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1.
7 p, 663.7 KB Common and rare TBK1 variants in early-onset Alzheimer disease in a European cohort / Verheijen, Jan (University of Antwerp) ; van der Zee, Julie (University of Antwerp) ; Gijselinck, Ilse (University of Antwerp) ; Van den Bossche, Tobi (University Hospital Antwerp (Bèlgica)) ; Dillen, Lubina (University of Antwerp) ; Heeman, Bavo (University of Antwerp) ; Gómez-Tortosa, Estrella (Hospital Universitario Fundación Jiménez Díaz) ; Lladó, Albert (Hospital Clínic i Provincial de Barcelona) ; Sanchez-Valle, Raquel (Hospital Clínic i Provincial de Barcelona) ; Graff, Caroline (Karolinska University Hospital and Karolinska Institutet (Suecia)) ; Pastor, Pau (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Pastor, Maria A. (Clínica Universidad de Navarra) ; Benussi, Luisa (Istituto Centro San Giovanni di Dio-Fatebenefratelli) ; Ghidoni, Roberta (Istituto Centro San Giovanni di Dio-Fatebenefratelli) ; Binetti, Giuliano (Istituto Centro San Giovanni di Dio-Fatebenefratelli) ; Clarimón, Jordi (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ; de Mendonça, Alexandre (University of Lisbon) ; Gelpi, Ellen (Hospital Clínic i Provincial de Barcelona) ; Tsolaki, Magda (Aristotle University of Thessaloniki) ; Diehl-Schmid, Janine (Technische Universität München) ; Nacmias, Benedetta (University of Florence) ; Almeida, Maria Rosário (University of Coimbra) ; Borroni, Barbara (University of Brescia) ; Matej, Radoslav (Thomayer Hospital in Prague) ; Ruiz, Agustín (Fundació ACE) ; Engelborghs, Sebastiaan (University Hospital Antwerp (Bèlgica)) ; Vandenberghe, Rik (University Hospitals Leuven (Bèlgica)) ; De Deyn, Peter P. (University Hospital Antwerp (Bèlgica)) ; Cruts, Marc (University of Antwerp) ; Van Broeckhoven, Christine (University of Antwerp) ; Sleegers, Kristel (University of Antwerp) ; Goeman, Johan ; Nuytten, Dirk ; Vandenbulcke, Mathieu ; Santens, Patrick 700 1_ ; Sieben, Anne ; Dermaut, Bart ; Versijpt, Jan ; Michotte, Alex ; Deryck, Olivier ; Bergmans, Bruno ; Willems, Christiana ; Ivanoiu, Adrian ; Salmon, Eric ; Alexopoulos, Panagiotis (Technische Universität München) ; Sorbi, Sandro ; Bessi, Valentina ; Bagnoli, Silvia ; Santana, Isabel ; Simões do Couto, Frederico ; Martins, Madalena ; Thonberg, Häkan ; Fratiglioni, Laura ; Padovani, Alessandro ; Rohan, Zdenek ; Razquin, Cristina ; Lorenzo, Elena ; Iglesias, Elena ; Seijo-Martínez, Manuel ; Rene, Ramon ; Gascon, Jordi ; Campdelacreu, Jaume ; Koutroumani, Maria ; Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ; Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ; Blesa, Rafael (Institut d'Investigació Biomèdica Sant Pau) ; Universitat Autònoma de Barcelona
TANK-binding kinase 1 (TBK1) loss-of-function (LoF) mutations are known to cause frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), often combined with memory deficits early in the disease course. [...]
2018 - 10.1016/j.neurobiolaging.2017.10.012
Neurobiology of Aging, Vol. 62 (february 2018) , p. 245.e1-245.e7  
2.
11 p, 1.1 MB Atrophy in the thalamus but not cerebellum is specific for C9orf72 FTD and ALS patients - An atlas-based volumetric MRI study / Schönecker, Sonja (Ludwig-Maximilians-Universität) ; Neuhofer, Christiane (Ludwig-Maximilians-Universität) ; Otto, Markus (University of Ulm) ; Ludolph, Albert (University of Ulm) ; Kassubek, Jan (University of Ulm) ; Landwehrmeyer, Bernhard (University of Ulm) ; Anderl-Straub, Sarah (University of Ulm) ; Semler, Elisa (University of Ulm) ; Diehl-Schmid, Janine (Technical University of Munich) ; Prix, Catharina (Ludwig-Maximilians-Universität) ; Vollmar, Christian (Ludwig-Maximilians-Universität) ; Fortea, Juan (Institut d'Investigació Sant Pau) ; Huppertz, Hans-Jürgen (Swiss Epilepsy Clinic) ; Arzberger, Thomas (Ludwig-Maximilians-Universität) ; Edbauer, Dieter (Munich Cluster for Systems Neurology (SyNergy)) ; Feddersen, Berend (Ludwig-Maximilians-Universität) ; Dieterich, Marianne (Munich Cluster for Systems Neurology (SyNergy)) ; Schroeter, Matthias L. (University Hospital Leipzig) ; Volk, Alexander E. (University Medical Center Hamburg-Eppendorf) ; Fließbach, Klaus (University Hospital Bonn (Bonn, Alemanya)) ; Schneider, Anja (University Hospital Bonn (Bonn, Alemanya)) ; Kornhuber, Johannes (Friedrich-Alexander University Erlangen-Nürnberg) ; Maler, Manuel (Friedrich-Alexander University Erlangen-Nürnberg) ; Prudlo, Johannes (German Center for Neurodegenerative Diseases (DZNE)) ; Jahn, Holger (AMEOS Klinikum Heiligenhafen) ; Boeckh-Behrens, Tobias (Technical University of Munich) ; Danek, Adrian (Ludwig-Maximilians-Universität) ; Klopstock, Thomas (Ludwig-Maximilians-Universität) ; Levin, Johannes (German Center for Neurodegenerative Diseases (DZNE)) ; Universitat Autònoma de Barcelona
The neuropathology of patients with frontotemporal dementia (FTD) or amyotrophic lateral sclerosis (ALS) due to a C9orf72 mutation is characterized by two distinct types of characteristic protein depositions containing either TDP-43 or so-called dipeptide repeat proteins that extend beyond frontal and temporal regions. [...]
2018 - 10.3389/fnagi.2018.00045
Frontiers in aging neuroscience, Vol. 10 Núm. FEB (15 2018) , p. 45  
3.
3 p, 377.7 KB No supportive evidence for TIA1 gene mutations in a European cohort of ALS-FTD spectrum patients / Baradaran-Heravi, Yalda (University of Antwerp) ; Dillen, Lubina (University of Antwerp) ; Nguyen, Hung Phuoc (University of Antwerp) ; Van Mossevelde, Sara (Antwerp University Hospital (UZA)) ; Baets, Jonathan (VIB-UAntwerp Center for Molecular Neurology) ; De Jonghe, Peter (VIB-UAntwerp Center for Molecular Neurology) ; Engelborghs, Sebastiaan (Hospital Network Antwerp (ZNA)) ; De Deyn, Peter Paul (Hospital Network Antwerp (ZNA)) ; Vandenbulcke, Mathieu (University Hospitals Leuven (Bèlgica)) ; Vandenberghe, Rik (University Hospitals Leuven (Bèlgica)) ; Van Damme, Philip (VIB) ; Cras, Patrick (Antwerp University Hospital (UZA)) ; Salmon, Eric (University of Liege and Memory Clinic) ; Synofzik, Matthis (German Center for Neurodegenerative Diseases (DZNE)) ; Heutink, Peter (German Center for Neurodegenerative Diseases (DZNE)) ; Wilke, Carlo (German Center for Neurodegenerative Diseases (DZNE)) ; Simón Sánchez, Javier (German Center for Neurodegenerative Diseases (DZNE)) ; Rojas-Garcia, Ricard (Institut d'Investigació Biomèdica Sant Pau) ; Turon-Sans, Janina (Institut d'Investigació Biomèdica Sant Pau) ; Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ; Illán-Gala, Ignacio (Institut d'Investigació Biomèdica Sant Pau) ; Clarimón, Jordi (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ; Borroni, Barbara (University of Brescia) ; Padovani, Alessandro (University of Brescia) ; Pastor, Pau (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ; Diez-Fairen, Monica (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ; Aguilar, Miquel Chávez (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ; Gelpi, Ellen (Hospital Clínic i Provincial de Barcelona) ; Sanchez-Valle, Raquel (Hospital Clínic i Provincial de Barcelona) ; Borrego-Écija, Sergi (Hospital Clínic i Provincial de Barcelona) ; Matej, Radoslav (Charles University) ; Parobkova, Eva (Charles University) ; Nacmias, Benedetta (University of Florence) ; Sorbi, Sandro (IRCCS Don Gnocchi) ; Bagnoli, Silvia (University of Florence) ; de Mendonça, Alexandre (University of Lisbon) ; Ferreira, Catarina B. (University of Lisbon) ; Fraidakis, Matthew Joseph (NeuroRARE Centre for Rare and Genetic Neurological & Neuromuscular Diseases & Neurogenetics) ; Diehl-Schmid, Janine (Technische Universität München) ; Alexopoulos, Panagiotis (Technische Universität München) ; Almeida, Maria (University of Coimbra) ; Santana, Isabel (University of Coimbra) ; Van Broeckhoven, Christine (University of Antwerp) ; Van der Zee, Julie (University of Antwerp) ; Goeman, Johan (BELNEU Consortium) ; Nuytten, Dirk (BELNEU Consortium) ; Sieben, Anne (BELNEU Consortium) ; De Bleecker, Jan L. (BELNEU Consortium) ; Santens, Patrick (BELNEU Consortium) ; Versijpt, Jan (BELNEU Consortium) ; Michotte, Alex (BELNEU Consortium) ; Ivanoiu, Adrian (BELNEU Consortium) ; Deryck, Olivier (BELNEU Consortium) ; Bergmans, Bruno (BELNEU Consortium) ; Willems, Christiana (BELNEU Consortium) ; De Klippel, Nina (BELNEU Consortium) ; Peeters, Dirk (BELNEU Consortium) ; Archettim, Silvana (EU EOD Consortium) ; Bonomi, Elisa (EU EOD Consortium) ; Piaceri, Irene (EU EOD Consortium) ; Ferrari, Camilla (EU EOD Consortium) ; Simões do Couto, Federico (EU EOD Consortium) ; Verdelho, Ana (EU EOD Consortium) ; Miltenberger-Miltényi, Gabriel (EU EOD Consortium) ; Universitat Autònoma de Barcelona
We evaluated the genetic contribution of the T cell-restricted intracellular antigen-1 gene (TIA1) in a European cohort of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) patients. [...]
2018 - 10.1016/j.neurobiolaging.2018.05.005
Neurobiology of Aging, Vol. 69 (september 2018) , p. 293.e9-293.e11  
4.
12 p, 1.2 MB Mendelian randomization implies no direct causal association between leukocyte telomere length and amyotrophic lateral sclerosis / Gao, Yixin (Xuzhou Medical University) ; Wang, Ting (Xuzhou Medical University) ; Yu, Xinghao (Xuzhou Medical University) ; Ferrari, Raffaele (Russell Square House) ; Hernandez, Dena G. (Queen Square) ; Nalls, Michael A. (National Institute on Aging (Bethesda, Estats Units d'Amèrica)) ; Rohrer, Jonathan D. (Queen Square) ; Ramasamy, Adaikalavan (University of Oxford) ; Kwok, John B.J. (University of New South Wales) ; Dobson-Stone, Carol (University of New South Wales) ; Brooks, William S. (University of New South Wales) ; Schofield, Peter R. (Neuroscience Research Australia) ; Halliday, Glenda M. (Neuroscience Research Australia) ; Hodges, John R. (Neuroscience Research Australia) ; Piguet, Olivier (Neuroscience Research Australia) ; Bartley, Lauren (Neuroscience Research Australia) ; Thompson, Elizabeth (University of Adelaide) ; Haan, Eric (University of Adelaide) ; Hernández, Isabel (Institut Català de Neurociéncies Aplicades) ; Ruiz, Agustín (Institut Català de Neurociéncies Aplicades) ; Boada, Mercè (Institut Català de Neurociéncies Aplicades) ; Borroni, Barbara (University of Brescia) ; Padovani, Alessandro (University of Brescia) ; Cruchaga, Carlos (Washington University School of Medicine) ; Cairns, Nigel J. (Washington University) ; Benussi, Luisa (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli) ; Binetti, Giuliano (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli) ; Ghidoni, Roberta (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli) ; Forloni, Gianluigi (IRCCS Istituto di Ricerche Farmacologiche. "Mario Negri") ; Albani, Diego (IRCCS Istituto di Ricerche Farmacologiche. "Mario Negri") ; Galimberti, Daniela (IRCCS Ospedale Maggiore Policlinico) ; Fenoglio, Chiara (IRCCS Ospedale Maggiore Policlinico) ; Serpente, Maria (IRCCS Ospedale Maggiore Policlinico) ; Scarpini, Elio (University of Milan) ; Clarimón, Jordi (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ; Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ; Blesa, Rafael (Institut d'Investigació Biomèdica Sant Pau) ; Waldö, Maria Landqvist (Lund University) ; Nilsson, Karin (Lund University) ; Nilsson, Christer (Lund University) ; Mackenzie, Ian R.A. (University of British Columbia) ; Hsiung, Ging-Yuek R. (University of British Columbia) ; Mann, David M. A. (Salford Royal Hospital) ; Grafman, Jordan (Northwestern University) ; Morris, Christopher M. (Newcastle University) ; Attems, Johannes (Newcastle University) ; Griffiths, Timothy D. (Newcastle University Medical School) ; McKeith, Ian G. (Newcastle University) ; Thomas, Alan J. (Newcastle University) ; Pietrini, Pietro (IMT School for Advanced Studies) ; Huey, Edward D. (Columbia University) ; Wassermann, Eric M. (National Insititutes of Health) ; Baborie, Atik (University of Alberta Edmonton) ; Jaros, Evelyn (Newcastle University) ; Tierney, Michael C. (National Insititutes of Health) ; Pastor, Pau (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Razquin, Cristina (Universidad de Navarra) ; Ortega-Cubero, Sara (Universidad de Navarra) ; Alonso, Elena (Universidad de Navarra) ; Perneczky, Robert (West London Mental Health Trust) ; Diehl-Schmid, Janine (Technische Universität München) ; Alexopoulos, Panagiotis (Technische Universität München) ; Kurz, Alexander (Technische Universität München) ; Rainero, Innocenzo (A.O. Città della Salute e della Scienza di Torino) ; Rubino, Elisa (A.O. Città della Salute e della Scienza di Torino) ; Pinessi, Lorenzo (A.O. Città della Salute e della Scienza di Torino) ; Rogaeva, Ekaterina (University of Toronto) ; George-Hyslop, Peter St (University of Cambridge) ; Rossi, Giacomina (Fondazione IRCCS Istituto Neurologico Carlo Besta) ; Tagliavini, Fabrizio (Fondazione IRCCS Istituto Neurologico Carlo Besta) ; Giaccone, Giorgio (Fondazione IRCCS Istituto Neurologico Carlo Besta) ; Rowe, James B. (Behavioural and Clinical Neuroscience Institute) ; Schlachetzki, Johannes C. M. (University of California San Diego) ; Uphill, James (University College London. Institute of Neurology) ; Collinge, John (University College London. Institute of Neurology) ; Mead, Simon (University College London. Institute of Neurology) ; Danek, Adrian (German Center for Neurodegenerative Diseases (DZNE)) ; Van Deerlin, Vivianna M. (University of Pennsylvania Perelman School of Medicine) ; Grossman, Murray (University of Pennsylvania Perelman School of Medicine) ; Trojanowski, John Q. (University of Pennsylvania Perelman School of Medicine) ; van der Zee, Julie (University of Antwerp) ; Cruts, Marc (University of Antwerp) ; Van Broeckhoven, Christine (University of Antwerp) ; Cappa, Stefano F. (Vita-Salute University and San Raffaele Scientific Institute) ; Leber, Isabelle (CNRS UMR 7225) ; Hannequin, Didier (Rouen University Hospital (França)) ; Golfier, Véronique (CH Saint Brieuc) ; Vercelletto, Martine (CHU Nantes) ; Brice, Alexis (AP-HP. Hôpital de la Salpêtrière) ; Nacmias, Benedetta (University of Florence) ; Sorbi, Sandro (University of Florence and IRCCS "Don Carlo Gnocchi" Firenze) ; Bagnoli, Silvia (University of Florence) ; Piaceri, Irene (University of Florence) ; Nielsen, Jørgen E. (Copenhagen University Hospital) ; Hjermind, Lena E. (University of Copenhagen) ; Riemenschneider, Matthias (Saarland University) ; Mayhaus, Manuel (Saarland University) ; Ibach, Bernd (University Regensburg) ; Gasparoni, Gilles (Saarland University) ; Pichler, Sabrina (Saarland University) ; Gu, Wei (University of Luxembourg) ; Rossor, Martin N. (Queen Square) ; Fox, Nick C. (University College London Queen Square Institute of Neurology. Dementia Research Centre) ; Warren, Jason D. (Queen Square) ; Spillantini, Maria Grazia (University of Cambridge) ; Morris, Huw R. (Russell Square House) ; Rizzu, Patrizia (German Center for Neurodegenerative Diseases-Tübingen) ; Heutink, Peter (German Center for Neurodegenerative Diseases-Tübingen) ; Snowden, Julie S. (University of Manchester) ; Rollinson, Sara (University of Manchester) ; Richardson, Anna (University of Manchester) ; Gerhard, Alexander (The University of Manchester) ; Bruni, Amalia C. (ASPCZ) ; Maletta, Raffaele (ASPCZ) ; Frangipane, Francesca (ASPCZ) ; Cupidi, Chiara (ASPCZ) ; Bernardi, Livia (ASPCZ) ; Anfossi, Maria (ASPCZ) ; Gallo, Maura (ASPCZ) ; Conidi, Maria Elena (ASPCZ) ; Smirne, Nicoletta (ASPCZ) ; Rademakers, Rosa (Mayo Clinic Jacksonville) ; Baker, Matt (Mayo Clinic Jacksonville) ; Dickson, Dennis W. (Mayo Clinic Jacksonville) ; Graff-Radford, Neill R. (Mayo Clinic Jacksonville) ; Petersen, Ronald C. (Mayo Clinic Rochester) ; Knopman, David (Mayo Clinic Rochester) ; Josephs, Keith A. (Mayo Clinic Rochester) ; Boeve, Bradley (Mayo Clinic Rochester) ; Parisi, Joseph E. (Mayo Clinic Rochester) ; Seeley, William W. (University of California) ; Miller, Bruce L. (University of California) ; Karydas, Anna M. (University of California) ; Rosen, Howard (University of California) ; van Swieten, John C. (VU University Medical Centre) ; Dopper, Elise G. P. (Erasmus Medical Centre) ; Seelaar, Harro (Erasmus Medical Centre) ; Pijnenburg, Yolande A. L. (VU University Medical Centre) ; Scheltens, Philip (VU University Medical Centre) ; Logroscino, Giancarlo (University of Bari) ; Capozzo, Rosa (University of Bari) ; Novelli, Valeria (Fondazione Policlinico Universitario A. Gemelli) ; Puca, Annibale A. (University of Salerno) ; Franceschi, Massimo (IRCCS Multimedica) ; Postiglione, Alfredo (University of Naples Federico II) ; Milan, Graziella (Geriatric Center Frullone- ASL Napoli 1 Centro) ; Sorrentino, Paolo (Geriatric Center Frullone- ASL Napoli 1 Centro) ; Kristiansen, Mark (Institute of Child Health (ICH)) ; Chiang, Huei-Hsin (Karolinska University Hospital and Karolinska Institutet (Suecia)) ; Graff, Caroline (Karolinska University Hospital and Karolinska Institutet (Suecia)) ; Pasquier, Florence (Univ Lille) ; Rollin, Adeline (Univ Lille) ; Deramecourt, Vincent (Univ Lille) ; Lebouvier, Thibaud (Univ Lille) ; Kapogiannis, Dimitrios (National Institute on Aging (NIA/NIH)) ; Ferrucci, Luigi (National Institute on Aging (Baltimore, Estats Units d'Amèrica)) ; Pickering-Brown, S. (University of Manchester) ; Singleton, Andrew B. (National Institute on Aging (Bethesda, Estats Units d'Amèrica)) ; Hardy, John (Russell Square House) ; Momeni, Parastoo (Texas Tech University Health Science Center) ; Zhao, Huashuo (Xuzhou Medical University) ; Zeng, Ping (Xuzhou Medical University) ; Universitat Autònoma de Barcelona
We employed Mendelian randomization (MR) to evaluate the causal relationship between leukocyte telomere length (LTL) and amyotrophic lateral sclerosis (ALS) with summary statistics from genome-wide association studies (n = ~ 38,000 for LTL and ~ 81,000 for ALS in the European population; n = ~ 23,000 for LTL and ~ 4,100 for ALS in the Asian population). [...]
2020 - 10.1038/s41598-020-68848-9
Scientific reports, Vol. 10 Núm. 1 (january 2020) , p. 12184  
5.
22 p, 1.4 MB Genome-wide meta-analysis for Alzheimer's disease cerebrospinal fluid biomarkers / Jansen, Iris (Vrije Universiteit Amsterdam) ; van der Lee, Sven J (Vrije Universiteit Amsterdam) ; Gomez-Fonseca, Duber (Washington University School of Medicine) ; De Rojas, Itziar (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Dalmasso, Maria Carolina (Neurosciences and Complex Systems Unit (ENyS). CONICET. Hospital El Cruce. National University A. Jauretche (UNAJ)) ; Grenier-Boley, Benjamin (Université de Lille) ; Zettergren, Anna (University of Gothenburg) ; Mishra, Aniket (Université de Bordeaux) ; Ali, Muhammad (Washington University School of Medicine) ; Andrade, Victor (University Hospital Bonn. Medical Faculty) ; Bellenguez, Céline (Université de Lille) ; Kleineidam, Luca (German Center for Neurodegenerative Diseases (DZNE)) ; Küçükali, Fahri (University of Antwerp. Department of Biomedical Sciences) ; Sung, Ju Sung (Washington University School of Medicine) ; Tesí, Niccolo (Vrije Universiteit Amsterdam) ; Vromen, Ellen (Amsterdam Neuroscience. Neurodegeneration) ; Wightman, Douglas P (Vrije Universiteit Amsterdam) ; Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ; Alegret, Montserrat (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Alvarez, Ignacio (Fundació per a la Recerca Biomèdica i Social Mútua de Terrassa) ; Amouyel, Philippe (Université de Lille) ; Athanasiu, Lavinia (NORMENT Centre. Institute of Clinical Medicine. University of Oslo and Division of Mental Health) ; Bahrami, Shahram (NORMENT Centre. Institute of Clinical Medicine. University of Oslo and Division of Mental Health) ; Bailly, Henri (Université Paris Cité) ; Belbin, Olivia (Institut d'Investigació Biomèdica Sant Pau) ; Bergh, Sverre (Vestfold Hospital Trust) ; Bertram, Lars (University of Lübeck) ; Biessels, Geert Jan (UMC Utrecht Brain Center) ; Blennow, Kaj (Sahlgrenska University Hospital (Suècia)) ; Blesa, Rafael (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ; Boada, Mercè (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Boland, Anne (Université Paris-Saclay. Centre National de Recherche en Génomique Humaine) ; Buerger, K. (Institute for Stroke and Dementia Research (ISD). University Hospital. LMU Munich) ; Carracedo, Ángel (Fundación Pública Galega de Medicina Xenómica-CIBERER-IDIS) ; Cervera Carles, Laura (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ; Chene, Geneviève (Department of Neurology. CHU de Bordeaux) ; Claassen, Jurgen (Donders Center for Medical Neuroscience) ; Debette, Stephanie (University School of Medicine) ; Deleuze, Jean‑Francois (Université Paris-Saclay. Centre National de Recherche en Génomique Humaine) ; De Deyn, Peter Paul (University Medical Center Groningen. Department of Neurology and Alzheimer Center Groningen.) ; Diehl-Schmid, Janine (kbo-Inn-Salzach-Hospital) ; Djurovic, Srdjan (University of Bergen. Department of Clinical Science. NORMENT Centre.) ; Dols Icardo, Oriol (Institut d'Investigació Biomèdica Sant Pau) ; Dufouil, Carole (Pôle de Santé Publique) ; Duron, Emmanuelle (Univerisité Paris-Saclay) ; Düzel, Emrah (Otto-von-Guericke University Magdeburg. Institute of Cognitive Neurology and Dementia Research) ; Fladby, Tormod (Akershus University Hospital. Department of Neurology.) ; Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ; Frölich, Lutz (Medical Faculty Mannheim. Department of Geriatric Psychiatry. Central Institute of Mental Health.) ; García-González, Pablo (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Garcia-Martinez, María (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) ; Giegling, Ina (Medical University of Vienna) ; Goldhardt, Oliver (Technical University of Munich) ; Gobom, Johan (Sahlgrenska University Hospital (Suècia)) ; Grimmer, Timo (Technical University of Munich) ; Haapasalo, Annakaisa (University of Eastern Finland A.I. Virtanen Institute for Molecular Sciences) ; Hampel, Harald (Neurology Business Group. Eisai Inc) ; Hanon, Olivier (Service gériatrie. Centre Mémoire de Ressources et Recherches Ile de France-Broca. AP-HP. Hôpital Broca) ; Hausner, Lucrezia (Central Institute of Mental Health. Department of Geriatric Psychiatry) ; Heilmann-Heimbach, Stefanie (Institute of Human Genetics. University of Bonn. School of Medicine and University Hospital Bonn) ; Helisalmi, Seppo (University of Eastern Finland. Institute of Clinical Medicine) ; Heneka, Michael (German Center for Neurodegenerative Diseases (DZNE)) ; Hernández, Isabel (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Herukka, Sanna‑Kaisa (University of Eastern Finland. Department of Neurology. Institute of Clinical Medicine) ; Holstege, Henne (Vrije Universiteit Amsterdam. Section Genomics of Neurodegenerative Diseases and Aging) ; Jarholm, Jonas (Akershus University Hospital. Department of Neurology.) ; Kern, Silke (Sahlgrenska University Hospital. Psychiatry. Cognition and Old Age Psychiatry Clinic) ; Knapskog, Anne‑Brita (Oslo University Hospital. Department of Geriatric Medicine) ; Koivisto, A.M. (Department of Neurology. Helsinki University Hospital) ; Kornhuber, Johannes (Friedrich-Alexander Universität Erlangen-Nürnberg) ; Kuulasmaa, Teemu (University of Eastern Finland) ; Lage, Carmen (University of California) ; Laske, Christoph (University of Tübingen. Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy.) ; Leinonen, Ville (Kuopio University Hospita. Department of Neurosurgery.) ; Lewczuk, Piotr (Medical University of Białystok. Department of Neurodegeneration Diagnostics.) ; Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ; López de Munain, Adolfo (University of The Basque Country) ; López-Garcia, Sara (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) ; Maier, Wolfgang (University Hospital Bonn. Department of Neurodegenerative Diseases and Geriatric Psychiatry) ; Marquié, Marta (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Mol, Merel O. (Erasmus Medical Centre. Department of Neurology) ; Montrreal, Laura (Universitat Internacional de Catalunya. Ace Alzheimer Center Barcelona) ; Moreno, Fermin (Biodonostia Osasun Ikerketako Institutura (País Basc)) ; Moreno-Grau, Sonia (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Nicolas, Gael (Normandie Univ. UNIROUEN. Department of Genetics and CNR-MAJ) ; Nöthen, Markus M. (Institute of Human Genetics. University of Bonn. School of Medicine and University Hospital Bonn) ; Orellana, Adelina (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Pålhaugen, Lene (Akershus University Hospital. Department of Neurology) ; Papma, Janne M. (Erasmus MC University Medical Center. Department of Neurology and Alzheimer Center Erasmus MC) ; Pasquier, Florence (Université Lille) ; Perneczky, Robert (Imperial College London. Ageing Epidemiology Research Unit) ; Peters, Oliver (German Center for Neurodegenerative Diseases (DZNE)) ; Pijnenburg, Yolande A.L. (Amsterdam Neuroscience. Neurodegeneration) ; Popp, Julius (University Hospital of Lausanne. Department of Psychiatry) ; Posthuma, Danielle (Vrije Universiteit Amsterdam) ; Pozueta, Ana (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) ; Priller, Josef (Technical University Munich. Department of Psychiatry and Psychotherapy) ; Puerta, Raquel (Universitat Internacional de Catalunya. Ace Alzheimer Center Barcelona) ; Quintela, Inés (Grupo de Medicina Xenómica. Centro Nacional de Genotipado (CEGEN-PRB3-ISCIII). Universidade de Santiago de Compostela) ; Ramakers, Inez (Maastricht University. Department of Psychiatry and Neuropsychologie) ; Rodríguez-Rodríguez, Eloy (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) ; Rujescu, Dan (Medical University of Vienna. Department of Psychiatry and Psychotherapy) ; Saltvedt, Ingvild (University Hospital of Trondheim. Department of Geriatrics) ; Sánchez-Juan, Pascual (Alzheimer's Centre Reina Sofia-CIEN Foundation-ISCIII) ; Scheltens, Philip (Amsterdam Neuroscience. Neurodegeneration) ; Scherbaum, Norbert (University of Duisburg-Essen) ; Schmid, Matthias (University Hospital of Bonn. Institute of Medical Biometry) ; Schneider, Anja (German Center for Neurodegenerative Diseases (DZNE)) ; Selbæk, Geir (Oslo University Hospital.Department of Geriatric Medicine) ; Selnes, Per (Akershus University Hospital. Department of Neurology) ; Shadrin, Alexey (University of Oslo and Division of Mental Health. Institute of Clinical Medicine) ; Skoog, Ingmar (Sahlgrenska University Hospital (Suècia)) ; Soininen, Hilkka (University of Eastern Finland. Institute of Clinical Medicine.) ; Tárraga, Lluís (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Teipel, Stefan (Rostock University Medical Center. Department of Psychosomatic Medicine) ; Tijms, Betty M (Amsterdam Neuroscience. Neurodegeneration) ; Tsolaki, Magda (Aristotle University of Thessaloniki) ; Van Broeckhoven, Christine (Neurodegenerative Brain Diseases Group. VIB Center for Molecular Neurology. VIB) ; Van Dongen, Jasper (University of Antwerp. Department of Biomedical Sciences) ; van Swieten, John C. (Erasmus MC University Medical Center) ; Vandenberghe, Rik (Leuven Brain Institute. Department of Neurosciences.) ; Vidal, Jean‑Sébastien (Université Paris Cité) ; Visser, Pieter J. (Division of Neurogeriatrics Karolinska Institutet. Department of Neurobiology) ; Vogelgsang, Jonathan (Harvard Medical School. Department of Psychiatry) ; Waern, Margda (Sahlgrenska University Hospital (Suècia)) ; Wagner, Michael (German Center for Neurodegenerative Diseases (DZNE)) ; Wiltfang, Jens W (Medical Science Department. iBiMED) ; Wittens, Mandy M.J. (Vrije Universiteit Brussel) ; Zetterberg, Henrik (Hong Kong Center for Neurodegenerative Diseases) ; Zulaica, Miren (Biodonostia Osasun Ikerketako Institutura (País Basc)) ; van Duijn, Cornelia M. (Nuffield Department of Population Health. Oxford University) ; Bjerke, Maria (Universitair Ziekenhuis Brussel) ; Engelborghs, Sebastiaan (Universitair Ziekenhuis Brussel. Department of Neurology) ; Jessen, Frank (University of Cologne) ; Teunissen, Charlotte E. (Vrije Universiteit Amsterdam) ; Pastor, Pau (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Hiltunen, Mikko (University of Eastern Finland. Institute of Biomedicine) ; Ingelsson, Martin (University of Toronto. Department of Medicine) ; Andreassen, Ole A (Oslo University Hospital (Oslo, Noruega)) ; Clarimón, Jordi (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ; Sleegers, Kristel (University of Antwerp. Department of Biomedical Sciences) ; Ruiz, Agustín (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Ramirez, Alfredo (Department of Psychiatry. Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases) ; Cruchaga, Carlos (Washington University School of Medicine. Hope Center for Neurological Disorders) ; Lambert, Jean-Charles (Institut Pasteur de Lille) ; van der Flier, Wiesje M (Amsterdam Neuroscience. Neurodegeneration) ; Universitat Autònoma de Barcelona
Amyloid-beta 42 (Aβ42) and phosphorylated tau (pTau) levels in cerebrospinal fluid (CSF) reflect core features of the pathogenesis of Alzheimer's disease (AD) more directly than clinical diagnosis. Initiated by the European Alzheimer & Dementia Biobank (EADB), the largest collaborative effort on genetics underlying CSF biomarkers was established, including 31 cohorts with a total of 13,116 individuals (discovery n = 8074; replication n = 5042 individuals). [...]
2022 - 10.1007/s00401-022-02454-z
Acta Neuropathologica, Vol. 144 Núm. 5 (november 2022) , p. 821-842  
6.
2 p, 2.0 MB Author Correction : Common variants in Alzheimer's disease and risk stratification by polygenic risk scores / De Rojas, Itziar (Universitat Internacional de Catalunya. Institut Català de Neurociències Aplicades) ; Moreno-Grau, Sonia (Universitat Internacional de Catalunya. Institut Català de Neurociències Aplicades) ; Tesi, Niccolo (Delft Univeristy of Technology) ; Grenier-Boley, Benjamin (Institut Pasteur de Lille) ; Andrade, Victor (University Clinic Bonn) ; Jansen, Iris E. (VU University) ; Pedersen, Nancy L. (Karolinska Institutet (Estocolm, Suècia)) ; Stringa, Najada (Amsterdam Public Health Research Institute) ; Zettergren, Anna (University of Gothenburg) ; Hernández, Isabel (Universitat Internacional de Catalunya. Institut Català de Neurociències Aplicades) ; Montrreal, Laura (Universitat Internacional de Catalunya. Institut Català de Neurociències Aplicades) ; Antúnez, Carmen (Hospital Clínico Universitario Virgen de la Arrixaca (El Palmar, Múrcia)) ; Antonell, Anna (Hospital Clínic i Provincial de Barcelona) ; Tankard, Rick M. (Murdoch University) ; Bis, Joshua C (University of Washington) ; Sims, Rebecca (Cardiff University) ; Bellenguez, Céline (Institut Pasteur de Lille) ; Quintela, Inés (Universidade de Santiago de Compostela) ; González-Perez, Antonio (Centro Andaluz de Estudios Bioinformáticos) ; Calero, Miguel (Fundación Reina Sofía) ; Franco-Macías, Emilio (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ; Macías, Juan (Hospital Universitario Virgen de Valme (Sevilla, Andalusia)) ; Blesa, Rafael (Institut d'Investigació Biomèdica Sant Pau) ; Cervera Carles, Laura (Institut d'Investigació Biomèdica Sant Pau) ; Mendez-Gonzalez, Manuel (Universidad de Oviedo) ; Frank-García, Ana (Universidad Autónoma de Madrid) ; Royo, Jose Luís (Universidad de Málaga) ; Moreno, Fermin (Biodonostia Osasun Ikerketako Institutura (País Basc)) ; Huerto Vilas, Raquel (Institut de Recerca Biomedica de Lleida (IRBLLeida)) ; Baquero, Miquel (Hospital Universitari i Politècnic La Fe (València)) ; Diez-Fairen, Monica (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ; Lage, Carmen (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) ; García-Madrona, Sebastián (Hospital Universitario Ramón y Cajal (Madrid)) ; García-González, Pablo (Universitat Internacional de Catalunya. Institut Català de Neurociències Aplicades) ; Alarcón-Martín, Emilio (Universitat Internacional de Catalunya. Institut Català de Neurociències Aplicades) ; Valero, Sergi (Universitat Internacional de Catalunya. Institut Català de Neurociències Aplicades) ; Sotolongo Grau, Oscar (Universitat Internacional de Catalunya. Institut Català de Neurociències Aplicades) ; Ullgren, Abbe (Karolinska University Hospital and Karolinska Institutet (Suecia)) ; Naj, Adam C. (University of Pennsylvania Perelman School of Medicine) ; Lemstra, Afina W. (Vrije Universiteit Amsterdam) ; Benaque, Alba (Universitat Internacional de Catalunya. Institut Català de Neurociències Aplicades) ; Pérez-Cordón, Alba (Universitat Internacional de Catalunya. Institut Català de Neurociències Aplicades) ; Benussi, Alberto (University of Brescia) ; Rábano, Alberto (BT-CIEN) ; Padovani, Alessandro (University of Brescia) ; Squassina, Alessio (University of Cagliari) ; de Mendonça, Alexandre (University of Lisbon) ; Arias Pastor, Alfonso (Institut de Recerca Biomedica de Lleida (IRBLLeida)) ; Kok, Almar A. L. (Amsterdam Public Health Research Institute) ; Meggy, Alun (Cardiff University) ; Pastor, Ana Belén (BT-CIEN) ; Espinosa, Ana (Universitat Internacional de Catalunya. Institut Català de Neurociències Aplicades) ; Corma-Gómez, Anaïs (Hospital Universitario Virgen de Valme (Sevilla, Andalusia)) ; Martín Montes, Angel (Hospital Universitario La Paz (Madrid)) ; Sanabria, Ángela (Universitat Internacional de Catalunya. Institut Català de Neurociències Aplicades) ; DeStefano, Anita L. (Boston University School of Public Health) ; Schneider, Anja (German Center for Neurodegenerative Diseases (DZNE)) ; Haapasalo, Annakaisa (University of Eastern Finland) ; Kinhult Ståhlbom, Anne (Karolinska University Hospital and Karolinska Institutet (Suecia)) ; Tybjærg-Hansen, Anne (University of Copenhagen) ; Hartmann, Annette M. (Martin-Luther-University Halle-Wittenberg) ; Spottke, Annika (University of Bonn) ; Corbatón-Anchuelo, Arturo (Hospital Clínico San Carlos (Madrid)) ; Rongve, Arvid (University of Bergen) ; Borroni, Barbara (University of Brescia) ; Arosio, Beatrice (IRCCS Ospedale Maggiore Policlinico) ; Nacmias, Benedetta (IRCCS Fondazione Don Carlo Gnocchi) ; Nordestgaard, Børge G. (Herlev Gentofte Hospital) ; Kunkle, Brian W. (University of Miami Miller School of Medicine) ; Charbonnier, Camille (Normandie Univ) ; Abdelnour, Carla (Universitat Internacional de Catalunya. Institut Català de Neurociències Aplicades) ; Masullo, Carlo (Catholic University of the Sacred Heart) ; Martínez Rodríguez, Carmen (Hospital Universitario de Cabueñes (Gijón)) ; Muñoz-Fernandez, Carmen (Hospital Universitario de Gran Canaria Dr.Negrín) ; Dufouil, Carole (CHU de Bordeaux) ; Graff, Caroline (Karolinska University Hospital and Karolinska Institutet (Suecia)) ; Ferreira, Catarina B. (Universidade de Lisboa) ; Chillotti, Caterina (University Hospital of Cagliari) ; Reynolds, Chandra A. (University of California-Riverside) ; Fenoglio, Chiara (University of Milan) ; Van Broeckhoven, Christine (University of Antwerp) ; Clark, Christopher (University of Zürich) ; Pisanu, Claudia (University of Cagliari) ; Satizabal, Claudia L. (UT Health San Antonio) ; Holmes, Clive (University of Southampton) ; Buiza-Rueda, Dolores (Instituto de Biomedicina de Sevilla) ; Aarsland, Dag (Stavanger University Hospital) ; Rujescu, Dan (Martin-Luther-University Halle-Wittenberg) ; Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ; Galimberti, Daniela (Ospedale Policlinico) ; Wallon, David (Normandie Univ) ; Seripa, Davide (Complex Structure of Geriatrics) ; Grünblatt, Edna (University of Zurich) ; Dardiotis, Efthimios (University of Thessaly) ; Düzel, Emrah (Otto-von-Guericke University) ; Scarpini, Elio (Ospedale Policlinico, Milan, Italy) ; Conti, Elisa (University of Milano-Bicocca and Milan Center for Neuroscience) ; Rubino, Elisa (AOU Città della Salute e della Scienza di Torino) ; Gelpi, Ellen (Medical University of Vienna) ; Rodríguez-Rodríguez, Eloy (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) ; Duron, Emmanuelle (Hôpital Broca) ; Boerwinkle, Eric (Baylor College of Medicine) ; Ferri, Evelyn (IRCCS Ospedale Maggiore Policlinico) ; Tagliavini, Fabrizio (Fondazione IRCCS Istituto Neurologico Carlo Besta) ; Küçükali, Fahri (University of Antwerp) ; Pasquier, Florence (CHU CNR-MAJ) ; Sanchez-Garcia, Florentino (Hospital Universitario de Gran Canaria Dr. Negrín) ; Mangialasche, Francesca (Karolinska Institutet (Estocolm, Suècia)) ; Jessen, Frank (University of Cologne) ; Nicolas, Gaël (Hospital Universitario de Cabueñes (Gijón)) ; Selbæk, Geir (University of Oslo) ; Ortega, Gemma (Universitat Internacional de Catalunya. Institut Català de Neurociències Aplicades) ; Chêne, Geneviève (CHU de Bordeaux) ; Hadjigeorgiou, Georgios (University of Cyprus) ; Rossi, Giacomina (Fondazione IRCCS Istituto Neurologico Carlo Besta) ; Spalletta, Gianfranco (Baylor College of Medicine) ; Giaccone, Giorgio (Fondazione IRCCS Istituto Neurologico Carlo Besta) ; Grande, Giulia (Karolinska Institutet and Stockholm University) ; Binetti, Giuliano (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli) ; Papenberg, Goran (Karolinska Institutet and Stockholm University) ; Hampel, Harald (Sorbonne University) ; Bailly, Henri (Université Paris Descartes) ; Zetterberg, Henrik (UCL Institute of Neurology (Regne Unit)) ; Soininen, Hilkka (Kuopio University Hospital ( Finlàndia)) ; Karlsson, Ida K. (Jönköping University) ; Alvarez, Ignacio (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ; Appollonio, Ildebrando (Ospedale San Gerardo (Itàlia)) ; Giegling, Ina (Martin-Luther-University Halle-Wittenberg) ; Skoog, Ingmar (University of Gothenburg) ; Saltvedt, Ingvild (Norwegian University of Science and Technhology) ; Rainero, Innocenzo (University of Torino) ; Rosas Allende, Irene (Hospital Universitario Central de Asturias) ; Hort, Jakub (St. Anne's University Hospital Brno) ; Diehl-Schmid, Janine (Technical University of Munich) ; Van Dongen, Jasper (Institute Born-Bunge) ; Vidal, Jean-Sébastien (Université Paris Descartes) ; Lehtisalo, Jenni (Finnish Institute for Health and Welfare) ; Wiltfang, Jens (University of Aveiro) ; Thomassen, Jesper Qvist (Copenhagen University Hospital Rigshospitalet) ; Kornhuber, Johannes (Friedrich-Alexander Universität Erlangen-Nürnberg) ; Haines, Jonathan L. (Case Western Reserve University) ; Vogelgsang, Jonathan (Harvard Medical School) ; Pineda, Juan A. (Hospital Universitario Virgen de Valme (Sevilla, Andalusia)) ; Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ; Popp, Julius (Lausanne University Hospital) ; Deckert, Jürgen (University Hospital) ; Buerger, Katharina (German Center for Neurodegenerative Diseases) ; Morgan, Kevin (University of Nottingham) ; Fließbach, Klaus (University Clinic Bonn) ; Sleegers, Kristel (University of Antwerp) ; Molina-Porcel, Laura (Hospital Clínic i Provincial de Barcelona) ; Kilander, Lena (Uppsala) ; Weinhold, Leonie (University Hospital of Bonn) ; Farrer, Lindsay A. (Boston University Schools of Medicine and Public Health) ; Wang, Li-San (University of Pennsylvania Perelman School of Medicine) ; Kleineidam, Luca (University Clinic Bonn) ; Farotti, Lucia (University of Perugia) ; Parnetti, Lucilla (University of Perugia) ; Tremolizzo, Lucio (Ospedale San Gerardo (Itàlia)) ; Hausner, Lucrezia (University of Heidelberg) ; Benussi, Luisa (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli) ; Froelich, Lutz (University of Heidelberg) ; Ikram, M. Arfan (Erasmus Medical Center) ; Deniz-Naranjo, M. Candida (Hospital Universitario de Gran Canaria Dr. Negrín) ; Tsolaki, Magda (1st Department of Neurology Aristotle University of Thessaloniki) ; Rosende-Roca, Maitée (Universitat Internacional de Catalunya. Institut Català de Neurociències Aplicades) ; Löwenmark, Malin (Uppsala) ; Hulsman, Marc (Vrije Universiteit Amsterdam) ; Spallazzi, Marco (Azienda Ospedaliero-Universitaria) ; Pericak-Vance, Margaret A (University of Miami Miller School of Medicine) ; Esiri, Margaret (Nuffield Department of Clinical Neurosciences) ; Bernal Sánchez-Arjona, María (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ; Dalmasso, Maria Carolina (University of Cologne) ; Martínez-Larrad, María Teresa (Hospital Clínico San Carlos (Madrid)) ; Arcaro, Marina (Ospedale Policlinico) ; Nöthen, Markus M. (University of Bonn) ; Fernández-Fuertes, Marta (Hospital Universitario Virgen de Valme (Sevilla, Andalusia)) ; Dichgans, Martin (Munich Cluster for Systems Neurology (SyNergy)) ; Ingelsson, Martin (Uppsala) ; Herrmann, Martin J. (University Hospital) ; Scherer, Martin (University Medical Centre Hamburg-Eppendorf) ; Vyhnalek, Martin (St. Anne's University Hospital Brno) ; Kosmidis, Mary H. (Aristotle University of Thessaloniki) ; Yannakoulia, Mary (Harokopio University) ; Schmid, Matthias (University Hospital of Bonn) ; Ewers, Michael (German Center for Neurodegenerative Diseases (DZNE)) ; Heneka, Michael T. (German Center for Neurodegenerative Diseases (DZNE)) ; Wagner, Michael (German Center for Neurodegenerative Diseases (DZNE)) ; Scamosci, Michela (University of Perugia) ; Kivipelto, Miia (Stockholms Sjukhem) ; Hiltunen, Mikko (University of Eastern Finland) ; Zulaica, Miren (Biodonostia Osasun Ikerketako Institutura (País Basc)) ; Alegret, Montserrat (Universitat Internacional de Catalunya. Institut Català de Neurociències Aplicades) ; Fornage, Myriam (University of Texas Health Sciences Center at Houston) ; Roberto, Natalia (Universitat Internacional de Catalunya. Institut Català de Neurociències Aplicades) ; van Schoor, Natasja M. (Amsterdam Public Health Research Institute) ; Seidu, Nazib M. (University of Gothenburg) ; Banaj, Nerisa (IRCCS Santa Lucia Foundation) ; Armstrong, Nicola (Murdoch University) ; Scarmeas, Nikolaos (Columbia University) ; Scherbaum, Norbert (University of Duisburg-Essen) ; Goldhardt, Oliver (Technical University of Munich) ; Hanon, Olivier (Université Paris Descartes) ; Peters, Oliver (German Center for Neurodegenerative Diseases) ; Skrobot, Olivia Anna (Southmead Hospital) ; Quenez, Olivier (Normandie Univ) ; Lerch, Ondrej (St. Anne's University Hospital Brno) ; Bossù, Paola (IRCCS Santa Lucia Foundation) ; Caffarra, Paolo (University of Parma) ; Dionigi Rossi, Paolo (IRCCS Ospedale Maggiore Policlinico) ; Sakka, Paraskevi (Athens Association of Alzheimer's disease and Related Disorders) ; Mecocci, Patrizia (University of Perugia) ; Hoffmann, Per (University Hospital Basel (Basilea, Suïssa)) ; Holmans, Peter (Cardiff University) ; Fischer, Peter (Social Medicine Center East- Donauspital) ; Riederer, Peter (University Hospital of Würzburg) ; Yang, Qiong (Boston University School of Public Health) ; Marshall, Rachel (Cardiff University) ; Kalaria, Rajesh N. (Campus for Ageing anf Vitality) ; Mayeux, Richard (Columbia University) ; Vandenberghe, Rik (University Hospitals Leuven (Bèlgica)) ; Cecchetti, Roberta (University of Perugia) ; Ghidoni, Roberta (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli) ; Frikke-Schmidt, Ruth (University of Copenhagen) ; Sorbi, Sandro (IRCCS Fondazione Don Carlo Gnocchi) ; Hägg, Sara (Karolinska Institutet (Estocolm, Suècia)) ; Engelborghs, Sebastiaan (VUB University Hospital Brussels) ; Helisalmi, Seppo (University of Eastern Finland) ; Botne Sando, Sigrid (Norwegian University of Science and Technology) ; Kern, Silke (University of Gothenburg) ; Archetti, Silvana (Brescia Hospital) ; Boschi, Silvia (University of Torino) ; Fostinelli, Silvia (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli) ; Gil, Silvia (Universitat Internacional de Catalunya. Institut Català de Neurociències Aplicades) ; Mendoza, Silvia (Instituto Andaluz de Neurociencia) ; Mead, Simon (University College London. Institute of Prion Diseases) ; Ciccone, Simona (IRCCS Ospedale Maggiore Policlinico) ; Djurovic, Srdjan (University of Bergen) ; Heilmann-Heimbach, Stefanie (School of Medicine & University Hospital Bonn) ; Riedel-Heller, Steffi (University of Leipzig) ; Kuulasmaa, Teemu (University of Eastern Finland) ; del Ser, Teodoro (Fundación Reina Sofía) ; Lebouvier, Thibaud (CHU CNR-MAJ) ; Polak, Thomas (University Hospital) ; Ngandu, Tiia (Finnish Institute for Health and Welfare) ; Grimmer, Timo (Technical University of Munich) ; Bessi, Valentina (Azienda Ospedaliero-Universitaria Careggi Largo Brambilla) ; Escott-Price, Valentina (Cardiff University) ; Giedraitis, Vilmantas (Uppsala) ; Deramecourt, Vincent (CHU CNR-MAJ) ; Maier, Wolfgang (German Center for Neurodegenerative Diseases) ; Jian, Xueqiu (Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases) ; Pijnenburg, Yolande A. L. (Vrije Universiteit Amsterdam) ; Kehoe, Patrick Gavin (University of Bristol) ; García-Ribas, Guillermo (Hospital Universitario Ramón y Cajal (Madrid)) ; Sánchez-Juan, Pascual (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) ; Pastor, Pau (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ; Pérez-Tur, Jordi (Instituto de Investigación Sanitaria La Fe) ; Piñol-Ripoll, Gerard (Institut de Recerca Biomedica de Lleida (IRBLLeida)) ; Lopez de Munain, Adolfo (Hospital de Donostia (Sant Sebastià, País Basc)) ; García-Alberca, Jose María (Instituto Andaluz de Neurociencia) ; Bullido, María J (Instituto de Investigación Sanitaria del Hospital Universitario La Paz) ; Álvarez, Victoria (Hospital Universitario Central de Asturias) ; Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ; Real, Luis M. (Universidad de Málaga) ; Mir, Pablo (Instituto de Biomedicina de Sevilla) ; Medina, Miguel (Fundación Reina Sofía) ; Scheltens, Philip (Vrije Universiteit Amsterdam) ; Holstege, Henne (Vrije Universiteit Amsterdam) ; Marquié, Marta (Universitat Internacional de Catalunya. Institut Català de Neurociències Aplicades) ; Sáez, María Eugenia (Centro Andaluz de Estudios Bioinformáticos) ; Carracedo, Ángel (Fundación Pública Galega de Medicina Xenómica) ; Amouyel, Philippe (Institut Pasteur de Lille) ; Schellenberg, Gerard D. (University of Pennsylvania Perelman School of Medicine) ; Williams, Julie (Cardiff University) ; Seshadri, Sudha (Framingham Heart Study) ; van Duijn, Cornelia M. (University of Oxford) ; Mather, Karen A (Neuroscience Research Australia) ; Sanchez-Valle, Raquel (Hospital Clínic i Provincial de Barcelona) ; Serrano-Ríos, Manuel (Hospital Clínico San Carlos (Madrid)) ; Orellana, Adelina (Universitat Internacional de Catalunya. Institut Català de Neurociències Aplicades) ; Tárraga, Lluís (Universitat Internacional de Catalunya. Institut Català de Neurociències Aplicades) ; Blennow, Kaj (Sahlgrenska Academy at the University of Gothenburg) ; Huisman, Martijn A (VU University) ; Andreassen, Ole A. (Oslo University Hospital (Oslo, Noruega)) ; Posthuma, Danielle (VU University) ; Clarimón, Jordi (Institut d'Investigació Biomèdica Sant Pau) ; Boada, Mercè (Universitat Internacional de Catalunya. Institut Català de Neurociències Aplicades) ; van der Flier, Wiesje M (Vrije Universiteit Amsterdam) ; Ramirez, Alfredo (Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases) ; Lambert, Jean-Charles (Institut Pasteur de Lille) ; van der Lee, Sven J. (Vrije Universiteit Amsterdam) ; Ruiz, Agustín (National Institute of Health Carlos III) ; Universitat Autònoma de Barcelona
Genetic discoveries of Alzheimer's disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. [...]
2023 - 10.1038/s41467-023-36192-x
Nature communications, Vol. 14 (february 2023)  
7.
33 p, 4.9 MB New insights into the genetic etiology of Alzheimer's disease and related dementias / Bellenguez, Céline (Université de Lille. INSERM. CHU Lille. Institut Pasteur Lille. U1167-RID-AGE. Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement) ; Küçükali, Fahri (University of Antwerp) ; Jansen, Iris E. (Department of Complex Trait Genetics. Center for Neurogenomics and Cognitive Research. Amsterdam Neuroscience. Vrije University) ; Kleineidam, Luca (German Center for Neurodegenerative Diseases (DZNE Bonn)) ; Moreno-Grau, Sonia (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Amin, Najaf (Nuffield Department of Population Health. Oxford University) ; Naj, Adam C. (University of Pennsylvania Perelman School of Medicine) ; Campos-Martin, Rafael (Universität zu Köln (Colònia, Alemaya). Department of Psychiatry and Psychotherapy) ; Grenier-Boley, Benjamin (Université de Lille. INSERM. CHU Lille. Institut Pasteur Lille. U1167-RID-AGE. Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement) ; Andrade, Victor (Universität zu Köln (Colònia, Alemaya). Department of Psychiatry and Psychotherapy) ; Holmans, Peter (MRC Centre for Neuropsychiatric Genetics and Genomics. Division of Psychological Medicine and Clinical Neuroscience. School of Medicine. Cardiff University) ; Boland, Anne (Université Paris-Saclay. Centre National de Recherche en Génomique Humaine) ; Damotte, Vincent (Université de Lille. INSERM. CHU Lille. Institut Pasteur Lille. U1167-RID-AGE. Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement) ; van der Lee, Sven J. (Vrije Universiteit Amsterdam) ; Costa, Marcos R. (Brain Institute. Federal University of Rio Grande do Norte) ; Kuulasmaa, Teemu (Institute of Biomedicine. University of Eastern Finland) ; Yang, Qiong (Framingham Heart Study) ; De Rojas, Itziar (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Bis, Joshua C (Cardiovascular Health Research Unit. Department of Medicine. University of Washington) ; Yaqub, Amber (Department of Epidemiology. Erasmus MC) ; Prokic, Ivana (Department of Epidemiology. Erasmus MC) ; Chapuis, Julien (Université de Lille. INSERM. CHU Lille. Institut Pasteur Lille. U1167-RID-AGE. Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement) ; Ahmad, Shahzad (LACDR) ; Giedraitis, Vilmantas (Department of Public Health and Carins Sciences/Geriatrics. Uppsala University) ; Aarsland, Dag (Institute of Psychiatry. Psychology & Neuroscience) ; Garcia-Gonzalez, Pablo (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Abdelnour, Carla (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Alarcón-Martín, Emilio (Department of Surgery. Biochemistry and Molecular Biology. School of Medicine. University of Málaga) ; Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ; Alegret, Montserrat (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Alvarez, Ignacio (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ; Alvarez, Victoria (Hospital Universitario Central de Asturias) ; Armstrong, N.icola J. (Mathematics and Statistics. Curtin University) ; Tsolaki, Anthoula (Alzheimer Hellas) ; Antúnez, Carmen (Hospital Clínico Universitario Virgen de la Arrixaca (El Palmar, Múrcia)) ; Appollonio, Ildebrando (Neurology Unit. San Gerardo Hospital) ; Arcaro, Marina (Fondazione IRCCS Ca'Granda. Ospedale Policlinico) ; Archetti, Silvana (Department of Laboratory Diagnostics. III Laboratory of Analysis. Brescia Hospital) ; Pastor, Alfonso A. (Institut de Recerca Biomedica de Lleida (IRBLLeida)) ; Arosio, Beatrice (Geriatic Unit. Fondazione Cà Granda. IRCCS Ospedale Maggiore Policlinico) ; Athanasiu, Lavinia (NORMENT Centre. University of Oslo) ; Bailly, Henri (EA 4468. Université de Paris. APHP. Hôpital Broca) ; Banaj, Nerisa (Laboratory of Neuropsychiatry. Department of Clinical and Behavioral Neurology. IRCCS Santa Lucia Foundation) ; Baquero, Miquel (Hospital Universitari i Politècnic La Fe (València)) ; Barral, Sandra (Gertrude H. Sergievsky Center. Columbia University) ; Beiser, Alexa (Boston University and the NHLBI's Framingham Heart Study) ; Pastor, Ana Belén (CIEN Foundation/Queen Sofia Foundation Alzheimer Center) ; Below, Jennifer E. (Human Genetics Center. Department of Epidemiology. Human Genetics. and Environmental Sciences. School of Public Health. The University of Texas Health Science Center at Houston) ; Benchek, Penelope (Department of Population and Quantitative Health Sciences. Case Western Reserve University) ; Benussi, Luisa (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli) ; Berr, Claudine (Université Montpellier, INSERM, Institute for Neurosciences of Montpellier) ; Besse, Céline (Université Paris-Saclay. Centre National de Recherche en Génomique Humaine) ; Bessi, Valentina (Azienda Ospedaliero-Universitaria Careggi) ; Binetti, Giuliano (MAC - Memory Clinic. IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli) ; Bizarro, Alessandra (Geriatrics Unit. Fondazione Policlinico A. Gemelli IRCCS) ; Blesa, Rafael (Institut d'Investigació Biomèdica Sant Pau) ; Boada, Mercè (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Boerwinkle, Eric (Baylor College of Medicine) ; Borroni, Barbara (Centre for Neurodegenerative Disorders. Department of Clinical and Experimental Sciences. University of Brescia) ; Boschi, Silvia (Department of Neuroscience "Rita Levi Montalcini". University of Torino) ; Bossù, Paola (Experimental Neuro-psychobiology Laboratory. Department of Clinical and Behavioral Neurology. IRCCS Santa Lucia Foundation) ; Bråthen, Geir (Department of Neuromedicine and Movement Science. Norwegian University of Science and Technology) ; Bressler, Jan (School of Public Health. University of Texas Health Science Center at Houston) ; Bresner, Catherine (MRC Centre for Neuropsychiatric Genetics and Genomics. Division of Psychological Medicine and Clinical Neuroscience. School of Medicine. Cardiff University) ; Brodaty, Henry (Dementia Centre for Research Collaboration. School of Psychiatry. University of New South Wales) ; Brookes, Keeley J. (Biosciences. School of Science and Technology. Nottingham Trent University) ; Brusco, Luis Ignacio (Hospital Interzonal General de Agudos Eva Perón. San Martín) ; Buiza-Rueda, Dolores (Department of Neurology. Erasmus MC) ; Bûrger, Katharina (German Center for Neurodegenerative Diseases (DZNE. Munich)) ; Burholt, Vanessa (Wales Centre for Ageing & Dementia Research. Swansea University) ; Bush, William S. (Department of Population & Quantitative Health Sciences. Case Western Reserve University) ; Calero, Miguel (UFIEC. Instituto de Salud Carlos III) ; Cantwell, Laura B (Department of Pathology and Laboratory Medicine. University of Pennsylvania) ; Chene, Geneviève (Pole Santé Publique. CHU de Bordeaux) ; Chung, Jaeyoon (Department of Medicine (Biomedical Genetics). Boston University School of Medicine) ; Cuccaro, MichaelL. (The John P. Hussman Institute for Human Genomics. University of Miami) ; Carracedo, Ángel (Fundación Pública Galega de Medicina Xenómica- CIBERER-IDIS. University of Santiago de Compostela) ; Cecchetti, Roberta (Institute of Gerontology and Geriatrics. Department of Medicine and Surgery. University of Perugia) ; Cervera Carles, Laura (Institut d'Investigació Biomèdica Sant Pau) ; Charbonnier, Camille (Department of Genetics and CNR-MAJ. Normandie University. UNIROUEN. INSERM U1245. CHU Rouen) ; Chen, Hung-Hsin (Division of Genetic Medicine. Vanderbilt University) ; Chillotti, Caterina (Unit of Clinical Pharmacology. University Hospital of Cagliari) ; Ciccone, Simona (Geriatic Unit. Fondazione Cà Granda. IRCCS Ospedale Maggiore Policlinico) ; Claassen, Jurgen A.H.R. (Radboudumc Alzheimer Center. Department of Geriatrics. Radboud University Medical Center) ; Clark, Christopher (Institute for Regenerative Medicine. University of Zürich) ; Conti, Elisa (School of Medicine and Surgery. University of Milano-Bicocca) ; Corma-Gómez, Anaïs (Hospital Universitario Virgen de Valme (Sevilla, Andalusia)) ; Costantini, Emanuele (Department of Neuroscience. Catholic University of Sacred Heart. Fondazione Policlinico Universitario A. Gemelli IRCCS) ; Custodero, Carlo (University of Bari. "A. Moro") ; Daian, Delphine (Université Paris-Saclay. Centre National de Recherche en Génomique Humaine) ; Dalmasso, Maria Carolina (Universität zu Köln (Colònia, Alemaya). Department of Psychiatry and Psychotherapy) ; Daniele, Antonio (Department of Neuroscience. Catholic University of Sacred Heart. Fondazione Policlinico Universitario A. Gemelli IRCCS) ; Dardiotis, Efthimios (School of Medicine. University of Thessaly) ; Dartigues, Jean-François (Bordeaux Population Health Research Center. University Bordeaux. INSERM) ; de Deyn, Peter Paul (Department of Neurology. University Medical Center Groningen) ; de Paiva Lopes, Katia (Department of Psychiatry. Icahn School of Medicine at Mount Sinai) ; de Witte, Lot D. (Department of Psychiatry. Icahn School of Medicine at Mount Sinai) ; Debette, Stéphanie (Bordeaux Population Health Research Center. University Bordeaux. INSERM) ; Deckert, Jürgen (Department of Psychiatry. Psychosomatics and Psychotherapy. Center of Mental Health. University Hospital) ; del Ser, Teodoro (CIEN Foundation/Queen Sofia Foundation Alzheimer Center) ; Denning, Nicola (UKDRI@ Cardiff. School of Medicine. Cardiff University) ; DeStefano, Anita (Department of Neurology. Boston University School of Medicine) ; Dichgans, Martin (Munich Cluster for Systems Neurology (SyNergy)) ; Diehl-Schmid, Janine (Klinikum rechts der Isar. Department of Psychiatry and Psychotherapy. Technical University of Munich. School of Medicine) ; Diez-Fairen, Mónica (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ; Rossi, Paolo Dionigi (Geriatic Unit. Fondazione Cà Granda. IRCCS Ospedale Maggiore Policlinico) ; Djurovic, Srdjan (NORMENT Centre. University of Oslo) ; Duron, Emmanuelle (EA 4468. Université de Paris. APHP. Hôpital Broca) ; Düzel, Emrah (German Center for Neurodegenerative Diseases (DZNE)) ; Dufouil, Carole (Pole Santé Publique. CHU de Bordeaux) ; Eiriksdottir, Gundy (Icelandic Heart Association) ; Engelborghs, Sebastiaan (Department of Neurology. UZ Brussel) ; Escott-Price, Valentina (UKDRI@ Cardiff. School of Medicine. Cardiff University) ; Espinosa, Ana (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Ewers, Michael (German Center for Neurodegenerative Diseases (DZNE. Munich)) ; Faber, Kelley M. (Department of Medical and Molecular Genetics. Indiana University) ; Fabrizio, Tagliavini (Fondazione IRCCS. Istituto Neurologico Carlo Besta) ; Nielsen, Sune Fallgaard (Department of Clinical Biochemistry. Herlev and Gentofte Hospital) ; Fardo, David W. (Sanders-Brown Center on Aging. Department of Biostatistics. University of Kentucky) ; Farotti, Lucia (Centre for Memory Disturbances. Lab of Clinical Neurochemistry. Section of Neurology. University of Perugia) ; Fenoglio, Chiara (University of Milan) ; Fernández-Fuertes, Marta (Hospital Universitario Virgen de Valme (Sevilla, Andalusia)) ; Ferrari, Raffaele (UCL Institute of Neurology (Regne Unit)) ; Ferreira, Catarina B. (Faculty of Medicine. University of Lisbon) ; Ferri, Evelyn (Geriatic Unit. Fondazione Cà Granda. IRCCS Ospedale Maggiore Policlinico) ; Fin, Bertrand (Université Paris-Saclay. Centre National de Recherche en Génomique Humaine) ; Fischer, Peter (Department of Psychiatry. Social Medicine Center East- Donauspital) ; Fladby, Tormod (Institute of Clinical Medicine. University of Oslo) ; Fließbach, Klaus (German Center for Neurodegenerative Diseases (DZNE Bonn)) ; Fongang, Bernard (Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases. University of Texas Health Sciences Center) ; Fornage, Myriam (School of Public Health. University of Texas Health Science Center at Houston) ; Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ; Foroud, Tatiana M. (Department of Medical and Molecular Genetics. Indiana University) ; Fostinelli, Silvia (Molecular Markers Laboratory. IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli) ; Fox, Nick C. (Dementia Research Centre. UCL Queen Square Institute of Neurology) ; Franco-Macías, Emilio (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ; Bullido, María J. (Centro de Biología Molecular Severo Ochoa (UAM-CSIC)) ; Frank-García, Ana (Hospital Universitario La Paz (Madrid)) ; Froelich, Lutz (Department of Geriatric Psychiatry. Central Institute for Mental Health. Mannheim. University of Heidelberg) ; Fulton-Howard, Brian (Department of Neuroscience. Ronald M. Loeb Center for Alzheimer's Disease. Icahn School of Medicine at Mount Sinai) ; Galimberti, Daniela (University of Milan) ; García-Alberca, Jose Maria (Instituto Andaluz de Neurociencia) ; García-González, Pablo (Research Center and Memory Clinic Fundació ACE. Institut Català de Neurociències Aplicades. Universitat Internacional de Catalunya) ; Garcia-Madrona, Sebastian (Hospital Universitario Ramón y Cajal (Madrid)) ; Garcia-Ribas, Guillermo (Hospital Universitario Ramón y Cajal (Madrid)) ; Ghidoni, Roberta (Molecular Markers Laboratory. IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli) ; Giegling, Ina (Department of Psychiatry and Psychotherapy. Medical University of Vienna) ; Giorgio, Giaccone (Fondazione IRCCS. Istituto Neurologico Carlo Besta) ; Goate, Alison M. (Department of Genetics and Genomic Sciences. Ronald M. Loeb Center for Alzheimer's Disease Icahn School of Medicine at Mount Sinai) ; Goldhardt, Oliver (Klinikum rechts der Isar. Department of Psychiatry and Psychotherapy. Technical University of Munich. School of Medicine) ; Gomez-Fonseca, Duber (Department of Biostatistics. Epidemiology. and Informatics Perelman School of Medicine. University of Pennsylvania) ; González-Pérez, Antonio (CAEBI. Centro Andaluz de Estudios Bioinformáticos) ; Graff, Caroline (Unit for Hereditary Dementias. Karolinska University Hospital-Solna) ; Grande, Giulia (Aging Research Center. Department of Neurobiology. Care Sciences and Society. Karolinska Institutet and Stockholm University) ; Green, Emma (Institute of Public Health. University of Cambridge) ; Grimmer, Timo (Klinikum rechts der Isar. Department of Psychiatry and Psychotherapy. Technical University of Munich. School of Medicine) ; Grünblatt, Edna (Zurich Center for Integrative Human Physiology. University of Zurich) ; Grunin, Michelle (Department of Population and Quantitative Health Sciences. Case Western Reserve University) ; Gudnason, Vilmundur (Icelandic Heart Association. Faculty of Medicine. University of Iceland) ; Guetta-Baranes, Tamar (Human Genetics. School of Life Sciences. Life Sciences Building. University Park. University of Nottingham) ; Haapasalo, Annakaisa (AI Virtanen Institute for Molecular Sciences. University of Eastern Finland) ; Hadjigeorgiou, Georgios (Department of Neurology. Medical School. University of Cyprus) ; Haines, Jonathan L. (Department of Population & Quantitative Health Sciences. Case Western Reserve University) ; Hamilton-Nelson, Kara L. (The John P. Hussman Institute for Human Genomics. University of Miami) ; Hampel, Harald (GRC 21. Alzheimer Precision Medicine Initiative (APMI). Sorbonne University. AP-HP. Pitié-Salpêtrière Hospital) ; Hanon, Olivier (EA 4468. Université de Paris. APHP. Hôpital Broca) ; Hardy, John (UCL Institute of Neurology (Regne Unit)) ; Hartmann, Annette M. (Department of Psychiatry and Psychotherapy. Medical University of Vienna) ; Hausner, Lucrezia (Department of Geriatric Psychiatry. Central Institute for Mental Health. Mannheim. University of Heidelberg) ; Harwood, Janet (MRC Centre for Neuropsychiatric Genetics and Genomics. Division of Psychological Medicine and Clinical Neuroscience. School of Medicine. Cardiff University) ; Heilmann-Heimbach, Stefanie (Institute of Human Genetics. University of Bonn. School of Medicine & University Hospital Bonn) ; Helisalmi, Seppo (Institute of Clinical Medicine. Internal Medicine. University of Eastern Finland) ; Heneka, Michael T. (German Center for Neurodegenerative Diseases (DZNE Bonn)) ; Hernández, Isabel (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Herrmann, Martin J. (Department of Psychiatry. Psychosomatics and Psychotherapy. Center of Mental Health. University Hospital) ; Hoffmann, Per (Institute of Human Genetics. University of Bonn. School of Medicine & University Hospital Bonn) ; Holmes, Clive (Clinical and Experimental Science. Faculty of Medicine. University of Southampton) ; Holstege, Henne (Section Genomics of Neurodegenerative Diseases and Aging. Department of Human Genetics Amsterdam UMC. Vrije Universiteit Amsterdam. Amsterdam UMC) ; Huerto Vilas, Raquel (Institut de Recerca Biomedica de Lleida (IRBLLeida)) ; Hulsman, Marc (Section Genomics of Neurodegenerative Diseases and Aging. Department of Human Genetics Amsterdam UMC. Vrije Universiteit Amsterdam. Amsterdam UMC) ; Humphrey, Jack (Nash Family Department of Neuroscience & Friedman Brain Institute. Icahn School of Medicine at Mount Sinai) ; Biessels, Geert Jan (Department of Neurology. UMC Utrecht Brain Center) ; Jian, Xueqiu (Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases. University of Texas Health Sciences Center) ; Johansson, Charlotte (Center for Alzheimer Research. Department NVS. Division of Neurogeriatrics. Karolinska Institutet) ; Jun, Gyungah R. (Medicine Biomedical Genetics Boston University School of Medicine) ; Kastumata, Yuriko (Biostatistics. University of Kentucky College of Public Health) ; Kauwe, John (Department of Biology. Brigham Young University) ; Kehoe, Patrick G. (Translational Health Sciences. Bristol Medical School. University of Bristol) ; Kilander, Lena (Department of Biostatistics. Boston University School of Public Health) ; Ståhlbom, Anne Kinhult (Center for Alzheimer Research. Department NVS. Division of Neurogeriatrics. Karolinska Institutet) ; Kivipelto, Miia (Research & Development. UnitStockholms Sjukhem) ; Koivisto, Anne (Department of Neurosciences. University of Helsinki and Department of Geriatrics. Helsinki University Hospital) ; Kornhuber, Johannes (Department of Psychiatry and Psychotherapy. Universitätsklinikum Erlangen. and Friedrich-Alexander Universität Erlangen-Nürnberg) ; Kosmidis, Mary H. (Laboratory of Cognitive Neuroscience. School of Psychology. Aristotle University of Thessaloniki) ; Kukull, Walter A. (Department of Epidemiology. University of Washington) ; Kuksa, Pavel P. (Department of Pathology and Laboratory Medicine. University of Pennsylvania Perelman School of Medicine) ; Kunkle, Brian W. (Department of Neurology. Medical School. University of Cyprus) ; Kuzma, Amanda B. (Department of Pathology and Laboratory Medicine. University of Pennsylvania) ; Lage, Carmen (Service of Neurology. University Hospital Marqués de Valdecilla. IDIVAL. University of Cantabria) ; Laukka, Erika J. (Stockholm Gerontology Research Center) ; Launer, Lenore (Intramural Research Program/National Institute on Aging/National Institutes of Health) ; Lauria, Alessandra (Geriatrics Unit. Fondazione Policlinico A. Gemelli IRCCS) ; Lee, Chien-Yueh (Department of Pathology and Laboratory Medicine. University of Pennsylvania Perelman School of Medicine) ; Lehtisalo, Jenni (Public Health Promotion Unit. Finnish Institute for Health and Welfare) ; Lerch, Ondrej (International Clinical Research Center. St. Anne's University Hospital Brno) ; Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ; Longstreth, William (Departments of Neurology and Epidemiology. University of Washington) ; Lopez, Oscar (Framingham Heart Study) ; Lopez de Munain, Adolfo (Department of Neurology. Hospital Universitario Donostia. OSAKIDETZA-Servicio Vasco de Salud) ; Love, Seth (Translational Health Sciences. Bristol Medical School. University of Bristol) ; Löwemark, Malin (Department of Biostatistics. Boston University School of Public Health) ; Luckcuck, Lauren (MRC Centre for Neuropsychiatric Genetics and Genomics. Division of Psychological Medicine and Clinical Neuroscience. School of Medicine. Cardiff University) ; Lunetta, Kathryn L. (Institute of Biomedicine. University of Eastern Finland) ; Ma, Yiyi (Department of Neurology. Columbia University) ; Macías, Juan (Hospital Universitario Virgen de Valme (Sevilla, Andalusia)) ; MacLeod, Catherine A. (School of Health Sciences. Bangor University) ; Maier, Wolfgang (German Center for Neurodegenerative Diseases (DZNE Bonn)) ; Mangialasche, Francesca (Division of Clinical Geriatrics. Center for Alzheimer Research. Care Sciences and Society (NVS). Karolinska Institutet) ; Spallazzi, Marco (Unit of Neurology. University of Parma and AOU) ; Marquié, Marta (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Marshall, Rachel (MRC Centre for Neuropsychiatric Genetics and Genomics. Division of Psychological Medicine and Clinical Neuroscience. School of Medicine. Cardiff University) ; Martin, Eden R. (The John P. Hussman Institute for Human Genomics. University of Miami) ; Martín Montes, Angel (Hospital Universitario La Paz (Madrid)) ; Martínez Rodríguez, Carmen (Servicio de Neurología. Hospital Universitario Central de Asturias- Oviedo and Instituto de Investigación Biosanitaria del Principado de Asturias) ; Masullo, Carlo (Institute of Neurology. Catholic University of the Sacred Heart) ; Mayeux, Richard (Gertrude H. Sergievsky Center. Columbia University) ; Mead, Simon (MRC Prion Unit at UCL. UCL Institute of Prion Diseases) ; Mecocci, Patrizia (Institute of Gerontology and Geriatrics. Department of Medicine and Surgery. University of Perugia) ; Medina, Miguel (CIEN Foundation/Queen Sofia Foundation Alzheimer Center) ; Meggy, Alun (UKDRI@ Cardiff. School of Medicine. Cardiff University) ; Mehrabian, Shima (Clinic of Neurology. UH 'Alexandrovska'. Medical University - Sofia) ; Mendoza, Silvia (Instituto Andaluz de Neurociencia) ; Menéndez-González, Manuel (Servicio de Neurología. Hospital Universitario Central de Asturias- Oviedo and Instituto de Investigación Biosanitaria del Principado de Asturias) ; Mir, Pablo (Unidad de Trastornos del Movimiento. Servicio de Neurología y Neurofisiología. Instituto de Biomedicina de Sevilla (IBiS). Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla) ; Moebus, Susanne (Institute for Urban Public Health. University Hospital of University Duisburg-Essen) ; Mol, Merel (Department of Neurology. Erasmus MC) ; Molina-Porcel, Laura (Alzheimer's Disease and Other Cognitive Disorders Unit. Neurology Department. Hospital Clinic) ; Montrreal, Laura (Research Center and Memory Clinic Fundació ACE. Institut Català de Neurociències Aplicades. Universitat Internacional de Catalunya) ; Morelli, Laura (Laboratory of Brain Aging and Neurodegeneration. FIL-CONICET) ; Moreno, Fermin (Department of Neurology. Hospital Universitario Donostia. OSAKIDETZA-Servicio Vasco de Salud) ; Morgan, Kevin (Human Genetics. School of Life Sciences. University of Nottingham) ; Mosley, Thomas (Memory Impairment and Neurodegenerative Dementia (MIND) Center. University of Mississippi Medical Center) ; Nöthen, Markus M. (Institute of Human Genetics. University of Bonn. School of Medicine & University Hospital Bonn) ; Muchnik, Carolina (Instituto de Investigaciones Médicas Alfredo Lanari (Buenos Aires, Argentina)) ; Mukherjee, Shubhabrata (Department of Medicine. University of Washington) ; Nacmias, Benedetta (IRCCS Fondazione Don Carlo Gnocchi) ; Ngandu, Tiia (Public Health Promotion Unit. Finnish Institute for Health and Welfare) ; Nicolas, Gael (Department of Genetics and CNR-MAJ. Normandie University. UNIROUEN. INSERM U1245. CHU Rouen) ; Nordestgaard, Børge G. (Department of Clinical Medicine. University of Copenhagen) ; Olaso, Robert (Université Paris-Saclay. Centre National de Recherche en Génomique Humaine) ; Orellana, Adelina (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Orsini, Michela (Department of Neuroscience. Catholic University of Sacred Heart. Fondazione Policlinico Universitario A. Gemelli IRCCS) ; Ortega, Gemma (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Padovani, Alessandro (Human Genome Sequencing Center. Baylor College of Medicine) ; Paolo, Caffarra (DIMEC. University of Parma) ; Papenberg, Goran (Aging Research Center. Department of Neurobiology. Care Sciences and Society. Karolinska Institutet and Stockholm University) ; Parnetti, Lucilla (Centre for Memory Disturbances. Lab of Clinical Neurochemistry. Section of Neurology. University of Perugia) ; Pasquier, Florence (Resources and Research Memory Center (MRRC) of Distalz. LicendUniversity of Lille. INSERM. CHU Lille. UMR1172) ; Pastor, Pau (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ; Peloso, Gina (Boston University and the NHLBI's Framingham Heart Study) ; Pérez-Cordón, Alba (Research Center and Memory Clinic Fundació ACE. Institut Català de Neurociències Aplicades. Universitat Internacional de Catalunya) ; Pérez-Tur, Jordi (Unitat Mixta de de Neurología y Genética. Institut d'Investigació Sanitària La Fe) ; Pericard, Pierre (US 41-UMS 2014-PLBS. bilille. Université de Lille. CNRS. INSERM. CHU Lille. Institut Pasteur de Lille) ; Peters, Oliver (German Center for Neurodegenerative Diseases (DZNE)) ; Pijnenburg, Yolande A.L. (Alzheimer Center Amsterdam. Department of Neurology. Amsterdam Neuroscience. Vrije Universiteit Amsterdam. Amsterdam UMC) ; Pineda, Juan A. (Hospital Universitario Virgen de Valme (Sevilla, Andalusia)) ; Piñol-Ripoll, Gerard (Institut de Recerca Biomedica de Lleida (IRBLLeida)) ; Pisanu, Claudia (Department of Biomedical Sciences. University of Cagliari) ; Polak, Thomas (Department of Psychiatry. Psychosomatics and Psychotherapy. Center of Mental Health. University Hospital) ; Popp, Julius (Department of Geriatric Psychiatry. University Hospital of Psychiatry Zürich) ; Posthuma, Danielle (Department of Complex Trait Genetics. Center for Neurogenomics and Cognitive Research. Amsterdam Neuroscience. Vrije University) ; Priller, Josef (Department of Neuropsychiatry and Laboratory of Molecular Psychiatry. Charité. Charitéplatz 1) ; Puerta, Raquel (Research Center and Memory Clinic Fundació ACE. Institut Català de Neurociències Aplicades. Universitat Internacional de Catalunya) ; Quenez, Olivier (Department of Genetics and CNR-MAJ. Normandie University. UNIROUEN. INSERM U1245. CHU Rouen) ; Quintela, Inés (Grupo de Medicina Xenómica. Centro Nacional de Genotipado (CEGEN-PRB3-ISCIII). Universidade de Santiago de Compostela) ; Thomassen, Jesper Qvist (Department of Clinical Biochemistry. Rigshospitalet) ; Rábano, Alberto (CIEN Foundation/Queen Sofia Foundation Alzheimer Center) ; Rainero, Innocenzo (Centre for Neurodegenerative Disorders. Department of Clinical and Experimental Sciences. University of Brescia) ; Rajabli, Farid (The John P. Hussman Institute for Human Genomics. University of Miami) ; Ramakers, Inez (Department of Psychiatry & Neuropsychologie. Maastricht University. Alzheimer Center Limburg) ; Real, Luis M. (Depatamento de Especialidades Quirúrgicas Bioquímica e Inmunología. Facultad de Medicina. Universidad de Málaga) ; Reinders, Marcel J.T. (Delft Bioinformatics Lab. Delft University of Technology) ; Reitz, Christiane (Taub Institute. Columbia University) ; Reyes-Dumeyer, Dolly (Taub Institute. Columbia University) ; Ridge, Perry (Bioinformatics. College of Life Sciences. Brigham Young University) ; Riedel-Heller, Steffi (Institute of Social Medicine. Occupational Health and Public Health. University of Leipzig) ; Riederer, Peter (Center of Mental Health. Clinic and Policlinic of Psychiatry. Psychosomatics and Psychotherapy. University Hospital of Würzburg) ; Roberto, Natalia (Research Center and Memory Clinic Fundació ACE. Institut Català de Neurociències Aplicades. Universitat Internacional de Catalunya) ; Rodriguez-Rodriguez, Eloy (Instituto de Investigación Sanitaria Valdecilla (Santander, País Basc)) ; Rongve, Arvid (Institute of Clinical Medicine (K1). The University of Bergen) ; Rosas Allende, Irene (Servicio de Neurología. Hospital Universitario Central de Asturias- Oviedo and Instituto de Investigación Biosanitaria del Principado de Asturias) ; Rosende-Roca, Maitée (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Royo, Jose Luis (Departamento de Especialidades Quirúrgicas. Bioquímicas e Inmunología. School of Medicine. University of Málaga) ; Rubino, Elisa (Department of Neuroscience and Mental Health. AOU Città della Salute e della Scienza di Torino) ; Rujescu, Dan (Department of Psychiatry and Psychotherapy. Medical University of Vienna) ; Sáez, María Eugenia (CAEBI. Centro Andaluz de Estudios Bioinformáticos) ; Sakka, Paraskevi (Athens Association of Alzheimer's Disease and Related Disorders) ; Saltvedt, Ingvild (Department of Geriatrics. St. Olav's Hospital. Trondheim University Hospital) ; Sanabria, Ángela (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Sánchez-Arjona, Maria B. (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ; Sanchez-Garcia, Florentino (Department of Immunology. Hospital Universitario Doctor Negrín. Las Palmas de Gran Canaria) ; Sánchez Juan, Pacual (Instituto de Investigación Sanitaria Valdecilla (Santander, País Basc)) ; Sánchez-Valle, Raquel (Neurology Department-Hospital Clínic. IDIBAPS. Universitat de Barcelona) ; Sando, Sigrid B. (Department of Neurology and Clinical Neurophysiology. University Hospital of Trondheim) ; Sarnowski, Chloé (Human Genetics Center. School of Public Health. University of Texas Health Science Center at Houston) ; Satizabal, Claudia L. (Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases. University of Texas Health Sciences Center) ; Scamosci, Michela (Institute of Gerontology and Geriatrics. Department of Medicine and Surgery. University of Perugia) ; Scarmeas, Nikolaos (First Department of Neurology. Aiginition Hospital. National and Kapodistrian University of Athens. Medical School) ; Scarpini, Elio (University of Milan) ; Scheltens, Philip (Alzheimer Center Amsterdam. Department of Neurology. Amsterdam Neuroscience. Vrije Universiteit Amsterdam. Amsterdam UMC) ; Scherbaum, Norbert (LVR-Hospital Essen. Department of Psychiatry and Psychotherapy. Medical Faculty. University of Duisburg-Essen) ; Scherer, Martin (Department of Primary Medical Care. University Medical Centre Hamburg-Eppendorf) ; Schmid, Matthias (Institute of Medical Biometry. Informatics and Epidemiology. University Hospital of Bonn) ; Schneider, Anja (German Center for Neurodegenerative Diseases (DZNE Bonn)) ; Schott, Jonathan M. (Dementia Research Centre. UCL Queen Square Institute of Neurology) ; Selbæk, Geir (Department of Geriatric Medicine. Oslo University Hospital) ; Seripa, Davide (Laboratory for Advanced Hematological Diagnostics. Department of Hematology and Stem Cell Transplant. Vito Fazzi Hospital) ; Serrano, Manuel (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas. CIBERDEM. Hospital Clínico San Carlos) ; Sha, Jin (Department of Biostatistics. Epidemiology. and Informatics. Penn Neurodegeneration Genomics Center. University of Pennsylvania Perelman School of Medicine) ; Shadrin, Alexey A. (NORMENT Centre. University of Oslo) ; Skrobot, Olivia (Translational Health Sciences. Bristol Medical School. University of Bristol) ; Slifer, Susan H. (The John P. Hussman Institute for Human Genomics. University of Miami) ; Snijders, Gijsje J.L. (Department of Psychiatry. Icahn School of Medicine at Mount Sinai) ; Soininen, Hilkka (Institute of Clinical Medicine. Neurology. University of Eastern) ; Solfrizzi, Vincenzo (University of Bari. "A. Moro") ; Solomon, Alina (Division of Clinical Geriatrics. Center for Alzheimer Research. Care Sciences and Society (NVS). Karolinska Institutet) ; Song, Yeunjoo (Department of Population and Quantitative Health Sciences. Case Western Reserve University) ; Sorbi, Sandro (IRCCS Fondazione Don Carlo Gnocchi) ; Sotolongo Grau, Oscar (Research Center and Memory Clinic Fundació ACE. Institut Català de Neurociències Aplicades. Universitat Internacional de Catalunya) ; Spalletta, Gianfranco (Laboratory of Neuropsychiatry. Department of Clinical and Behavioral Neurology. IRCCS Santa Lucia Foundation) ; Spottke, Annika (Department of Neurology. University of Bonn) ; Squassina, Alessio (Department of Biomedical Sciences. Section of Neuroscience and Clinical Pharmacology. University of Cagliari) ; Stordal, Eystein (Department of Psychiatry. Namsos Hospital) ; Tartan, Juan Pablo (Research Center and Memory Clinic Fundació ACE. Institut Català de Neurociències Aplicades. Universitat Internacional de Catalunya) ; Tárraga, Lluís (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Tesí, Niccolo (Section Genomics of Neurodegenerative Diseases and Aging. Department of Human Genetics Amsterdam UMC. Vrije Universiteit Amsterdam. Amsterdam UMC) ; Thalamuthu, Anbupalam (Centre for Healthy Brain Ageing. School of Psychiatry. Faculty of Medicine. University of New South Wales) ; Thomas, Tegos (Alzheimer Hellas) ; Tosto, Giuseppe (Department of Neurology. Columbia University) ; Traykov, Latchezar (Clinic of Neurology. UH 'Alexandrovska'. Medical University - Sofia) ; Tremolizzo, Lucio (Neurology Unit. San Gerardo Hospital) ; Tybjærg-Hansen, Anne (Department of Clinical Biochemistry. Rigshospitalet) ; Uitterlinden, Andre (Department of Internal Medicine and Biostatistics. Erasmus MC) ; Ullgren, Abbe (Center for Alzheimer Research. Department NVS. Division of Neurogeriatrics. Karolinska Institutet) ; Ulstein, Ingun (Department of Geriatric Medicine. Oslo University Hospital) ; Valero, Sergi (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Valladares, Otto (Department of Pathology and Laboratory Medicine. University of Pennsylvania Perelman School of Medicine) ; Van Broeckhoven, Christine (Neurodegenerative Brain Diseases Group. VIB Center for Molecular Neurology. VIB) ; Vance, Jeffery (Dr. John T. Macdonald Foundation Department of Human Genetics. University of Miami) ; Vardarajan, Badri N. (Taub Institute on Alzheimer's Disease and the Aging Brain. Department of Neurology. Columbia University) ; van der Lugt, Aad (Department of Neurology. ErasmusMC) ; Van Dongen, Jasper (Department of Biomedical Sciences. University of Antwerp) ; van Rooij, Jeroen (Department of Neurology. ErasmusMC) ; van Swieten, John (Department of Neurology. Erasmus MC) ; Vandenberghe, Rik (Neurology Department. University Hospitals Leuven) ; Verhey, Frans (Department of Psychiatry & Neuropsychologie. Maastricht University. Alzheimer Center Limburg) ; Vidal, Jean-Sébastien (EA 4468. Université de Paris. APHP. Hôpital Broca) ; Vogelgsang, Jonathan (Department of Psychiatry. Harvard Medical School. McLean Hospital) ; Vyhnalek, Martin (International Clinical Research Center. St. Anne's University Hospital Brno) ; Wagner, Michael (German Center for Neurodegenerative Diseases (DZNE Bonn)) ; Wallon, David (Department of Neurology and CNR-MAJ. F 76000. Normandy Center for Genomic and Personalized Medicine. Normandie University. UNIROUEN. INSERM U1245. CHU Rouen) ; Wang, Li-San (Department of Pathology and Laboratory Medicine. University of Pennsylvania Perelman School of Medicine) ; Wang, Ruiqi (Department of Biostatistics. Boston University School of Public Health) ; Weinhold, Leonie (Institute of Medical Biometry. Informatics and Epidemiology. University Hospital of Bonn) ; Wiltfang, Jens (Medical Science Department. iBiMED) ; Windle, Gill (School of Health Sciences. Bangor University) ; Woods, Bob (School of Health Sciences. Bangor University) ; Yannakoulia, Mary (Department of Nutrition and Diatetics. Harokopio University) ; Zare, Habil (Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases. University of Texas Health Sciences Center) ; Zhao, Yi (Laboratory of Neuropsychiatry. Department of Clinical and Behavioral Neurology. IRCCS Santa Lucia Foundation) ; Zhang, Xiaoling (Department of Medicine (Biomedical Genetics). Boston University School of Medicine) ; Zhu, Congcong (Department of Medicine (Biomedical Genetics). Boston University School of Medicine) ; Zulaica, Miren (Neurosciences Area. Instituto Biodonostia) ; Laczo, Jan (International Clinical Research Center. St. Anne's University Hospital Brno) ; Matoska, Vaclav (Department of Clinical Biochemistry. Hematology and Immunology. Na Homolce Hospital) ; Serpente, Maria (University of Milan) ; Assogna, Francesca (Laboratory of Neuropsychiatry. Department of Clinical and Behavioral Neurology. IRCCS Santa Lucia Foundation) ; Piras, Fabrizio (Laboratory of Neuropsychiatry. Department of Clinical and Behavioral Neurology. IRCCS Santa Lucia Foundation) ; Ciullo, Valentina (Laboratory of Neuropsychiatry. Department of Clinical and Behavioral Neurology. IRCCS Santa Lucia Foundation) ; Shofany, Jacob (Laboratory of Neuropsychiatry. Department of Clinical and Behavioral Neurology. IRCCS Santa Lucia Foundation) ; Ferrarese, Carlo (Neurology Unit. San Gerardo Hospital) ; Andreoni, Simona (School of Medicine and Surgery. University of Milano-Bicocca) ; Sala, Gessica (School of Medicine and Surgery. University of Milano-Bicocca) ; Zoia, Chiara Paola (School of Medicine and Surgery. University of Milano-Bicocca) ; Zompo, Maria del (Department of Biomedical Sciences. Section of Neuroscience and Clinical Pharmacology. University of Cagliari) ; Benussi, Alberto (Centre for Neurodegenerative Disorders. Department of Clinical and Experimental Sciences. University of Brescia) ; Bastiani, Patrizia (Institute of Gerontology and Geriatrics. Department of Medicine. University of Perugia) ; Takalo, Mari (Insitute of Biomedicine. University of Eastern Finland) ; Natunen, Teemu (Insitute of Biomedicine. University of Eastern Finland) ; Laatikainen, Tiina (Public Health Promotion Unit. Finnish Institute for Health and Welfare) ; Tuomilehto, Jaakko (Public Health Promotion Unit. Finnish Institute for Health and Welfare) ; Antikainen, Riitta (Medical Research Center Oulu. Oulu University Hospital) ; Strandberg, Timo (Helsinki University Hospital) ; Lindström, Jaana (Public Health Promotion Unit. Finnish Institute for Health and Welfare) ; Peltonen, Markku (Public Health Promotion Unit. Finnish Institute for Health and Welfare) ; Abraham, Richard (Division of Psychological Medicine and Clinial Neurosciences. MRC Centre for Neuropsychiatric Genetics and Genomics. Cardiff University) ; Al-Chalabi, Ammar (Institute of Psychiatry. Psychology and Neuroscience. Kings College London) ; Bass, Nicholas J. (Division of Psychiatry. University College London) ; Brayne, Carol (Institute of Public Health. University of Cambridge) ; Brown, Kristelle S. (Institute of Genetics. Queens Medical Centre. University of Nottingham) ; Collinge, John (MRC Prion Unit at UCL. UCL Institute of Prion Diseases) ; Craig, David (Ageing Group. Centre for Public Health. School of Medicine. Dentistry and Biomedical Sciences. Queen's University Belfast) ; Deloukas, Pangiotis (The Wellcome Trust Sanger Institute. Wellcome Trust Genome Campus. Hinxton) ; Fox, Nick (Dementia Research Centre. Department of Neurodegenerative Disease. UCL Institute of Neurology) ; Gerrish, Amy (Dementia Research Centre. Department of Neurodegenerative Disease. UCL Institute of Neurology) ; Gill, Michael (Mercer's Institute for Research on Ageing. St James' Hospital) ; Gwilliam, Rhian (The Wellcome Trust Sanger Institute. Wellcome Trust Genome Campus. Hinxton) ; Harold, Denise (School of Biotechnology. Dublin City University) ; Hollingworth, Paul (Division of Psychological Medicine and Clinial Neurosciences. MRC Centre for Neuropsychiatric Genetics and Genomics. Cardiff University) ; Johnston, Jarret A. (Centre for Public Health. School of Medicine. Dentistry and Biomedical Sciences. Queens University) ; Jones, Lesley (Division of Psychological Medicine and Clinial Neurosciences. MRC Centre for Neuropsychiatric Genetics and Genomics. Cardiff University) ; Lawlor, Brian (Mercer's Institute for Research on Ageing. St James' Hospital) ; Livingston, Gill (Division of Psychiatry. University College London) ; Lovestone, Simon (Department of Psychiatry. University of Oxford) ; Lupton, Michelle (Department of Basic and Clinical Neuroscience. Institute of Psychiatry. Psychology and Neuroscience. Kings College London) ; Lynch, Aoibhinn (Mercer's Institute for Research on Ageing. St James' Hospital) ; Mann, David (Division of Neuroscience and Experimental Psychology. School of Biological Sciences. Faculty of Biology. Medicine and Health. University of Manchester. Manchester Academic Health Science Centre) ; McGuinness, Bernadette (Centre for Public Health. School of Medicine. Dentistry and Biomedical Sciences. Queens University) ; McQuillin, Andrew (Division of Psychiatry. University College London) ; O'Donovan, Michael C. (Division of Psychological Medicine and Clinial Neurosciences. MRC Centre for Neuropsychiatric Genetics and Genomics. Cardiff University) ; Owen, Michael J. (Division of Psychological Medicine and Clinial Neurosciences. MRC Centre for Neuropsychiatric Genetics and Genomics. Cardiff University) ; Passmore, Peter (Centre for Public Health. School of Medicine. Dentistry and Biomedical Sciences. Queens University) ; Powell, John F. (Department of Basic and Clinical Neuroscience. Institute of Psychiatry. Psychology and Neuroscience. Kings College London) ; Proitsi, Petra (Department of Basic and Clinical Neuroscience. Institute of Psychiatry. Psychology and Neuroscience. Kings College London) ; Rossor, Martin (Dementia Research Centre. Department of Neurodegenerative Disease. UCL Institute of Neurology) ; Shaw, Christopher E. (Institute of Psychiatry. Psychology and Neuroscience. Kings College London) ; Smith, A. David (Oxford Project to Investigate Memory and Ageing (OPTIMA). University of Oxford. Level 4. John Radcliffe Hospital) ; Gurling, Hugh (Department of Mental Health Sciences. University College London) ; Todd, Stephen (Ageing Group. Centre for Public Health. School of Medicine. Dentistry and Biomedical Sciences. Queen's University Belfast) ; Mummery, Catherine (Dementia Research Centre. UCL) ; Ryan, Nathalie (Dementia Research Centre. UCL) ; Lacidogna, Giordano (Department of Neuroscience. Catholic University of Sacred Heart. Fondazione Policlinico Universitario A. Gemelli IRCCS) ; Adarmes-Gómez, A.D (Department of Neurology. Erasmus MC) ; Mauleón, Ana (Research Center and Memory Clinic Fundació ACE. Institut Català de Neurociències Aplicades. Universitat Internacional de Catalunya) ; Pancho, Ana (Research Center and Memory Clinic Fundació ACE. Institut Català de Neurociències Aplicades. Universitat Internacional de Catalunya) ; Gailhajenet, Anna (Research Center and Memory Clinic Fundació ACE. Institut Català de Neurociències Aplicades. Universitat Internacional de Catalunya) ; Lafuente, Asunción (Research Center and Memory Clinic Fundació ACE. Institut Català de Neurociències Aplicades. Universitat Internacional de Catalunya) ; Macias-García, D. (Unidad de Trastornos del Movimiento. Servicio de Neurología y Neurofisiología. Instituto de Biomedicina de Sevilla (IBiS). Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla) ; Martín, Elvira (Research Center and Memory Clinic Fundació ACE. Institut Català de Neurociències Aplicades. Universitat Internacional de Catalunya) ; Pelejá, Esther (Research Center and Memory Clinic Fundació ACE. Institut Català de Neurociències Aplicades. Universitat Internacional de Catalunya) ; Carrillo, F. (Unidad de Trastornos del Movimiento. Servicio de Neurología y Neurofisiología. Instituto de Biomedicina de Sevilla (IBiS). Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla) ; Sastre Merlín, Isabel (Centro de Biología Molecular Severo Ochoa (UAM-CSIC)) ; Garrote-Espina, L. (Unidad de Trastornos del Movimiento. Servicio de Neurología y Neurofisiología. Instituto de Biomedicina de Sevilla (IBiS). Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla) ; Vargas, Liliana (Research Center and Memory Clinic Fundació ACE. Institut Català de Neurociències Aplicades. Universitat Internacional de Catalunya) ; Carrión-Claro, M. (Unidad de Trastornos del Movimiento. Servicio de Neurología y Neurofisiología. Instituto de Biomedicina de Sevilla (IBiS). Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla) ; Marín, M. (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ; Labrador, Ma (Department of Neurology. Erasmus MC) ; Buendia, Mar (Research Center and Memory Clinic Fundació ACE. Institut Català de Neurociències Aplicades. Universitat Internacional de Catalunya) ; Alonso, María Dolores (Servei de Neurologia. Hospital Clínic Universitari de València) ; Guitart, Marina (Research Center and Memory Clinic Fundació ACE. Institut Català de Neurociències Aplicades. Universitat Internacional de Catalunya) ; Moreno, Mariona (Research Center and Memory Clinic Fundació ACE. Institut Català de Neurociències Aplicades. Universitat Internacional de Catalunya) ; Ibarria, Marta (Research Center and Memory Clinic Fundació ACE. Institut Català de Neurociències Aplicades. Universitat Internacional de Catalunya) ; Periñán, Mt (Department of Neurology. Erasmus MC) ; Aguilera, Nuria (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Gómez-Garre, P. (Unidad de Trastornos del Movimiento. Servicio de Neurología y Neurofisiología. Instituto de Biomedicina de Sevilla (IBiS). Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla) ; Cañabate, Pilar (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Escuela, R. (Unidad de Trastornos del Movimiento. Servicio de Neurología y Neurofisiología. Instituto de Biomedicina de Sevilla (IBiS). Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla) ; Pineda-Sánchez, R. (Unidad de Trastornos del Movimiento. Servicio de Neurología y Neurofisiología. Instituto de Biomedicina de Sevilla (IBiS). Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla) ; Vigo-Ortega, R. (Unidad de Trastornos del Movimiento. Servicio de Neurología y Neurofisiología. Instituto de Biomedicina de Sevilla (IBiS). Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla) ; Jesús, S. (Unidad de Trastornos del Movimiento. Servicio de Neurología y Neurofisiología. Instituto de Biomedicina de Sevilla (IBiS). Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla) ; Preckler, S. (Research Center and Memory Clinic Fundació ACE. Institut Català de Neurociències Aplicades. Universitat Internacional de Catalunya) ; Rodrigo-Herrero, S. (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ; Diego, Susana (Research Center and Memory Clinic Fundació ACE. Institut Català de Neurociències Aplicades. Universitat Internacional de Catalunya) ; Vacca, Alessandro (Department of Neuroscience "Rita Levi Montalcini". University of Torino) ; Roveta, F. (Department of Neuroscience "Rita Levi Montalcini". University of Torino) ; Salvadori, N. (Institute of Cognitive Neurology and Dementia Research (IKND). Otto-Von-Guericke University) ; Chipi, E. (Institute of Cognitive Neurology and Dementia Research (IKND). Otto-Von-Guericke University) ; Boecker, H. (Department of Radiology. University Hospital Bonn) ; Laske, C. (Section for Dementia Research. Department of Psychiatry. Hertie Institute for Clinical Brain Research) ; Perneczky, R. (Department of Psychiatry and Psychotherapy. University Hospital. LMU Munich) ; Anastasiou, C. (Department of Nutrition and Diatetics. Harokopio University) ; Janowitz, D. (Institute for Stroke and Dementia Research. Klinikum der Universität München. Ludwig Maximilians Universität (LMU)) ; Malik, R. (Institute for Stroke and Dementia Research. Klinikum der Universität München. Ludwig Maximilians Universität (LMU)) ; Anastasiou, A. (First Department of Neurology. Medical School. Aristotle University of Thessaloniki) ; Parveen, K. (Department of Neurodegenerative Diseases and Geriatric Psychiatry. University Hospital Bonn) ; Lage, C. (Service of Neurology. University Hospital Marqués de Valdecilla. IDIVAL. University of Cantabria) ; López-García, S. (Service of Neurology. University Hospital Marqués de Valdecilla. IDIVAL. University of Cantabria) ; Antonell, A. (Neurology Department-Hospital Clínic. IDIBAPS. Universitat de Barcelona) ; Mihova, K.Y. (Molecular Medicine Center. Department of Medical chemistry and biochemistry. Medical University of Sofia) ; Belezhanska, D. (Clinic of Neurology. UH 'Alexandrovska'. Medical University - Sofia) ; Weber, H. (Department of Psychiatry. Psychosomatics and Psychotherapy. Center of Mental Health. University Hospital of Würzburg) ; Kochen, S. (ENYS (Estudio en Neurociencias y Sistemas Complejos) CONICET- Hospital El Cruce "Nestor Kirchner"- UNAJ) ; Solis, P. (ENYS (Estudio en Neurociencias y Sistemas Complejos) CONICET- Hospital El Cruce "Nestor Kirchner"- UNAJ) ; Medel, N. (ENYS (Estudio en Neurociencias y Sistemas Complejos) CONICET- Hospital El Cruce "Nestor Kirchner"- UNAJ) ; Lisso, J. (ENYS (Estudio en Neurociencias y Sistemas Complejos) CONICET- Hospital El Cruce "Nestor Kirchner"- UNAJ) ; Sevillano, Z. (ENYS (Estudio en Neurociencias y Sistemas Complejos) CONICET- Hospital El Cruce "Nestor Kirchner"- UNAJ) ; Politis, D.G. (HIGA Eva Perón) ; Cores, V. (HIGA Eva Perón) ; Cuesta, C. (HIGA Eva Perón) ; Ortiz, C. (Neurología Clinica) ; Bacha, J.I. (Neurología Clinica) ; Rios, M. (Dirección de Atención de Adultos Mayores del Min. Salud Desarrollo Social y Deportes de la Pcia. de Mendoza) ; Saenz, A. (Dirección de Atención de Adultos Mayores del Min. Salud Desarrollo Social y Deportes de la Pcia. de Mendoza) ; Abalos, M.S. (Laboratorio de Genética Forense del Ministerio Público de la Pcia de La Pampa) ; Kohler, E. (Fundacion Sinapsis) ; Palacio, D.L. (Hospital Dr. Lucio Molas. Santa Rosa; Fundacion Ayuda Enfermo Renal y Alta Complejidad (FERNAC)) ; Etchepareborda, I. (Hospital Dr. Lucio Molas. Santa Rosa; Fundacion Ayuda Enfermo Renal y Alta Complejidad (FERNAC)) ; Kohler, M. (Hospital Dr. Lucio Molas. Santa Rosa; Fundacion Ayuda Enfermo Renal y Alta Complejidad (FERNAC)) ; Novack, G. (Laboratory of Brain Aging and Neurodegeneration (FIL)) ; Prestia, F.A. (Laboratory of Brain Aging and Neurodegeneration (FIL)) ; Galeano, P. (Laboratory of Brain Aging and Neurodegeneration (FIL)) ; Castaño, E.M. (Laboratory of Brain Aging and Neurodegeneration (FIL)) ; Germani, S. (Centro de Neuropsiquiatría y Neurología de la Conducta (CENECON). Facultad de Medicina. Universidad de Buenos Aires (UBA). C.A.B.A.) ; Toso, C.R. (Centro de Neuropsiquiatría y Neurología de la Conducta (CENECON). Facultad de Medicina. Universidad de Buenos Aires (UBA). C.A.B.A.) ; Rojo, M. (Centro de Neuropsiquiatría y Neurología de la Conducta (CENECON). Facultad de Medicina. Universidad de Buenos Aires (UBA). C.A.B.A.) ; Ingino, C. (Centro de Neuropsiquiatría y Neurología de la Conducta (CENECON). Facultad de Medicina. Universidad de Buenos Aires (UBA). C.A.B.A.) ; Mangone, C. (Centro de Neuropsiquiatría y Neurología de la Conducta (CENECON). Facultad de Medicina. Universidad de Buenos Aires (UBA). C.A.B.A.) ; Rubinsztein, D.C. (Cambridge Institute for Medical Research and UK Dementia Research Institute. University of Cambridge) ; Teipel, S. (German Center for Neurodegenerative Diseases (DZNE)) ; Fievet, N. (Université de Lille. INSERM. CHU Lille. Institut Pasteur Lille. U1167-RID-AGE. Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement) ; Deramerourt, V. (Resources and Research Memory Center (MRRC) of Distalz. LicendUniversity of Lille. INSERM. CHU Lille. UMR1172) ; Forsell, C. (Unit for Hereditary Dementias. Karolinska University Hospital-Solna) ; Thonberg, H. (Unit for Hereditary Dementias. Karolinska University Hospital-Solna) ; Bjerke, M. (Grupo de Medicina Xenómica. Centro Nacional de Genotipado (CEGEN-PRB3-ISCIII). Universidade de Santiago de Compostela) ; Roeck, E.D. (Grupo de Medicina Xenómica. Centro Nacional de Genotipado (CEGEN-PRB3-ISCIII). Universidade de Santiago de Compostela) ; Martínez-Larrad, M.T. (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas. CIBERDEM. Hospital Clínico San Carlos) ; Olivar, N. (Centro de Neuropsiquiatría y Neurología de la Conducta (CENECON). Facultad de Medicina. Universidad de Buenos Aires (UBA). C.A.B.A.) ; Aguilera, N. (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Cano, A. (Research Center and Memory Clinic Fundació ACE. Institut Català de Neurociències Aplicades. Universitat Internacional de Catalunya) ; Cañabate, P. (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Macias, J. (Hospital Universitario Virgen de Valme (Sevilla, Andalusia)) ; Maroñas, O. (Grupo de Medicina Xen'omica. Centro Nacional de Genotipado (CEGEN-PRB3-ISCIII). Universidad de Santiago de Compostela) ; Nuñez-Llaves, R. (Research Center and Memory Clinic Fundació ACE. Institut Català de Neurociències Aplicades. Universitat Internacional de Catalunya) ; Olivé, C. (Research Center and Memory Clinic Fundació ACE. Institut Català de Neurociències Aplicades. Universitat Internacional de Catalunya) ; Pelejá, E. (Research Center and Memory Clinic Fundació ACE. Institut Català de Neurociències Aplicades. Universitat Internacional de Catalunya) ; Adarmes-Gómez, A.D (Unidad de Trastornos del Movimiento. Servicio de Neurología y Neurofisiología. Instituto de Biomedicina de Sevilla (IBiS). Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla) ; Alonso, M.D. (Servei de Neurologia. Hospital Clínic Universitari de València) ; Amer-Ferrer, G. (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ; Antequera, M. (Hospital Clínico Universitario Virgen de la Arrixaca (El Palmar, Múrcia)) ; Burguera, J.A. (Hospital Universitari i Politècnic La Fe (València)) ; Carrillo, F. (Unidad de Trastornos del Movimiento. Servicio de Neurología y Neurofisiología. Instituto de Biomedicina de Sevilla (IBiS). Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla) ; Carrión-Claro, M. (Unidad de Trastornos del Movimiento. Servicio de Neurología y Neurofisiología. Instituto de Biomedicina de Sevilla (IBiS). Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla) ; Casajeros, M.J. (Hospital Universitario Ramón y Cajal (Madrid)) ; Martinez de Pancorbo, M. (BIOMICs. País Vasco; Centro de Investigación Lascaray. Universidad del País Vasco UPV/EHU) ; Escuela, R. (Unidad de Trastornos del Movimiento. Servicio de Neurología y Neurofisiología. Instituto de Biomedicina de Sevilla (IBiS). Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla) ; Garrote-Espina, L. (Unidad de Trastornos del Movimiento. Servicio de Neurología y Neurofisiología. Instituto de Biomedicina de Sevilla (IBiS). Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla) ; Gómez-Garre, P. (Unidad de Trastornos del Movimiento. Servicio de Neurología y Neurofisiología. Instituto de Biomedicina de Sevilla (IBiS). Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla) ; Hevilla, S. (Instituto Andaluz de Neurociencia) ; Jesús, S. (Unidad de Trastornos del Movimiento. Servicio de Neurología y Neurofisiología. Instituto de Biomedicina de Sevilla (IBiS). Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla) ; Espinosa, M.A.L. (Unidad de Trastornos del Movimiento. Servicio de Neurología y Neurofisiología. Instituto de Biomedicina de Sevilla (IBiS). Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla) ; Legaz, A. (Hospital Clínico Universitario Virgen de la Arrixaca (El Palmar, Múrcia)) ; López-García, S. (Service of Neurology. University Hospital Marqués de Valdecilla. IDIVAL. University of Cantabria) ; Macias-García, D. (Unidad de Trastornos del Movimiento. Servicio de Neurología y Neurofisiología. Instituto de Biomedicina de Sevilla (IBiS). Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla) ; Manzanares, S. (Fundación para la Formación e Investigación Sanitarias de la Región de Murcia) ; Marín, M. (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ; Marín-Muñoz, J. (Hospital Clínico Universitario Virgen de la Arrixaca (El Palmar, Múrcia)) ; Marín, T. (Instituto Andaluz de Neurociencia) ; Martínez, B. (Hospital Clínico Universitario Virgen de la Arrixaca (El Palmar, Múrcia)) ; Martínez, V. (Hospital Clínico Universitario Virgen de la Arrixaca (El Palmar, Múrcia)) ; Martínez-Lage Álvarez, P. (Centro de Investigación y Terapias Avanzadas. Fundación CITA-Alzheimer) ; Iriarte, M.M. (Navarrabiomed) ; Periñán-Tocino, M.T. (Unidad de Trastornos del Movimiento. Servicio de Neurología y Neurofisiología. Instituto de Biomedicina de Sevilla (IBiS). Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla) ; Pineda-Sánchez, R. (Unidad de Trastornos del Movimiento. Servicio de Neurología y Neurofisiología. Instituto de Biomedicina de Sevilla (IBiS). Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla) ; Real de Asúa, D. (Hospital Universitario de la Princesa (Madrid)) ; Rodrigo, S. (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ; Sastre, I. (Centro de Biología Molecular Severo Ochoa (UAM-CSIC)) ; Vicente, M. P. (Hospital Clínico Universitario Virgen de la Arrixaca (El Palmar, Múrcia)) ; Vigo-Ortega, R. (Unidad de Trastornos del Movimiento. Servicio de Neurología y Neurofisiología. Instituto de Biomedicina de Sevilla (IBiS). Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla) ; Vivancos, L. (Hospital Clínico Universitario Virgen de la Arrixaca (El Palmar, Múrcia)) ; Epelbaum, J. (UMR 7179 CNRS/MNHN) ; Hannequin, D. (Department of Neurology and CNR-MAJ. F 76000. Normandy Center for Genomic and Personalized Medicine. Normandie University. UNIROUEN. INSERM U1245. CHU Rouen) ; campion, D. (Department of Genetics and CNR-MAJ. Normandie University. UNIROUEN. INSERM U1245. CHU Rouen) ; Deramecourt, V. (Resources and Research Memory Center (MRRC) of Distalz. LicendUniversity of Lille. INSERM. CHU Lille. UMR1172) ; Tzourio, C. (Bordeaux Population Health Research Center. University Bordeaux. INSERM) ; Brice, A. (Sorbonne Université. Paris Brain Institute. APHP. INSERM. CNRS) ; Dubois, B. (Department of Neurology. Institute of Memory and Alzheimer's Disease (IM2A). Pitié-Salpêtrière Hospital. AP-HP. Boulevard de l'Hôpital) ; Williams, A. (MRC Centre for Neuropsychiatric Genetics and Genomics. Division of Psychological Medicine and Clinical Neuroscience. School of Medicine. Cardiff University) ; Thomas, C. (MRC Centre for Neuropsychiatric Genetics and Genomics. Division of Psychological Medicine and Clinical Neuroscience. School of Medicine. Cardiff University) ; Davies, C. (MRC Centre for Neuropsychiatric Genetics and Genomics. Division of Psychological Medicine and Clinical Neuroscience. School of Medicine. Cardiff University) ; Nash, W. (MRC Centre for Neuropsychiatric Genetics and Genomics. Division of Psychological Medicine and Clinical Neuroscience. School of Medicine. Cardiff University) ; Dowzell, K. (MRC Centre for Neuropsychiatric Genetics and Genomics. Division of Psychological Medicine and Clinical Neuroscience. School of Medicine. Cardiff University) ; Morales, A.C. (UKDRI@ Cardiff. School of Medicine. Cardiff University) ; Bernardo-Harrington, M. (UKDRI@ Cardiff. School of Medicine. Cardiff University) ; Turton, J. (Institute of Genetics. Queen's Medical Centre. University of Nottingham) ; Lord, J. (Institute of Genetics. Queen's Medical Centre. University of Nottingham) ; Brown, K. (Institute of Genetics. Queens Medical Centre. University of Nottingham) ; Vardy, E. (Institute for Ageing and Health. Newcastle University. Campus for Ageing and Vitality) ; Fisher, E. (Department of Neurodegenerative Disease. UCL Institute of Neurology) ; Warren, J.D. (Department of Neurodegenerative Disease. UCL Institute of Neurology) ; Rossor, M. (Dementia Research Centre. Department of Neurodegenerative Disease. UCL Institute of Neurology) ; Ryan, N.S. (Dementia Research Centre. UCL) ; Guerreiro, R. (Department of Neurodegenerative Disease. UCL Institute of Neurology) ; Uphill, J. (MRC Prion Unit at UCL. UCL Institute of Prion Diseases) ; Bass, N. (Division of Psychiatry. University College London) ; Heun, R. (Department of Old Age Psychiatry. Institute of Psychiatry. Psychology and Neuroscience. King's College London) ; Kölsch, H. (Department of Psychiatry and Psychotherapy. University of Bonn) ; Schürmann, B. (Department of Psychiatry and Psychotherapy. University of Bonn) ; Lacour, A. (German Center for Neurodegenerative Diseases (DZNE Bonn)) ; Herold, C. (German Center for Neurodegenerative Diseases (DZNE Bonn)) ; Johnston, J.A. (Centre for Public Health. School of Medicine. Dentistry and Biomedical Sciences. Queens University) ; Passmore, P. (Centre for Public Health. School of Medicine. Dentistry and Biomedical Sciences. Queens University) ; Powell, J. (Department of Basic and Clinical Neuroscience. Institute of Psychiatry. Psychology and Neuroscience. Kings College London) ; Patel, Y. (University of Toronto) ; Hodges, A. (Department of Old Age Psychiatry. Institute of Psychiatry. Psychology and Neuroscience. King's College London) ; Becker, T. (Institute for Medical Biometry. Informatics and Epidemiology. University of Bonn) ; Warden, D. (Oxford Project to Investigate Memory and Ageing (OPTIMA). University of Oxford. Level 4. John Radcliffe Hospital) ; Wilcock, G. (Oxford Project to Investigate Memory and Ageing (OPTIMA). University of Oxford. Level 4. John Radcliffe Hospital) ; Clarke, R. (Department of Neurodegenerative Disease. UCL Institute of Neurology) ; Deloukas, P. (The Wellcome Trust Sanger Institute. Wellcome Trust Genome Campus. Hinxton) ; Ben-Shlomo, Y. (Population Health Sciences. Bristol Medical School. University of Bristol) ; Hooper, N.M. (Division of Neuroscience and Experimental Psychology. School of Biological Sciences. Faculty of Biology. Medicine and Health. University of Manchester. Manchester Academic Health Science Centre) ; Pickering-Brown, S. (University of Manchester. Manchester Academic Health Science Centre) ; Sussams, R. (Division of Clinical Neurosciences. School of Medicine. University of Southampton) ; Warner, N. (Somerset Partnership NHS Trust) ; Bayer, A. (Institute of Primary Care and Public Health. Cardiff University. University Hospital of Wales) ; Heuser, I. (Department of Psychiatry and Psychotherapy. Charité University Medicine) ; Drichel, D. (Universität zu Köln (Colònia, Alemaya). Cologne Center for Genomics) ; Klopp, N. (Institute of Epidemiology. Helmholtz Zentrum München. German Research Center for Environmental Health. Neuherberg) ; Mayhaus, M. (Department of Psychiatry and Psychotherapy. University Hospital) ; Riemenschneider, M. (Department of Psychiatry and Psychotherapy. University Hospital) ; Pinchler, S. (Department of Psychiatry and Psychotherapy. University Hospital) ; Feulner, T. (Department of Psychiatry and Psychotherapy. University Hospital) ; Gu, W. (Department of Psychiatry and Psychotherapy. University Hospital) ; van den Bussche, H. (Department of Primary Medical Care. University Medical Centre Hamburg-Eppendorf) ; Hüll, M. (Department of Psychiatry. University of Freiburg) ; Frölich, L. (Central Institute of Mental Health. Medical Faculty Mannheim. University of Heidelberg) ; Wichmann, H.E. (Institute of Epidemiology. Helmholtz Zentrum München. German Research Center for Environmental Health. Neuherberg) ; Jöckel, K.H. (Institute for Medical Informatics. Biometry and Epidemiology. University Hospital of Essen. University Duisburg-Essen) ; O'Donovan, M. (Division of Psychological Medicine and Clinial Neurosciences. MRC Centre for Neuropsychiatric Genetics and Genomics. Cardiff University) ; Owen, M. (Division of Psychological Medicine and Clinial Neurosciences. MRC Centre for Neuropsychiatric Genetics and Genomics. Cardiff University) ; Bahrami, S. (Division of Mental Health and Addiction. Oslo University Hospital) ; Bosnes, I. (Department of Psychiatry. Hospital Namsos. Nord-Trøndelag Health Trust) ; Selnes, P. (Department of Neurology. Akershus University Hospital) ; Bergh, S. (Centre for Old Age Psychiatry Research. Innlandet Hospital Trust) ; Palotie, A. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Daly, M. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Jacob, H. (AbbVie) ; Matakidou, A. (Astra Zeneca) ; Runz, H. (Biogen) ; John, S. (Biogen) ; Plenge, R. (Celgene) ; McCarthy, M. (Genentech) ; Hunkapiller, J. (Genentech) ; Ehm, M. (GlaxoSmithKline) ; Waterworth, D. (GlaxoSmithKline) ; Fox, C. (Merck) ; Malarstig, A. (Pfizer) ; Klinger, K. (Sanofi) ; Call, K. (Sanofi) ; Behrens, T. (Maze Therapeutics) ; Loerch, P. (Janssen Biotech) ; Mäkelä, T. (HiLIFE. University of Helsinki) ; Kaprio, Jaakko (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Virolainen, P. (Auria Biobank. University of Turku. Hospital District of Southwest Finland) ; Pulkki, K. (Auria Biobank. University of Turku. Hospital District of Southwest Finland) ; Kilpi, T. (THL Biobank. The National Institute of Health and Welfare Helsinki) ; Perola, M. (THL Biobank. The National Institute of Health and Welfare Helsinki) ; Partanen, J. (Finnish Red Cross Blood Service. Finnish Hematology Registry and Clinical Biobank) ; Pitkäranta, A. (Helsinki Biobank. Helsinki University and Hospital District of Helsinki and Uusimaa) ; Kaarteenaho, R. (Northern Finland Biobank Borealis. University of Oulu. Northern Ostrobothnia Hospital District) ; Vainio, S. (Northern Finland Biobank Borealis. University of Oulu. Northern Ostrobothnia Hospital District) ; Turpeinen, M. (Northern Finland Biobank Borealis. University of Oulu. Northern Ostrobothnia Hospital District) ; Serpi, R. (Northern Finland Biobank Borealis. University of Oulu. Northern Ostrobothnia Hospital District) ; Laitinen, T. (Oxford Healthy Aging Project. Clinical Trial Service Unit. University of Oxford) ; Mäkelä, J. (Finnish Clinical Biobank Tampere. University of Tampere. Pirkanmaa Hospital District) ; Kosma, V.M. (Biobank of Eastern Finland. University of Eastern Finland / Northern Savo Hospital District) ; Kujala, U. (Central Finland Biobank. University of Jyväskylä. Central Finland Health Care District) ; Tuovila, O. (Business Finland) ; Hendolin, M. (Business Finland) ; Pakkanen, R. (Business Finland) ; Waring, J. (AbbVie) ; Riley-Gillis, B. (AbbVie) ; Liu, J. (Biogen) ; Biswas, S. (Celgene) ; Diogo, D. (Merck) ; Marshall, C. (Pfizer) ; Hu, X. (Pfizer) ; Gossel, M. (Sanofi) ; Graham, R. (Maze Therapeutics) ; Cummings, B. (Janssen Biotech) ; Ripatti, Samuli (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Schleutker, J. (Auria Biobank. University of Turku. Hospital District of Southwest Finland) ; Arvas, M. (Finnish Red Cross Blood Service. Finnish Hematology Registry and Clinical Biobank) ; Carpén, O. (Helsinki Biobank. Helsinki University and Hospital District of Helsinki and Uusimaa) ; Hinttala, R. (Northern Finland Biobank Borealis. University of Oulu. Northern Ostrobothnia Hospital District) ; Kettunen, J. (Northern Finland Biobank Borealis. University of Oulu. Northern Ostrobothnia Hospital District) ; Mannermaa, A. (Biobank of Eastern Finland. University of Eastern Finland / Northern Savo Hospital District) ; Laukkanen, J. (Central Finland Biobank. University of Jyväskylä. Central Finland Health Care District) ; Julkunen, V. (Northern Savo Hospital District) ; Remes, A. (Northern Savo Hospital District) ; Kälviäinen, R. (Northern Savo Hospital District) ; Peltola, J. (Pirkanmaa Hospital District) ; Tienari, P. (Hospital District of Helsinki and Uusimaa) ; Rinne, J. (Hospital District of Southwest Finland) ; Ziemann, A. (AbbVie) ; Waring, J. (AbbVie) ; Esmaeeli, S. (AbbVie) ; Smaoui, N. (AbbVie) ; Lehtonen, A. (AbbVie) ; Eaton, S. (Biogen) ; Lahdenperä, S. (Biogen) ; van Adelsberg, J. (Celgene) ; Michon, J. (Genentech) ; Kerchner, G. (Genentech) ; Bowers, N. (Genentech) ; Teng, E. (Genentech) ; Eicher, J. (Genentech) ; Mehta, V. (Merck) ; Gormley, P. (Merck) ; Linden, K. (Pfizer) ; Whelan, C. (Pfizer) ; Xu, F. (GlaxoSmithKline) ; Pulford, D. (GlaxoSmithKline) ; Färkkilä, M. (Hospital District of Helsinki and Uusimaa) ; Pikkarainen, S. (Hospital District of Helsinki and Uusimaa) ; Jussila, A. (Pirkanmaa Hospital District) ; Blomster, T. (Northern Ostrobothnia Hospital District) ; Kiviniemi, M. (Northern Savo Hospital District) ; Voutilainen, M. (Hospital District of Southwest Finland) ; Georgantas, B. (AbbVie) ; Heap, G. (AbbVie) ; Rahimov, F. (AbbVie) ; Usiskin, K. (Celgene) ; Lu, T. (Department of Complex Trait Genetics. Center for Neurogenomics and Cognitive Research. Amsterdam Neuroscience. Vrije University) ; Oh, D. (Genentech) ; Kalpala, K. (Pfizer) ; Miller, M. (Pfizer) ; McCarthy, L. (GlaxoSmithKline) ; Eklund, K. (Hospital District of Helsinki and Uusimaa) ; Palomäki, A. (Hospital District of Southwest Finland) ; Isomäki, P. (Pirkanmaa Hospital District) ; Pirilä, L. (Hospital District of Southwest Finland) ; Kaipiainen-Seppänen, O. (Northern Savo Hospital District) ; Huhtakangas, J. (Northern Ostrobothnia Hospital District) ; Lertratanakul, A. (AbbVie) ; Hochfeld, M. (Celgene) ; Bing, N. (Pfizer) ; Gordillo, J.E. (GlaxoSmithKline) ; Mars, N. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Pelkonen, M. (Northern Savo Hospital District) ; Kauppi, P. (Hospital District of Helsinki and Uusimaa) ; Kankaanranta, H. (Pirkanmaa Hospital District) ; Harju, T. (Northern Ostrobothnia Hospital District) ; Close, D. (Astra Zeneca) ; Greenberg, S. (Celgene) ; Chen, H. (Genentech) ; Betts, J. (GlaxoSmithKline) ; Ghosh, S. (GlaxoSmithKline) ; Salomaa, V. (The National Institute of Health and Welfare Helsinki) ; Niiranen, T. (The National Institute of Health and Welfare Helsinki) ; Juonala, M. (Hospital District of Southwest Finland) ; Metsärinne, K. (Hospital District of Southwest Finland) ; Kähönen, M. (Pirkanmaa Hospital District) ; Junttila, J. (Northern Ostrobothnia Hospital District) ; Laakso, Markku (Northern Savo Hospital District) ; Pihlajamäki, J. (Northern Savo Hospital District) ; Sinisalo, J. (Hospital District of Helsinki and Uusimaa) ; Taskinen, M.R. (Hospital District of Helsinki and Uusimaa) ; Tuomi, T. (Hospital District of Helsinki and Uusimaa) ; Challis, B. (Astra Zeneca) ; Peterson, A. (Genentech) ; Chu, A. (Merck) ; Parkkinen, J. (Pfizer) ; Muslin, A. (Sanofi) ; Joensuu, H. (Hospital District of Helsinki and Uusimaa) ; Meretoja, T. (Hospital District of Helsinki and Uusimaa) ; Aaltonen, L. (Hospital District of Helsinki and Uusimaa) ; Mattson, J. (Hospital District of Helsinki and Uusimaa) ; Auranen, A. (Pirkanmaa Hospital District) ; Karihtala, P. (Northern Ostrobothnia Hospital District) ; Kauppila, S. (Northern Ostrobothnia Hospital District) ; Auvinen, P. (Northern Ostrobothnia Hospital District) ; Elenius, K. (Hospital District of Southwest Finland) ; Popovic, R. (AbbVie) ; Schutzman, J. (Genentech) ; Loboda, A. (Merck) ; Chhibber, A. (Merck) ; Lehtonen, H. (Pfizer) ; McDonough, S. (Pfizer Worldwide Research and Development) ; Crohns, M. (Sanofi) ; Kulkarni, D. (GlaxoSmithKline) ; Kaarniranta, K. (Northern Savo Hospital District) ; Turunen, J.A. (Hospital District of Helsinki and Uusimaa) ; Ollila, T. (Hospital District of Helsinki and Uusimaa) ; Seitsonen, S. (Hospital District of Helsinki and Uusimaa) ; Uusitalo, H. (Pirkanmaa Hospital District) ; Aaltonen, V. (Hospital District of Southwest Finland) ; Uusitalo-Järvinen, H. (Pirkanmaa Hospital District) ; Luodonpää, M. (Northern Ostrobothnia Hospital District) ; Hautala, N. (Northern Ostrobothnia Hospital District) ; Loomis, S. (Biogen) ; Strauss, E. (Genentech) ; Chen, H. (Genentech) ; Podgornaia, A. (Merck) ; Hoffman, J. (GlaxoSmithKline) ; Tasanen, K. (Northern Ostrobothnia Hospital District) ; Huilaja, L. (Northern Ostrobothnia Hospital District) ; Hannula-Jouppi, K. (Hospital District of Helsinki and Uusimaa) ; Salmi, T. (Pirkanmaa Hospital District) ; Peltonen, S. (Hospital District of Helsinki and Uusimaa) ; Koulu, L. (Hospital District of Helsinki and Uusimaa) ; Harvima, I. (Northern Savo Hospital District) ; Wu, Y. (German Center for Neurodegenerative Diseases (DZNE Bonn)) ; Choy, D. (Genentech) ; Pussinen, P. (Hospital District of Helsinki and Uusimaa) ; Salminen, A. (Hospital District of Helsinki and Uusimaa) ; Salo, T. (Hospital District of Helsinki and Uusimaa) ; Rice, D. (Hospital District of Helsinki and Uusimaa) ; Nieminen, P. (Hospital District of Helsinki and Uusimaa) ; Palotie, U. (Hospital District of Helsinki and Uusimaa) ; Siponen, M. (Northern Savo Hospital District) ; Suominen, L. (Northern Savo Hospital District) ; Mäntylä, P. (Northern Savo Hospital District) ; Gursoy, U. (Hospital District of Southwest Finland) ; Anttonen, V. (Northern Ostrobothnia Hospital District) ; Sipilä, K. (Northern Ostrobothnia Hospital District) ; Davis, J.W. (AbbVie) ; Quarless, D. (AbbVie) ; Petrovski, S. (Astra Zeneca) ; Wigmore, E. (Astra Zeneca) ; Chen, C.Y. (Biogen) ; Bronson, P. (Biogen) ; Tsai, E. (Biogen) ; Huang, Y. (Biogen) ; Maranville, J. (Celgene) ; Shaikho, E. (Celgene) ; Mohammed, E. (Celgene) ; Wadhawan, S. (Bristol Myers Squibb) ; Kvikstad, E. (Bristol Myers Squibb) ; Caliskan, M. (Bristol Myers Squibb) ; Chang, D. (Genentech) ; Bhangale, T. (Genentech) ; Pendergrass, S. (Genentech) ; Holzinger, E. (Merck) ; Chen, X. (Pfizer) ; Hedman, Å. (Pfizer) ; King, K.S. (GlaxoSmithKline) ; Wang, C. (Sanofi) ; Xu, E. (Sanofi) ; Auge, F. (Sanofi) ; Chatelain, C. (Sanofi) ; Rajpal, D. (Sanofi) ; Liu, D. (Population Health Sciences. German Center for Neurodegenerative Diseases (DZNE)) ; Call, K. (Sanofi) ; Xia, T.h. (Sanofi) ; Brauer, M. (Maze Therapeutics) ; Kurki, M. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Karjalainen, J. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Havulinna, A. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Jalanko, A. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Palta, P. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; della Briotta Parolo, P. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Zhou, W. (Broad Institute) ; Lemmelä, S. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Rivas, M. (University of Stanford) ; Harju, J. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Lehistö, A. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Ganna, A. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Llorens, V. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Laivuori, H. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Rüeger, S. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Niemi, M.E. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Tukiainen, T. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Reeve, M.P. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Heyne, H. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Palin, K. (University of Helsinki) ; Garcia-Tabuenca, J. (University of Tampere) ; Siirtola, H. (University of Tampere) ; Kiiskinen, T. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Lee, J. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Tsuo, K. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Elliott, A. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Kristiansson, K. (THL Biobank. The National Institute of Health and Welfare Helsinki) ; Hyvärinen, K. (Finnish Red Cross Blood Service) ; Ritari, J. (Finnish Red Cross Blood Service) ; Koskinen, M. (Helsinki Biobank. Helsinki University and Hospital District of Helsinki and Uusimaa) ; Pylkäs, K. (Northern Finland Biobank Borealis. University of Oulu. Northern Ostrobothnia Hospital District) ; Kalaoja, M. (Northern Finland Biobank Borealis. University of Oulu. Northern Ostrobothnia Hospital District) ; Karjalainen, M. (Northern Finland Biobank Borealis. University of Oulu. Northern Ostrobothnia Hospital District) ; Mantere, T. (Northern Finland Biobank Borealis. University of Oulu. Northern Ostrobothnia Hospital District) ; Kangasniemi, E. (Finnish Clinical Biobank Tampere. University of Tampere. Pirkanmaa Hospital District) ; Heikkinen, S. (Biobank of Eastern Finland. University of Eastern Finland / Northern Savo Hospital District) ; Laakkonen, E. (Central Finland Biobank. University of Jyväskylä. Central Finland Health Care District) ; Sipeky, C. (University of Turku) ; Heron, S. (University of Turku) ; Karlsson, A. (Auria Biobank. University of Turku. Hospital District of Southwest Finland) ; Jambulingam, D. (University of Turku) ; Rathinakannan, V.S. (University of Turku) ; Kajanne, R. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Aavikko, M. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Jiménez, M.G. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; della Briotta Parola, P. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Lehistö, A. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Kanai, M. (Broad Institute) ; Kaunisto, M. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Kilpeläinen, E. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Sipilä, T.P. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Brein, G. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Awaisa, G. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Shcherban, A. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Donner, K. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Loukola, A. (Helsinki Biobank. Helsinki University and Hospital District of Helsinki and Uusimaa) ; Laiho, P. (THL Biobank. The National Institute of Health and Welfare Helsinki) ; Sistonen, T. (THL Biobank. The National Institute of Health and Welfare Helsinki) ; Kaiharju, E. (THL Biobank. The National Institute of Health and Welfare Helsinki) ; Laukkanen, M. (THL Biobank. The National Institute of Health and Welfare Helsinki) ; Järvensivu, E. (THL Biobank. The National Institute of Health and Welfare Helsinki) ; Lähteenmäki, S. (THL Biobank. The National Institute of Health and Welfare Helsinki) ; Männikkö, L. (THL Biobank. The National Institute of Health and Welfare Helsinki) ; Wong, R. (THL Biobank. The National Institute of Health and Welfare Helsinki) ; Mattsson, H. (THL Biobank. The National Institute of Health and Welfare Helsinki) ; Hiekkalinna, T. (THL Biobank. The National Institute of Health and Welfare Helsinki) ; Paajanen, T. (THL Biobank. The National Institute of Health and Welfare Helsinki) ; Pärn, K. (Institute for Molecular Medicine Finland. HiLIFE. University of Helsinki) ; Gracia-Tabuenca, J. (University of Tampere) ; Abner, E. (Sanders-Brown Center on Aging. Department of Epidemiology. College of Public Health. University of Kentucky) ; Adams, P.M. (Department of Psychiatry. University of Texas Southwestern Medical Center) ; Aguirre, A. (Department of Neurology. Dell Medical School. University of Texas at Austin) ; Albert, M.S. (Department of Neurology. Johns Hopkins University) ; Albin, R.L. (Michigan Alzheimer's Disease Center. University of Michigan) ; Allen, M. (Department of Neuroscience. Mayo Clinic) ; Alvarez, L. (Department of Pharmacology and Neuroscience. University of North Texas Health Science Center) ; Apostolova, L.G. (Indiana Alzheimer's Disease Research Center. Indiana University School of Medicine) ; Arnold, S.E. (Department of Psychiatry. Perelman School of Medicine. University of Pennsylvania) ; Asthana, S. (Wisconsin Alzheimer's Disease Research Center) ; Atwood, C.S. (Wisconsin Alzheimer's Disease Research Center) ; Ayres, G. (Department of Neurology. Dell Medical School. University of Texas at Austin) ; Baldwin, C.T. (Department of Medicine (Biomedical Genetics). Boston University School of Medicine) ; Barber, R.C. (Department of Pharmacology and Neuroscience. University of North Texas Health Science Center) ; Barnes, L.L. (Rush Alzheimer's Disease Center. Rush University Medical Center) ; Barral, S. (Gertrude H. Sergievsky Center. Columbia University) ; Beach, T.G. (Civin Laboratory for Neuropathology. Banner Sun Health Research Institute) ; Beecham, G.W. (The John P. Hussman Institute for Human Genomics. University of Miami) ; Beekly, D. (National Alzheimer's Coordinating Center. University of Washington) ; Below, J.E. (Human Genetics Center. Department of Epidemiology. Human Genetics. and Environmental Sciences. School of Public Health. The University of Texas Health Science Center at Houston) ; Benchek, P. (Department of Population and Quantitative Health Sciences. Case Western Reserve University) ; Benitez, B.A. (Department of Psychiatry and Hope Center Program on Protein Aggregation and Neurodegeneration. Washington University School of Medicine) ; Bennett, D. (Rush Alzheimer's Disease Center. Rush University Medical Center) ; Bertelson, J. (Department of Psychiatry. University of Texas at Austin/Dell Medical School) ; Margaret, F.E. (Cognitive Neurology and Alzheimer's Disease Center. Northwestern University Feinberg School of Medicine) ; Bird, T.D. (VA Puget Sound Health Care System/GRECC) ; Blacker, D. (Department of Psychiatry. Massachusetts General Hospital/Harvard Medical School) ; Boeve, B.F. (Department of Neurology. Mayo Clinic) ; Bowen, J.D. (Swedish Medical Center) ; Boxer, A. (Department of Neurology. University of California San Francisco) ; Brewer, J. (Department of Neurosciences. University of California San Diego) ; Burke, J.R. (Department of Medicine. Duke University) ; Burns, J.M. (University of Kansas Alzheimer's Disease Center. University of Kansas Medical Center) ; Bush, W.S. (Department of Population & Quantitative Health Sciences. Case Western Reserve University) ; Buxbaum, J.D. (Nash Family Department of Neuroscience & Friedman Brain Institute. Icahn School of Medicine at Mount Sinai) ; Cairns, N.J. (Department of Pathology and Immunology. Washington University) ; Cao, C. (USF Health Byrd Alzheimer's Institute. University of South Florida) ; Carlson, C.S. (Fred Hutchinson Cancer Research Center) ; Carlsson, C.M. (Wisconsin Alzheimer's Disease Research Center) ; Carney, R.M. (Mental Health and Behavioral Science Service. Bruce W. Carter VA Medical Center) ; Carrasquillo, M.M. (Department of Neuroscience. Mayo Clinic) ; Chasse, S. (Department of Genetics. University of North Carolina at Chapel Hill) ; Chesselet, M.F. (Neurogenetics Program. University of California. Los Angeles) ; Chesi, A. (Department of Biostatistics. Epidemiology. and Informatics. Penn Neurodegeneration Genomics Center. University of Pennsylvania Perelman School of Medicine) ; Chin, N.A. (Department of Medicine. University of Wisconsin) ; Chui, H.C. (Department of Neurology. University of Southern California) ; Craft, S. (Section of Gerontology and Geriatric Medicine Research. Wake Forest School of Medicine) ; Crane, P.K. (Department of Medicine. University of Washington) ; Cribbs, D.H. (Department of Neurology. University of California. Irvine) ; Crocco, E.A. (Department of Psychiatry and Behavioral Sciences. Miller School of Medicine. University of Miami) ; Cruchaga, C. (Department of Psychiatry. Washington University in St. Louis) ; Cullum, M. (Department of Psychiatry. University of Texas Southwestern Medical Center) ; Darby, E. (Alzheimer's Disease and Memory Disorders Center. Baylor College of Medicine) ; Davis, B. (Department of Population and Data Sciences. University of Texas Southwestern Medical Center) ; De Jager, P.L. (Center for Translational and Computational Neuroimmunology. Department of Neurology. Columbia University Medical Center) ; DeCarli, C. (Department of Neurology. University of California. Davis) ; DeToledo, J. (Departments of Neurology. Pharmacology and Neuroscience. Texas Tech University Health Science Center) ; Dick, M. (Institute for Memory Impairments and Neurological Disorders. University of California. Irvine) ; Dickson, D.W. (Department of Neuroscience. Mayo Clinic) ; Dombroski, B.A. (Department of Biostatistics. Epidemiology. and Informatics. Penn Neurodegeneration Genomics Center. University of Pennsylvania Perelman School of Medicine) ; Doody, R.S. (Alzheimer's Disease and Memory Disorders Center. Baylor College of Medicine) ; Duara, R. (Wien Center for Alzheimer's Disease and Memory Disorders. Mount Sinai Medical Center) ; Ertekin-Taner, N. (Department of Neurology. Mayo Clinic) ; Evans, D.A. (Rush Institute for Healthy Aging. Department of Internal Medicine. Rush University Medical Center) ; Fairchild, T.J. (Office of Strategy and Measurement. University of North Texas Health Science Center) ; Fallon, K.B. (Department of Pathology. University of Alabama at Birmingham) ; Farlow, M.R. (Department of Neurology. Indiana University) ; Farrell, J.J. (Department of Medicine (Biomedical Genetics). Boston University School of Medicine) ; Fernandez-Hernandez, V. (Department of Psychiatry and Hope Center Program on Protein Aggregation and Neurodegeneration. Washington University School of Medicine) ; Ferris, S. (Department of Psychiatry. New York University) ; Frosch, M.P. (C.S. Kubik Laboratory for Neuropathology. Massachusetts General Hospital) ; Fulton-Howard, B. (Department of Neuroscience. Ronald M. Loeb Center for Alzheimer's Disease. Icahn School of Medicine at Mount Sinai) ; Galasko, D.R. (Department of Neurosciences. University of California San Diego) ; Gamboa, A. (Department of Health Management and Policy. School of Public Health. University of North Texas Health Science Center) ; Gearing, M. (Emory Alzheimer's Disease Center. Emory University) ; Geschwind, D.H. (NeuroGenomics and Informatics. Washington University in St. Louis) ; Ghetti, Bernardino (Department of Pathology and Laboratory Medicine. Indiana University) ; Gilbert, J.R. (The John P. Hussman Institute for Human Genomics. University of Miami) ; Grabowski, T.J. (Department of Radiology. University of Washington) ; Graff-Radford, N.R. (Department of Neurology. Mayo Clinic) ; Grant, S.F.A. (Department of Genetics. Perelman School of Medicine. University of Pennsylvania) ; Green, R.C. (Division of Genetics. Department of Medicine and Partners Center for Personalized Genetic Medicine. Brigham and Women's Hospital and Harvard Medical School) ; Growdon, J.H. (Department of Neurology. Massachusetts General Hospital/Harvard Medical School) ; Haines, J.L. (Department of Population & Quantitative Health Sciences. Case Western Reserve University) ; Hakonarson, H. (Division of Human Genetics. Department of Pediatrics. Perelman School of Medicine. University of Pennsylvania) ; Hall, J. (Department of Pharmacology and Neuroscience. University of North Texas Health Science Center) ; Hamilton, R.L. (Department of Pathology (Neuropathology). University of Pittsburgh) ; Harari, O. (Department of Psychiatry. Washington University in St. Louis) ; Harrell, L.E. (Department of Neurology. University of Alabama at Birmingham) ; Haut, J. (Department of Biostatistics. Epidemiology. and Informatics. Penn Neurodegeneration Genomics Center. University of Pennsylvania Perelman School of Medicine) ; Head, E. (Department of Pathology and Laboratory Medicine. University of California Irvine) ; Henderson, V.W. (Department of Neurology and Neurological Sciences. Stanford University) ; Hernandez, M. (Departments of Neurology. Pharmacology and Neuroscience. Texas Tech University Health Science Center) ; Hohman, T. (Vanderbilt Memory and Alzheimer's Center. Department of Neurology. Vanderbilt University Medical Center) ; Honig, L.S. (Taub Institute on Alzheimer's Disease and the Aging Brain. Department of Neurology. Columbia University) ; Huebinger, R.M. (Department of Surgery. University of Texas Southwestern Medical Center) ; Huentelman, M.J. (Neurogenomics Division. Translational Genomics Research Institute) ; Hulette, C.M. (Department of Pathology. Duke University) ; Hyman, B.T. (Department of Neurology. Massachusetts General Hospital/Harvard Medical School) ; Hynan, L.S. (Department of Neurological Surgery. University of Texas Southwestern Medical Center) ; Ibanez, L. (Hope Center Program on Protein Aggregation and Neurodegeneration. Washington University School of Medicine) ; Jarvik, G.P. (Department of Genome Sciences. University of Washington) ; Jayadev, S. (Departments of Neurology and Epidemiology. University of Washington) ; Jin, L.W. (Department of Pathology and Laboratory Medicine. University of California. Davis) ; Johnson, K. (Departments of Neurology. Pharmacology and Neuroscience. Texas Tech University Health Science Center) ; Johnson, L. (Department of Health Behavior and Health Systems. University of North Texas Health Science Center) ; Kamboh, M.I. (Alzheimer's Disease Research Center. University of Pittsburgh) ; Karydas, A.M. (Department of Neurology. University of California San Francisco) ; Katz, M.J. (Department of Neurology. Albert Einstein College of Medicine) ; Kaye, J.A. (Department of Neurology. Portland Veterans Affairs Medical Center) ; Keene, C.D. (Department of Laboratory Medicine and Pathology. University of Washington) ; Khaleeq, A. (Alzheimer's Disease and Memory Disorders Center. Baylor College of Medicine) ; Kim, R. (Department of Pathology and Laboratory Medicine. University of California Irvine) ; Knebl, J. (Department of Health Behavior and Health Systems. University of North Texas Health Science Center) ; Kowall, N.W. (Department of Pathology. Boston University) ; Kramer, J.H. (Department of Neuropsychology. University of California San Francisco) ; Kuksa, P.P. (Department of Pathology and Laboratory Medicine. University of Pennsylvania Perelman School of Medicine) ; LaFerla, F.M. (Department of Neurobiology and Behavior. University of California Irvine) ; Lah, J.J. (Department of Neurology. Emory University) ; Larson, E.B. (Kaiser Permanente Washington Health Research Institute) ; Lee, C.Y. (Department of Pathology and Laboratory Medicine. University of Pennsylvania Perelman School of Medicine) ; Lee, E.B. (Department of Biostatistics. Epidemiology. and Informatics. Penn Neurodegeneration Genomics Center. University of Pennsylvania Perelman School of Medicine) ; Lerner, A. (Department of Population and Quantitative Health Sciences. Case Western Reserve University) ; Leung, Y.Y. (Department of Biostatistics. Epidemiology. and Informatics. Penn Neurodegeneration Genomics Center. University of Pennsylvania Perelman School of Medicine) ; Leverenz, J.B. (Cleveland Clinic Lou Ruvo Center for Brain Health. Cleveland Clinic) ; Levey, A.I. (Department of Neurology. Emory University) ; Li, M. (Department of Biostatistics. Epidemiology. and Informatics. Penn Neurodegeneration Genomics Center. University of Pennsylvania Perelman School of Medicine) ; Lieberman, A.P. (Department of Pathology. University of Michigan) ; Lipton, R.B. (Department of Neurology. Albert Einstein College of Medicine) ; Logue, M. (National Center for PTSD at Boston VA Healthcare System) ; Lyketsos, C.G. (Department of Psychiatry. Johns Hopkins University) ; Malamon, J. (Department of Biostatistics. Epidemiology. and Informatics. Penn Neurodegeneration Genomics Center. University of Pennsylvania Perelman School of Medicine) ; Mains, D. (Department of Health Management and Policy. School of Public Health. University of North Texas Health Science Center) ; Marson, D.C. (Department of Neurology. University of Alabama at Birmingham) ; Martiniuk, F. (Department of Medicine (Pulmonary). New York University) ; Mash, D.C. (Department of Neurology. Miller School of Medicine. University of Miami) ; Masliah, E. (Department of Pathology. University of California San Diego) ; Massman, P. (Alzheimer's Disease and Memory Disorders Center. Baylor College of Medicine) ; Masurkar, A. (Department of Psychiatry. New York University) ; McCormick, W.C. (Department of Medicine. University of Washington) ; McCurry, S.M. (School of Nursing Northwest Research Group on Aging. University of Washington) ; McDavid, A.N. (Fred Hutchinson Cancer Research Center) ; McDonough, S. (Pfizer Worldwide Research and Development) ; McKee, A.C. (Department of Pathology. Boston University) ; Mesulam, M. (Cognitive Neurology and Alzheimer's Disease Center. Northwestern University Feinberg School of Medicine) ; Mez, J. (Institute of Biomedicine. University of Eastern Finland) ; Miller, B.L. (Weill Institute for Neurosciences. Memory and Aging Center. University of California. San Francisco) ; Miller, C.A. (Department of Pathology. University of Southern California) ; Miller, J.W. (Department of Pathology and Laboratory Medicine. University of California. Davis) ; Montine, T.J. (Department of Pathology. Stanford University School of Medicine) ; Monuki, E.S. (Department of Pathology and Laboratory Medicine. University of California Irvine) ; Morris, J.C. (Department of Neurology. Washington University at St. Louis) ; Myers, A.J. (Department of Psychiatry and Behavioral Sciences. Miller School of Medicine. University of Miami) ; Nguyen, T. (Department of Neurology. University of Texas Southwestern Medical Center) ; O'Bryant, S. (Institute for Translational Research. University of North Texas Health Science Center) ; Olichney, J.M. (Center for Mind and Brain and Department of Neurology. University of California. Davis) ; Ory, M. (Center for Population Health and Aging. Texas A&M University Health Science Center) ; Palmer, R. (Department of Family and Community Medicine. University of Texas Health Science Center San Antonio) ; Parisi, J.E. (Department of Laboratory Medicine and Pathology. Mayo Clinic) ; Paulson, H.L. (Michigan Alzheimer's Disease Center. University of Michigan) ; Pavlik, V. (Alzheimer's Disease and Memory Disorders Center. Baylor College of Medicine) ; Paydarfar, D. (Department of Neurology. Dell Medical School. University of Texas at Austin) ; Perez, V. (Departments of Neurology. Pharmacology and Neuroscience. Texas Tech University Health Science Center) ; Peskind, E. (Department of Psychiatry and Behavioral Sciences. University of Washington School of Medicine) ; Phillips-Cremins, J.E. (Department of Bioengineering. University of Pennsylvania) ; Pierce, A. (Department of Neurology. University of California. Irvine) ; Polk, M. (Alzheimer's Disease Center. New York University) ; Poon, W.W. (Institute for Memory Impairments and Neurological Disorders. University of California. Irvine) ; Potter, H. (Department of Neurology. University of Colorado School of Medicine) ; Qu, L. (Department of Biostatistics. Epidemiology. and Informatics. Penn Neurodegeneration Genomics Center. University of Pennsylvania Perelman School of Medicine) ; Quiceno, M. (Department of Medical Education. TCU/UNTHSC School of Medicine) ; Quinn, J.F. (Department of Neurology. Portland Veterans Affairs Medical Center) ; Raj, A. (USF Health Byrd Alzheimer's Institute. University of South Florida) ; Raskind, M. (Department of Psychiatry and Behavioral Sciences. University of Washington School of Medicine) ; Reiman, E.M. (Department of Psychiatry. University of Arizona) ; Reisberg, B. (Alzheimer's Disease Center. New York University) ; Reisch, J.S. (Department of Population and Data Sciences. University of Texas Southwestern Medical Center) ; Ringman, J.M. (Department of Neurology. University of Southern California) ; Roberson, E.D. (Department of Neurology. University of Alabama at Birmingham) ; Rodriguear, M. (Alzheimer's Disease and Memory Disorders Center. Baylor College of Medicine) ; Rogaeva, E. (Tanz Centre for Research in Neurodegenerative Disease. University of Toronto) ; Rosen, H.J. (Department of Neurology. University of California San Francisco) ; Rosenberg, R.N. (Department of Neurology. University of Texas Southwestern Medical Center) ; Royall, D.R. (Department of Family and Community Medicine. University of Texas Health Science Center San Antonio) ; Sager, M.A. (Department of Medicine. University of Wisconsin) ; Sano, M. (Department of Psychiatry. Icahn School of Medicine at Mount Sinai) ; Saykin, A.J. (Department of Radiology and Imaging Sciences. Indiana University) ; Schneider, J.A. (Department of Pathology (Neuropathology). Rush University Medical Center) ; Schneider, L.S. (Department of Psychiatry. University of Southern California) ; Seeley, W.W. (Department of Neurology. University of California San Francisco) ; Slifer, S.H. (The John P. Hussman Institute for Human Genomics. University of Miami) ; Small, S. (Gertrude H. Sergievsky Center. Columbia University) ; Smith, A.G. (USF Health Byrd Alzheimer's Institute. University of South Florida) ; Smith, J.P. (Department of Population and Data Sciences. University of Texas Southwestern Medical Center) ; Song, Y.E. (Department of Population and Quantitative Health Sciences. Case Western Reserve University) ; Sonnen, J.A. (Department of Laboratory Medicine and Pathology. University of Washington) ; Spina, S. (Department of Pathology and Laboratory Medicine. Indiana University) ; George-Hyslop, Peter St (University of Toronto) ; Stern, R.A. (Institute of Biomedicine. University of Eastern Finland) ; Stevens, A.B. (College of Medicine. Texas A&M University Health Science Center) ; Strittmatter, S.M. (Program in Cellular Neuroscience. Neurodegeneration and Repair. Yale University School of Medicine) ; Sultzer, D. (Department of Psychiatry and Human Behavior. University of California. Irvine) ; Swerdlow, R.H. (University of Kansas Alzheimer's Disease Center. University of Kansas Medical Center) ; Tanzi, R.E. (Department of Neurology. Massachusetts General Hospital/Harvard Medical School) ; Tilson, J.L. (Renaissance Computing Institute. University of North Carolina at Chapel Hill) ; Trojanowski, J.Q. (Department of Biostatistics. Epidemiology. and Informatics. Penn Neurodegeneration Genomics Center. University of Pennsylvania Perelman School of Medicine) ; Troncoso, J.C. (Department of Pathology. Johns Hopkins University) ; Tsuang, D.W. (Department of Psychiatry and Behavioral Sciences. University of Washington School of Medicine) ; Valladares, Otto (Department of Pathology and Laboratory Medicine. University of Pennsylvania Perelman School of Medicine) ; Van Deerlin, V.M. (Department of Biostatistics. Epidemiology. and Informatics. Penn Neurodegeneration Genomics Center. University of Pennsylvania Perelman School of Medicine) ; van Eldik, L.J. (Sanders-Brown Center on Aging. Department of Biostatistics. University of Kentucky) ; Vassar, R. (Cognitive Neurology and Alzheimer's Disease Center. Northwestern University Feinberg School of Medicine) ; Vinters, H.V. (Department of Pathology and Laboratory Medicine. University of California. Los Angeles) ; Vonsattel, J.P. (Taub Institute on Alzheimer's Disease and the Aging Brain. Department of Neurology. Columbia University) ; Weintraub, S. (Department of Psychiatry and Behavioral Sciences. Northwestern University Feinberg School of Medicine) ; Welsh-Bohmer, K.A. (Department of Psychiatry and Behavioral Sciences. Duke University) ; Whitehead, P.L. (The John P. Hussman Institute for Human Genomics. University of Miami) ; Wijsman, E.M. (Department of Biostatistics. University of Washington) ; Wilhelmsen, K.C. (Department of Genetics. University of North Carolina at Chapel Hill) ; Williams, B. (Section of Gerontology and Geriatric Medicine Research. Wake Forest School of Medicine) ; Williamson, J. (Taub Institute on Alzheimer's Disease and the Aging Brain. Department of Neurology. Columbia University) ; Wilms, H. (Departments of Neurology. Pharmacology and Neuroscience. Texas Tech University Health Science Center) ; Wingo, T.S. (Department of Neurology. Emory University) ; Wisniewski, T. (Center for Cognitive Neurology and Departments of Neurology and Pathology. New York University Grossman School of Medicine) ; Woltjer, R.L. (Department of Pathology. Oregon Health and Science University) ; Woon, M. (Department of Psychiatry. University of Texas at Austin/Dell Medical School) ; Wright, C.B. (Evelyn F. McKnight Brain Institute. Department of Neurology. Miller School of Medicine. University of Miami) ; Wu, C.K. (Departments of Neurology. Pharmacology and Neuroscience. Texas Tech University Health Science Center) ; Younkin, S.G. (Department of Neurology. Mayo Clinic) ; Yu, C.E. (Department of Medicine. University of Washington) ; Yu, L. (Rush Alzheimer's Disease Center. Rush University Medical Center) ; Zhang, Y. (Center for Applied Genomics. Children's Hospital of Philadelphia) ; Zhao, Y. (Laboratory of Neuropsychiatry. Department of Clinical and Behavioral Neurology. IRCCS Santa Lucia Foundation) ; Zhu, X. (Department of Pathology. Case Western Reserve University) ; Adams, Hieab (Université de Lille. INSERM. CHU Lille. Institut Pasteur Lille. U1167-RID-AGE. Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement) ; Akinyemi, R.O. (Centre for Genomic and Precision Medicine. College of Medicine. UI) ; Ali, M. (Washington University at St. Louis) ; Aparicio, H.J. (Department of Neurology. Boston University School of Medicine) ; Bahadori, M. (Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases. University of Texas Health Sciences Center) ; Becker, James T. (University of Pittsburgh) ; Breteler, M. (Population Health Sciences. German Center for Neurodegenerative Diseases (DZNE)) ; Chasman, D. (Brigham and Women's Hospital. Harvard University) ; Chauhan, G. (INSERM U1219. University of Bordeaux) ; Comic, H. (Department of Epidemiology. Erasmus MC) ; Cox, S. (University of Edinburgh) ; Cupples, A.L. (Department of Biostatistics. Boston University School of Public Health) ; Davies, G. (Centre for Cognitive Ageing and Cognitive Epidemiology. University of Edinburgh) ; DeCarli, C.S. (Department of Neurology and Center for Neuroscience. University of California. Davis) ; Duperron, M.G. (Bordeaux Population Health Research Center. Team VIN-TAGE. UMR 1219. University of Bordeaux. INSERM) ; Dupuis, J. (Department of Biostatistics. Boston University School of Public Health) ; Evans, T. (Department of Epidemiology. Erasmus MC) ; Fan, F. (University of Pittsburgh) ; Fitzpatrick, A. (Department of Family Medicine. University of Washington) ; Fohner, A.E. (Cardiovascular Health Research Unit. Department of Medicine. University of Washington) ; Ganguli, M. (University of Pittsburgh) ; Geerlings, M. (University Medical Center Utrecht) ; Glatt, S.J. (Psychiatric Genetic Epidemiology & Neurobiology Laboratory (PsychGENe Lab). Department of Psychiatry and Behavioral Sciences. SUNY Upstate Medical University) ; Gonzalez, H.M. (University of California. San Diego) ; Goss, M. (Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases. University of Texas Health Sciences Center) ; Grabe, H. (Department of Psychiatry and Psychotherapy. University Medicine Greifswald) ; Habes, M. (Department of Radiology. University of Texas Health Science Center at San Antonio) ; Heckbert, S.R. (School of Public Health. University of Texas Health Science Center at Houston) ; Hofer, E. (Clinical Division of Neurogeriatrics. Department of Neurology. Medical University of Graz) ; Hong, E. (University of Maryland) ; Hughes, T. (Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases. University of Texas Health Sciences Center) ; Kautz, T.F. (Department of General Medicine. University of Texas Health Science Center) ; Knol, M. (Department of Epidemiology. Erasmus MC) ; Kremen, W. (Department of Epidemiology. Erasmus MC) ; Lacaze, P. (Monash University Clayton Campus) ; Lahti, J. (University of Helsinki) ; Grand, Q.L. (Bordeaux Population Health Research Center. Team VIN-TAGE. UMR 1219. University of Bordeaux. INSERM) ; Litkowski, E. (University of Colorado Anschutz Medical Center) ; Li, S. (Department of Biostatistics. Boston University School of Public Health) ; Liu, D. (Population Health Sciences. German Center for Neurodegenerative Diseases (DZNE)) ; Liu, X. (Department of Biostatistics. Boston University School of Public Health) ; Loitfelder, M. (Medical University of Graz) ; Manning, A. (Massachusetts General Hospital. Harvard University) ; Maillard, P. (Imaging of Dementia and Aging (IDeA) Laboratory. Department of Neurology. University of California. Davis) ; Marioni, R. (University of Staffmail) ; Mazoyer, B. (University of Bordeaux. IMN) ; van Lent, D.M. (Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases. University of Texas Health Sciences Center) ; Mei, H. (University of Mississippi Medical Center) ; Mishra, Aniket (Université de Bordeaux) ; Nyquist, P. (Johns Hopkins University School of Medicine) ; O'Connell, J. (University of Maryland) ; Patel, Y. (University of Toronto) ; Paus, T. (University of Montreal. Centre Hospitalier Universitaire Saint-Justine) ; Pausova, Z. (Hospital for Sick Children. University of Toronto) ; Raikkonen-Talvitie, K. (University of Helsinki) ; Riaz, M. (Monash University Clayton Campus) ; Rich, S. (Monash University Clayton Campus) ; Harbor-UCLA Medical Center. Los Angeles Biomedical Research Institute and Pediatrics ; Romero, J. (Boston Medical Center) ; Roshchupkin, G. (Department of Epidemiology. Erasmus MC) ; Saba, Y. (Gottfried Schatz Research Center. Department of Molecular Biology and Biochemistry. Medical University of Graz) ; Sargurupremraj, M. (Gottfried Schatz Research Center. Department of Molecular Biology and Biochemistry. Medical University of Graz) ; Schmidt, H. (Gottfried Schatz Research Center. Department of Molecular Biology and Biochemistry. Medical University of Graz) ; Schmidt, R. (Clinical Division of Neurogeriatrics. Department of Neurology. Medical University of Graz) ; Shulman, J.M. (Departments of Neurology. Molecular & Human Genetics. and Neuroscience and Program in Developmental Biology. Baylor College of Medicine) ; Smith, J. (Department of Epidemiology. School of Public Health. University of Michigan) ; Sekhar, H. (Bordeaux Population Health Research Center. Team VIN-TAGE. UMR 1219. University of Bordeaux. INSERM) ; Rajula, R. (Bordeaux Population Health Research Center. Team VIN-TAGE. UMR 1219. University of Bordeaux. INSERM) ; Shin, J. (Hospital for Sick Children. University of Toronto) ; Simino, J. (University of Mississippi Medical Center) ; Sliz, E. (University of Mississippi Medical Center) ; Teumer, A. (Institute for Community Medicine. University Medicine Greifswald) ; Thomas, A. (University of North Carolina) ; Tin, A. (University of Mississippi Medical Center) ; Tucker-Drob, E. (University of Texas) ; Vojinovic, D. (Department of Epidemiology. Erasmus MC) ; Wang, Y. (German Center for Neurodegenerative Diseases (DZNE Bonn)) ; Weinstein, G. (Clinical Division of Neurogeriatrics. Department of Neurology. Medical University of Graz) ; Williams, D. (Karolinska Institutet (Estocolm, Suècia)) ; Wittfeld, K. (German Center for Neurodegenerative Diseases (DZNE). Site Rostock/Greifswald) ; Yanek, L. (GeneSTAR Research Program. Department of Neurology. Johns Hopkins University School of Medicine) ; Yang, Y. (Institute of Molecular Medicine. University of Texas Health Science Center at Houston McGovern Medical School) ; Farrer, L.A. (Department of Neurology. Boston University School of Medicine) ; Psaty, B.M. (Department of Health Service. University of Washington) ; Ghanbari, M. (Department of Epidemiology. Erasmus MC) ; Raj, T. (Nash Family Department of Neuroscience & Friedman Brain Institute. Icahn School of Medicine at Mount Sinai) ; Sachdev, Perminder S. (University of New South Wales) ; Mather, Karen A (Centre for Healthy Brain Ageing. School of Psychiatry. Faculty of Medicine. University of New South Wales) ; Jessen, F. (German Center for Neurodegenerative Diseases (DZNE Bonn)) ; Ikram, M. Arfan (Department of Epidemiology. Erasmus MC) ; de Mendonça, A. (Faculty of Medicine. University of Lisbon) ; Hort, J. (Memory Clinic. Department of Neurology. Charles University. 2nd Faculty of Medicine and Motol University Hospital) ; Tsolaki, M. (Alzheimer Hellas) ; Pericak-Vance, Margaret A (AI Virtanen Institute for Molecular Sciences. University of Eastern Finland) ; Amouyel, Philippe (Université de Lille. INSERM. CHU Lille. Institut Pasteur Lille. U1167-RID-AGE. Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement) ; Williams, J. (UKDRI@ Cardiff. School of Medicine. Cardiff University) ; Frikke-Schmidt, R. (Department of Clinical Biochemistry. Rigshospitalet) ; Clarimón, Jordi (Institut d'Investigació Biomèdica Sant Pau) ; Deleuze, J.F. (Université Paris-Saclay. Centre National de Recherche en Génomique Humaine) ; Rossi, G. (Fondazione IRCCS. Istituto Neurologico Carlo Besta) ; Seshadri, S. (Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases. University of Texas Health Sciences Center) ; Andreassen, Ole A. (NORMENT Centre. University of Oslo) ; Ingelsson, Martin (Department of Public Health and Carins Sciences/Geriatrics. Uppsala University) ; Hiltunen, M. (Brain Institute. Federal University of Rio Grande do Norte) ; Sleegers, Kristel (Department of Biomedical Sciences. University of Antwerp) ; Schellenberg, G.D. (Department of Pathology and Laboratory Medicine. University of Pennsylvania Perelman School of Medicine) ; van Duijn, C.M. (Nuffield Department of Population Health. Oxford University) ; Sims, Rebecca (MRC Centre for Neuropsychiatric Genetics and Genomics. Division of Psychological Medicine and Clinical Neuroscience. School of Medicine. Cardiff University) ; van der Flier, Wiesje M (Alzheimer Center Amsterdam. Department of Neurology. Amsterdam Neuroscience. Vrije Universiteit Amsterdam. Amsterdam UMC) ; Ruiz, A. (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Ramirez, A. (Universität zu Köln (Colònia, Alemaya). Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD)) ; Lambert, Jean-Charles (Université de Lille. INSERM. CHU Lille. Institut Pasteur Lille. U1167-RID-AGE. Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement) ; Universitat Autònoma de Barcelona
Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. [...]
2022 - 10.1038/s41588-022-01024-z
Nature genetics, Vol. 54 Núm. 4 (April 2022) , p. 412-436  
8.
16 p, 4.3 MB Common variants in Alzheimer's disease and risk stratification by polygenic risk scores / De Rojas, Itziar (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Moreno-Grau, Sonia (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Tesi, Niccolo (Delft Univeristy of Technology) ; Grenier-Boley, Benjamin (Institut Pasteur de Lille) ; Andrade, Victor (University Clinic Bonn) ; Jansen, Iris E. (Vrije Universiteit Amsterdam) ; Pedersen, Nancy L. (Karolinska Institutet (Estocolm, Suècia)) ; Stringa, Najada (Amsterdam UMC-Vrije Universiteit Amsterdam) ; Zettergren, Anna (University of Gothenburg) ; Hernández, Isabel (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Montrreal, Laura (Universitat Internacional de Catalunya) ; Antúnez, Carmen (Hospital Clínico Universitario Virgen de la Arrixaca (El Palmar, Múrcia)) ; Antonell, Anna (Universitat de Barcelona) ; Tankard, Rick M. (Murdoch University) ; Bis, Joshua C. (University of Washington) ; Sims, Rebecca (Cardiff University) ; Bellenguez, Céline (Institut Pasteur de Lille) ; Quintela, Inés (Universidade de Santiago de Compostela) ; González-Perez, Antonio (Centro Andaluz de Estudios Bioinformáticos, Sevilla) ; Calero, Miguel (CIEN Foundation/Queen Sofia Foundation Alzheimer Center) ; Franco-Macías, Emilio (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ; Macías, Juan (Hospital Universitario Virgen de Valme (Sevilla, Andalusia)) ; Blesa, Rafael (Institut d'Investigació Biomèdica Sant Pau) ; Cervera Carles, Laura (Institut d'Investigació Biomèdica Sant Pau) ; Mendez-Gonzalez, Manuel (Universidad de Oviedo) ; Frank-García, Ana (Universidad Autónoma de Madrid) ; Royo, Jose Luís (Universidad de Málaga) ; Moreno, Fermin (Biodonostia Osasun Ikerketako Institutura (País Basc)) ; Huerto Vilas, Raquel (Institut de Recerca Biomèdica) ; Baquero, Miquel (Hospital Universitari i Politècnic La Fe (València)) ; Diez-Fairen, Monica (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ; Lage, Carmen (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) ; García-Madrona, Sebastián (Hospital Universitario Ramón y Cajal (Madrid)) ; García-González, Pablo (Universitat Internacional de Catalunya) ; Alarcón-Martín, Emilio (Universidad de Málaga) ; Valero, Sergi (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Sotolongo Grau, Oscar (Universitat Internacional de Catalunya) ; Ullgren, Abbe (Karolinska University Hospital and Karolinska Institutet (Suècia)) ; Naj, Adam C. (University of Pennsylvania) ; Lemstra, Afina W. (Vrije Universiteit Amsterdam) ; Benaque, Alba (Universitat Internacional de Catalunya) ; Pérez-Cordón, Alba (Universitat Internacional de Catalunya) ; Benussi, Alberto (University of Brescia) ; Rábano, Alberto (BT-CIEN, Madrid, Spain) ; Padovani, Alessandro (University of Brescia) ; Squassina, Alessio (University of Cagliari) ; de Mendonça, Alexandre (University of Lisbon) ; Arias Pastor, Alfonso (Institut de Recerca Biomèdica) ; Kok, Almar A. L. (Vrije Universiteit Amsterdam) ; Meggy, Alun (Cardiff University) ; Pastor, Ana Belén (BT-CIEN, Madrid, Spain) ; Espinosa, Ana (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Corma-Gómez, Anaïs (Hospital Universitario Virgen de Valme (Sevilla, Andalusia)) ; Martín Montes, Angel (Hospital Universitario La Paz (Madrid)) ; Sanabria, Ángela (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; DeStefano, Anita L. (Boston University) ; Schneider, Anja (German Center for Neurodegenerative Diseases (DZNE)) ; Haapasalo, Annakaisa (University of Eastern Finland) ; Kinhult Ståhlbom, Anne (Karolinska University Hospital and Karolinska Institutet (Suècia)) ; Tybjærg-Hansen, Anne (University of Copenhagen) ; Hartmann, Annette M. (Martin-Luther-University Halle-Wittenberg) ; Spottke, Annika (University of Bonn) ; Corbatón-Anchuelo, Arturo (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas) ; Rongve, Arvid (University of Bergen) ; Borroni, Barbara (University of Brescia) ; Arosio, Beatrice (IRCCS Ospedale Maggiore Policlinico) ; Nacmias, Benedetta (IRCCS Fondazione Don Carlo Gnocchi) ; Nordestgaard, Børge G. (Herlev Gentofte Hospital) ; Kunkle, Brian W. (University of Miami) ; Charbonnier, Camille (Normandie Univ, UNIROUEN) ; Abdelnour, Carla (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Masullo, Carlo (Catholic University of the Sacred Heart) ; Martínez Rodríguez, Carmen (Hospital Universitario de Cabueñes (Gijón)) ; Muñoz-Fernandez, Carmen (Hospital Universitario de Gran Canaria Dr. Negrín) ; Dufouil, Carole (CHU de Bordeaux) ; Graff, Caroline (Karolinska University Hospital and Karolinska Institutet (Suècia)) ; Ferreira, Catarina B. (Universidade de Lisboa) ; Chillotti, Caterina (University Hospital of Cagliari) ; Reynolds, Chandra A. (University of California-Riverside) ; Fenoglio, Chiara (Dino Ferrari Center. University of Milan) ; Van Broeckhoven, Christine (University of Antwerp) ; Clark, Christopher (University of Zürich) ; Pisanu, Claudia (University of Cagliari) ; Satizabal, Claudia L. (UT Health San Antonio) ; Holmes, Clive (University of Southampton) ; Buiza-Rueda, Dolores (Universidad de Sevilla) ; Aarsland, Dag (Stavanger University Hospital) ; Rujescu, Dan (Martin-Luther-University Halle-Wittenberg) ; Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ; Galimberti, Daniela (Fondazione IRCCS Ca' Granda, Ospedale Policlinico) ; Wallon, David (Normandie Univ, UNIROUEN) ; Seripa, Davide (Fondazione IRCCS Casa Sollievo della Sofferenza) ; Grünblatt, Edna (University of Zurich) ; Dardiotis, Efthimios (University of Thessaly. School of Medicine) ; Düzel, Emrah (Otto-von-Guericke University) ; Scarpini, Elio (Fondazione IRCCS Ca' Granda, Ospedale Policlinico) ; Conti, Elisa (University of Milano-Bicocca) ; Rubino, Elisa (AOU Città della Salute e della Scienza di Torino) ; Gelpi, Ellen (Medical University of Vienna) ; Rodríguez-Rodríguez, Eloy (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) ; Duron, Emmanuelle (APHP, Hôpital Broca) ; Boerwinkle, Eric (Baylor College of Medicine) ; Ferri, Evelyn (IRCCS Ospedale Maggiore Policlinico) ; Tagliavini, Fabrizio (Fondazione IRCCS Istituto Neurologico Carlo Besta) ; Küçükali, Fahri (University of Antwerp) ; Pasquier, Florence (CHU CNR-MAJ, Lille) ; Sanchez-Garcia, Florentino (Hospital Universitario de Gran Canaria Dr. Negrín) ; Mangialasche, Francesca (Karolinska Institutet (Estocolm, Suècia)) ; Jessen, Frank (University of Cologne) ; Nicolas, Gaël (Hospital Universitario de Cabueñes (Gijón)) ; Selbæk, Geir (University of Oslo) ; Ortega, Gemma (National Institute of Health Carlos III) ; Chêne, Geneviève (CHU de Bordeaux, Pole de Santé Publique) ; Hadjigeorgiou, Georgios (University of Cyprus) ; Rossi, Giacomina (Fondazione IRCCS Istituto Neurologico Carlo Besta) ; Spalletta, Gianfranco (Baylor College of Medicine) ; Giaccone, Giorgio (Fondazione IRCCS Istituto Neurologico Carlo Besta) ; Grande, Giulia (Karolinska Institutet and Stockholm University) ; Binetti, Giuliano (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli) ; Papenberg, Goran (Karolinska Institutet and Stockholm University) ; Hampel, Harald (Pitié-Salpêtrière Hospital) ; Bailly, Henri (Université Paris Descartes) ; Zetterberg, Henrik (UCL Institute of Neurology (Regne Unit). UK Dementia Research Institute) ; Soininen, Hilkka (Kuopio University Hospital ( Finlàndia)) ; Karlsson, Ida K. (Jönköping University) ; Alvarez, Ignacio (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ; Appollonio, Ildebrando (San Gerardo hospital) ; Giegling, Ina (Martin-Luther-University Halle-Wittenberg) ; Skoog, Ingmar (University of Gothenburg) ; Saltvedt, Ingvild (Norwegian University of Science and Technhology) ; Rainero, Innocenzo (University of Torino) ; Rosas Allende, Irene (Hospital Universitario Central de Asturias) ; Hort, Jakub (St. Anne's University Hospital Brno) ; Diehl-Schmid, Janine (Technical University of Munich) ; Van Dongen, Jasper (Institute Born-Bunge) ; Vidal, Jean-Sébastien (Université Paris Descartes) ; Lehtisalo, Jenni (Finnish Institute for Health and Welfare) ; Wiltfang, Jens (University of Aveiro) ; Thomassen, Jesper Qvist (Copenhagen University Hospital Rigshospitalet) ; Kornhuber, Johannes (Friedrich-Alexander Universität Erlangen-Nürnberg) ; Haines, Jonathan L. (Case Western Reserve University) ; Vogelgsang, Jonathan (Harvard Medical School) ; Pineda, Juan A. (Hospital Universitario Virgen de Valme (Sevilla, Andalusia)) ; Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ; Popp, Julius (Lausanne University Hospital) ; Deckert, Jürgen (University Hospital, Wuerzburg) ; Buerger, Katharina (German Center for Neurodegenerative Diseases) ; Morgan, Kevin (University of Nottingham) ; Fließbach, Klaus (University Clinic Bonn) ; Sleegers, Kristel (University of Antwerp) ; Molina-Porcel, Laura (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Kilander, Lena (Department of Public Health and Caring Sciences/Geriatrics, Uppsala) ; Weinhold, Leonie (University Hospital of Bonn) ; Farrer, Lindsay A. (Boston University) ; Wang, Li-San (University of Pennsylvania) ; Kleineidam, Luca (University Clinic Bonn) ; Farotti, Lucia (University of Perugia) ; Parnetti, Lucilla (University of Perugia) ; Tremolizzo, Lucio (Ospedale San Gerardo (Itàlia)) ; Hausner, Lucrezia (University of Heidelberg) ; Benussi, Luisa (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli) ; Froelich, Lutz (University of Heidelberg) ; Ikram, M. Arfan (Erasmus Medical Center) ; Deniz-Naranjo, M. Candida (Hospital Universitario de Gran Canaria Dr. Negrín) ; Tsolaki, Magda (University of Thessaloniki) ; Rosende-Roca, Maitée (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Löwenmark, Malin (Department of Public Health and Caring Sciences/Geriatrics, Uppsala) ; Hulsman, Marc (Vrije Universiteit Amsterdam) ; Spallazzi, Marco (Azienda Ospedaliero-Universitaria) ; Pericak-Vance, Margaret A. (University of Miami) ; Esiri, Margaret (Nuffield Department of Clinical Neurosciences) ; Bernal Sánchez-Arjona, María (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ; Dalmasso, Maria Carolina (University of Cologne) ; Martínez-Larrad, María Teresa (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas) ; Arcaro, Marina (Fondazione IRCCS Ca' Granda, Ospedale Policlinico) ; Nöthen, Markus M. (University of Bonn) ; Fernández-Fuertes, Marta (Hospital Universitario Virgen de Valme (Sevilla, Andalusia)) ; Dichgans, Martin (Munich Cluster for Systems Neurology) ; Ingelsson, Martin (Department of Public Health and Caring Sciences/Geriatrics, Uppsala) ; Herrmann, Martin J. (University Hospital, Wuerzburg) ; Scherer, Martin (University Medical Centre Hamburg-Eppendorf) ; Vyhnalek, Martin (St. Anne's University Hospital Brno) ; Kosmidis, Mary H. (Aristotle University of Thessaloniki) ; Yannakoulia, Mary (Harokopio University) ; Schmid, Matthias (University Hospital of Bonn) ; Ewers, Michael (German Center for Neurodegenerative Diseases) ; Heneka, Michael T. (German Center for Neurodegenerative Diseases) ; Wagner, Michael (German Center for Neurodegenerative Diseases) ; Scamosci, Michela (University of Perugia) ; Kivipelto, Miia (Stockholms Sjukhem, Research & Development Unit, Stockholm, Sweden) ; Hiltunen, Mikko (University of Eastern Finland. Institute of Biomedicine) ; Zulaica, Miren (Biodonostia Osasun Ikerketako Institutura (País Basc)) ; Alegret, Montserrat (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Fornage, Myriam (University of Texas) ; Roberto, Natalia (Universitat Internacional de Catalunya) ; van Schoor, Natasja M. (Vrije Universiteit Amsterdam) ; Seidu, Nazib M. (University of Gothenburg) ; Banaj, Nerisa (IRCCS Santa Lucia Foundation) ; Armstrong, Nicola (Murdoch University) ; Scarmeas, Nikolaos (Columbia University) ; Scherbaum, Norbert (University of Duisburg-Essen) ; Goldhardt, Oliver (Technical University of Munich) ; Hanon, Olivier (Université Paris Descartes) ; Peters, Oliver (German Center for Neurodegenerative Diseases) ; Skrobot, Olivia Anna (University of Bristol) ; Quenez, Olivier (FHU G4 Génomique. Normandie Univ) ; Lerch, Ondrej (St. Anne's University Hospital Brno) ; Bossù, Paola (IRCCS Santa Lucia Foundation) ; Caffarra, Paolo (University of Parma) ; Dionigi Rossi, Paolo (IRCCS Ospedale Maggiore Policlinico) ; Sakka, Paraskevi (Athens Association of Alzheimer's disease and Related Disorders) ; Hoffmann, Per (University Hospital Basel (Basilea, Suïssa)) ; Holmans, Peter (Cardiff University) ; Fischer, Peter (Social Medicine Center East- Donauspital) ; Riederer, Peter (University Hospital of Würzburg) ; Yang, Qiong (Boston University) ; Marshall, Rachel (Cardiff University) ; Kalaria, Rajesh N. (Campus for Ageing anf Vitality, Newcastle upon Tyne) ; Mayeux, Richard (Columbia University) ; Vandenberghe, Rik (University Hospitals Leuven (Bèlgica)) ; Cecchetti, Roberta (University of Perugia) ; Ghidoni, Roberta (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli) ; Frikke-Schmidt, Ruth (University of Copenhagen) ; Sorbi, Sandro (IRCCS Fondazione Don Carlo Gnocchi) ; Hägg, Sara (Karolinska Institutet (Estocolm, Suècia)) ; Engelborghs, Sebastiaan (VUB University Hospital Brussels) ; Helisalmi, Seppo (University of Eastern Finland) ; Botne Sando, Sigrid (Norwegian University of Science and Technology) ; Kern, Silke (University of Gothenburg) ; Archetti, Silvana (Brescia Hospital) ; Boschi, Silvia (University of Torino) ; Fostinelli, Silvia (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli) ; Gil, Silvia (Universitat Internacional de Catalunya) ; Mendoza, Silvia (Instituto Andaluz de Neurociencia) ; Mead, Simon (University College London. Institute of Prion Diseases) ; Ciccone, Simona (IRCCS Ospedale Maggiore Policlinico) ; Djurovic, Srdjan (University of Bergen) ; Heilmann-Heimbach, Stefanie (University of Bonn) ; Riedel-Heller, Steffi (University of Leipzig) ; Kuulasmaa, Teemu (University of Eastern Finland) ; del Ser, Teodoro (CIEN Foundation/Queen Sofia Foundation Alzheimer Center) ; Lebouvier, Thibaud (CHU CNR-MAJ, Lille, France) ; Polak, Thomas (University Hospital, Wuerzburg) ; Ngandu, Tiia (Finnish Institute for Health and Welfare. Population Health Unit) ; Grimmer, Timo (Technical University of Munich) ; Bessi, Valentina (Azienda Ospedaliero-Universitaria Careggi Largo Brambilla) ; Escott-Price, Valentina (Cardiff University) ; Giedraitis, Vilmantas (Department of Public Health and Caring Sciences/Geriatrics, Uppsala) ; Deramecourt, Vincent (CHU CNR-MAJ, Lille, France) ; Maier, Wolfgang (German Center for Neurodegenerative Diseases) ; Jian, Xueqiu (Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases) ; Pijnenburg, Yolande (Vrije Universiteit Amsterdam) ; Kehoe, Patrick Gavin (German Center for Neurodegenerative Diseases) ; García-Ribas, Guillermo (Hospital Universitario Ramón y Cajal (Madrid)) ; Sánchez-Juan, Pascual (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) ; Pastor, Pau (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ; Pérez-Tur, Jordi (Instituto de Investigación Sanitaria La Fe) ; Piñol-Ripoll, Gerard (Institut de Recerca Biomèdica) ; Lopez de Munain, Adolfo (Universidad del País Vasco) ; García-Alberca, Jose María (Instituto Andaluz de Neurociencia) ; Bullido, María J. (Hospital Universitario La Paz (Madrid)) ; Álvarez, Victoria (Hospital Universitario Central de Asturias) ; Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ; Real, Luis M. (Universidad de Málaga) ; Mir, Pablo (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ; Medina, Miguel (CIEN Foundation/Queen Sofia Foundation Alzheimer Center) ; Scheltens, Philip (Vrije Universiteit Amsterdam) ; Holstege, Henne (Vrije Universiteit Amsterdam) ; Marquié, Marta (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Sáez, María Eugenia (Centro Andaluz de Estudios Bioinformáticos, Sevilla) ; Carracedo, Ángel (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Amouyel, Philippe (Institut Pasteur de Lille) ; Schellenberg, Gerard D. (University of Pennsylvania) ; Williams, Julie (Cardiff University) ; Seshadri, Sudha (Framingham Heart Study) ; van Duijn, Cornelia M. (University of Oxford) ; Mather, Karen A. (Neuroscience Research Australia) ; Sanchez-Valle, Raquel (Universitat de Barcelona) ; Serrano-Ríos, Manuel (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas) ; Orellana, Adelina (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Tárraga, Lluís (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Blennow, Kaj (University of Gothenburg) ; Huisman, Martijn A (Vrije Universiteit Amsterdam) ; Andreassen, Ole A. (Oslo University Hospital (Oslo, Noruega)) ; Posthuma, Danielle (Vrije Universiteit Amsterdam) ; Clarimón, Jordi (Institut d'Investigació Biomèdica Sant Pau) ; Boada, Mercè (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; van der Flier, Wiesje M. (Vrije Universiteit Amsterdam) ; Ramirez, Alfredo (Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases) ; Lambert, Jean-Charles (Institut Pasteur de Lille) ; van der Lee, Sven J. (Vrije Universiteit Amsterdam) ; Ruiz, Agustín (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Universitat Autònoma de Barcelona
Genetic discoveries of Alzheimer's disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. [...]
2021 - 10.1038/s41467-021-22491-8
Nature communications, Vol. 12 (june 2021)  
9.
15 p, 570.6 KB C9orf72, age at onset, and ancestry help discriminate behavioral from language variants in FTLD cohorts / Costa, Beatrice ; Manzoni, Claudia ; Bernal-Quiros, Manuel ; Kia, Demis A. ; Aguilar Barberà, Miquel ; Alvarez, Ignacio ; Alvarez, Victoria ; Andreassen, Ole A. ; Anfossi, Maria ; Bagnoli, Silvia ; Benussi, Luisa ; Bernardi, Livia ; Binetti, Giuliano ; Blackburn, Daniel ; Boada, Mercè ; Borroni, Barbara ; Bowns, Lucy ; Bråthen, Geir ; Bruni, Amalia ; Chiang, Huei-Hsin ; Clarimón, Jordi (Institut d'Investigació Biomèdica Sant Pau) ; Colville, Shuna ; Conidi, Maria E. ; Cope, Tom E. ; Cruchaga, Carlos ; Cupidi, Chiara ; Di Battista, Maria Elena ; Diehl-Schmid, Janine ; Diez-Fairen, Monica ; Dols Icardo, Oriol (Institut d'Investigació Biomèdica Sant Pau) ; Durante, Elisabetta ; Flisar, Dušan ; Frangipane, Francesca ; Galimberti, Daniela ; Gallo, Maura ; Gallucci, Maurizio ; Ghidoni, Roberta ; Graff, Caroline ; Grafman, Jordan H. ; Grossman, Murray ; Hardy, John ; Hernández, Isabel ; Holloway, Guy J. T. ; Huey, Edward D. ; Illán-Gala, Ignacio (Institut d'Investigació Biomèdica Sant Pau) ; Karydas, Anna ; Khoshnood, Behzad ; Kramberger, Milica G. ; Kristiansen, Mark ; Lewis, Patrick ; Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ; Madhan, Gaganjit K. ; Maletta, Raffaele ; Maver, Aleš ; Menendez-Gonzalez, Manuel ; Milan, Graziella ; Miller, Bruce L. ; Mol, Merel O. ; Momeni, Parastoo ; Moreno-Grau, Sonia ; Morris, Chris M. ; Nacmias, Benedetta ; Nilsson, Christer ; Novelli, Valeria ; Öijerstedt, Linn ; Padovani, Alessandro ; Pal, Suvankar ; Panchbhaya, Yasmin ; Pastor, Pau ; Peterlin, Borut ; Piaceri, Irene ; Pickering-Brown, S. ; Pijnenburg, Yolande ; Puca, Annibale A. ; Rainero, Innocenzo ; Rendina, Antonella ; Richardson, Anna M. T. ; Rogaeva, Ekaterina ; Rogelj, Boris ; Rollinson, Sara ; Rossi, Giacomina ; Rossmeier, Carola ; Rowe, James B. ; Rubino, Elisa ; Ruiz, Agustín ; Sanchez-Valle, Raquel ; Sando, Sigrid B. ; Santillo, Alexander F. ; Saxon, Jennifer ; Scarpini, Elio ; Serpente, Maria ; Smirne, Nicoletta ; Sorbi, Sandro ; Suh, EunRan ; Tagliavini, Fabrizio ; Thompson, Jennifer C. ; Trojanowski, John Q. ; Van Deerlin, Vivianna M. ; Van der Zee, Julie ; Van Broeckhoven, Christine ; van Rooij, Jeroen ; Van Swieten, John C. ; Veronesi, Arianna ; Vitale, Emilia ; Waldö, Maria L. ; Woodward, Cathy ; Yokoyama, Jennifer ; Escott-Price, Valentina ; Polke, James M. ; Ferrari, Raffaele ; Universitat Autònoma de Barcelona
We sought to characterize C9orf72 expansions in relation to genetic ancestry and age at onset (AAO) and to use these measures to discriminate the behavioral from the language variant syndrome in a large pan-European cohort of frontotemporal lobar degeneration (FTLD) cases. [...]
2020 - 10.1212/WNL.0000000000010914
Neurology, Vol. 95 (december 2020) , p. e3288-e3302  
10.
13 p, 722.8 KB A C6orf10 / LOC101929163 locus is associated with age of onset in C9orf72 carriers / Zhang, Ming (Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada) ; Ferrari, Raffaele (University College London. Institute of Neurology) ; Tartaglia, Maria Carmela (Department of Medicine, Division of Neurology, University of Toronto, Toronto, ON, Canada) ; Keith, Julia (Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada) ; Surace, Ezequiel I (Instituto de Investigaciones Neurológicas Dr. Raúl Carrea (Buenos Aires, Argentina)) ; Wolf, Uri (University of Toronto. Department of Psychiatry) ; Sato, Christine (Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada) ; Grinberg, Mark (Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada) ; Liang, Yan (Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada) ; Xi, Zhengrui (Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada) ; Dupont, Kyle (Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada) ; McGoldrick, Philip (Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada) ; Weichert, Anna (Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada) ; McKeever, Paul M. (Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada) ; Schneider, Raphael (Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada) ; McCorkindale, Michael D. (University College London. Institute of Neurology) ; Manzoni, Claudia (School of Pharmacy, University of Reading, Whiteknights, Reading, UK) ; Rademakers, Rosa (Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA) ; Graff-Radford, Neill R. (Department of Neurology, Mayo Clinic, Jacksonville, FL, USA) ; Dickson, Dennis W. (Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA) ; Parisi, Joseph E. (Department of Laboratory Medicine and Pathology and Department of Neurology, Mayo Clinic, Rochester, MN, USA) ; Boeve, Bradley (Department of Neurology, Mayo Clinic, Rochester, MN, USA) ; Petersen, Ronald C. (Department of Neurology, Mayo Clinic, Rochester, MN, USA) ; Miller, Bruce L. (Department of Neurology, University of California San Francisco Memory and Aging Center, San Francisco, CA, USA) ; Seeley, William W. (Department of Neurology and Department of Pathology, University of California San Francisco Memory and Aging Center, San Francisco, CA, USA) ; van Swieten, John C. (Department of Neurology, Erasmus MC, Rotterdam, The Netherlands) ; van Rooij, Jeroen (Department of Neurology, Erasmus MC, Rotterdam, The Netherlands) ; Pijnenburg, Yolande (Amsterdam UMC. University Medical Center) ; van der Zee, Julie (Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium) ; Van Broeckhoven, Christine (Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium) ; Le Ber, Isabelle (Reference Center for Rare and Young Dementias, Institute of Memory and Alzheimer's Disease (IM2A), Department of Neurology, Hopital Pitié-Salpêtrière, Paris, France) ; Van Deerlin, Vivianna (University of Pennsylvania) ; Suh, EunRan (University of Pennsylvania) ; Rohrer, Jonathan D. (University College London. Institute of Neurology) ; Mead, Simon (University College London. Institute of Prion Diseases) ; Graff, Caroline (Karolinska University Hospital and Karolinska Institutet (Suècia)) ; Öijerstedt, Linn (Karolinska University Hospital and Karolinska Institutet (Suècia)) ; Pickering-Brown, S. (Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, University of Manchester, UK) ; Rollinson, Sara (Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, University of Manchester, UK) ; Rossi, Giacomina (Division of Neurology V and Neuropathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy) ; Tagliavini, Fabrizio (Scientific Directorate, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy) ; Brooks, William S. (Neuroscience Research Australia and Prince of Wales Clinical School, University of New South Wales, Sydney, Australia) ; Dobson-Stone, Carol (School of Medical Sciences, University of New South Wales, Sydney, Australia) ; Halliday, Glenda M. (University of Sydney. Brain and Mind Centre) ; Hodges, John R. (Australian Research Council Centre of Excellence in Cognition and its Disorders, Sydney, Australia) ; Piguet, Olivier (School of Psychology and Brain and Mind Centre, University of Sydney, Sydney, Australia) ; Binetti, Giuliano (MAC Memory Center, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy) ; Benussi, Luisa (Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy) ; Ghidoni, Roberta (Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy) ; Nacmias, Benedetta (Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy) ; Sorbi, Sandro (IRCCS Don Gnocchi, Florence, Italy) ; Bruni, Amalia (Regional Neurogenetic Centre, Lamezia Terme, Azienda Sanitaria Provinciale Catanzaro, Italy) ; Galimberti, Daniela (Neurodegenerative Disease Unit, University of Milan, Fondazione Ca' Granda, IRCCS Ospedale Policlinico, Milan, Italy) ; Scarpini, Elio (Neurodegenerative Disease Unit, University of Milan, Fondazione Ca' Granda, IRCCS Ospedale Policlinico, Milan, Italy) ; Rainero, Innocenzo (Department of Neuroscience "Rita Levi Montalcini", University of Torino, Torino, Italy) ; Rubino, Elisa (Department of Neuroscience "Rita Levi Montalcini", University of Torino, Torino, Italy) ; Clarimón, Jordi (Institut d'Investigació Biomèdica Sant Pau) ; Lleó, Alberto (Universitat Autònoma de Barcelona. Departament de Medicina) ; Ruiz, Agustin (Institut Català de Neurociènces Aplicades) ; Hernández, Isabel (Institut Català de Neurociènces Aplicades) ; Pastor, Pau (Fundació per la Recerca Biomèdica i Social Mútua de Terrassa) ; Diez-Fairen, Monica (Fundació per la Recerca Biomèdica i Social Mútua de Terrassa) ; Borroni, Barbara (Centre for Neurodegenerative Disorders, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy) ; Pasquier, Florence (Centre Hospitalier Régional Universitaire de Lille) ; Deramecourt, Vincent (Centre Hospitalier Régional Universitaire de Lille) ; Lebouvier, Thibaud (Centre Hospitalier Régional Universitaire de Lille) ; Perneczky, Robert (Imperial College London. School of Public Health) ; Diehl-Schmid, Janine (Technische Universität München) ; Grafman, Jordan (Weinberg College of Arts and Sciences Northwestern University (Chicago, Estats Units d'Amèrica)) ; Huey, Edward D. (The Taub Institute for Research on Alzheimer's Disease and the Aging Brain (Columbia, Estats Units d'Amèrica)) ; Mayeux, Richard (The Gertrude H. Sergievsky Center, The Departments of Neurology, Psychiatry, Epidemiology, School of Public Health, Columbia University, New York, NY, USA) ; Nalls, Michael A.. (National Institute on Aging (Bethesda, Estats Units d'Amèrica)) ; Hernandez, Dena (National Institute on Aging (Bethesda, Estats Units d'Amèrica)) ; Singleton, Andrew B (National Institute on Aging (Bethesda, Estats Units d'Amèrica)) ; Momeni, Parastoo (Rona Holdings, Silicon Valley, CA, USA) ; Zeng, Zhen (Merck & Co., Inc, Kenilworth, NJ, USA) ; Hardy, John (University College London. Institute of Neurology) ; Robertson, Janice (Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada) ; Zinman, Lorne (Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada) ; Rogaeva, Ekaterina (Department of Medicine, Division of Neurology, University of Toronto, Toronto, ON, Canada)
Discovery of disease age-of-onset modifiers is important for clinical trials and drug design. Zhang et al. perform a genome-wide analysis of epigenetic functional polymorphisms and identify an association between the C6orf10/LOC101929163 locus and age of FTD/ALS onset. [...]
2018 - 10.1093/brain/awy238
Brain, Vol. 141 (september 2018) , p. 2895-2907  

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5 Diehl-Schmid, J.
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