'Investigació Biomèdica de Girona) ;
Martin-Castillo, Begoña (Institut Català d'Oncologia) ;
Alarcón Cor, Tomás (Universitat Autònoma de Barcelona. Departament de Matemàtiques) ;
Lupu, Ruth (Mayo Clinic Cancer Center) ;
Bosch-Barrera, J (Universitat de Girona. Departament de Ciències Mèdiques) ;
Menendez, Javier A. (Institut d'Investigació Biomèdica de Girona)
One of the greatest challenges in the cancer immunotherapy field is the need to biologically rationalize and broaden the clinical utility of immune checkpoint inhibitors (ICIs). The balance between metabolism and immune response has critical implications for overcoming the major weaknesses of ICIs, including their lack of universality and durability. [...]
2020 -  10.3390/cancers12071757
Cancers, Vol. 12, Issue 7 (July 2020) , art. 1757
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21 p, 2.1 MB |
The LSD1 inhibitor iadademstat (ORY-1001) targets SOX2-driven breast cancer stem cells : a potential epigenetic therapy in luminal-B and HER2-positive breast cancer subtypes
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Cuyàs, Elisabet (Institut d'Investigació Biomèdica de Girona) ;
Gumuzio, Juan (StemTek Therapeutics (Bilbao)) ;
Verdura, Sara (Institut d'Investigació Biomèdica de Girona) ;
Brunet, Joan (Institut d'Investigació Biomèdica de Girona) ;
Bosch-Barrera, J (Universitat de Girona. Departament de Medicina) ;
Martin-Castillo, Begoña (Institut Català d'Oncologia) ;
Alarcón Cor, Tomás (Universitat Autònoma de Barcelona. Departament de Matemàtiques) ;
Encinar, José Antonio (Universidad Miguel Hernández de Elche. Instituto de Investigación. Desarrollo e Innovación en Biotecnología Sanitaria de Elche) ;
Martin, Ángel G. (StemTek Therapeutics (Bilbao)) ;
Menendez, Javier A. (Institut d'Investigació Biomèdica de Girona)
SOX2 is a core pluripotency-associated transcription factor causally related to cancer initiation, aggressiveness, and drug resistance by driving the self-renewal and seeding capacity of cancer stem cells (CSC). [...]
2020 - 10.18632/aging.102887
Aging (Albany NY), Vol. 12, Issue 6 (March 2020) , p. 4794-4814
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11 p, 2.0 MB |
In silico clinical trials for anti-aging therapies
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Menendez, Javier A. (Institut d'Investigació Biomèdica de Girona) ;
Cuyàs, Elisabet (Institut d'Investigació Biomèdica de Girona) ;
Folguera Blasco, Núria (The Francis Crick Institute. Quantitative Cell Biology Lab) ;
Verdura, Sara (Institut d'Investigació Biomèdica de Girona) ;
Martin-Castillo, Begoña (Institut Català d'Oncologia) ;
Joven, Jorge (Institut d'Investigació Sanitària Pere Virgili) ;
Alarcón Cor, Tomás (Universitat Autònoma de Barcelona. Departament de Matemàtiques)
Therapeutic strategies targeting the hallmarks of aging can be broadly grouped into four categories, namely systemic (blood) factors, metabolic manipulation (diet regimens and dietary restriction mimetics), suppression of cellular senescence (senolytics), and cellular reprogramming, which likely have common characteristics and mechanisms of action. [...]
2019 - 10.18632/aging.102180
Aging (Albany NY), Vol. 11, Issue 16 (August 2019) , p. 6591-6601
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27 p, 3.0 MB |
A multiscale model of epigenetic heterogeneity-driven cell fate decision-making
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Folguera Blasco, Núria (Universitat Autònoma de Barcelona. Departament de Matemàtiques) ;
Pérez Carrasco, Rubén (University College London. Department of Mathematics) ;
Cuyàs, Elisabet (Institut d'Investigació Biomèdica de Girona) ;
Menendez, Javier A. (Institut d'Investigació Biomèdica de Girona) ;
Alarcón Cor, Tomás (Universitat Autònoma de Barcelona. Departament de Matemàtiques) ;
Centre de Recerca Matemàtica
The inherent capacity of somatic cells to switch their phenotypic status in response to damage stimuli in vivo might have a pivotal role in ageing and cancer. However, how the entryexit mechanisms of phenotype reprogramming are established remains poorly understood. [...]
2019 - 10.1371/journal.pcbi.1006592
PLoS computational biology, Vol. 15, Issue 4 (April 2019) , art. e1006592
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18 p, 8.3 MB |
Suppression of endogenous lipogenesis induces reversion of the malignant phenotype and normalized differentiation in breast cancer
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Gonzalez-Guerrico, Anatilde M. (Department of Laboratory Medicine and Pathology, Division of Experimental Pathology, Mayo Clinic, Rochester, MN, USA) ;
Espinoza, Ingrid (Department of Biochemistry, University of Mississippi Medical Center, Jackson, MS, USA) ;
Schroeder, Barbara (Department of Laboratory Medicine and Pathology, Division of Experimental Pathology, Mayo Clinic, Rochester, MN, USA) ;
Park, Cheol Hong (Department of Laboratory Medicine and Pathology, Division of Experimental Pathology, Mayo Clinic, Rochester, MN, USA) ;
Chandra Mohan, KVP (Department of Laboratory Medicine and Pathology, Division of Experimental Pathology, Mayo Clinic, Rochester, MN, USA) ;
Khurana, Ashwani (Department of Laboratory Medicine and Pathology, Division of Experimental Pathology, Mayo Clinic, Rochester, MN, USA) ;
Corominas-Faja, Bruna (Institut d'Investigació Biomèdica de Girona) ;
Cuyàs, Elisabet (Institut d'Investigació Biomèdica de Girona) ;
Alarcón Cor, Tomás (Universitat Autònoma de Barcelona. Departament de Matemàtiques) ;
Kleer, Celina (Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA) ;
Menendez, Javier A. (Institut d'Investigació Biomèdica de Girona) ;
Lupu, Ruth (Mayo Clinic Cancer Center, Rochester, MN, USA)
The correction of specific signaling defects can reverse the oncogenic phenotype of tumor cells by acting in a dominant manner over the cancer genome. Unfortunately, there have been very few successful attempts at identifying the primary cues that could redirect malignant tissues to a normal phenotype. [...]
2016 - 10.18632/oncotarget.9463
Oncotarget, Vol. 7 (may 2016) , p. 71151-71168
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13 p, 3.9 MB |
Accelerated geroncogenesis in hereditary breast-ovarian cancer syndrome
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Menendez, Javier A. (Institut d'Investigació Biomèdica de Girona) ;
Folguera Blasco, Núria (Centre de Recerca Matemàtica) ;
Cuyàs, Elisabet (Institut d'Investigació Biomèdica de Girona) ;
Fernández-Arroyo, Salvador (Hospital Universitari de Sant Joan) ;
Joven, Jorge (Hospital Universitari de Sant Joan) ;
Alarcón Cor, Tomás (Universitat Autònoma de Barcelona. Departament de Matemàtiques)
The geroncogenesis hypothesis postulates that the decline in metabolic cellular health that occurs naturally with aging drives a "field effect" predisposing normal tissues for cancer development. We propose that mutations in the cancer susceptibility genes BRCA1/2 might trigger "accelerated geroncogenesis" in breast and ovarian epithelia. [...]
2016 - 10.18632/oncotarget.7867
Oncotarget, Vol. 7, issue 11 (March 2016) , p. 11959-11971
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11 p, 2.4 MB |
Oncometabolic nuclear reprogramming of cancer stemness
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Menendez, Javier A. (Institut Català d'Oncologia) ;
Corominas-Faja, Bruna (Institut d'Investigació Biomèdica de Girona) ;
Cuyàs, Elisabet (Institut d'Investigació Biomèdica de Girona) ;
García, María G. (Instituto Universitario de Oncología del Principado de Asturias) ;
Fernández-Arroyo, Salvador (Hospital Universitari de Sant Joan) ;
Fernández, Agustín F. (Instituto Universitario de Oncología del Principado de Asturias) ;
Joven, Jorge (Hospital Universitari de Sant Joan) ;
Fraga, Mario F.. (Instituto Universitario de Oncología del Principado de Asturias) ;
Alarcón Cor, Tomás (Centre de Recerca Matemàtica)
By impairing histone demethylation and locking cells into a reprogramming-prone state, oncometabolites can partially mimic the process of induced pluripotent stem cell generation. Using a systems biology approach, combining mathematical modeling, computation, and proof-of-concept studies with live cells, we found that an oncometabolite-driven pathological version of nuclear reprogramming increases the speed and efficiency of dedifferentiating committed epithelial cells into stem-like states with only a minimal core of stemness transcription factors. [...]
2016 - 10.1016/j.stemcr.2015.12.012
Stem cell reports, Vol. 6, issue 3 (March 2016) , p. 273-283
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