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Resultados globales: 7 registros encontrados en 0.03 segundos.
Artículos, Encontrados 7 registros
Artículos Encontrados 7 registros  
1.
7 p, 2.8 MB Paper-Based Analytical Devices for Accurate Assessment of Transferrin Saturation in Diagnosed Clinical Samples from Ischemic Stroke Patients / Dortez, Silvia (Universidad de Alcalá) ; De Gregorio-Rocasolano, Nuria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Millán, Mònica (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Gasull Dalmau, Teresa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Crevillen, Agustín G. (Universidad Nacional de Educacion a Distancia (UNED)) ; Escarpa, Alberto (Universidad de Alcalá) ; Universitat Autònoma de Barcelona
For the first time, a paper-based analytical device (PAD) was developed for the assessment of transferrin saturation (TSAT), which is defined as the ratio between iron bound to transferrin (Tf) and the total iron-binding capacity (TIBC) of Tf. [...]
2023 - 10.1021/acs.analchem.3c01982
Analytical chemistry, Vol. 95 (07 2023) , p. 12391-12397  
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2.
18 p, 4.0 MB Targeting Pro-Oxidant Iron with Exogenously Administered Apotransferrin Provides Benefits Associated with Changes in Crucial Cellular Iron Gate Protein TfR in a Model of Intracerebral Hemorrhagic Stroke in Mice / García Serran, Alexia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Ordoño, Jesus (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; De Gregorio-Rocasolano, Nuria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Melià Sorolla, Marc (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Odendaal, Karla (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Martí-Sistac, Octavi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Gasull Dalmau, Teresa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Universitat Autònoma de Barcelona
We have previously demonstrated that the post-stroke administration of iron-free transferrin (apotransferrin, ATf) is beneficial in different models of ischemic stroke (IS) through the inhibition of the neuronal uptake of pro-oxidant iron. [...]
2023 - 10.3390/antiox12111945
Antioxidants, Vol. 12 Núm. 11 (October 2023)  
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3.
16 p, 7.7 MB Establishment of a reproducible and minimally invasive ischemic stroke model in swine / Castaño, Carlos (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Melià Sorolla, Marc (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; García Serran, Alexia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; De Gregorio-Rocasolano, Nuria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; García-Sort, Maria Rosa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Hernández-Pérez, María (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Valls-Carbó, Adrián (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Pino, Osvaldo (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Grífols, Jordi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Iruela-Sánchez, Alba (Canon Medical Systems) ; Palomar-García, Alicia (Canon Medical Systems) ; Puig, Josep (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Martí-Sistac, Octavi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Dávalos, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Gasull Dalmau, Teresa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Universitat Autònoma de Barcelona
The need for advances in the management/treatment options for ischemic stroke patients requires that upcoming preclinical research uses animals with more human-like brain characteristics. The porcine brain is considered appropriate, although the presence of the rete mirabile (RM) prevents direct catheterization of the intracranial arteries to produce focal cerebral ischemia. [...]
2023 - 10.1172/jci.insight.163398
JCI Insight, Vol. 8 (april 2023)  
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4.
15 p, 1.7 MB Article targeting pro-oxidant iron with deferoxamine as a treatment for ischemic stroke : safety and optimal dose selection in a randomized clinical trial / Millán, Mónica (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; De Gregorio-Rocasolano, Nuria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; de la Ossa Pérez, Natàlia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Reverté, Silvia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Costa, Joan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Giner, Pilar (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Silva, Yolanda (Hospital Universitari de Girona Doctor Josep Trueta) ; Sobrino, Tomás (Hospital Clínico Universitario (Santiago de Compostela, Galícia)) ; Rodríguez-Yáñez, Manuel (Hospital Clínico Universitario. Departamento de Neurología) ; Nombela, Florentino (Hospital Universitario de la Princesa (Madrid)) ; Campos, Francisco (Hospital Clínico Universitario (Santiago de Compostela, Galícia)) ; Serena, Joaquín (Hospital Universitari de Girona Doctor Josep Trueta) ; Vivancos, José (Hospital Universitario de la Princesa (Madrid)) ; Martí-Sistac, Octavi (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Cortés, Jordi (Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa) ; Dávalos, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Gasull Dalmau, Teresa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
A role of iron as a target to prevent stroke-induced neurodegeneration has been recently revisited due to new evidence showing that ferroptosis inhibitors are protective in experimental ischemic stroke and might be therapeutic in other neurodegenerative brain pathologies. [...]
2021 - 10.3390/antiox10081270
Antioxidants, Vol. 10, p. 1270  
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5.
21 p, 4.5 MB Comparative Proteomics Unveils LRRFIP1 as a New Player in the DAPK1 Interactome of Neurons Exposed to Oxygen and Glucose Deprivation / De Gregorio-Rocasolano, Nuria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Guirao, Verónica (Institut Germans Trias i Pujol) ; Ponce, Jovita (Institut Germans Trias i Pujol) ; Melià Sorolla, Marc (Institut Germans Trias i Pujol) ; Aliena-Valero, Alicia (Universitat de València. Unidad Mitxa de Investigación Cerebrovascular) ; García Serran, Alexia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Salom, Juan B. (Universitat de València. Unidad Mitxa de Investigación Cerebrovascular) ; Dávalos, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Martí-Sistac, Octavi (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Gasull Dalmau, Teresa (Institut Germans Trias i Pujol)
Death-associated protein kinase 1 (DAPK1) is a pleiotropic hub of a number of networked distributed intracellular processes. Among them, DAPK1 is known to interact with the excitotoxicity driver NMDA receptor (NMDAR), and in sudden pathophysiological conditions of the brain, e. [...]
2020 - 10.3390/antiox9121202
Antioxidants, Vol. 9 Núm. 12 (2020) , p. 1202  
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6.
30 p, 861.2 KB Relevance of Porcine Stroke Models to Bridge the Gap from Pre-Clinical Findings to Clinical Implementation / Melià Sorolla, Marc (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; De Gregorio-Rocasolano, Nuria (Institut Germans Trias i Pujol) ; Rodríguez-Esparragoza, Luis (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Dávalos, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Martí-Sistac, Octavi (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Gasull Dalmau, Teresa (Institut Germans Trias i Pujol) ; Castaño, Carlos (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
In the search of animal stroke models providing translational advantages for biomedical research, pigs are large mammals with interesting brain characteristics and wide social acceptance. Compared to rodents, pigs have human-like highly gyrencephalic brains. [...]
2020 - 10.3390/ijms21186568
International journal of molecular sciences, Vol. 21 Núm. 18 (2020) , p. 6568  
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7.
17 p, 2.0 MB Deciphering the iron side of stroke : Neurodegeneration at the crossroads between iron dyshomeostasis, excitotoxicity, and ferroptosis / De Gregorio-Rocasolano, Nuria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Martí-Sistac, O. (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Gasull Dalmau, Teresa (Institut Germans Trias i Pujol)
In general, iron represents a double-edged sword in metabolism in most tissues, especially in the brain. Although the high metabolic demands of brain cells require iron as a redox-active metal for ATP-producing enzymes, the brain is highly vulnerable to the devastating consequences of excessive iron-induced oxidative stress and, as recently found, to ferroptosis as well. [...]
2019 - 10.3389/fnins.2019.00085
Frontiers in Neuroscience, Vol. 13 Núm. FEB (2019) , p. 85  
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