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8 p, 167.3 KB |
Baseline Prediction of Combination Therapy Outcome in Hepatitis C Virus 1b Infected Patients by Discriminant Analysis Using Viral and Host Factors
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Saludes, Verónica (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bracho, Maria Alma (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
Valero, Oliver (Universitat Autònoma de Barcelona. Departament de Matemàtiques) ;
Ardèvol, Mercè (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Planas, Ramón (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
González-Candelas, Fernando (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
Ausina, Vicente (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martró, Elisa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona.
Departament de Genètica i de Microbiologia
Current treatment of chronic hepatitis C virus (HCV) infection has limited efficacy −especially among genotype 1 infected patients−, is costly, and involves severe side effects. Thus, predicting non-response is of major interest for both patient wellbeing and health care expense. [...]
2010 -  10.1371/journal.pone.0014132
PloS one, Vol. 5 (november 2010)
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9 p, 376.9 KB |
Fujifilm silvamp tb-lam for the diagnosis of tuberculosis in nigerian adults
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Comella-del-Barrio, Patricia (Institut Germans Trias i Pujol) ;
Bimba, John (Bingham University. Zankli Research Centre and Department of Community Medicine) ;
Adelakun, Ramota (Liverpool School of Tropical Medicine. Department of Clinical Sciences) ;
Kontogianni, Konstantina (Liverpool School of Tropical Medicine. Department of Clinical Sciences) ;
Molina-Moya, Barbara (Institut Germans Trias i Pujol) ;
Osazuwa, Okoedoh (Bingham University. Zankli Research Centre and Department of Community Medicine) ;
Creswell, Jacob (TB REACH. Stop TB Partnership) ;
Cuevas, Luis E. (Liverpool School of Tropical Medicine. Department of Clinical Sciences.) ;
Domínguez, José (Institut Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona.
Departament de Genètica i de Microbiologia
There is a need for diagnostics for tuberculosis (TB) that are easy to use, able to screen non-sputum samples, and able to provide rapid results for the management of both immunocompromised and immunocompetent individuals. [...]
2021 - 10.3390/jcm10112514
Journal of clinical medicine, Vol. 10 Núm. 11 (june 2021) , p. 2514
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21 p, 4.1 MB |
Phenotypic and transcriptomic analyses of seven clinical Stenotrophomonas maltophilia isolates identify a small set of shared and commonly regulated genes involved in the biofilm lifestyle
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Alio, Ifey (Universität Hamburg. Department of Microbiology and Biotechnology (Germany)) ;
Gudzuhn, Mirja (Universität Hamburg. Department of Microbiology and Biotechnology (Germany)) ;
Pérez García, Pablo (Universität Hamburg. Department of Microbiology and Biotechnology (Germany)) ;
Danso, Dominik (Universität Hamburg. Department of Microbiology and Biotechnology (Germany)) ;
Schoelmerich, Marie Charlotte (Universität Hamburg. Department of Microbiology and Biotechnology (Germany)) ;
Mamat, Uwe (Research Center Borstel. Priority Area Infections. Molecular and Experimental Mycobacteriology (Germany)) ;
Schaible, Ulrich E. (Research Center Borstel. Priority Area Infections. Molecular and Experimental Mycobacteriology (Germany)) ;
Steinmann, Jörg (Universitätsinstitut der Paracelsus Medizinischen Privatuniversität Klinikum Nürnberg. Institut für Klinikhygiene, Medizinische Mikrobiologie und Klinische Infektiologie (Germany)) ;
Yero, Daniel (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Gibert, Isidre (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Kohl, Thomas A. (Research Center Borstel. Molecular and Experimental Mycobacteriology (Germany)) ;
Niemann, Stefan (Research Center Borstel. Molecular and Experimental Mycobacteriology (Germany)) ;
Gröschel, Matthias I. (Harvard Medical School. Department of Biomedical Informatics (USA)) ;
Haerdter, Johanna (Universität Hamburg. Institute of Organic Chemistry (Germany)) ;
Hackl, Thomas (Universität Hamburg. Institute of Organic Chemistry (Germany)) ;
Vollstedt, Christel (Universität Hamburg. Department of Microbiology and Biotechnology (Germany)) ;
Bömeke, Mechthild (Georg-August University of Göttingen. Institute of Microbiology and Genetics. Department of Genomic and Applied Microbiology (Germany)) ;
Egelkamp, Richard (Georg-August University of Göttingen. Institute of Microbiology and Genetics. Department of Genomic and Applied Microbiology (Germany)) ;
Daniel, Rolf (Georg-August University of Göttingen. Institute of Microbiology and Genetics. Department of Genomic and Applied Microbiology (Germany)) ;
Poehlein, Anja (Georg-August University of Göttingen. Institute of Microbiology and Genetics. Department of Genomic and Applied Microbiology (Germany)) ;
Streit, Wolfgang R. (Universität Hamburg. Department of Microbiology and Biotechnology (Germany)) ;
Universitat Autònoma de Barcelona.
Departament de Genètica i de Microbiologia
Stenotrophomonas maltophilia is one of the most frequently isolated multidrug-resistant nosocomial opportunistic pathogens. It contributes to disease progression in cystic fibrosis (CF) patients and is frequently isolated from wounds, infected tissues, and catheter surfaces. [...]
2020 - 10.1128/AEM.02038-20
Applied and Environmental Microbiology, Vol. 86, Issue 24 (December 2020) , art. e02038
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9 p, 3.5 MB |
Stable anchoring of bacteria-based protein nanoparticles for surface enhanced cell guidance
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Martínez Miguel, Marc (Institut de Ciència de Materials de Barcelona) ;
Kyvik, Adriana R. (Institut de Ciència de Materials de Barcelona) ;
Ernst, Lena M. (Institut de Ciència de Materials de Barcelona) ;
Martínez Moreno, Albert (Institut de Ciència de Materials de Barcelona) ;
Cano-Garrido, Olivia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Garcia-Fruitos, Elena (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Vázquez Gómez, Esther (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Ventosa, Nora (Institut de Ciència de Materials de Barcelona) ;
Guasch, Judith (Institut de Ciència de Materials de Barcelona) ;
Veciana i Miró, Jaume (Institut de Ciència de Materials de Barcelona) ;
Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Ratera Bastardas, Imma (Institut de Ciència de Materials de Barcelona) ;
Universitat Autònoma de Barcelona.
Departament de Genètica i de Microbiologia
In tissue engineering, biological, physical, and chemical inputs have to be combined to properly mimic cellular environments and successfully build artificial tissues which can be designed to fulfill different biomedical needs such as the shortage of organ donors or the development of in vitro disease models for drug testing. [...]
2020 - 10.1039/d0tb00702a
Journal of materials chemistry B, Vol. 8, Issue 23 (June 2020) , p. 5080-5088
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38 p, 2.2 MB |
Engineering secretory amyloids for remote and highly selective destruction of metastatic foci
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Céspedes, María Virtudes (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Cano-Garrido, Olivia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Álamo, Patricia (Institut d'Investigació Biomèdica Sant Pau) ;
Sala, Rita (Institut d'Investigació Biomèdica Sant Pau) ;
Gallardo, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Serna, Naroa (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Falgàs, Aïda (Institut d'Investigació Biomèdica Sant Pau) ;
Voltà-Durán, Eric (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Casanova Rigat, Isolda (Institut d'Investigació Biomèdica Sant Pau) ;
Sánchez Chardi, Alejandro (Universitat Autònoma de Barcelona. Servei de Microscòpia) ;
López-Laguna, Hèctor (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Sánchez-García, Laura (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Sanchez, Julieta M. (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Unzueta Elorza, Ugutz (Institut d'Investigació Biomèdica Sant Pau) ;
Vázquez Gómez, Esther (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Mangues, Ramon 1957- (Institut d'Investigació Biomèdica Sant Pau) ;
Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Universitat Autònoma de Barcelona.
Departament de Genètica i de Microbiologia
Functional amyloids produced in bacteria as nanoscale inclusion bodies are intriguing but poorly explored protein materials with wide therapeutic potential. Since they release functional polypeptides under physiological conditions, these materials can be potentially tailored as mimetic of secretory granules for slow systemic delivery of smart protein drugs. [...]
2020 - 10.1002/adma.201907348
Advanced materials, Vol. 32, Issue 7 (February 2020) , art. 1907348
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29 p, 854.3 KB |
Nanostructured antimicrobial peptides : The last push towards clinics
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Carratalá, José Vicente (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Serna, Naroa (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Vázquez Gómez, Esther (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Ferrer-Miralles, Neus (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Universitat Autònoma de Barcelona.
Departament de Genètica i de Microbiologia
Peptide drugs hold great potential for the treatment of infectious diseases due to their unconventional mechanisms of action, biocompatibility, biodegradability and ease of synthesis and modification. [...]
2020 - 10.1016/j.biotechadv.2020.107603
Biotechnology advances, Vol. 44 (November 2020) , art. 107603
7 documents
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8.
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25 p, 743.6 KB |
Recruiting potent membrane penetrability in tumor cell-targeted protein-only nanoparticles
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Serna, Naroa (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Sanchez, Julieta M. (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Unzueta Elorza, Ugutz (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Sánchez-Garcia, Laura (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Sánchez Chardi, Alejandro (Universitat Autònoma de Barcelona. Servei de Microscòpia) ;
Mangues, Ramon 1957- (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Vázquez Gómez, Esther (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Universitat Autònoma de Barcelona.
Departament de Genètica i de Microbiologia
The membrane pore-forming activities of the antimicrobial peptide GWH1 have been evaluated in combination with the CXCR4-binding properties of the peptide T22, in self-assembling protein nanoparticles with high clinical potential. [...]
2019 - 10.1088/1361-6528/aaf959
Nanotechnology, Vol. 30, Issue 11 (March 2019) , art. 115101
7 documents
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9.
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19 p, 701.6 KB |
Engineering protein venoms as self-assembling CXCR4-targeted cytotoxic nanoparticles
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Serna, Naroa (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Cano-Garrido, Olivia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Sánchez-García, Laura (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Pesarrodona Roches, Mireia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Unzueta Elorza, Ugutz (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Sánchez Chardi, Alejandro (Universitat Autònoma de Barcelona. Servei de Microscòpia) ;
Mangues, Ramon 1957- (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Vázquez Gómez, Esther (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Universitat Autònoma de Barcelona.
Departament de Genètica i de Microbiologia
Protein venoms are effective cytotoxic molecules that when conveniently targeted to tumoral markers can be exploited as promising anticancer drugs. Here, it is explored whether the structurally unrelated melittin, gomesin, and CLIP71 could be functionally active when engineered, in form of GFP fusions, as self-assembling multimeric nanoparticles. [...]
2020 - 10.1002/ppsc.202000040
Particle & particle systems characterization, Vol. 37, Issue 6 (June 2020) , art. 2000040
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