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Purification and Characterization of a Novel Thermostable Papain Inhibitor from Moringa oleifera with Antimicrobial and Anticoagulant Properties
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Cotabarren, Juliana (Universidad Nacional de La Plata. Departamento de Ciencias Biológicas) ;
Claver, Santiago (Universidad Nacional de La Plata. Departamento de Ciencias Biológicas) ;
Payrol, Juan Abreu (Escuela Latinoamericana de Medicina) ;
Garcia-Pardo, Javier (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Obregón, Walter David (Universidad Nacional de La Plata. Departamento de Ciencias Biológicas) ;
Universitat Autònoma de Barcelona.
Departament de Bioquímica i de Biologia Molecular
Plant cystatins (or phytocystatins) comprise a large superfamily of natural bioactive small proteins that typically act as protein inhibitors of papain-like cysteine proteases. In this report, we present the purification and characterization of the first phytocystatin isolated from Moringa oleifera (MoPI). [...]
2021 -  10.3390/pharmaceutics13040512
Pharmaceutics, Vol. 13, Issue 4 (April 2021) , art. 512
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15 p, 1.8 MB |
Extracellular Tau Oligomers Produce An Immediate Impairment of LTP and Memory
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Fá, M. (Columbia University. Department of Pathology and Cell Biology) ;
Puzzo, D. (University of Catania. Department of Biomedical and Biotechnological Sciences) ;
Piacentini, R. (Università Cattolica del Sacro Cuore. Institute of Human Physiology) ;
Staniszewski, A. (Columbia University. Department of Pathology) ;
Zhang, H. (Columbia University. Department of Pathology) ;
Baltrons Soler, Ma. Antonia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Li Puma, D. D. (Università Cattolica del Sacro Cuore. Institute of Human Physiology) ;
Chatterjee, I. (Oligomerix) ;
Li, J. (Third Military Medical University. Department of Neurology) ;
Saeed, F. (Columbia University. Department of Pathology and Cell Biology) ;
Berman, H. L. (Columbia University. Department of Pathology) ;
Ripoli, C. (Università Cattolica del Sacro Cuore. Institute of Human Physiology) ;
Gulisano, W. (University of Catania. Department of Biomedical and Biotechnological Sciences) ;
Gonzalez, J. (Rockefeller University. Translational Technology Core Laboratory) ;
Tian, H. (Tempe. Department of Chemical Engineering) ;
Costa, J. A. (Columbia University. Department of Pathology and Cell Biology) ;
Lopez, P. (Oligomerix) ;
Davidowitz, E. (Oligomerix) ;
Yu, W. H. (Columbia University. Department of Pathology and Cell Biology) ;
Haroutunian, V. (The Mount Sinai School of Medicine. Department of Psychiatry) ;
Brown, L. M. (Columbia University. Department of Biological Sciences) ;
Palmeri, A. (University of Catania. Department of Biomedical and Biotechnological Sciences) ;
Sigurdsson, E. M. (NYU Langone Medical Center. Department of Neuroscience and Physiology) ;
Duff, K. E. (Columbia University. Department of Pathology and Cell Biology) ;
Teich, A. F. (Columbia University. Department of Pathology and Cell Biology) ;
Honig, L. S. (Columbia University. Department of Pathology and Cell Biology) ;
Sierks, M. (Rockefeller University. Translational Technology Core Laboratory) ;
Moe, J. G. (Oligomerix) ;
D'Adamio, L. (Einstein College of Medicine. Department of Microbiology and Immunology) ;
Grassi, C. (Hospitalization and Health Care) ;
Kanaan, N. M. (College of Human Medicine. Department of Translational Science and Molecular Medicine) ;
Fraser, P. E. (University of Toronto. Department of Medical Biophysics) ;
Arancio, Ottavio (Columbia University. Department of Pathology and Cell Biology) ;
Universitat Autònoma de Barcelona.
Departament de Bioquímica i de Biologia Molecular
Non-fibrillar soluble oligomeric forms of amyloid-β peptide (oAβ) and tau proteins are likely to play a major role in Alzheimer's disease (AD). The prevailing hypothesis on the disease etiopathogenesis is that oAβ initiates tau pathology that slowly spreads throughout the medial temporal cortex and neocortices independently of Aβ, eventually leading to memory loss. [...]
2016 - 10.1038/srep19393
Scientific reports, Vol. 6 (January 2016) , art. 19393
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Characterization of the TLR Family in Branchiostoma lanceolatum and Discovery of a Novel TLR22-Like Involved in dsRNA Recognition in Amphioxus
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Ji, Jie (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Ramos-Vicente, David (Institut d'Investigació Biomèdica Sant Pau) ;
Navas-Pérez, Enrique (Institut d'Investigació Biomèdica de Bellvitge) ;
Herrera-Úbeda, Carlos (Institut d'Investigació Biomèdica de Bellvitge) ;
Lizcano de Vega, José Miguel (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
García-Fernández, Jordi (Institut d'Investigació Biomèdica de Bellvitge) ;
Escrivà, Hector (Sorbonne Université. Biologie Intégrative des Organismes Marins) ;
Bayés, Àlex (Institut d'Investigació Biomèdica Sant Pau) ;
Roher Armentia, Nerea (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Universitat Autònoma de Barcelona.
Departament de Bioquímica i de Biologia Molecular
Toll-like receptors (TLRs) are important for raising innate immune responses in both invertebrates and vertebrates. Amphioxus belongs to an ancient chordate lineage which shares key features with vertebrates. [...]
2018 - 10.3389/fimmu.2018.02525
Frontiers in immunology, Vol. 9 (November 2018) , art. 2525
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14 p, 3.2 MB |
Copper(II) N, N, O -Chelating Complexes as Potential Anticancer Agents
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Peña, Quim (Universitat Autònoma de Barcelona. Departament de Química) ;
Sciortino, Giuseppe (Universitat Autònoma de Barcelona. Departament de Química) ;
Maréchal, Jean-Didier (Universitat Autònoma de Barcelona. Departament de Química) ;
Bertaina, Sylvain (Aix-Marseille Université) ;
Simaan, A. Jalila (Aix-Marseille Université) ;
Lorenzo Rivera, Julia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Capdevila Vidal, Mercè (Universitat Autònoma de Barcelona. Departament de Química) ;
Bayón Rueda, Joan Pau (Universitat Autònoma de Barcelona. Departament de Química) ;
Iranzo, Olga (Aix-Marseille Université) ;
Palacios Bonilla, Òscar (Universitat Autònoma de Barcelona. Departament de Química) ;
Universitat Autònoma de Barcelona.
Departament de Bioquímica i de Biologia Molecular
Three novel dinuclear Cu(II) complexes based on a N,N,O-chelating salphen-like ligand scaffold and bearing varying aromatic substituents (−H, −Cl, and −Br) have been synthesized and characterized. [...]
2021 - 10.1021/acs.inorgchem.0c02932
Inorganic Chemistry, Vol. 60, Issue 5 (March 2021) , p. 2939-2952
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Adenosine A2A Receptor Antagonists Affects NMDA Glutamate Receptor Function. Potential to Address Neurodegeneration in Alzheimer's Disease
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Franco, Rafael (Universitat de Barcelona. Departament de Bioquímica i Biomedicina Molecular) ;
Rivas-Santisteban, Rafael (Universitat de Barcelona. Departament de Bioquímica i Biomedicina Molecular) ;
Casanovas, Mireia (Universitat de Barcelona. Departament de Bioquímica i Biomedicina Molecular) ;
Lillo, Alejandro (Universitat de Barcelona. Departament de Bioquímica i Fisiologia) ;
Saura, Carlos A. (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Navarro, Gemma (Universitat de Barcelona. Departament de Bioquímica i Fisiologia) ;
Universitat Autònoma de Barcelona.
Departament de Bioquímica i de Biologia Molecular
(1) Background. N-methyl d-aspartate (NMDA) ionotropic glutamate receptor (NMDAR), which is one of the main targets to combat Alzheimer's disease (AD), is expressed in both neurons and glial cells. The aim of this paper was to assess whether the adenosine A2A receptor (A2AR), which is a target in neurodegeneration, may affect NMDAR functionality. [...]
2020 - 10.3390/cells9051075
Cells, Vol. 9 Núm. 5 (april 2020)
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20 p, 10.5 MB |
Binding site profiles and N-terminal minor groove interactions of the master quorum-sensing regulator LuxR enable flexible control of gene activation and repression
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Zhang, Jun (East China University of Science and Technology. State Key Laboratory of Bioreactor Engineering (China)) ;
Liu, Bing (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Gu, Dan (Yangzhou University. Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses (China)) ;
Hao, Yuan (East China University of Science and Technology. State Key Laboratory of Bioreactor Engineering (China)) ;
Chen, Mo (East China University of Science and Technology. State Key Laboratory of Bioreactor Engineering (China)) ;
Ma, Yue (East China University of Science and Technology. State Key Laboratory of Bioreactor Engineering (China)) ;
Zhou, Xiaohui (University of Connecticut. Department of Pathobiology and Veterinary Science (USA)) ;
Reverter i Cendrós, David (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Zhang, Yuanxing (Southern Marine Science and Engineering Guangdong Laboratory (China)) ;
Wang, Qiyao (East China University of Science and Technology. State Key Laboratory of Bioreactor Engineering (China)) ;
Universitat Autònoma de Barcelona.
Departament de Bioquímica i de Biologia Molecular
LuxR is a TetR family master quorum sensing (QS) regulator activating or repressing expression of hundreds of genes that control collective behaviors in Vibrios with underlying mechanism unknown. To illuminate how this regulator controls expression of various target genes, we applied ChIP-seq and DNase I-seq technologies. [...]
2021 - 10.1093/nar/gkab150
Nucleic acids research, Vol. 49, Issue 6 (April 2021) , p. 3274-3293
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9 p, 1.1 MB |
Atomistic fibrillar architectures of polar prion-inspired heptapeptides
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Peccati, Francesca (Centro de Investigación Cooperativa en Biociencias. Basque Research and Technology Alliance) ;
Díaz-Caballero, Marta (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Navarro, Susanna (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Rodríguez Santiago, Luis (Universitat Autònoma de Barcelona. Departament de Química) ;
Ventura, Salvador (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Sodupe Roure, Mariona (Universitat Autònoma de Barcelona. Departament de Química) ;
Universitat Autònoma de Barcelona.
Departament de Bioquímica i de Biologia Molecular ;
Universitat Autònoma de Barcelona.
Departament de Química
This article provides the computational prediction of the atomistic architectures resulting from self-assembly of the polar heptapeptide sequences NYNYNYN, SYSYSYS and GYGYGYG. Using a combination of molecular dynamics and a newly developed tool for non-covalent interaction analysis, we uncover the properties of a new class of bionanomaterials, including hydrogen-bonded polar zippers, and the relationship between peptide composition, fibril geometry and weak interaction networks. [...]
2020 - 10.1039/d0sc05638c
Chemical science, Vol. 11, Issue 48 (December 2020) , p. 13143-13151
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