1.
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14 p, 3.2 MB |
Copper(II) N, N, O -Chelating Complexes as Potential Anticancer Agents
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Peña, Quim (Universitat Autònoma de Barcelona. Departament de Química) ;
Sciortino, Giuseppe (Universitat Autònoma de Barcelona. Departament de Química) ;
Maréchal, Jean-Didier (Universitat Autònoma de Barcelona. Departament de Química) ;
Bertaina, Sylvain (Aix-Marseille Université) ;
Simaan, A. Jalila (Aix-Marseille Université) ;
Lorenzo Rivera, Julia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Capdevila Vidal, Mercè (Universitat Autònoma de Barcelona. Departament de Química) ;
Bayón Rueda, Joan Pau (Universitat Autònoma de Barcelona. Departament de Química) ;
Iranzo, Olga (Aix-Marseille Université) ;
Palacios Bonilla, Òscar (Universitat Autònoma de Barcelona. Departament de Química) ;
Universitat Autònoma de Barcelona.
Departament de Bioquímica i de Biologia Molecular
Three novel dinuclear Cu(II) complexes based on a N,N,O-chelating salphen-like ligand scaffold and bearing varying aromatic substituents (−H, −Cl, and −Br) have been synthesized and characterized. [...]
2021 - 10.1021/acs.inorgchem.0c02932
Inorganic Chemistry, Vol. 60, Issue 5 (March 2021) , p. 2939-2952
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2.
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3.
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16 p, 2.7 MB |
Adenosine A2A Receptor Antagonists Affects NMDA Glutamate Receptor Function. Potential to Address Neurodegeneration in Alzheimer's Disease
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Franco, Rafael (Universitat de Barcelona. Departament de Bioquímica i Biomedicina Molecular) ;
Rivas-Santisteban, Rafael (Universitat de Barcelona. Departament de Bioquímica i Biomedicina Molecular) ;
Casanovas, Mireia (Universitat de Barcelona. Departament de Bioquímica i Biomedicina Molecular) ;
Lillo, Alejandro (Universitat de Barcelona. Departament de Bioquímica i Fisiologia) ;
Saura, Carlos A. (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Navarro, Gemma (Universitat de Barcelona. Departament de Bioquímica i Fisiologia) ;
Universitat Autònoma de Barcelona.
Departament de Bioquímica i de Biologia Molecular
(1) Background. N-methyl d-aspartate (NMDA) ionotropic glutamate receptor (NMDAR), which is one of the main targets to combat Alzheimer's disease (AD), is expressed in both neurons and glial cells. The aim of this paper was to assess whether the adenosine A2A receptor (A2AR), which is a target in neurodegeneration, may affect NMDAR functionality. [...]
2020 - 10.3390/cells9051075
Cells, Vol. 9 Núm. 5 (april 2020)
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4.
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15 p, 2.9 MB |
MED15 prion-like domain forms a coiled-coil responsible for its amyloid conversion and propagation
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Batlle Carreras, Cristina (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Calvo, Isabel (Institut de Ciència i Tecnologia de Barcelona. Institut de Recerca en Biomedicina) ;
Iglesias, Valentin (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
J. Lynch, Cian (Institut de Ciència i Tecnologia de Barcelona. Institut de Recerca en Biomedicina) ;
Gil-Garcia, Marcos (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Serrano, Manuel (Institut de Ciència i Tecnologia de Barcelona. Institut de Recerca en Biomedicina) ;
Ventura, Salvador (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Universitat Autònoma de Barcelona.
Departament de Bioquímica i de Biologia Molecular
A disordered to β-sheet transition was thought to drive the functional switch of Q/N-rich prions, similar to pathogenic amyloids. However, recent evidence indicates a critical role for coiled-coil (CC) regions within yeast prion domains in amyloid formation. [...]
2021 - 10.1038/s42003-021-01930-8
Communications Biology, Vol. 4 (March 2021) , art. 414
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5.
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20 p, 10.5 MB |
Binding site profiles and N-terminal minor groove interactions of the master quorum-sensing regulator LuxR enable flexible control of gene activation and repression
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Zhang, Jun (East China University of Science and Technology. State Key Laboratory of Bioreactor Engineering (China)) ;
Liu, Bing (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Gu, Dan (Yangzhou University. Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses (China)) ;
Hao, Yuan (East China University of Science and Technology. State Key Laboratory of Bioreactor Engineering (China)) ;
Chen, Mo (East China University of Science and Technology. State Key Laboratory of Bioreactor Engineering (China)) ;
Ma, Yue (East China University of Science and Technology. State Key Laboratory of Bioreactor Engineering (China)) ;
Zhou, Xiaohui (University of Connecticut. Department of Pathobiology and Veterinary Science (USA)) ;
Reverter i Cendrós, David (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Zhang, Yuanxing (Southern Marine Science and Engineering Guangdong Laboratory (China)) ;
Wang, Qiyao (East China University of Science and Technology. State Key Laboratory of Bioreactor Engineering (China)) ;
Universitat Autònoma de Barcelona.
Departament de Bioquímica i de Biologia Molecular
LuxR is a TetR family master quorum sensing (QS) regulator activating or repressing expression of hundreds of genes that control collective behaviors in Vibrios with underlying mechanism unknown. To illuminate how this regulator controls expression of various target genes, we applied ChIP-seq and DNase I-seq technologies. [...]
2021 - 10.1093/nar/gkab150
Nucleic acids research, Vol. 49, Issue 6 (April 2021) , p. 3274-3293
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6.
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9 p, 1.1 MB |
Atomistic fibrillar architectures of polar prion-inspired heptapeptides
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Peccati, Francesca (Centro de Investigación Cooperativa en Biociencias. Basque Research and Technology Alliance) ;
Díaz-Caballero, Marta (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Navarro, Susanna (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Rodríguez Santiago, Luis (Universitat Autònoma de Barcelona. Departament de Química) ;
Ventura, Salvador (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Sodupe Roure, Mariona (Universitat Autònoma de Barcelona. Departament de Química) ;
Universitat Autònoma de Barcelona.
Departament de Bioquímica i de Biologia Molecular ;
Universitat Autònoma de Barcelona.
Departament de Química
This article provides the computational prediction of the atomistic architectures resulting from self-assembly of the polar heptapeptide sequences NYNYNYN, SYSYSYS and GYGYGYG. Using a combination of molecular dynamics and a newly developed tool for non-covalent interaction analysis, we uncover the properties of a new class of bionanomaterials, including hydrogen-bonded polar zippers, and the relationship between peptide composition, fibril geometry and weak interaction networks. [...]
2020 - 10.1039/d0sc05638c
Chemical science, Vol. 11, Issue 48 (December 2020) , p. 13143-13151
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7.
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18 p, 1.7 MB |
MIRRAGGE - Minimum Information Required for Reproducible AGGregation Experiments
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Martins, Pedro M. (Universidade do Porto. Instituto de Ciências Biomédicas Abel Salazar) ;
Navarro, Susanna (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Silva, Alexandra (Universidade do Porto. Instituto de Biologia Molecular e Celular and Instituto de Investigação e Inovação em Saúde) ;
Pinto, Maria F. (Universidade do Porto. Instituto de Biologia Molecular e Celular and Instituto de Investigação e Inovação em Saúde) ;
Sárkány, Zsuzsa (Universidade do Porto. Instituto de Biologia Molecular e Celular and Instituto de Investigação e Inovação em Saúde) ;
Figueiredo, Francisco (Universidade do Porto. Instituto de Ciências Biomédicas Abel Salazar) ;
Barbosa Pereira, Pedro José (Universidade do Porto. Instituto de Biologia Molecular e Celular and Instituto de Investigação e Inovação em Saúde) ;
Pinheiro, Francisca (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Bednarikova, Zuzana (Slovak Academy of Sciences. Department of Biophysics) ;
Burdukiewicz, Michal (Warsaw University of Technology. Faculty of Mathematics and Information Science) ;
Galzitskaya, Oxxana V. (Russian Academy of Sciences. Institute of Theoretical and Experimental Biophysics) ;
Gazova, Zuzana (Slovak Academy of Sciences. Department of Biophysics) ;
Gomes, Cláudio M. (Universidade de Lisboa. Departamento de Química e Bioquímica) ;
Pastore, Annalisa (Centre at King's College London. the Maurice Wohl Clinical Neuroscience Institute) ;
Serpell, Louise C. (University of Sussex. School of Life Sciences) ;
Skrabana, Rostislav (Slovak Academy of Sciences. Institute of Neuroimmunology) ;
Smirnovas, Vytautas (Vilnius University. Institute of Biotechnology) ;
Ziaunys, Mantas (Vilnius University. Institute of Biotechnology) ;
Otzen, Daniel E. (Aarhus University. Department of Molecular Biology and Genetics) ;
Ventura, Salvador (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Macedo-Ribeiro, Sandra (Universidade do Porto. Instituto de Biologia Molecular e Celular and Instituto de Investigação e Inovação em Saúde) ;
Universitat Autònoma de Barcelona.
Departament de Bioquímica i de Biologia Molecular
Reports on phase separation and amyloid formation for multiple proteins and aggregation-prone peptides are recurrently used to explore the molecular mechanisms associated with several human diseases. [...]
2020 - 10.3389/fnmol.2020.582488
Frontiers in molecular neuroscience, Vol. 13 (November 2020) , art. 582488
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8.
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12 p, 2.4 MB |
Inhibition of α-synuclein aggregation and mature fibril disassembling with a minimalistic compound, ZPDm
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Peña Díaz, Samuel (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Pujols, Jordi (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Pinheiro, Francisca (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Santos, Jaime (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Pallarès i Goitiz, Irantzu (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Navarro, Susanna (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Conde Giménez, María (Universidad de Zaragoza. Instituto Aragonés de Investigaciones Sanitarias) ;
García, Jesús (Institut de Recerca Biomèdica de Lleida) ;
Salvatella, Xavier (Institució Catalana de Recerca i Estudis Avançats) ;
Dalfo Capella, Esther (Universitat Autònoma de Barcelona. Facultat de Medicina) ;
Sancho, Javier (Universidad de Zaragoza. Instituto Aragonés de Investigaciones Sanitarias) ;
Ventura, Salvador (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Universitat Autònoma de Barcelona.
Departament de Bioquímica i de Biologia Molecular
Synucleinopathies are a group of disorders characterized by the accumulation of α-Synuclein amyloid inclusions in the brain. Preventing α-Synuclein aggregation is challenging because of the disordered nature of the protein and the stochastic nature of fibrillogenesis, but, at the same time, it is a promising approach for therapeutic intervention in these pathologies. [...]
2020 - 10.3389/fbioe.2020.588947
Frontiers in Bioengineering and Biotechnology, Vol. 8 (October 2020) , art. 588947
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9.
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10 p, 3.4 MB |
Rational design of small molecules able to inhibit α-synuclein amyloid aggregation for the treatment of Parkinson's disease
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Vittorio, Serena (Università degli Studi di Messina Viale Palatucci. Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche e Ambientali) ;
Adornato, Ilenia (Università degli Studi di Messina Viale Palatucci. Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche e Ambientali) ;
Gitto, Rosaria (Università degli Studi di Messina Viale Palatucci. Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche e Ambientali) ;
Peña Díaz, Samuel (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Ventura, Salvador (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
De Luca, Laura (Università degli Studi di Messina Viale Palatucci. Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche e Ambientali) ;
Universitat Autònoma de Barcelona.
Departament de Bioquímica i de Biologia Molecular
Parkinson's disease is one of the most common neurodegenerative disorders in elderly age. One of the mechanisms involved in the neurodegeneration appears related to the aggregation of the presynaptic protein alpha synuclein (α-syn) into toxic oligomers and fibrils. [...]
2020 - 10.1080/14756366.2020.1816999
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol. 35, Issue 1 (September 2020) , p. 1727-1735
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10.
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22 p, 7.3 MB |
Yeast Ppz1 protein phosphatase toxicity involves the alteration of multiple cellular targets
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Velázquez, Diego (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Albacar, Marcel (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Zhang, Chunyi (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Calafí, Carlos (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
López Malo, María (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Torres Torronteras, Javier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Martí, Ramón 1915-1994 (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Kovalchuk, Sergey I. (University of Southern Denmark. Department of Biochemistry and Molecular Biology) ;
Pinson, Benoit (Centre National de la Recherche Scientifique (França)) ;
Jensen, Ole N. (University of Southern Denmark. Department of Biochemistry and Molecular Biology) ;
Daignan-Fornier, Bertrand (Centre National de la Recherche Scientifique (França)) ;
Casamayor Gracia, Antonio (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Ariño Carmona, Joaquín (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Universitat Autònoma de Barcelona.
Departament de Bioquímica i de Biologia Molecular
Control of the protein phosphorylation status is a major mechanism for regulation of cellular processes, and its alteration often lead to functional disorders. Ppz1, a protein phosphatase only found in fungi, is the most toxic protein when overexpressed in Saccharomyces cerevisiae. [...]
2020 - 10.1038/s41598-020-72391-y
Scientific reports (Nature Publishing Group), Vol. 10 (September 2020) , art. 15613
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