Results overview: Found 6 records in 0.02 seconds.
Articles, 6 records found
Articles 6 records found  
1.
17 p, 2.4 MB Epigenomic profiling of primate lymphoblastoid cell lines reveals the evolutionary patterns of epigenetic activities in gene regulatory architectures / García Perez, Raquel (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ; Esteller-Cucala, Paula (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ; Mas, Glòria (Centre de Regulació Genòmica) ; Lobón, Irene (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ; Di Carlo, Valerio (Centre de Regulació Genòmica) ; Riera, Meritxell (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ; Kuhlwilm, Martin (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ; Navarro, Arcadi (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ; Blancher, Antoine (Centre de Physiopathologie Toulouse-Purpan) ; Di Croce, Luciano (Centre de Regulació Genòmica) ; Gomez-Skarmeta, José Luis (Centro Andaluz de Biología del Desarrollo) ; Juan, David (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ; Marques-Bonet, Tomas (Institut Català de Paleontologia Miquel Crusafont)
Changes in the epigenetic regulation of gene expression have a central role in evolution. Here, we extensively profiled a panel of human, chimpanzee, gorilla, orangutan, and macaque lymphoblastoid cell lines (LCLs), using ChIP-seq for five histone marks, ATAC-seq and RNA-seq, further complemented with whole genome sequencing (WGS) and whole genome bisulfite sequencing (WGBS). [...]
2021 - 10.1038/s41467-021-23397-1
Nature communications, Vol. 12 (May 2021) , art. 3116  
2.
32 p, 2.0 MB Comprehensive identification of somatic nucleotide variants in human brain tissue / Wang, Yifan (University of Michigan Medical School. Department of Computational Medicine and Bioinformatics) ; Bae, Taejeong (Mayo Clinic. Center for Individualized Medicine. Department of Health Sciences Research) ; Thorpe, Jeremy (Johns Hopkins School of Medicine. Program in Biochemistry, Cellular and Molecular Biology) ; Sherman, Maxwell A. (Harvard Medical School) ; Jones, Attila G. (Icahn School of Medicine at Mount Sinai. Department of Genetics and Genomic Sciences) ; Cho, Sean (Kennedy Krieger Institute. Department of Neurology) ; Daily, Kenneth (Sage Bionetworks (Seattle, Estats Units)) ; Dou, Yanmei (Harvard Medical School. Department of Biomedical Informatics) ; Ganz, Javier (Harvard Medical School. Departments of Neurology and Pediatrics) ; Galor, Alon (Harvard Medical School. Department of Biomedical Informatics) ; Lobon, Irene (Universitat de Barcelona. Departament de Biologia Cel·lular, Fisiologia i Immunologia) ; Pattni, Reenal (Stanford University School of Medicine. Department of Genetics) ; Rosenbluh, Chaggai (Icahn School of Medicine at Mount Sinai. Department of Cell, Developmental and Regenerative Biology) ; Tomasi, Simone (Yale University. Child Study Center) ; Tomasini, Livia (Yale University. Child Study Center) ; Yang, Xiaoxu (Rady Children's Institute for Genomic Medicine) ; Zhou, Bo (Stanford University School of Medicine. Department of Genetics) ; Akbarian, Schahram (Icahn School of Medicine at Mount Sinai. Department of Psychiatry) ; Ball, Laurel L. (Rady Children's Institute for Genomic Medicine) ; Bizzotto, Sara (Broad Institute of MIT and Harvard) ; Emery, Sarah B. (University of Michigan Medical School. Department of Human Genetics) ; Doan, Ryan (Broad Institute of MIT and Harvard) ; Fasching, Liana (Yale University. Child Study Center) ; Jang, Yeongjun (Mayo Clinic. Center for Individualized Medicine. Department of Health Sciences Research) ; Juan, David (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ; Lizano, Esther (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ; Luquette, Lovelace J. (Harvard Medical School. Department of Biomedical Informatics) ; Moldovan, John B. (University of Michigan Medical School. Department of Human Genetics) ; Narurkar, Rujuta (Lieber Institute for Brain Development) ; Oetjens, Matthew T. (University of Michigan Medical School. Department of Human Genetics) ; Rodin, Rachel E. (Broad Institute of MIT and Harvard) ; Sekar, Shobana (Mayo Clinic. Center for Individualized Medicine. Department of Health Sciences Research) ; Shin, Joo Heon (Johns Hopkins School of Medicine. Department of Neurology) ; Soriano García, Eduardo (Universitat de Barcelona. Departament de Biologia Cel·lular, Fisiologia i Immunologia) ; Straub, Richard E. (Lieber Institute for Brain Development) ; Zhou, Weichen (University of Michigan Medical School. Department of Computational Medicine and Bioinformatics) ; Chess, Andrew (Icahn School of Medicine at Mount Sinai. Department of Genetics and Genomic Sciences) ; Gleeson, Joseph G. (Rady Children's Institute for Genomic Medicine) ; Marques-Bonet, Tomas (Institut Català de Paleontologia Miquel Crusafont) ; Park, Peter J. (Harvard Medical School. Department of Biomedical Informatics) ; Peters, Mette A. (Sage Bionetworks) ; Pevsner, Jonathan (Johns Hopkins School of Medicine. Department of Psychiatry and Behavioral Sciences) ; Walsh, Christopher A. (Broad Institute of MIT and Harvard) ; Weinberger, Daniel R. (Johns Hopkins School of Medicine. Department of Neuroscience) ; Vaccarino, Flora M. (Yale University. Department of Neuroscience) ; Moran, John V. (University of Michigan Medical School. Department of Internal Medicine) ; Urban, Alexander E. (Stanford University School of Medicine. Department of Psychiatry and Behavioral Sciences) ; Kidd, Jeffrey M. (University of Michigan Medical School. Department of Computational Medicine and Bioinformatics) ; Mills, Ryan E. (University of Michigan Medical School. Department of Computational Medicine and Bioinformatics) ; Abyzov, Alexej (Mayo Clinic. Center for Individualized Medicine. Department of Health Sciences Research) ; Brain Somatic Mosaicism Network
Post-zygotic mutations incurred during DNA replication, DNA repair, and other cellular processes lead to somatic mosaicism. Somatic mosaicism is an established cause of various diseases, including cancers. [...]
2021 - 10.1186/s13059-021-02285-3
Genome biology, Vol. 22 (march 2021)  
3.
9 p, 2.2 MB Extreme differences between human germline and tumor mutation densities are driven by ancestral human-specific deviations / Heredia-Genestar, José María (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ; Marques-Bonet, Tomas (Institut Català de Paleontologia Miquel Crusafont) ; Juan, David (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ; Navarro, Arcadi (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona))
Mutations do not accumulate uniformly across the genome. Human germline and tumor mutation density correlate poorly, and each is associated with different genomic features. Here, we use non-human great ape (NHGA) germlines to determine human germline- and tumor-specific deviations from an ancestral-like great ape genome-wide mutational landscape. [...]
2020 - 10.1038/s41467-020-16296-4
Nature communications, Vol. 11 (May 2020) , art. 2512  
4.
35 p, 2.6 MB Copy number variants and fixed duplications among 198 rhesus macaques (Macaca mulatta) / Brasó-Vives, Marina (Laboratoire de Biométrie et Biologie Évolutive UMR 5558, Université de Lyon, Université Lyon 1, CNRS, Villeurbanne, France) ; Povolotskaya, Inna S. (Veltischev Research and Clinical Institute for Pediatrics of the Pirogov Russian National Research Medical University, Moscow, Russia) ; Hartasánchez, Diego A. (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ; Farré, Xavier (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ; Fernández , Marcos (National Centre for Genomic Analysis-Centre for Genomic Regulation, Barcelona Institute of Science and Technology, Barcelona, Catalonia, Spain) ; Raveendran, Muthuswamy (Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America) ; Harris, R. Alan (Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America) ; Rosene, Douglas L. (Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, Massachusetts, United States of America) ; Lorente-Galdos, Belen (Department of Neuroscience, Yale School of Medicine, New Haven, Connecticut, United States of America) ; Navarro, A, 1975- (Institució Catalana de Recerca i Estudis Avançats) ; Marques-Bonet, Tomas, 1975- (Institut Català de Paleontologia Miquel Crusafont) ; Rogers, Jeffrey (Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America) ; Juan, David (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona))
The rhesus macaque is an abundant species of Old World monkeys and a valuable model organism for biomedical research due to its close phylogenetic relationship to humans. Copy number variation is one of the main sources of genomic diversity within and between species and a widely recognized cause of inter-individual differences in disease risk. [...]
2020 - 10.1371/journal.pgen.1008742
PLoS Genetics, Vol. 16 (may 2020)  
5.
8 p, 1.1 MB Selective single molecule sequencing and assembly of a human Y chromosome of African origin / Kuderna, Lukas (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ; Lizano, Esther (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ; Julià, Eva (Institut Hospital del Mar d'Investigacions Mèdiques) ; Gómez-Garrido, Jessica (Centre de Regulació Genòmica) ; Serres-Armero, Aitor (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ; Kuhlwilm, Martin (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ; Antoni Alandes, Regina (Centre de Regulació Genòmica) ; Alvarez-Estape, Marina (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ; David Juan (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ; Heath, Simon (Centre de Regulació Genòmica) ; Alioto, Tyler (Centre de Regulació Genòmica) ; Gut, Marta (Centre de Regulació Genòmica) ; Gut, Ivo (Centre de Regulació Genòmica) ; Heide Schierup, Mikkel (Aarhus University. Bioinformatics Research Center) ; Fornas, Oscar (Centre de Regulació Genòmica) ; Marques-Bonet, Tomas, 1975- (Institut Català de Paleontologia Miquel Crusafont)
Mammalian Y chromosomes are often neglected from genomic analysis. Due to their inherent assembly difficulties, high repeat content, and large ampliconic regions, only a handful of species have their Y chromosome properly characterized. [...]
2019 - 10.1038/s41467-018-07885-5
Nature communications, Vol. 10 (January 2019) , art. 4  
6.
24 p, 190.5 KB Imaginación y reacción en los Campamentos de refugiados saharauis : construcción de la cotidianeidad e identidad frente al otro extranjero (nasrani) en el contexto de la diáspora / Juan Canales, David de
Los Campamentos de refugiados son una parte dramática de la historia del pueblo saharaui con poca referencia bibliográfica. Esta situación ha impuesto una serie de límites ante los cuales la imaginación de la sociedad civil ha reaccionado y ha generado un espacio alternativo donde vivir. [...]
Saharawi refugee camps, with little references, are part of the recent tragic history. This situation has imposed a series of limits to which the imagination of civil society has reacted and has generated an alternative space in which to live. [...]

2009 - 10.5565/rev/periferia.523
Perifèria : revista de recerca i formació en antropologia, Núm. 10 (2009)  

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