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14 p, 2.0 MB |
Differential Immunodominance Hierarchy of CD8 + T-Cell Responses in HLA-B*27:05- and -B*27:02-Mediated Control of HIV-1 Infection
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Adland, Emily ;
Hill, Matilda ;
Lavandier, Nora ;
Csala, Anna ;
Edwards, Anne ;
Chen, Fabian ;
Radkowski, Marek ;
Kowalska, Justyna D. ;
Paraskevis, Dimitrios ;
Hatzakis, Angelos ;
Valenzuela-Ponce, Humberto ;
Pfafferott, Katja ;
Williams, Ian ;
Pellegrino, Pierre ;
Borrow, Persephone ;
Mori, Masahiko ;
Rockstroh, Jürgen ;
Prado, Julia G. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Mothe, Beatriz (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Dalmau, Judith (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Martinez-Picado, Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Tudor-Williams, Gareth ;
Frater, John ;
Stryhn, Anette ;
Buus, Soren ;
Teran, Gustavo Reyes ;
Mallal, Simon ;
John, Mina ;
Buchbinder, Susan ;
Kirk, Gregory ;
Martin, Jeffrey ;
Michael, Nelson ;
Fellay, Jacques ;
Deeks, Steve ;
Walker, Bruce ;
Avila-Rios, Santiago ;
Cole, David ;
Brander, Christian (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Carrington, Mary ;
Goulder, Philip ;
Universitat Autònoma de Barcelona
The well-characterized association between HLA-B*27:05 and protection against HIV disease progression has been linked to immunodominant HLA-B*27:05-restricted CD8 + T-cell responses toward the conserved Gag KK10 (residues 263 to 272) and polymerase (Pol) KY9 (residues 901 to 909) epitopes. [...]
2018 -  10.1128/JVI.01685-17
Journal of Virology, Vol. 92 (january 2018)
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11 p, 679.0 KB |
Does rapid HIV disease progression prior to combination antiretroviral therapy hinder optimal CD4 + T-cell recovery once HIV-1 suppression is achieved?
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Jarrin, Inma (Instituto de Salud Carlos III, Madrid, Spain) ;
Pantazis, Nikos (Athens University Medical School, Athens, Greece) ;
Dalmau, Judith (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Phillips, Andrew N. (Research Department of Infection and Population Health) ;
Olson, Ashley (Medical Research Council Clinical Trials Unit, University College London, London, UK) ;
Mussini, Cristina (Institute of Infectious Diseases, University of Modena and Reggio Emilia, Modena, Italy) ;
Boufassa, Faroudy (Univ Paris-Sud, Le Kremlim Bicetre) ;
Costagliola, Dominique (INSERM, Paris, France) ;
Porter, Kholoud (Medical Research Council Clinical Trials Unit, University College London, London, UK) ;
Blanco, Juliá (Universitat de Vic, Universitat Central de Catalunya (UVic-UCC)) ;
Del Amo, Julia (Instituto de Salud Carlos III, Madrid, Spain) ;
Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
This article compares trends in CD4 + T-cell recovery and proportions achieving optimal restoration (≥500 cells/μl) after viral suppression following combination antiretroviral therapy (cART) initiation between rapid and nonrapid progressors. [...]
2015 - 10.1097/QAD.0000000000000805
AIDS (London, England), Vol. 29 (october 2015) , p. 2323-2333
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11 p, 527.4 KB |
Deep Molecular Characterization of HIV-1 Dynamics under Suppressive HAART
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Buzón, Maria J. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Codoñer, Francisco M. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Frost, Simon D. W. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Puertas, Maria C. (Institut de Recerca de la SIDA, IrsiCaixa, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Spain) ;
Massanella, Marta (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Dalmau, Judith (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Llibre, Josep M. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Stevenson, Mario (University of Miami Miller School of Medicine, Miami, Florida, United States of America) ;
Blanco, Julià (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Clotet, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Paredes, Roger (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Martinez-Picado, Javier (Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain) ;
Universitat Autònoma de Barcelona
In order to design strategies for eradication of HIV-1 from infected individuals, detailed insight into the HIV-1 reservoirs that persist in patients on suppressive antiretroviral therapy (ART) is required. [...]
2011 - 10.1371/journal.ppat.1002314
PLoS pathogens, Vol. 7 (october 2011)
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7 p, 617.5 KB |
Identification of Siglec-1 null individuals infected with HIV-1
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Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
McLaren, Paul J. (National HIV and Retrovirology Laboratory (Winnipeg, Canadà)) ;
Erkizia, Itziar (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Martin, Maureen P. (Frederick National Laboratory for Cancer Research (Maryland, Estats Units d'Amèrica)) ;
Benet, Susana (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Rotger, Margalida (University of Lausanne (Suïssa)) ;
Dalmau, Judith (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ouchi, Dan (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Wolinsky, Steven M. (Northwestern University Feinberg School of Medicine (Chicago, Estats Units d'Amèrica)) ;
Penugonda, Sudhir (Northwestern University Feinberg School of Medicine (Chicago, Estats Units d'Amèrica)) ;
Günthard, Huldrych F. (University Hospital Zurich (Suïssa)) ;
Fellay, Jacques (École Polytechnique Fédérale de Lausanne (Suïssa)) ;
Carrington, Mary (Frederick National Laboratory for Cancer Research (Maryland, Estats Units d'Amèrica)) ;
Izquierdo Useros, Nuria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Telenti, Amalio (J. Craig Venter Institute (La Jolla, Estats Units d'Amèrica))
Siglec-1/CD169 is a myeloid-cell surface receptor critical for HIV-1 capture and infection of bystander target cells. To dissect the role of SIGLEC1 in natura, we scan a large population genetic database and identify a loss-of-function variant (Glu88Ter) that is found in ∼1% of healthy people. [...]
2016 - 10.1038/ncomms12412
Nature communications, Vol. 7 Núm. 12412 (August 2016)
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15 p, 3.1 MB |
HIV-1 immune activation induces Siglec-1 expression and enhances viral trans-infection in blood and tissue myeloid cells
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Pino, Maria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Erkizia, Itziar (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Benet, Susana (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Erikson, Elina (University of Frankfurt (Alemanya)) ;
Fernández Figueras, Maria Teresa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Guerrero, Dolores (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Dalmau, Judith (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ouchi, Dan (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Rausell, Antonio (University of Lausanne (Suïssa)) ;
Ciuffi, Angela (University of Lausanne (Suïssa)) ;
Keppler, Oliver T. (University of Frankfurt (Alemanya)) ;
Telenti, Amalio (University of Lausanne (Suïssa)) ;
Kräusslich, Hans-Georg (University of Heidelberg (Alemanya)) ;
Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Izquierdo Useros, Nuria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Universitat Autònoma de Barcelona
Myeloid cells are key players in the recognition and response of the host against invading viruses. Paradoxically, upon HIV-1 infection, myeloid cells might also promote viral pathogenesis through trans-infection, a mechanism that promotes HIV-1 transmission to target cells via viral capture and storage. [...]
2015 - 10.1186/s12977-015-0160-x
Retrovirology, Vol 12, article 37 (May 2015)
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