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11 p, 247.4 KB |
HLA and microtubule-associated protein tau H1 haplotype associations in anti-IgLON5 disease
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Gaig, Carles (Hospital Clinic, CIBERehd. Department of Pathology) ;
Ercilla, Guadalupe (Hospital Clínic i Provincial de Barcelona) ;
Daura i Ribera, Xavier (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Ezquerra, Mario (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Fernández Santiago, Rubén (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Palou, Eduard (Hospital Clínic i Provincial de Barcelona) ;
Sabater, Lidia (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Höftberger, Romana (Medical University of Vienna) ;
Heidbreder, Anna (University Hospital Muenster) ;
Högl, Birgit (Medical University of Innsbruck) ;
Iranzo, Alex (Hospital Clínic i Provincial de Barcelona) ;
Santamaria, Joan (Hospital Clínic i Provincial de Barcelona) ;
Dalmau, Josep (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Graus Ribas, Francesc (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
We investigated the associations with HLA and microtubule-associated protein tau (MAPT) H1 haplotype in anti-IgLON5 disease, a recently identified disorder characterized by gait instability, brainstem dysfunction, and a prominent sleep disorder in association with IgLON5 antibodies and pathologic findings of a novel neuronal-specific tauopathy. [...]
2019 -  10.1212/NXI.0000000000000605
Neurology® neuroimmunology & neuroinflammation, Vol. 6, issue 6 (Nov. 2019)
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14 p, 3.3 MB |
Interaction of camel Lactoferrin derived peptides with DNA : a molecular dynamics study
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Pirkhezranian, Zana (Ferdowsi University of Mashhad. Department of Animal Science) ;
Tahmoorespur, Mojtaba. (Ferdowsi University of Mashhad. Department of Animal Science) ;
Daura i Ribera, Xavier (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Monhemi, Hassan (University of Neyshabur. Department of Chemistry) ;
Sekhavati, Mohammad Hadi (Ferdowsi University of Mashhad. Department of Animal Science)
Background: lactoferrampin (LFampin), Lactoferricin (LFcin), and LFchimera are three well-known antimicrobial peptides derived from Lactoferrin and proposed as alternatives for antibiotics. Although the intracellular activity of these peptides has been previously demonstrated, their mode of action is not yet fully understood. [...]
2020 - 10.1186/s12864-020-6458-7
BMC genomics, Vol. 21 (2020) , art. 60
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3.
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4 p, 2.2 MB |
The fusogenic peptide HA2 impairs selectivity of CXCR4-targeted protein nanoparticles
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Sánchez García, Laura (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Serna Romero, Naroa (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Mattanovich, M. (University of Natural Resources and Life Sciences. Department of Biotechnology) ;
Cazzanelli, P. (University of Natural Resources and Life Sciences. Department of Biotechnology) ;
Sánchez Chardi, Alejandro (Universitat Autònoma de Barcelona. Servei de Microscòpia) ;
Conchillo-Solé, Oscar (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Cortés, Fran (Universitat Autònoma de Barcelona. Servei de Cultius Cel·lulars, Producció d'Anticossos i Citometria) ;
Daura i Ribera, Xavier (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Unzueta Elorza, Ugutz (Institut d'Investigació Biomèdica Sant Pau) ;
Mangues, Ramon (Institut d'Investigació Biomèdica Sant Pau) ;
Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Vázquez Gómez, Esther (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Universitat Autònoma de Barcelona
We demonstrate here that the genetic incorporation of the fusogenic peptide HA2 into a CXCR4-targeted protein nanoparticle dramatically reduces the specificity of the interaction between nanoparticles and cell receptors, a factor to be considered when designing tumor-homing drug vehicles displaying endosomal-escape agents. [...]
2017 - 10.1039/c6cc09900a
Chemical communications, Vol. 53, issue 33 (April 2017) , p. 4565-4568
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4.
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10 p, 1.4 MB |
Heterogeneous colistin-resistance phenotypes coexisting in stenotrophomonas maltophiliaisolates influence colistin susceptibility testing
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Martínez-Servat, Sònia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Yero Corona, Daniel (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Huedo Moreno, Pol (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Marquez, Roser (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Molina, Gara (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Daura i Ribera, Xavier (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Gibert, Isidre (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
The polymyxin antibiotic colistin shows in vitro activity against Stenotrophomonas maltophilia. However, an increased incidence of colistin-resistant isolates has been recently observed. In addition, in vitro evaluation of colistin susceptibility for this organism has been problematic. [...]
2018 - 10.3389/fmicb.2018.02871
Frontiers in microbiology, Vol. 9 (Nov. 2018) , art. 2871
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45 p, 777.6 KB |
Aggregation-prone peptides modulate activity of bovine interferon gamma released from naturally occurring protein nanoparticles
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Carratalá, José Vicente (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Cano-Garrido, Olivia (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Sánchez, Julieta María (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Membrado, Cristina (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Pérez, Eudald (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Conchillo-Solé, Oscar (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Daura i Ribera, Xavier (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Sánchez Chardi, Alejandro (Universitat Autònoma de Barcelona. Servei de Microscòpia) ;
Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Arís i Giralt, Anna (Institut de Recerca i Tecnologia Agroalimentàries) ;
García Fruitós, Elena (Institut de Recerca i Tecnologia Agroalimentàries) ;
Ferrer Miralles, Neus (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Efficient protocols for the production of recombinant proteins are indispensable for the development of the biopharmaceutical sector. Accumulation of recombinant proteins in naturally-occurring protein aggregates is detrimental to biopharmaceutical development. [...]
2020 - 10.1016/j.nbt.2020.02.001
New Biotechnolgy, Vol. 57 (July 2020) , p. 11-19
2 documents
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14 p, 7.6 MB |
BPSL1626 : reverse and structural vaccinology reveal a novel candidate for vaccine design against Burkholderia pseudomallei
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Capelli, Riccardo (Center for Complexity and Biosystems and Dipartimento di Fisica, Università degli Studi di Milano) ;
Peri, Claudio (Consiglio Nazionale delle Ricerche. Istituto di Chimica del Riconoscimento Molecolare) ;
Villa, Riccardo (Department of Biosciences, Università degli Studi di Milano) ;
Nithichanon, Arnone (Khon Kaen University. Centre for Research and Development of Medical Diagnostic Laboratories) ;
Conchillo-Solé, Oscar (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Yero Corona, Daniel (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Gagni, Paola (Istituto di Chimica del Riconoscimento Molecolare, Consiglio Nazionale delle Ricerche) ;
Chiari, Marcella (Istituto di Chimica del Riconoscimento Molecolare, Consiglio Nazionale delle Ricerche) ;
Lertmemongkolchai, Ganjana (Center for Research and Development of Medical Diagnostic Laboratories (CMDL), Faculty of Associated Medical Sciences, Khon Kaen University) ;
Cretich, Marina (Istituto di Chimica del Riconoscimento Molecolare, Consiglio Nazionale delle Ricerche) ;
Daura i Ribera, Xavier (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Bolognesi, Martino (Università degli Studi di Milano. Centro di Eccellenza Interdisciplinare Materiali e Interfacce Nanostrutturati) ;
Colombo, Giorgio (Consiglio Nazionale delle Ricerche. Istituto di Chimica del Riconoscimento Molecolare) ;
Gourlay, Louise J. (Università degli Studi di Milano. Centro di Eccellenza Interdisciplinare Materiali e Interfacce Nanostrutturati)
Due to significant advances in computational biology, protein prediction, together with antigen and epitope design, have rapidly moved from conventional methods, based on experimental approaches, to in silico-based bioinformatics methods. [...]
2018 - 10.3390/antib7030026
Antibodies, Vol. 7 (2018) , p. 1-14
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20 p, 2.1 MB |
Sequence- and structure-based immunoreactive epitope discovery for Burkholderia pseudomallei flagellin
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Nithichanon, Arnone (Khon Kaen University. Centre for Research and Development of Medical Diagnostic Laboratories) ;
Rinchai, Darawan (Khon Kaen University. Centre for Research and Development of Medical Diagnostic Laboratories) ;
Gori, Alessandro (Consiglio Nazionale delle Ricerche. Istituto di Chimica del Riconoscimento Molecolare) ;
Lassaux, Patricia (Università degli Studi di Milano. Centro di Eccellenza Interdisciplinare Materiali e Interfacce Nanostrutturati) ;
Peri, Claudio (Consiglio Nazionale delle Ricerche. Istituto di Chimica del Riconoscimento Molecolare) ;
Conchillo-Solé, Oscar (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Ferrer Navarro, Mario (Universitat de Barcelona. Departament de Microbiologia Clínica) ;
Gourlay, Louise J. (Università degli Studi di Milano. Centro di Eccellenza Interdisciplinare Materiali e Interfacce Nanostrutturati) ;
Nardini, Marco (Università degli Studi di Milano. Centro di Eccellenza Interdisciplinare Materiali e Interfacce Nanostrutturati) ;
Vila, Jordi (Universitat de Barcelona. Departament de Microbiologia Clínica) ;
Daura i Ribera, Xavier (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Colombo, Giorgio (Consiglio Nazionale delle Ricerche. Istituto di Chimica del Riconoscimento Molecolare) ;
Bolognesi, Martino (Università degli Studi di Milano. Centro di Eccellenza Interdisciplinare Materiali e Interfacce Nanostrutturati) ;
Lertmemonkolchai, Ganjana (Khon Kaen University. Centre for Research and Development of Medical Diagnostic Laboratories)
Burkholderia pseudomallei is a Gram-negative bacterium responsible for melioidosis, a serious and often fatal infectious disease that is poorly controlled by existing treatments. Due to its inherent resistance to the major antibiotic classes and its facultative intracellular pathogenicity, an effective vaccine would be extremely desirable, along with appropriate prevention and therapeutic management. [...]
2015 - 10.1371/journal.pntd.0003917
PLoS neglected tropical diseases, Vol. 9, Issue 7 (July 2015) , e0003917
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7 p, 1.8 MB |
PrionW : a server to identify proteins containing glutamine/asparagine rich prion-like domains and their amyloid cores
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Zambrano, Rafael (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Conchillo-Solé, Oscar (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Iglesias, Valentin (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Illa, Ricard (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Rousseau, Frederic (KU Leuven. Department for Cellular and Molecular Medicine) ;
Schymkowitz, Joost (KU Leuven. Department for Cellular and Molecular Medicine) ;
Sabate, Raimon (Universitat de Barcelona. Departament de Fisicoquímica) ;
Daura i Ribera, Xavier (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Prions are a particular type of amyloids with the ability to self-perpetuate and propagate in vivo. Prion-like conversion underlies important biological processes but is also connected to human disease. [...]
2015 - 10.1093/nar/gkv490
Nucleic acids research, Vol. 43 (2015) , Web Server issue W331-W337
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12 p, 984.2 KB |
Human leukocyte antigen (HLA)-DRB1*15:01 and HLA-DRB5*01:01 present complementary peptide repertoires
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Scholz, Erika Margaret (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Marcilla, Miguel (Centro Nacional de Biotecnología (Espanya). Unidad de Proteómica) ;
Daura i Ribera, Xavier (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Arribas-Layton, David (Benaroya Research Institute at Virginia Mason) ;
James, Eddie A. (Benaroya Research Institute at Virginia Mason) ;
Álvarez Angulo, Iñaki (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Human leukocyte antigen (HLA)-DR15 is a haplotype associated with multiple sclerosis. It contains the two DRB* genes DRB1*1501 (DR2b) and DRB5*0101 (DR2a). The reported anchor motif of the corresponding HLA-DR molecules was determined in 1994 based on a small number of peptide ligands and binding assays. [...]
2017 - 10.3389/fimmu.2017.00984
Frontiers in immunology, Vol. 8 (Aug. 2017) , art. 984
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