1.
|
40 p, 6.4 MB |
Roadmap on nanomedicine for the central nervous system
/
Ciofani, Gianni (Italian Institute of Technology) ;
Campisi, Marco (Polytechnic University of Turin) ;
Mattu, Clara (Polytechnic University of Turin) ;
Kamm, Roger D. (Massachusetts Institute of Technology) ;
Chiono, Valeria (Polytechnic University of Turin) ;
Raynold, Aji Alex Moothedathu (University of Coimbra) ;
Freitas, João S. (University of Coimbra) ;
Redolfi Riva, Eugenio (Scuola Superiore Sant'Anna) ;
Micera, Silvestro (Scuola Superiore Sant'Anna) ;
Pucci, Carlotta (Italian Institute of Technology) ;
Novio Vázquez, Fernando (Universitat Autònoma de Barcelona. Departament de Química) ;
Lorenzo Rivera, Julia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Ruiz-Molina, Daniel (Institut Català de Nanociència i Nanotecnologia) ;
Sierri, Giulia (University of Milano-Bicocca) ;
Re, Francesca (University of Milano-Bicocca) ;
Wunderlich, Hannah (Technical University of Munich) ;
Kumari, Prachi (Technical University of Munich) ;
Kozielski, Kristen L. (Technical University of Munich) ;
Chami, Mounia (Institut de Pharmacologie Moléculaire et Cellulaire) ;
Marino, Attilio (Italian Institute of Technology) ;
Ferreira, Lino (University of Coimbra) ;
Universitat Autònoma de Barcelona.
Departament de Bioquímica i de Biologia Molecular
In recent years, a great deal of effort has been undertaken with regards to treatment of pathologies at the level of the central nervous system (CNS). Here, the presence of the blood-brain barrier acts as an obstacle to the delivery of potentially effective drugs and makes accessibility to, and treatment of, the CNS one of the most significant challenges in medicine. [...]
2023 - 10.1088/2515-7639/acab88
JPhys materials, Vol. 6, Issue 2 (April 2023) , art. 22501
|
|
2.
|
23 p, 5.3 MB |
Selection of an Aptamer against the Enzyme 1-deoxy-D-xylulose-5-phosphate Reductoisomerase from Plasmodium falciparum
/
Roca, Carlota (Universitat de Barcelona) ;
Avalos-Padilla, Yunuen (Universitat de Barcelona) ;
Prieto-Simón, Beatriz (Institució Catalana de Recerca i Estudis Avançats) ;
Iglesias, Valentin (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Ramírez, Miriam (Hospital Clínic i Provincial de Barcelona) ;
Imperial, Santiago (Universitat de Barcelona) ;
Fernàndez-Busquets, Xavier (Universitat de Barcelona) ;
Universitat Autònoma de Barcelona.
Departament de Bioquímica i de Biologia Molecular
The methyl erythritol phosphate (MEP) pathway of isoprenoid biosynthesis is essential for malaria parasites and also for several human pathogenic bacteria, thus representing an interesting target for future antimalarials and antibiotics and for diagnostic strategies. [...]
2022 - 10.3390/pharmaceutics14112515
Pharmaceutics, Vol. 14, Num. 11 (November 2022) , art. 2515
|
|
3.
|
13 p, 2.0 MB |
A Multifunctional Trypsin Protease Inhibitor from Yellow Bell Pepper Seeds : Uncovering Its Dual Antifungal and Hypoglycemic Properties
/
Cotabarren, Juliana (Universidad Nacional de la Plata. Centro de Investigación de Proteínas Vegetales) ;
Ozón, Brenda (Universidad Nacional de la Plata. Centro de Investigación de Proteínas Vegetales) ;
Claver, Santiago (Universidad Nacional de la Plata. Centro de Investigación de Proteínas Vegetales) ;
Geier, Florencia (Universidad Nacional de la Plata. Centro de Investigación de Proteínas Vegetales) ;
Rossotti, Martina (Universidad Nacional de la Plata. Centro de Investigación de Proteínas Vegetales) ;
Garcia-Pardo, Javier (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Obregón, Walter David (Universidad Nacional de la Plata. Centro de Investigación de Proteínas Vegetales) ;
Universitat Autònoma de Barcelona.
Departament de Bioquímica i de Biologia Molecular
Fungal infections are a growing public health concern worldwide and the emergence of antifungal resistance has limited the number of therapeutic options. Therefore, developing novel strategies for identifying and developing new antifungal compounds is an active area of research in the pharmaceutical industry. [...]
2023 - 10.3390/pharmaceutics15030781
Pharmaceutics, Vol. 15, Issue 3 (March 2023) , art. 781
|
|
4.
|
14 p, 13.3 MB |
Molecular Insights into the Regulation of 3-Phosphoinositide-Dependent Protein Kinase 1 : Modeling the Interaction between the Kinase and the Pleckstrin Homology Domains
/
García Viloca, Mireia (Universitat Autònoma de Barcelona. Departament de Química) ;
Bayascas Ramírez, José Ramón (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Lluch López, Josep Maria (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
González-Lafont, Àngels (Universitat Autònoma de Barcelona. Departament de Química) ;
Universitat Autònoma de Barcelona.
Departament de Bioquímica i de Biologia Molecular
The 3-phosphoinositide-dependent protein kinase 1 (PDK1) K465E mutant kinase can still activate protein kinase B (PKB) at the membrane in a phosphatidylinositol-3,4,5-trisphosphate (PIP3, PtdIns(3,4,5)P3) independent manner. [...]
2022 - 10.1021/acsomega.2c02020
ACS omega, Vol. 7, Issue 29 (July 2022) , p. 25186-25199
|
|
5.
|
27 p, 943.8 KB |
Squaramide-based Pt(II) complexes as potential oxygen-regulated light-triggered photocages
/
Morales, Kevin (Universitat Autònoma de Barcelona. Departament de Química) ;
Samper, Katia G. (Universitat Autònoma de Barcelona. Departament de Química) ;
Peña, Quim (Universitat Autònoma de Barcelona. Departament de Química) ;
Hernando Campos, Jordi (Universitat Autònoma de Barcelona. Departament de Química) ;
Lorenzo Rivera, Julia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Rodríguez-Diéguez, Antonio (Universidad de Granada. Departamento de Química Inorgánica) ;
Capdevila Vidal, Mercè (Universitat Autònoma de Barcelona. Departament de Química) ;
Figueredo Galimany, Marta (Universitat Autònoma de Barcelona. Departament de Química) ;
Palacios Bonilla, Òscar (Universitat Autònoma de Barcelona. Departament de Química) ;
Bayón, Joan Carles (Universitat Autònoma de Barcelona. Departament de Química) ;
Universitat Autònoma de Barcelona.
Departament de Bioquímica i de Biologia Molecular
Two new squaramide-based platinum(II) complexes C1 and C2 have been synthesized and fully characterized. Their photoresponse has been assessed and is discussed. A remarkable enhancement in the DNA binding activity has been observed for both complexes, up on irradiation. [...]
2018 - 10.1021/acs.inorgchem.8b02854
Inorganic Chemistry, Vol. 57, Issue 24 (December 2018) , p. 15517-15525
|
|
6.
|
|
7.
|
12 p, 1.5 MB |
Purification and identification of novel antioxidant peptides isolated from geoffroea decorticans seeds with anticoagulant activity
/
Cotabarren, Juliana (Universidad Nacional de La Plata. Departamento de Ciencias Biológicas) ;
Ozón, Brenda (Universidad Nacional de La Plata. Departamento de Ciencias Biológicas) ;
Claver, Santiago (Universidad Nacional de La Plata. Departamento de Ciencias Biológicas) ;
Garcia-Pardo, Javier (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Obregón, Walter David (Universidad Nacional de La Plata. Departamento de Ciencias Biológicas) ;
Universitat Autònoma de Barcelona.
Departament de Bioquímica i de Biologia Molecular
Geoffroea decorticans is a xerophilous deciduous tree present in most arid forests of southern South America, which is commonly used in traditional medicine. The seeds of this tree have been previously investigated for their singular chemical composition, but their protein content has been poorly investigated. [...]
2021 - 10.3390/pharmaceutics13081153
Pharmaceutics, Vol. 13, Issue 8 (August 2021) , art. 1153
|
|
8.
|
11 p, 827.1 KB |
Purification and Characterization of a Novel Thermostable Papain Inhibitor from Moringa oleifera with Antimicrobial and Anticoagulant Properties
/
Cotabarren, Juliana (Universidad Nacional de La Plata. Departamento de Ciencias Biológicas) ;
Claver, Santiago (Universidad Nacional de La Plata. Departamento de Ciencias Biológicas) ;
Payrol, Juan Abreu (Escuela Latinoamericana de Medicina) ;
Garcia-Pardo, Javier (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Obregón, Walter David (Universidad Nacional de La Plata. Departamento de Ciencias Biológicas) ;
Universitat Autònoma de Barcelona.
Departament de Bioquímica i de Biologia Molecular
Plant cystatins (or phytocystatins) comprise a large superfamily of natural bioactive small proteins that typically act as protein inhibitors of papain-like cysteine proteases. In this report, we present the purification and characterization of the first phytocystatin isolated from Moringa oleifera (MoPI). [...]
2021 - 10.3390/pharmaceutics13040512
Pharmaceutics, Vol. 13, Issue 4 (April 2021) , art. 512
|
|
9.
|
11 p, 14.5 MB |
Fragment C Domain of Tetanus Toxin Mitigates Methamphetamine Neurotoxicity and Its Motor Consequences in Mice
/
Mendieta, Liliana (Instituto Cajal, Consejo Superior de Investigaciones Científicas, CSIC) ;
Granado, Noelia (Instituto Cajal, Consejo Superior de Investigaciones Científicas, CSIC) ;
Aguilera, José (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Tizabi, Yousef (Instituto Cajal, Consejo Superior de Investigaciones Científicas, CSIC) ;
Moratalla, Rosario (Instituto Cajal, Consejo Superior de Investigaciones Científicas, CSIC) ;
Universitat Autònoma de Barcelona.
Departament de Bioquímica i de Biologia Molecular
The C-terminal domain of the heavy chain of tetanus toxin (Hc-TeTx) is a nontoxic peptide with demonstrated in vitro and in vivo neuroprotective effects against striatal dopaminergic damage induced by 1-methyl-4-phenylpyridinium and 6-hydoxydopamine, suggesting its possible therapeutic potential in Parkinson's disease. [...]
2016 - 10.1093/ijnp/pyw021
International journal of neuropsychopharmacology, Vol. 19 (march 2016)
|
|
10.
|
15 p, 1.8 MB |
Extracellular Tau Oligomers Produce An Immediate Impairment of LTP and Memory
/
Fá, M. (Columbia University. Department of Pathology and Cell Biology) ;
Puzzo, D. (University of Catania. Department of Biomedical and Biotechnological Sciences) ;
Piacentini, R. (Università Cattolica del Sacro Cuore. Institute of Human Physiology) ;
Staniszewski, A. (Columbia University. Department of Pathology) ;
Zhang, H. (Columbia University. Department of Pathology) ;
Baltrons Soler, Ma. Antonia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Li Puma, D. D. (Università Cattolica del Sacro Cuore. Institute of Human Physiology) ;
Chatterjee, I. (Oligomerix) ;
Li, J. (Third Military Medical University. Department of Neurology) ;
Saeed, F. (Columbia University. Department of Pathology and Cell Biology) ;
Berman, H. L. (Columbia University. Department of Pathology) ;
Ripoli, C. (Università Cattolica del Sacro Cuore. Institute of Human Physiology) ;
Gulisano, W. (University of Catania. Department of Biomedical and Biotechnological Sciences) ;
Gonzalez, J. (Rockefeller University. Translational Technology Core Laboratory) ;
Tian, H. (Tempe. Department of Chemical Engineering) ;
Costa, J. A. (Columbia University. Department of Pathology and Cell Biology) ;
Lopez, P. (Oligomerix) ;
Davidowitz, E. (Oligomerix) ;
Yu, W. H. (Columbia University. Department of Pathology and Cell Biology) ;
Haroutunian, V. (The Mount Sinai School of Medicine. Department of Psychiatry) ;
Brown, L. M. (Columbia University. Department of Biological Sciences) ;
Palmeri, A. (University of Catania. Department of Biomedical and Biotechnological Sciences) ;
Sigurdsson, E. M. (NYU Langone Medical Center. Department of Neuroscience and Physiology) ;
Duff, K. E. (Columbia University. Department of Pathology and Cell Biology) ;
Teich, A. F. (Columbia University. Department of Pathology and Cell Biology) ;
Honig, L. S. (Columbia University. Department of Pathology and Cell Biology) ;
Sierks, M. (Rockefeller University. Translational Technology Core Laboratory) ;
Moe, J. G. (Oligomerix) ;
D'Adamio, L. (Einstein College of Medicine. Department of Microbiology and Immunology) ;
Grassi, C. (Hospitalization and Health Care) ;
Kanaan, N. M. (College of Human Medicine. Department of Translational Science and Molecular Medicine) ;
Fraser, P. E. (University of Toronto. Department of Medical Biophysics) ;
Arancio, Ottavio (Columbia University. Department of Pathology and Cell Biology) ;
Universitat Autònoma de Barcelona.
Departament de Bioquímica i de Biologia Molecular
Non-fibrillar soluble oligomeric forms of amyloid-β peptide (oAβ) and tau proteins are likely to play a major role in Alzheimer's disease (AD). The prevailing hypothesis on the disease etiopathogenesis is that oAβ initiates tau pathology that slowly spreads throughout the medial temporal cortex and neocortices independently of Aβ, eventually leading to memory loss. [...]
2016 - 10.1038/srep19393
Scientific reports, Vol. 6 (January 2016) , art. 19393
|
|