Resultados globales: 27 registros encontrados en 0.02 segundos.
Artículos, Encontrados 24 registros
Documentos de investigación, Encontrados 3 registros
Artículos Encontrados 24 registros  1 - 10siguientefinal  ir al registro:
1.
14 p, 3.3 MB Interaction of camel Lactoferrin derived peptides with DNA : a molecular dynamics study / Pirkhezranian, Zana (Ferdowsi University of Mashhad. Department of Animal Science) ; Tahmoorespur, Mojtaba. (Ferdowsi University of Mashhad. Department of Animal Science) ; Daura i Ribera, Xavier (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Monhemi, Hassan (University of Neyshabur. Department of Chemistry) ; Sekhavati, Mohammad Hadi (Ferdowsi University of Mashhad. Department of Animal Science)
Background: lactoferrampin (LFampin), Lactoferricin (LFcin), and LFchimera are three well-known antimicrobial peptides derived from Lactoferrin and proposed as alternatives for antibiotics. Although the intracellular activity of these peptides has been previously demonstrated, their mode of action is not yet fully understood. [...]
2020 - 10.1186/s12864-020-6458-7
BMC genomics, Vol. 21 (2020) , art. 60  
2.
4 p, 2.2 MB The fusogenic peptide HA2 impairs selectivity of CXCR4-targeted protein nanoparticles / Sánchez García, Laura (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Serna Romero, Naroa (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Mattanovich, M. (University of Natural Resources and Life Sciences. Department of Biotechnology) ; Cazzanelli, P. (University of Natural Resources and Life Sciences. Department of Biotechnology) ; Sánchez Chardi, Alejandro (Universitat Autònoma de Barcelona. Servei de Microscòpia) ; Conchillo-Solé, Óscar (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Cortés, Fran (Universitat Autònoma de Barcelona. Servei de Cultius Cellulars, Produccio' d'Anticossos i Citometria) ; Daura i Ribera, Xavier (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Unzueta, Ugutz (Institut d'Investigació Biomèdica Sant Pau) ; Mangues, Ramon (Institut d'Investigació Biomèdica Sant Pau) ; Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Vázquez Gómez, Esther (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
We demonstrate here that the genetic incorporation of the fusogenic peptide HA2 into a CXCR4-targeted protein nanoparticle dramatically reduces the specificity of the interaction between nanoparticles and cell receptors, a factor to be considered when designing tumor-homing drug vehicles displaying endosomal-escape agents. [...]
2017 - 10.1039/c6cc09900a
Chemical communications, Vol. 53, issue 33 (April 2017) , p. 4565-4568  
3.
10 p, 1.4 MB Heterogeneous colistin-resistance phenotypes coexisting in stenotrophomonas maltophiliaisolates influence colistin susceptibility testing / Martínez-Servat, Sònia (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Yero Corona, Daniel (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Huedo Moreno, Pol (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Marquez, Roser (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Molina, Gara (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Daura i Ribera, Xavier (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Gibert, Isidre (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
The polymyxin antibiotic colistin shows in vitro activity against Stenotrophomonas maltophilia. However, an increased incidence of colistin-resistant isolates has been recently observed. In addition, in vitro evaluation of colistin susceptibility for this organism has been problematic. [...]
2018 - 10.3389/fmicb.2018.02871
Frontiers in microbiology, Vol. 9 (Nov. 2018) , art. 2871  
4.
45 p, 777.6 KB Aggregation-prone peptides modulate activity of bovine interferon gamma released from naturally occurring protein nanoparticles / Carratalá, José Vicente (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Cano Garrido, Olivia (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Sánchez, Julieta María (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Membrado, Cristina (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Pérez, Eudald (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Conchillo-Solé, Oscar (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Daura i Ribera, Xavier (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Sánchez Chardi, Alejandro (Universitat Autònoma de Barcelona. Servei de Microscòpia) ; Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Arís i Giralt, Anna (Institut de Recerca i Tecnologia Agroalimentàries) ; García Fruitós, Elena (Institut de Recerca i Tecnologia Agroalimentàries) ; Ferrer Miralles, Neus (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Efficient protocols for the production of recombinant proteins are indispensable for the development of the biopharmaceutical sector. Accumulation of recombinant proteins in naturally-occurring protein aggregates is detrimental to biopharmaceutical development. [...]
2020 - 10.1016/j.nbt.2020.02.001
New Biotechnolgy, Vol. 57 (July 2020) , p. 11-19
2 documentos
5.
14 p, 7.6 MB BPSL1626 : reverse and structural vaccinology reveal a novel candidate for vaccine design against Burkholderia pseudomallei / Capelli, Riccardo (Center for Complexity and Biosystems and Dipartimento di Fisica, Università degli Studi di Milano) ; Peri, Claudio (Consiglio Nazionale delle Ricerche. Istituto di Chimica del Riconoscimento Molecolare) ; Villa, Riccardo (Department of Biosciences, Università degli Studi di Milano) ; Nithichanon, Arnone (Khon Kaen University. Centre for Research and Development of Medical Diagnostic Laboratories) ; Conchillo-Solé, Oscar (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Yero Corona, Daniel (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Gagni, Paola (Istituto di Chimica del Riconoscimento Molecolare, Consiglio Nazionale delle Ricerche) ; Chiari, Marcella (Istituto di Chimica del Riconoscimento Molecolare, Consiglio Nazionale delle Ricerche) ; Lertmemongkolchai, Ganjana (Center for Research and Development of Medical Diagnostic Laboratories (CMDL), Faculty of Associated Medical Sciences, Khon Kaen University) ; Cretich, Marina (Istituto di Chimica del Riconoscimento Molecolare, Consiglio Nazionale delle Ricerche) ; Daura i Ribera, Xavier (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Bolognesi, Martino (Università degli Studi di Milano. Centro di Eccellenza Interdisciplinare Materiali e Interfacce Nanostrutturati) ; Colombo, Giorgio (Consiglio Nazionale delle Ricerche. Istituto di Chimica del Riconoscimento Molecolare) ; Gourlay, Louise J. (Università degli Studi di Milano. Centro di Eccellenza Interdisciplinare Materiali e Interfacce Nanostrutturati)
Due to significant advances in computational biology, protein prediction, together with antigen and epitope design, have rapidly moved from conventional methods, based on experimental approaches, to in silico-based bioinformatics methods. [...]
2018 - 10.3390/antib7030026
Antibodies, Vol. 7 (2018) , p. 1-14  
6.
8 p, 975.2 KB Quorum sensing signaling and quenching in the multidrug-resistant pathogen stenotrophomonas maltophilia / Huedo Moreno, Pol (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Coves, Xavier (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Daura i Ribera, Xavier (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Gibert, Isidre (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Yero Corona, Daniel (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Stenotrophomonas maltophilia is an opportunistic Gram-negative pathogen with increasing incidence in clinical settings. The most critical aspect of S. maltophilia is its frequent resistance to a majority of the antibiotics of clinical use. [...]
2018 - 10.3389/fcimb.2018.00122
Frontiers in cellular and infection microbiology, Vol. 8 (April 2018) , art. 122  
7.
20 p, 2.1 MB Sequence- and structure-based immunoreactive epitope discovery for Burkholderia pseudomallei flagellin / Nithichanon, Arnone (Khon Kaen University. Centre for Research and Development of Medical Diagnostic Laboratories) ; Rinchai, Darawan (Khon Kaen University. Centre for Research and Development of Medical Diagnostic Laboratories) ; Gori, Alessandro (Consiglio Nazionale delle Ricerche. Istituto di Chimica del Riconoscimento Molecolare) ; Lassaux, Patricia (Università degli Studi di Milano. Centro di Eccellenza Interdisciplinare Materiali e Interfacce Nanostrutturati) ; Peri, Claudio (Consiglio Nazionale delle Ricerche. Istituto di Chimica del Riconoscimento Molecolare) ; Conchillo-Solé, Oscar (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Ferrer Navarro, Mario (Universitat de Barcelona. Departament de Microbiologia Clínica) ; Gourlay, Louise J. (Università degli Studi di Milano. Centro di Eccellenza Interdisciplinare Materiali e Interfacce Nanostrutturati) ; Nardini, Marco (Università degli Studi di Milano. Centro di Eccellenza Interdisciplinare Materiali e Interfacce Nanostrutturati) ; Vila, Jordi (Universitat de Barcelona. Departament de Microbiologia Clínica) ; Daura i Ribera, Xavier (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Colombo, Giorgio (Consiglio Nazionale delle Ricerche. Istituto di Chimica del Riconoscimento Molecolare) ; Bolognesi, Martino (Università degli Studi di Milano. Centro di Eccellenza Interdisciplinare Materiali e Interfacce Nanostrutturati) ; Lertmemonkolchai, Ganjana (Khon Kaen University. Centre for Research and Development of Medical Diagnostic Laboratories)
Burkholderia pseudomallei is a Gram-negative bacterium responsible for melioidosis, a serious and often fatal infectious disease that is poorly controlled by existing treatments. Due to its inherent resistance to the major antibiotic classes and its facultative intracellular pathogenicity, an effective vaccine would be extremely desirable, along with appropriate prevention and therapeutic management. [...]
2015 - 10.1371/journal.pntd.0003917
PLoS neglected tropical diseases, Vol. 9, Issue 7 (July 2015) , e0003917  
8.
7 p, 1.8 MB PrionW : a server to identify proteins containing glutamine/asparagine rich prion-like domains and their amyloid cores / Zambrano, Rafael (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Conchillo-Solé, Óscar (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Iglesias, Valentin (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Illa, Ricard (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biomedicina Molecular) ; Rousseau, Frederic (KU Leuven. Department for Cellular and Molecular Medicine) ; Schymkowitz, Joost (KU Leuven. Department for Cellular and Molecular Medicine) ; Sabate, Raimon (Universitat de Barcelona. Departament de Fisicoquímica) ; Daura i Ribera, Xavier (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular)
Prions are a particular type of amyloids with the ability to self-perpetuate and propagate in vivo. Prion-like conversion underlies important biological processes but is also connected to human disease. [...]
2015 - 10.1093/nar/gkv490
Nucleic acids research, Vol. 43 (2015) , Web Server issue W331-W337  
9.
12 p, 984.2 KB Human leukocyte antigen (HLA)-DRB1*15:01 and HLA-DRB5*01:01 present complementary peptide repertoires / Scholz, Erika Margaret (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Marcilla, Miguel (Centro Nacional de Biotecnología (Espanya). Unidad de Proteómica) ; Daura i Ribera, Xavier (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Arribas-Layton, David (Benaroya Research Institute at Virginia Mason) ; James, Eddie A. (Benaroya Research Institute at Virginia Mason) ; Álvarez Angulo, Iñaki (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia. Unitat de Fisiologia)
Human leukocyte antigen (HLA)-DR15 is a haplotype associated with multiple sclerosis. It contains the two DRB* genes DRB1*1501 (DR2b) and DRB5*0101 (DR2a). The reported anchor motif of the corresponding HLA-DR molecules was determined in 1994 based on a small number of peptide ligands and binding assays. [...]
2017 - 10.3389/fimmu.2017.00984
Frontiers in immunology, Vol. 8 (Aug. 2017) , art. 984  
10.
35 p, 1.1 MB Conformational and functional variants of CD44-targeted protein nanoparticles bio-produced in bacteria. / Pesarrodona Roches, Mireia (Universitat Autònoma de Barcelona. Department de Genètica i de Microbiologia) ; Fernández, Yolanda (CIBER de Bioingeniería, Biomateriales y Nanomedicina (Barcelona)) ; Foradada, Laia (Hospital Vall d'Hebron. CIBBIM-Nanomedicine) ; Sánchez Chardi, Alejandro (Universitat Autònoma de Barcelona. Servei de Microscòpia) ; Conchillo-Solé, Oscar (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Unzueta Elorza, Ugutz (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Xu, Zhikun (CIBER de Bioingeniería, Biomateriales y Nanomedicina (Barcelona)) ; Roldán, Mónica (Universitat Autònoma de Barcelona. Servei de Microscòpia) ; Villegas Hernández, Sandra (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Ferrer Miralles, Neus (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Schwartz, Simó (CIBER de Bioingeniería, Biomateriales y Nanomedicina (Barcelona)) ; Rinas, Ursula (Leibniz University of Hannover. Technical Chemistry & Life Science) ; Daura i Ribera, Xavier (Institució Catalana de Recerca i Estudis Avançats) ; Abasolo, Ibane (CIBER de Bioingeniería, Biomateriales y Nanomedicina (Barcelona)) ; Vázquez, Esther (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Biofabrication is attracting interest as a means to produce nanostructured functional materials because of its operational versatility and full scalability. Materials based on proteins are especially appealing, as the structure and functionality of proteins can be adapted by genetic engineering. [...]
2016
Biofabrication, Vol. 8 Núm 2 (Abril 2016) , p. 25001  

Artículos : Encontrados 24 registros   1 - 10siguientefinal  ir al registro:
Documentos de investigación Encontrados 3 registros  
1.
199 p, 2.7 MB Evaluation of clinical strategies to cure HIV-1 infection in patients receiving antiretroviral therapy / Morón López, Sara ; Martínez Picado, Francisco Javier, dir. ; Daura i Ribera, Xavier, dir. ; Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular
El desenvolupament de fàrmacs que inhibeixen el cicle de replicació del virus de la immunodeficiència humana tipus 1 (VIH-1), coneguts com teràpia antiretroviral combinada (TAR), va ser un dels majors èxits clínics del segle XX. [...]
El desarrollo de fármacos que inhiben el ciclo de replicación del virus de la inmunodeficiencia humana tipo 1 (VIH-1), conocidos como terapia antirretroviral combinada (TAR), fue uno de los mayores éxitos clínicos del siglo XX. [...]
The development of drugs that inhibit the human immunodeficiency virus type 1 (HIV-1) replication cycle, known as combination antiretroviral therapy (ART), was one of the major clinical successes of the 20th century. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2016  
2.
93 p, 2.4 MB Structure and evolution of protein allosteric sites / Panjkovich, Alejandro ; Daura i Ribera, Xavier, dir. (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí"
La presente tesis estudia los sitios alostéricos desde una perspectiva estructural y evolutiva. La regulación alostérica es un aspecto fundamental de la vida a nivel molecular, ya que es el mecanismo más potente y frecuente en la regulación de la actividad proteica: mediante la unión de un ligando a un sitio que no es el sitio activo. [...]
This thesis studies protein allosteric sites from a structural and evolutionary perspective. Allostery is a fundamental aspect of life at the molecular level, the most common and powerful mechanism of protein activity regulation: through binding of a ligand to a site which is not the active site. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2014  
3.
240 p, 4.8 MB Estudio estructural y funcional de un inhibidor proteínico monodominio de doble faz, sermetstatina, en complejo con dos peptidasas de diferente clase, subtilisina y esnapalisina / Trillo Muyo, Sergio ; Gomis Rüth, F. Xavier, dir. (Institut de Biologia Molecular de Barcelona) ; López Arolas, Joan, dir. (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Daura i Ribera, Xavier, tutor (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí"
Los Inhibidores de peptidasas representan un mecanismo fisiológico para la regulación de las enzimas proteolíticas. Mientras que mayoría de los inhibidores monodominio tienen un único sitio reactivo mediante el cual interaccionan con sus peptidasas dianas de un tipo catalítico específico, algunos de ellos inhiben dos moléculas de peptidasa simultáneamente, dando lugar a la formación de complejos ternarios. [...]
Protein inhibitors provide a physiological mechanism for the regulation of proteolytic enzymes. While most single-domain inhibitors have one reactive site with which they target peptidases of a specific catalytic class, selected specimens inhibit two peptidase molecules simultaneously, thus giving rise to ternary complexes. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2013  

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