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Association of Apolipoprotein e with Intracerebral Hemorrhage Risk by Race/Ethnicity : A Meta-analysis
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Marini, S. (Massachusetts General Hospital) ;
Crawford, K. (Massachusetts General Hospital) ;
Morotti, A. (Fondazione Mondino IRCCS, Pavia) ;
Lee, M.J. (Massachusetts General Hospital) ;
Pezzini, A. (Università degli Studi di Brescia) ;
Moomaw, C.J. (University of Cincinnati) ;
Flaherty, M.L. (University of Cincinnati) ;
Montaner, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Roquer Gonzalez, Jaume (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Jimenez Conde, Jordi (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Giralt Steinhauer, Eva (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Elosua, Roberto (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Cuadrado Godia, Elisa (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Soriano Tarraga, Carolina (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Slowik, A. (Jagiellonian University Medical College, Kraków) ;
Jagiella, J.M. (Jagiellonian University Medical College, Kraków) ;
Pera, J. (Jagiellonian University Medical College, Kraków) ;
Urbanik, A. (Jagiellonian University Medical College, Kraków) ;
Pichler, A. (Jagiellonian University Medical College, Kraków) ;
Hansen, B.M. (Lund University) ;
McCauley, J.L. (John P. Hussman Institute for Human Genomics, Miami) ;
Tirschwell, D.L. (University of Washington) ;
Selim, M. (Beth Israel Deaconess Medical Center, Boston) ;
Brown, D.L. (University of Michigan) ;
Silliman, S.L. (University of Florida College of Medicine) ;
Worrall, B.B. (University of Virginia Health System) ;
Meschia, J.F. (Mayo Clinic, Jacksonville, Florida) ;
Kidwell, C.S. (University of Arizona) ;
Testai, F.D. (University of Illinois) ;
Kittner, S.J. (University of Maryland School of Medicine) ;
Schmidt, H. (Medical University of Graz) ;
Enzinger, C. (Medical University of Graz) ;
Deary, I.J. (University of Edinburgh) ;
Rannikmae, K. (University of Edinburgh) ;
Samarasekera, N. (University of Edinburgh) ;
Salman, R.A.S. (University of Edinburgh) ;
Sudlow, C.L. (University of Edinburgh) ;
Klijn, C.J.M. (UMC Utrecht Brain Center Rudolf Magnus) ;
Van Nieuwenhuizen, K.M. (UMC Utrecht Brain Center Rudolf Magnus) ;
Fernandez Cadenas, Israel (Institut d'Investigació Biomèdica Sant Pau) ;
Delgado Martínez, María Pilar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Norrving, B. (Lund University) ;
Lindgren, A. (Lund University) ;
Goldstein, J.N. (Massachusetts General Hospital) ;
Viswanathan, A. (Massachusetts General Hospital) ;
Greenberg, S.M. (Massachusetts General Hospital) ;
Falcone, G.J. (Yale University) ;
Biffi, A. (Massachusetts General Hospital) ;
Langefeld, C.D. (Wake Forest University, Winston-Salem, North Carolina) ;
Woo, D. (University of Cincinnati College of Medicine) ;
Rosand, J. (Massachusetts General Hospital) ;
Anderson, C.D. (Massachusetts General Hospital) ;
Universitat Autònoma de Barcelona
Importance: Genetic studies of intracerebral hemorrhage (ICH) have focused mainly on white participants, but genetic risk may vary or could be concealed by differing nongenetic coexposures in nonwhite populations. [...]
2019 -  10.1001/jamaneurol.2018.4519
JAMA Neurology, Vol. 76 Núm. 4 (april 2019) , p. 480-491
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11 p, 168.8 KB |
Genetic variants in CETP increase risk of intracerebral hemorrhage
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Anderson, Christopher D. (Program in Medical and Population Genetics, Broad Institute) ;
Falcone, Guido J. (Departments of Epidemiology and Biostatistics, Harvard T. H. Chan School of Public Health) ;
Phuah, Chia-Ling (Program in Medical and Population Genetics, Broad Institute) ;
Radmanesh, Farid (Program in Medical and Population Genetics, Broad Institute) ;
Brouwers, H. Bart (Program in Medical and Population Genetics, Broad Institute) ;
Battey, Thomas W. K. (Program in Medical and Population Genetics, Broad Institute) ;
Biffi, Alessandro (Division of Psychiatry, Department of Psychiatry, MGH) ;
Peloso, Gina M. (Program in Medical and Population Genetics, Broad Institute) ;
Liu, Dajiang J. (Institute of Personalized Medicine, Penn State College of Medicine) ;
Ayres, Alison M. (J. Philip Kistler Stroke Research Center, Department of Neurology, MGH) ;
Goldstein, Joshua N. (Department of Emergency Medicine, MGH) ;
Viswanathan, Anand (J. Philip Kistler Stroke Research Center, Department of Neurology, MGH) ;
Greenberg, Steven M. (J. Philip Kistler Stroke Research Center, Department of Neurology, MGH) ;
Selim, Magdy (Beth Israel Deaconess Medical Center) ;
Meschia, James F. (Mayo Clinic) ;
Brown, Devin L. (University of Michigan Health System) ;
Worrall, Bradford B. (University of Virginia Health System) ;
Silliman, Scott L. (University of Florida College of Medicine) ;
Tirschwell, David L. (University of Washington) ;
Flaherty, Matthew L. (University of Cincinnati College of Medicine) ;
Kraft, Peter (Departments of Epidemiology and Biostatistics, Harvard T. H. Chan School of Public Health) ;
Jagiella, Jeremiasz M. (Jagiellonian University Medical College) ;
Schmidt, Helena (Medical University Graz) ;
Hansen, Björn M. (Skåne University Hospital) ;
Jimenez-Conde, Jordi (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Giralt Steinhauer, Eva (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Elosua Llanos, Roberto (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Cuadrado-Godia, Elisa (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Soriano Tàrraga, Carolina (Institut Hospital del Mar d'Investigacions Mèdiques) ;
van Nieuwenhuizen, Koen M. (University Medical Center Utrecht) ;
Klijn, Catharina J. M. (Donders Institute for Brain, Cognition, and Behavior, Radboud University Medical Center) ;
Rannikmae, Kristiina (University of Edinburgh) ;
Samarasekera, Neshika (University of Edinburgh) ;
Salman, Rustam Al-Shahi (University of Edinburgh) ;
Sudlow, Catherine L. (University of Edinburgh) ;
Deary, Ian J. (University of Edinburgh) ;
Morotti, Andrea (Neurology Clinic, University of Brescia) ;
Pezzini, Alessandro (Neurology Clinic, University of Brescia) ;
Pera, Joanna (Jagiellonian University Medical College) ;
Urbanik, Andrzej (Jagiellonian University Medical College) ;
Pichler, Alexander (Medical University of Graz) ;
Enzinger, Christian (Medical University of Graz) ;
Norrving, Bo (Skåne University Hospital) ;
Montaner, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Fernandez-Cadenas, Israel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Delgado Martínez, Pilar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Roquer González, Jaume (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Lindgren, Arne (Skåne University Hospital) ;
Slowik, Agnieszka (Jagiellonian University Medical College) ;
Schmidt, Reinhold (Medical University of Graz) ;
Kidwell, Chelsea S. (University of Arizona) ;
Kittner, Steven J. (Baltimore Veterans Administration Medical Center and University of Maryland School of Medicine) ;
Waddy, Salina P. (National Institutes of Health) ;
Langefeld, Carl D. (Wake Forest University) ;
Abecasis, Goncalo (University of Michigan School of Public Health) ;
Willer, Cristen J. (University of Michigan Medical School) ;
Kathiresan, Sekar (Cardiovascular Disease Prevention Center, MGH) ;
Woo, Daniel (University of Cincinnati College of Medicine) ;
Rosand, Jonathan (Program in Medical and Population Genetics, Broad Institute) ;
Universitat Autònoma de Barcelona.
Departament de Neurologia
In observational epidemiologic studies, higher plasma high-density lipoprotein cholesterol (HDL-C) has been associated with increased risk of intracerebral hemorrhage (ICH). DNA sequence variants that decrease cholesteryl ester transfer protein (CETP) gene activity increase plasma HDL-C; as such, medicines that inhibit CETP and raise HDL-C are in clinical development. [...]
2016 - 10.1002/ana.24780
Annals of Neurology, Vol. 80 (october 2016) , p. 730-740
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