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15 p, 620.2 KB Endometrial gene expression profile of pregnant sows with extreme phenotypes for reproductive efficiency / Córdoba, Sarai (Centre de Recerca en Agrigenòmica) ; Balcells Ortega, Ingrid (Centre de Recerca en Agrigenòmica) ; Castelló, Anna (Centre de Recerca en Agrigenòmica) ; Ovilo, Cristina (Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria) ; Noguera Jiménez, José Luis (Institut de Recerca i Tecnologia Agroalimentàries) ; Timoneda i Heredia, Oriol (Centre de Recerca en Agrigenòmica) ; Sánchez Bonastre, Armando (Centre de Recerca en Agrigenòmica) ; Universitat Autònoma de Barcelona. Departament de Genètica Animal
2015 0) and low (L, EBV 0) prolificacy phenotypes. For each sample, mRNA and small RNA libraries were RNA-sequenced, identifying 141 genes and 10 miRNAs differentially expressed between H and L groups. We selected four miRNAs based on their role in reproduction, and five genes displaying the highest differences and a positive mapping into known reproductive QTLs for RT-qPCR validation on the whole extreme population. Significant differences were validated for genes: PTGS2 (p = 0.03; H/L ratio = 3.50), PTHLH (p = 0.03; H/L ratio = 3.69), MMP8 (p = 0.01; H/L ratio = 4.41) and SCNN1G (p = 0.04; H/L ratio = 3.42). Although selected miRNAs showed similar expression levels between H and L groups, significant correlation was found between the expression level of ssc-miR-133a (p 0.01) and sscmiR-92a (p 0.01) and validated genes. These results provide a better understanding of the genetic architecture of prolificacy-related traits and embryo implantation failure in pigs. - 10.1038/srep14416
Scientific Reports, Vol. 5 (October 2015) , art. 14416  

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