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1.
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13 p, 849.9 KB |
Altered T-cell subset distribution in the viral reservoir in HIV-1-infected individuals with extremely low proviral DNA (LoViReTs)
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Gálvez, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Urrea, Víctor (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
García Guerrero, María del Carmen (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bernal, Sílvia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Benet, Susana (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Mothe, Beatriz (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bailón, Lucía (Institut Germans Trias i Pujol. Fundació Lluita Contra les Infeccions) ;
Dalmau, Judith (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martinez, Andrea (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Nieto Gil-Ortega, Aroa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Leal, Lorna (Hospital Clínic i Provincial de Barcelona) ;
García, Felipe (Hospital Clínic i Provincial de Barcelona) ;
Clotet Sala, Bonaventura (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Salgado, Maria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
HIV cure strategies aim to eliminate viral reservoirs that persist despite successful antiretroviral therapy (ART). We have previously described that 9% of HIV-infected individuals who receive ART harbor low levels of provirus (LoViReTs). [...]
2022 -  10.1111/joim.13484
Journal of Internal Medicine, Vol. 292 (march 2022) , p. 308-320
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2.
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11 p, 2.0 MB |
Enhancement of Antiviral CD8 + T-Cell Responses and Complete Remission of Metastatic Melanoma in an HIV-1-Infected Subject Treated with Pembrolizumab
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Blanch-Lombarte, Oscar (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Gálvez, Cristina (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Revollo, Boris (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Jiménez-Moyano, Esther (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Llibre, Josep M.. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Manzano, José Luís (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Boada, Aram (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Dalmau, Judith (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
E. Speiser, Daniel (University of Lausanne, Switzerland) ;
Clotet Sala, Bonaventura (Universitat Autònoma de Barcelona. Departament de Medicina) ;
G. Prado, Julia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Background: Pembrolizumab is an immune checkpoint inhibitor against programmed cell death protein-1 (PD-1) approved for therapy in metastatic melanoma. PD-1 expression is associated with a diminished functionality in HIV-1 specific-CD8 + T cells. [...]
2019 - 10.3390/jcm8122089
Journal of clinical medicine, Vol. 8 (december 2019)
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3.
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9 p, 3.7 MB |
The Genome-wide Methylation Profile of CD4+ T Cells From Individuals With Human Immunodeficiency Virus (HIV) Identifies Distinct Patterns Associated With Disease Progression
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Moron-Lopez, Sara (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Urrea, Víctor (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Dalmau, Judith (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Lopez, Miguel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Puertas, Maria C.. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ouchi, Dan (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Gómez Moruno, Antonio (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Passaes, Caroline (Institut Pasteur) ;
Mothe, Beatriz (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Brander, Christian (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Saez-Cirion, Asier (Institut Pasteur) ;
Clotet Sala, Bonaventura (Institut Germans Trias i Pujol. Fundació de Lluita Contra la Sida) ;
Esteller, M. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Berdasco, Maria (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Martinez-Picado, Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
BACKGROUND: Human genetic variation-mostly in the human leukocyte antigen (HLA) and C-C chemokine receptor type 5 (CCR5) regions-explains 25% of the variability in progression of human immunodeficiency virus (HIV) infection. [...]
2021 - 10.1093/cid/ciaa1047
Clinical Infectious Diseases, Vol. 72 Núm. 9 (april 2021) , p. e256-e264
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4.
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17 p, 2.5 MB |
Dissemination of Mycobacterium tuberculosis is associated to a SIGLEC1 null variant that limits antigen exchange via trafficking extracellular vesicles
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Benet, Susana (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Gálvez, Cristina (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Drobniewski, Francis (Imperial College) ;
Kontsevaya, Irina (N.V. Postnikov Samara Region Clinical Tuberculosis Dispensary) ;
Arias, Lilibeth (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Monguió-Tortajada, Marta (Universitat Autònoma de Barcelona) ;
Erkizia, Itziar (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Urrea, Víctor (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ong, Ruo-Yan (University of Dundee) ;
Luquín Fernández, M. (Marina) (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Dupont, Maeva (International associated laboratory (LIA) CNRS "IM-TB/HIV" (1167)) ;
Chojnacki, Jakub (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Dalmau, Judith (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Cardona, Paula (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Neyrolles, Olivier (International associated laboratory (LIA) CNRS "IM-TB/HIV" (1167)) ;
Lugo-Villarino, Geanncarlo (International associated laboratory (LIA) CNRS "IM-TB/HIV" (1167)) ;
Vérollet, Christel (International associated laboratory (LIA) CNRS "IM-TB/HIV" (1167)) ;
Julián Gómez, Esther (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Furrer, Hansjakob (University of Bern) ;
Günthard, Huldrych F. (University of Zurich) ;
Crocker, Paul R. (University of Dundee) ;
Tapia, Gustavo (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Borràs i Serres, Francesc Enric (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Fellay, Jacques (Lausanne University Hospital) ;
McLaren, Paul J. (University of Manitoba) ;
Telenti, Amalio (The Scripps Research Institute) ;
Cardona, Pere-Joan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pérez-Álvarez, Núria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Vilaplana, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Izquierdo Useros, Nuria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
The identification of individuals with null alleles enables studying how the loss of gene function affects infection. We previously described a non-functional variant in SIGLEC1, which encodes the myeloid-cell receptor Siglec-1/CD169 implicated in HIV-1 cell-to-cell transmission. [...]
2021 - 10.1002/jev2.12046
Journal of extracellular vesicles, Vol. 10 (january 2021)
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5.
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12 p, 1.1 MB |
Extremely low viral reservoir in treated chronically HIV-1-infected individuals
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Gálvez, Cristina (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Urrea, Víctor (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Dalmau, Judith (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Jiménez Valero, Montserrat (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Pérez-Álvarez, Núria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Monceaux, Valérie (Institut Pasteur, Unité HIV Inflammation et Persistance, Paris, France) ;
Huot, Nicolas (Institut Pasteur, Unité HIV Inflammation et Persistance, Paris, France) ;
Leal, Lorna (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
González Soler, Victoria (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
González-Cao, María (Hospital Universitari Dexeus (Barcelona, Catalunya)) ;
Müller-Trutwin, Michaela (Institut Pasteur, Unité HIV Inflammation et Persistance, Paris, France) ;
Sáez-Cirión, Asier (Institut Pasteur, Unité HIV Inflammation et Persistance, Paris, France) ;
García, Felipe (Institut Pasteur, Unité HIV Inflammation et Persistance, Paris, France) ;
Blanco, Julià (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Salgado, Maria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Universitat Autònoma de Barcelona
Small viral reservoirs are found predominantly in HIV-1 controllers and individuals treated during acute/early HIV-1 infection. However, other HIV + individuals could naturally also harbour low viral reservoirs. [...]
2020 - 10.1016/j.ebiom.2020.102830
EBioMedicine, Vol. 57 (june 2020)
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6.
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14 p, 2.0 MB |
Differential Immunodominance Hierarchy of CD8 + T-Cell Responses in HLA-B*27:05- and -B*27:02-Mediated Control of HIV-1 Infection
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Adland, Emily ;
Hill, Matilda ;
Lavandier, Nora ;
Csala, Anna ;
Edwards, Anne ;
Chen, Fabian ;
Radkowski, Marek ;
Kowalska, Justyna D. ;
Paraskevis, Dimitrios ;
Hatzakis, Angelos ;
Valenzuela-Ponce, Humberto ;
Pfafferott, Katja ;
Williams, Ian ;
Pellegrino, Pierre ;
Borrow, Persephone ;
Mori, Masahiko ;
Rockstroh, Jürgen ;
Prado, Julia G.. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Mothe, Beatriz (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Dalmau, Judith (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Martinez-Picado, Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Tudor-Williams, Gareth ;
Frater, John ;
Stryhn, Anette ;
Buus, Soren ;
Teran, Gustavo Reyes ;
Mallal, Simon ;
John, Mina ;
Buchbinder, Susan ;
Kirk, Gregory ;
Martin, Jeffrey ;
Michael, Nelson ;
Fellay, Jacques ;
Deeks, Steve ;
Walker, Bruce D ;
Avila-Rios, Santiago ;
Cole, David ;
Brander, Christian (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Carrington, Mary ;
Goulder, Philip ;
Universitat Autònoma de Barcelona
The well-characterized association between HLA-B*27:05 and protection against HIV disease progression has been linked to immunodominant HLA-B*27:05-restricted CD8 + T-cell responses toward the conserved Gag KK10 (residues 263 to 272) and polymerase (Pol) KY9 (residues 901 to 909) epitopes. [...]
2018 - 10.1128/JVI.01685-17
Journal of Virology, Vol. 92 (january 2018)
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7.
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11 p, 679.0 KB |
Does rapid HIV disease progression prior to combination antiretroviral therapy hinder optimal CD4 + T-cell recovery once HIV-1 suppression is achieved?
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Jarrin, Inma (Instituto de Salud Carlos III) ;
Pantazis, Nikos (Athens University Medical School, Athens, Greece) ;
Dalmau, Judith (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Phillips, Andrew N. (Research Department of Infection and Population Health) ;
Olson, Ashley (Medical Research Council Clinical Trials Unit, University College London, London, UK) ;
Mussini, Cristina (Institute of Infectious Diseases, University of Modena and Reggio Emilia, Modena, Italy) ;
Boufassa, Faroudy (Univ Paris-Sud, Le Kremlim Bicetre) ;
Costagliola, Dominique (INSERM, Paris, France) ;
Porter, Kholoud (Medical Research Council Clinical Trials Unit, University College London, London, UK) ;
Blanco, Julià (Universitat de Vic - Universitat Central de Catalunya) ;
Del Amo, Julia (Instituto de Salud Carlos III) ;
Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
This article compares trends in CD4 + T-cell recovery and proportions achieving optimal restoration (≥500 cells/μl) after viral suppression following combination antiretroviral therapy (cART) initiation between rapid and nonrapid progressors. [...]
2015 - 10.1097/QAD.0000000000000805
AIDS (London, England), Vol. 29 (october 2015) , p. 2323-2333
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8.
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11 p, 527.4 KB |
Deep Molecular Characterization of HIV-1 Dynamics under Suppressive HAART
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Buzón, Maria José (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Codoñer, Francisco M. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Frost, Simon D. W. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Puertas, Maria C. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Massanella, Marta (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Dalmau, Judith (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Llibre, Josep M.. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Stevenson, Mario (University of Miami Miller School of Medicine, Miami, Florida, United States of America) ;
Blanco, Julià (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Clotet Sala, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Paredes, Roger (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Martinez-Picado, Javier (Institució Catalana de Recerca i Estudis Avançats) ;
Universitat Autònoma de Barcelona
In order to design strategies for eradication of HIV-1 from infected individuals, detailed insight into the HIV-1 reservoirs that persist in patients on suppressive antiretroviral therapy (ART) is required. [...]
2011 - 10.1371/journal.ppat.1002314
PLOS pathogens, Vol. 7 (october 2011)
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9.
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7 p, 617.5 KB |
Identification of Siglec-1 null individuals infected with HIV-1
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Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
McLaren, Paul J. (National HIV and Retrovirology Laboratory (Winnipeg, Canadà)) ;
Erkizia, Itziar (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Martin, Maureen P. (Frederick National Laboratory for Cancer Research (Maryland, Estats Units d'Amèrica)) ;
Benet, Susana (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Rotger, Margalida (University of Lausanne (Suïssa)) ;
Dalmau, Judith (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ouchi, Dan (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Wolinsky, Steven M. (Northwestern University Feinberg School of Medicine (Chicago, Estats Units d'Amèrica)) ;
Penugonda, Sudhir (Northwestern University Feinberg School of Medicine (Chicago, Estats Units d'Amèrica)) ;
Günthard, Huldrych F. (University Hospital Zurich (Suïssa)) ;
Fellay, Jacques (École Polytechnique Fédérale de Lausanne (Suïssa)) ;
Carrington, Mary (Frederick National Laboratory for Cancer Research (Maryland, Estats Units d'Amèrica)) ;
Izquierdo Useros, Nuria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Telenti, Amalio (J. Craig Venter Institute (La Jolla, Estats Units d'Amèrica))
Siglec-1/CD169 is a myeloid-cell surface receptor critical for HIV-1 capture and infection of bystander target cells. To dissect the role of SIGLEC1 in natura, we scan a large population genetic database and identify a loss-of-function variant (Glu88Ter) that is found in ∼1% of healthy people. [...]
2016 - 10.1038/ncomms12412
Nature communications, Vol. 7 Núm. 12412 (August 2016)
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10.
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15 p, 3.1 MB |
HIV-1 immune activation induces Siglec-1 expression and enhances viral trans-infection in blood and tissue myeloid cells
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Pino, Maria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Erkizia, Itziar (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Benet, Susana (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Erikson, Elina (University of Frankfurt (Alemanya)) ;
Fernandez Figueras, Maria Teresa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Guerrero, Dolores (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Dalmau, Judith (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ouchi, Dan (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Rausell, Antonio (University of Lausanne (Suïssa)) ;
Ciuffi, Angela (University of Lausanne (Suïssa)) ;
Keppler, Oliver T. (University of Frankfurt (Alemanya)) ;
Telenti, Amalio (University of Lausanne (Suïssa)) ;
Kräusslich, Hans-Georg (University of Heidelberg (Alemanya)) ;
Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Izquierdo Useros, Nuria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Universitat Autònoma de Barcelona
Myeloid cells are key players in the recognition and response of the host against invading viruses. Paradoxically, upon HIV-1 infection, myeloid cells might also promote viral pathogenesis through trans-infection, a mechanism that promotes HIV-1 transmission to target cells via viral capture and storage. [...]
2015 - 10.1186/s12977-015-0160-x
Retrovirology, Vol 12, article 37 (May 2015)
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