Results overview: Found 6 records in 0.02 seconds.
Articles, 6 records found
Articles 6 records found  
1.
14 p, 7.0 MB Structural insights into positive and negative allosteric regulation of a G protein-coupled receptor through protein-lipid interactions. / Bruzzese, Agustín (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Gil Giró, Carles (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Dalton, James A.R. (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Giraldo, Jesús (Universitat Autònoma de Barcelona. Institut de Neurociències)
Lipids are becoming known as essential allosteric modulators of G protein-coupled receptor (GPCRs). However, how they exert their efects on GPCR conformation at the atomic level is still unclear. In light of recent experimental data, we have performed several long-timescale molecular dynamics (MD) simulations, totalling 24 μs, to rigorously map allosteric modulation and conformational changes in the β2 adrenergic receptor (β2AR) that occur as a result of interactions with three diferent phospholipids. [...]
2018 - 10.1038/s41598-018-22735-6
Scientific Reports, Vol. 8 (2018) , art. 4456  
2.
11 p, 2.3 MB Illuminating phenylazopyridines to photoswitch metabotropic glutamate receptors : from the flask to the animals / Gómez-Santacana, Xavier (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Pittolo, Silvia (Institut de Bioenginyeria de Catalunya) ; Rovira, Xavier (Université de Montpellier. Institute of Functional Genomics) ; Lopez, Marc (Universitat de Barcelona. Unitat de Farmacologia) ; Zussy, Charleine (Université de Montpellier. Institute of Functional Genomics) ; Dalton, James A.R. (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Faucherre, Adèle (Université de Montpellier. Institute of Functional Genomics) ; Jopling, Chris (Université de Montpellier. Institute of Functional Genomics) ; Pin, Jean-Philippe (Université de Montpellier. Institute of Functional Genomics) ; Ciruela, Francisco (Universitat de Barcelona. Unitat de Farmacologia) ; Goudet, Cyril (Université de Montpellier. Institute of Functional Genomics) ; Giraldo, Jesús (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Gorostiza, Pau (Institut de Bioenginyeria de Catalunya) ; Llebaria, Amadeu (Instituto de Química Avanzada de Cataluña)
Phenylazopyridines are photoisomerizable compounds with high potential to control biological functions with light. We have obtained a series of phenylazopyridines with light dependent activity as negative allosteric modulators (NAM) of metabotropic glutamate receptor subtype 5 (mGlu). [...]
2017 - 10.1021/acscentsci.6b00353
ACS Central Science, Vol. 3, issue 1 (Jan. 2017) , p. 81-91  
3.
9 p, 2.9 MB GNAO1 encephalopathy : further delineation of a severe neurodevelopmental syndrome affecting females / Marcé-Grau, Anna (Vall d'Hebron Hospitals. Institut de Recerca) ; Dalton, James A.R. (Universitat Autònoma de Barcelona. Institut de Neurociències) ; López-Pisón, Javier (Sección de Neuropediatría, Hospital Universitario Miguel Servet) ; García-Jiménez, María Concepción (Sección de Metabolismo, Hospital Universitario Miguel Servet) ; Monge-Galindo, Lorena (Secciones de Neuropediatría y Metabolismo, Hospital Universitario Miguel Servet) ; Cuenca-León, Ester (Vall d'Hebron Hospitals. Institut de Recerca) ; Giraldo, Jesús (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Macaya, Alfons (Pediatric Neurology Section, Hospital Universitari Vall d'Hebron)
De novo heterozygous mutations in the GNAO1 gene, encoding the Gα o subunit of G-proteins, are the cause of a severe neurodevelopmental disorder, featuring early infantile seizures, profound cognitive dysfunction and, occasionally, movement disorder (early infantile epileptic encephalopathy-17). [...]
2016 - 10.1186/s13023-016-0416-0
Orphanet Journal of Rare Diseases, Vol. 11 (april 2016)  
4.
14 p, 23.8 MB Shining Light On An mGlu5 Photoswitchable NAM : A Theoretical Perspective / Dalton, James A.R. (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Lans, Isaias (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Rovira Algans, Xavier (Institut de Génomique Fonctionnelle) ; Malhaire, Fanny (Institut de Génomique Fonctionnelle) ; Gómez-Santacana, Xavier (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Pittolo, Silvia (Institute for Bioengineering of Catalonia (IBEC)) ; Gorostiza, Pau (Institute for Bioengineering of Catalonia (IBEC)) ; Llebaria, Amadeu (Institut de Química Avançada de Catalunya) ; Goudet, Cyril (Institut de Génomique Fonctionnelle) ; Pin, Jean-Philippe (Institut de Génomique Fonctionnelle) ; Giraldo, Jesús (Universitat Autònoma de Barcelona. Institut de Neurociències)
Metabotropic glutamate receptors (mGluRs) are important drug targets because of their involvement in several neurological diseases. Among mGluRs, mGlu5 is a particularly high-profile target because its positive or negative allosteric modulation can potentially treat schizophrenia or anxiety and chronic pain, respectively. [...]
2016 - 10.2174/1570159X13666150407231417
Curr Neuropharmacol, Vol. 14, Num. 5 (2016) , p. 441-454  
5.
15 p, 1.6 MB Quantifying conformational changes in GPCRs : glimpse of a common functional mechanism / Dalton, James A.R. (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Lans, Isaias (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Giraldo, Jesús (Universitat Autònoma de Barcelona. Institut de Neurociències)
Background: G-protein-coupled receptors (GPCRs) are important drug targets and a better understanding of their molecular mechanisms would be desirable. The crystallization rate of GPCRs has accelerated in recent years as techniques have become more sophisticated, particularly with respect to Class A GPCRs interacting with G-proteins. [...]
2015 - 10.1186/s12859-015-0567-3
BMC Bioinformatics, Vol. 16 N. 124 (April 2015) , p. 1-15  
6.
23 p, 1.5 MB Rational design of a peptide capture agent for CXCL8 based on a model of the CXCL8:CXCR1 complex / Helme, Dorothea (Technische Universität Darmstadt. Clemens-Schöpf-Institut) ; Rink, Ina (Technische Universität Darmstadt. Clemens-Schöpf-Institut) ; Dalton, James A.R. (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Brahm, Kevin (Technische Universität Darmstadt. Clemens-Schöpf-Institut) ; Jöst, Marina (Technische Universität Darmstadt. Clemens-Schöpf-Institut) ; Nargang, Tobias M. (Karlsruhe Institute of Technology. Institute of Microstructure Technology) ; Blum, Witali (Technische Universität Darmstadt. Clemens-Schöpf-Institut) ; Wadhwani, Parvesh (Karlsruhe Institute of Technology. Institute of Biological Interfaces) ; Brenner-Weiss, Gerald (Karlsruhe Institute of Technology. Institute of Functional Interfaces) ; Rapp, Bastian E. (Karlsruhe Institute of Technology. Institute of Microstructure Technology) ; Giraldo, Jesús (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Schmitz, Katja (Technische Universität Darmstadt. Clemens-Schöpf-Institut)
Protein-capture agents are widely used for the detection, immobilization and isolation of proteins and are the foundation for the development of in vitro diagnostic chips. The chemokine CXCL8 is an interesting protein target due to its involvement in the human inflammatory response. [...]
2015 - 10.1039/C4RA13749C
RSC Advances, Vol. 5 Núm. 33 (2015) , p. 25657-25668  

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7 Dalton, James A.R.
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