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1.
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13 p, 1.9 MB |
Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis : A systematic review and meta-analysis
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Hegen, Harald (Medical University of Innsbruck) ;
Walde, Janette (University of Innsbruck) ;
Berek, Klaus (University of Innsbruck) ;
Arrambide, Georgina (Hospital Universitari Vall d'Hebron) ;
Gnanapavan, Sharmilee (Queen Mary University of London) ;
Kaplan, Batia (Sheba Medical Center (Israel)) ;
Khalil, Michael (Medical University of Graz) ;
Saadeh, Ruba (Clínica Mayo) ;
Teunissen, Charlotte E (Vrije Universiteit) ;
Tumani, Hayrettin (University of Ulm) ;
Villar, Luisa M (Hospital Universitario Ramón y Cajal (Madrid)) ;
Willrich, Maria Alice V (Clínica Mayo) ;
Zetterberg, Henrik (Sahlgrenska University Hospital (Suècia)) ;
Deisenhammer, Florian ;
Universitat Autònoma de Barcelona
Intrathecal immunoglobulin-G synthesis is a hallmark of multiple sclerosis (MS), which can be detected by oligoclonal IgG bands (OCB) or by κ-free light chains (κ-FLC) in cerebrospinal fluid. To perform a systematic review and meta-analysis to evaluate whether κ-FLC index has similar diagnostic value to identify patients with clinically isolated syndrome (CIS) or MS compared to OCB, and to determine κ-FLC index cut-off. [...]
2022 -  10.1177/13524585221134213
Multiple sclerosis, Vol. 29 (december 2022) , p. 169-181
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2.
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14 p, 1.1 MB |
Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis : A consensus statement
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Hegen, Harald (Medical University of Innsbruck) ;
Arrambide, Georgina (Hospital Universitari Vall d'Hebron) ;
Gnanapavan, Sharmilee (Queen Mary University of London) ;
Kaplan, Batia (Sheba Medical Center) ;
Khalil, Michael (Medical University of Graz) ;
Saadeh, Ruba (Mayo Clinic (Rochester)) ;
Teunissen, Charlotte E (Amsterdam UMC) ;
Tumani, Hayrettin (University of Ulm) ;
Villar, Luisa Maria (Hospital Universitario Ramón y Cajal (Madrid)) ;
Willrich, Maria Alice V (Mayo Clinic) ;
Zetterberg, Henrik (Sahlgrenska University Hospital (Suècia)) ;
Deisenhammer, Florian (Medical University of Innsbruck) ;
Universitat Autònoma de Barcelona
Cerebrospinal fluid (CSF) analysis is of utmost importance for diagnosis and differential diagnosis of patients with suspected multiple sclerosis (MS). Evidence of intrathecal immunoglobulin G (IgG) synthesis proves the inflammatory nature of the disease, increases diagnostic certainty and substitutes for dissemination in time according to current diagnostic criteria. [...]
2022 - 10.1177/13524585221134217
Multiple sclerosis, Vol. 29 (december 2022) , p. 182-195
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3.
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27 p, 1.5 MB |
Clinicogenomic factors of biotherapy immunogenicity in autoimmune disease : A prospective multicohort study of the ABIRISK consortium
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Hässler, Signe (Hôpital Pitié-Salpêtrière) ;
Bachelet, Delphine (Hôpital Bichat) ;
Duhaze, Julianne (CHU Ste-Justine Research Center) ;
Szely, Natacha (Paris-Sud University) ;
Gleizes, Aude (Le Kremlin-Bicêtre Hospital) ;
Hacein-Bey Abina, Salima (Paris-Descartes-Sorbonne-Cite University) ;
Aktas, Orhan (University of Düsseldorf) ;
Auer, Michael (Innsbruck Medical University) ;
Avouac, Jerôme (Cochin Hospital) ;
Birchler, Mary (GlaxoSmithKline (Estats Units d'Amèrica)) ;
Bouhnik, Yoram (GETAID (França)) ;
Brocq, Olivier (Princess Grace Hospital) ;
Buck-Martin, Dorothea (Technische Universität München) ;
Cadiot, Guillaume (University Hospital of Reims) ;
Carbonnel, Franck (Hôpital Kremlin-Bicêtre) ;
Chowers, Yehuda (Rambam Health Care Campus) ;
Comabella, Manuel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Derfuss, Tobias (University Hospital Basel (Basilea, Suïssa)) ;
Sikkema, Dan (University of Amsterdam) ;
Donnellan, Naoimh (Ipsen Biopharm (Regne Unit)) ;
Doukani, Abiba (Sorbonne Université) ;
Guger, Michael (Kepler University Hospital) ;
Hartung, Hans-Peter (University of Düsseldorf) ;
Kubala Havrdova, Eva (Charles University and General University Hospital, Prague, Czech Republic) ;
Hemmer, Bernhard (Munich Cluster for Systems Neurology) ;
Huizinga, Tom (Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands) ;
Ingenhoven, Kathleen (University of Düsseldorf, Medical Faculty, Department of Neurology, Düsseldorf, Germany) ;
Hyldgaard-Jensen, Poul Erik (Copenhagen University Hospital Rigshospitalet) ;
Jury, Elizabeth C. (University College London) ;
Khalil, Michael (Medical University of Graz) ;
Kieseier, Bernd (University of Düsseldorf) ;
Lindberg, Raija (University Hospital Basel (Basilea, Suïssa)) ;
Loercher, Amy (GlaxoSmithKline (Estats Units d'Amèrica)) ;
Maggi, Enrico (Bambino Gesù Children's Hospital) ;
Manson, Jessica (University College London Hospital) ;
Mauri, Claudia (University College London) ;
Mohand Oumoussa, Badreddine (Sorbonne Université) ;
Montalban, Xavier (St. Michael's Hospital) ;
Nachury, Maria (University Hospital of Lille (França)) ;
Nytrova, Petra (Charles University. Faculty of Medicine in Hradec Králové) ;
Richez, Christophe (Bordeaux University) ;
Ryner, Malin (Karolinska Institutet (Estocolm, Suècia)) ;
Sellebjerg, Finn (Copenhagen University Hospital Rigshospitalet) ;
Sievers, Claudia (University Hospital Basel (Basilea, Suïssa)) ;
Sikkema, Dan (Quanterix Corporation (Estats Units d'Amèrica)) ;
Soubrier, Martin (University Hospital of Clermont Ferrand) ;
Tourdot, Sophie (Paris-Sud University) ;
Trang, Caroline (CHU de Nantes) ;
Vultaggio, Alessandra (Università di Firenze) ;
Warnke, Clemens (University Hospital Köln) ;
Spindeldreher, Sebastian (Integrated Biologix GmbH (Suïssa)) ;
Dönnes, Pierre (SciCross AB (Suècia)) ;
Hickling, Timothy P. (Pfizer (Estats Units d'Amèrica)) ;
Hincelin Mery, Agnès (Sanofi, Chilly-Mazarin, France) ;
Allez, Matthieu (Hôpital Saint-Louis, AP-HP) ;
Deisenhammer, Florian (Innsbruck Medical University) ;
Fogdell-Hahn, Anna (Karolinska Institutet (Estocolm, Suècia)) ;
Mariette, Xavier (Université Paris-Saclay) ;
Pallardy, Marc (Paris-Sud University) ;
Broët, Philippe (Paris-Sud University Hospitals) ;
Universitat Autònoma de Barcelona
Biopharmaceutical products (BPs) are widely used to treat autoimmune diseases, but immunogenicity limits their efficacy for an important proportion of patients. Our knowledge of patient-related factors influencing the occurrence of antidrug antibodies (ADAs) is still limited. [...]
2020 - 10.1371/journal.pmed.1003348
PLoS Medicine, Vol. 17 (october 2020)
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4.
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11 p, 5.6 MB |
New Algorithms Improving PML Risk Stratification in MS Patients Treated With Natalizumab
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Toboso, Inmaculada (Hospital Universitario Ramón y Cajal (Madrid)) ;
Tejeda-Velarde, Amalia (Hospital Universitario Ramón y Cajal (Madrid)) ;
Alvarez-Lafuente, Roberto (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ;
Arroyo, Rafael (Hospital Universitario Quiron Salud) ;
Hegen, Harald (Medical University of Innsbruck) ;
Deisenhammer, Florian (Medical University of Innsbruck) ;
Sainz de la Maza, Susana (Hospital Universitario Ramón y Cajal (Madrid)) ;
Alvarez-Cermeño, José C. (Hospital Universitario Ramón y Cajal (Madrid)) ;
Izquierdo, Guillermo (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ;
Paramo, Dolores (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ;
Oliva, Pedro (Hospital Universitario Central de Asturias) ;
Casanova, Bonaventura (Hospital Universitari i Politècnic La Fe (València)) ;
Agüera-Morales, Eduardo (Hospital Universitario Reina Sofía (Còrdova, Espanya)) ;
Franciotta, Diego (Istituti di Recovero e Cura a Carattere Scientifico (IRCCS) Mondino Foundation) ;
Gastaldi, Matteo (Istituti di Recovero e Cura a Carattere Scientifico (IRCCS) Mondino Foundation) ;
Fernández, Oscar (Hospital Regional Universitario de Málaga) ;
Urbaneja, Patricia (Hospital Regional Universitario de Málaga) ;
Garcia-Dominguez, José M. (Hospital General Universitario Gregorio Marañón) ;
Romero, Fernando (Hospital General Universitario Gregorio Marañón) ;
Laroni, Alicia (University of Genoa, Ospedale Policlinico San Martino) ;
Uccelli, Antonio (University of Genoa, Ospedale Policlinico San Martino) ;
Perez-Sempere, Angel (Hospital General Universitario de Alicante (Alacant, País Valencià)) ;
Saiz, Albert (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Blanco, Yolanda (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Galimberti, Daniela (University of Milan) ;
Scarpini, Elio (University of Milan) ;
Espejo, Carmen (Hospital Universitari Vall d'Hebron) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron) ;
Rasche, Ludwig (Humboldt-Universität zu Berlin) ;
Paul, Friedemann (Charité - Universitätsmedizin Berlin) ;
González, Inés (Hospital Álvaro Cunqueiro (Vigo)) ;
Álvarez, Elena (Hospital Álvaro Cunqueiro (Vigo)) ;
Ramo-Tello, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Caminero, Ana B. (Hospital Nuestra Señora de Sonsoles (Àvila)) ;
Aladro, Yolanda (Hospital Universitario Getafe) ;
Calles, Carmen (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ;
Eguía, Pablo (Hospital Doctor Jose Molina Orosa) ;
Belenguer-Benavides, Antonio (Consorci Hospitalari Provincial de Castelló) ;
Ramió-Torrentà, Lluís (Hospital Universitari de Girona Doctor Josep Trueta) ;
Quintana, Ester (Hospital Universitari de Girona Doctor Josep Trueta) ;
Martínez-Rodríguez, José E. (Hospital del Mar (Barcelona, Catalunya)) ;
Oterino, Agustín (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) ;
López de Silanes, Carlos (Hospital Universitario de Torrejón) ;
Casanova, Luis I. (Hospital Universitario de Torrejón) ;
Landete Pascual, Lamberto (Hospital Universitari Doctor Peset (València)) ;
Frederiksen, Jette (Glostrup University Hospital Copenhagen) ;
Bsteh, Gabriel (Medical University of Innsbruck) ;
Mulero, P. (Hospital Universitari Vall d'Hebron) ;
Comabella, Manuel (Hospital Universitari Vall d'Hebron) ;
Hernández, Miguel A. (Hospital Universitario Nuestra Señora de Candelaria (Santa Cruz de Tenerife)) ;
Espiño, Mercedes (Hospital Universitario Ramón y Cajal (Madrid)) ;
Prieto, José M. (Hospital Clínico Universitario (Santiago de Compostela, Galícia)) ;
Pérez, Domingo (Hospital del Bierzo (Ponferrada, Lleó)) ;
Otano, María (Complejo Hospitalario de Navarra) ;
Padilla, Francisco (Hospital Universitario Virgen de la Victoria (Màlaga, Andalusia)) ;
García-Merino, Juan A. (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Navarro Cantó, Laura (Hospital General Universitario de Elche) ;
Muriel, Alfonso (Hospital Universitario Ramón y Cajal (Madrid)) ;
Frossard, Lucienne Costa (Hospital Universitario Ramón y Cajal (Madrid)) ;
Villar, Luisa M. (Hospital Universitario Ramón y Cajal (Madrid)) ;
Universitat Autònoma de Barcelona
Overview: We assessed the role of age and disease activity as new factors contributing to establish the risk of progressive multifocal leucoencephalopathy in multiple sclerosis patients treated with natalizumab in 36 University Hospitals in Europe. [...]
2020 - 10.3389/fneur.2020.579438
Frontiers in neurology, Vol. 11 (december 2020)
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5.
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12 p, 774.2 KB |
Kappa free light chains is a valid tool in the diagnostics of MS : A large multicenter study
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Leurs, C. E. ;
Twaalfhoven, HAM ;
Lissenberg-Witte, B. I. ;
van Pesch, V ;
Dujmovic, Irena ;
Drulovic, Jelena ;
Castellazzi, M. ;
Bellini, T. ;
Pugliatti, M. ;
Kuhle, Jens ;
Villar, L. M. ;
Alvarez-Cermeño, José C ;
Alvarez-Lafuente, Roberto ;
Hegen, Harald ;
Deisenhammer, Florian ;
Walchhofer, L. M. ;
Thouvenot, Eric ;
Comabella, Manuel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Montalban, X (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Vécsei, L. ;
Rajda, C. ;
Galimberti, Daniela ;
Scarpini, E. ;
Altintas, Ayse ;
Rejdak, K. ;
Frederiksen, J. L. ;
Pihl-Jensen, G. ;
Jensen, PEH ;
Khalil, Michael ;
Voortman, Margarete ;
Fazekas, F. ;
Saiz, Albert ;
La Puma, D. ;
Vercammen, M. ;
Vanopdenbosch, L. ;
Uitdehaag, BMJ ;
Killestein, Joep ;
Bridel, C. ;
Teunissen, Charlotte E. ;
Universitat Autònoma de Barcelona
To validate kappa free light chain (KFLC) and lambda free light chain (LFLC) indices as a diagnostic biomarker in multiple sclerosis (MS). We performed a multicenter study including 745 patients from 18 centers (219 controls and 526 clinically isolated syndrome (CIS)/MS patients) with a known oligoclonal IgG band (OCB) status. [...]
2019 - 10.1177/1352458519845844
Multiple sclerosis, Vol. 26 (may 2019) , p. 912-923
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