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10 p, 1.6 MB |
SNPs in bone-related miRNAs are associated with the osteoporotic phenotype
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De-Ugarte, Laura (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Caro-Molina, Enrique (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Rodríguez-Sanz, Maria (Institut Hospital del Mar d'Investigacions Mèdiques) ;
García-Pérez, Miguel Angel (Universitat de València) ;
Olmos, José M. (Instituto de Investigación Sanitaria Valdecilla (Santander, Cantàbria)) ;
Sosa-Henríquez, Manuel (Universidad de Las Palmas de Gran Canaria) ;
Pérez-Cano, Ramón (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ;
Gómez-Alonso, Carlos (Hospital Universitario Central de Asturias) ;
Del Rio, Luis (CETIR Grup Mèdic, Barcelona) ;
Mateo-Agudo, Jesús (Hospital Universitario Miguel Servet (Saragossa)) ;
Blázquez-Cabrera, José Antonio (Complejo Hospitalario Universitario de Albacete) ;
González-Macías, Jesús (Universidad de Cantabria) ;
Pino-Montes, Javier del (Instituto de Investigación Biomédica de Salamanca) ;
Muñoz-Torres, Manuel (Hospital Universitario San Cecilio (Granada)) ;
Diaz-Curiel, Manuel (Hospital Universitario Fundación Jiménez Díaz) ;
Malouf, Jorge (Institut d'Investigació Biomèdica Sant Pau) ;
Cano, Antonio (Universitat de València) ;
Pérez-Castrillon, José Luis (Hospital Universitario Río Hortega (Valladolid)) ;
Nogués Solán, Xavier (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Garcia-Giralt, Natalia (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Díez Pérez, Adolfo (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Universitat Autònoma de Barcelona
Biogenesis and function of microRNAs can be influenced by genetic variants in the pri-miRNA sequences leading to phenotypic variability. This study aims to identify single nucleotide polymorphisms (SNPs) affecting the expression levels of bone-related mature microRNAs and thus, triggering an osteoporotic phenotype. [...]
2017 -  10.1038/s41598-017-00641-7
Scientific reports, Vol. 7 (march 2017)
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2.
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16 p, 967.2 KB |
Assessment of Cardiovascular Safety of Anti-Osteoporosis Drugs
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Fuggle, N. R. (University of Southampton) ;
Cooper, Cyrus (University of Oxford) ;
Harvey, N. C. (University of Southampton) ;
Al-Daghri, Nasser (King Saud University) ;
Brandi, Maria Luisa (University Hospital of Florence) ;
Bruyère, Olivier (WHO Collaborating Centre for Public Health Aspects of Musculoskeletal Health and Aging, Liège, Belgium) ;
Cano, A. (University of Valencia) ;
Dennison, E. M. (University of Southampton) ;
Díez Pérez, Adolfo (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Kaufman, J.-M. (Universitair Ziekenhuis Gent) ;
Palacios, S. (The Palacios Institute of Women's Health, Madrid) ;
Prieto-Alhambra, D. (University of Oxford) ;
Rozenberg, S. (CHU St Pierre, Bruxelles) ;
Thomas, T. (CHU de Saint-Etienne, France) ;
Tremollieres, F. (Toulouse University Hospital) ;
Rizzoli, R. (Hôpitaux Universitaires Genève) ;
Kanis, J. A. (Australian Catholic University) ;
Reginster, Jean-Yves (King Saud University) ;
Universitat Autònoma de Barcelona
The incidence of osteoporosis and cardiovascular disease increases with age, and there are potentially shared mechanistic associations between the two conditions. It is therefore highly relevant to understand the cardiovascular implications of osteoporosis medications. [...]
2020 - 10.1007/s40265-020-01364-2
Drugs, Vol. 80 (july 2020) , p. 1537-1552
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3.
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8 p, 242.1 KB |
Associations between Bone Material Strength Index, Calcaneal Quantitative Ultrasound, and Bone Mineral Density in Men
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Rufus-Membere, Pamela (Deakin University, IMPACT - Institute for Mental and Physical Health and Clinical Translation) ;
Holloway-Kew, Kara L. (Deakin University, IMPACT - Institute for Mental and Physical Health and Clinical Translation) ;
Díez Pérez, Adolfo (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Kotowicz, Mark A. (Barwon Health) ;
Pasco, Julie A. (Barwon Health)
Impact micro-indentation (IMI) measures bone material strength index (BMSi) in vivo. This study investigated how IMI is associated with calcaneal quantitative ultrasound and bone densitometry parameters in men. [...]
2020 - 10.1210/jendso/bvaa179
Journal of the Endocrine Society, Vol. 5 (november 2020)
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4.
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11 p, 619.1 KB |
In-hospital care, complications, and 4-month mortality following a hip or proximal femur fracture : the Spanish registry of osteoporotic femur fractures prospective cohort study
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Prieto-Alhambra, Daniel (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) ;
Reyes, Carles (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) ;
Sainz, Miguel Sanz (Instituto de Investigación Sanitaria de Aragón) ;
González-Macías, Jesús (Instituto de Investigación Sanitaria Valdecilla (Santander, Cantàbria)) ;
Delgado, Luis Gracia (Hospital Universitario Reina Sofía (Córdoba, Espanya)) ;
Bouzón, Cristina Alonso (Hospital Universitario de Getafe (Madrid)) ;
Gañan, Sarah Mills (Hospital Universitario La Paz (Madrid)) ;
Miedes, Damián Mifsut (Hospital Clínic Universitari (València)) ;
Vaquero-Cervino, Eduardo (Complejo Hospitalario Universitario de Pontevedra) ;
Bardaji, Manuel Francisco Bravo (Hospital Regional Universitario de Málaga) ;
Ezquerra, Laura (Hospital Clínico Universitario "Lozano Blesa" de Zaragoza) ;
Baztán, Fátima Brañas (Hospital Universitario Infanta Leonor) ;
Ferrer, Bartolomé Lladó (Hospital Universitari Son Llàtzer (Palma de Mallorca, Balears)) ;
Perez-Coto, Ivan (Hospital Universitario San Agustín (Avilés)) ;
Bueno, Gaspar Adrados (Hospital Infanta Cristina. Internal Medicine Unit) ;
Mora-Fernandez, Jesús (Hospital Clínico San Carlos (Madrid)) ;
Doñate, Teresa Espallargas (Hospital Obispo Polanco) ;
Blasco, Jorge Martínez-Iñiguez (Hospital San Pedro de Alcántara) ;
Aguado-Maestro, Ignacio (Hospital Universitario Río Hortega (Valladolid)) ;
Sáez-López, Pilar (Instituto de Investigación Sanitaria del Hospital Universitario La Paz) ;
Doménech, Monica Salomó (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Climent-Peris, Vicente (Traumatology and Orthopaedics Unit, Hospital Públic Lluis Alcanyis de Xàtiva, Carretera Xátiva-Silla, Km 2, 46800 Xàtiva, Valencia Spain) ;
Rodríguez, Ángel Díez (Hospital Virgen del Puerto. Traumatology and Orthopaedics Unit) ;
Sardiñas, Humberto Kessel (Complejo Hospitalario Torrecárdenas (Almeria)) ;
Gómez, Óscar Tendero (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ;
Serra, Jordi Teixidor (Hospital Universitari Vall d'Hebron) ;
Caeiro Rey, José Ramón (Complejo Hospitalario Universitario de Santiago de Compostela) ;
Cano, Ignacio Andrés (Hospital Universitario Puerta del Mar (Cadis, Andalusia)) ;
Carsi, Mariano Barrés (Hospital Universitari i Politècnic La Fe de València) ;
Etxebarria-Foronda, Iñigo (Department of Orthopaedic, Alto Deba Hospital, Arrasate-Mondragon, Gipuzkoa Spain) ;
Hernández, Juan Dionisio Avilés (Hospital Clínico Universitario Virgen de la Arrixaca (El Palmar, Múrcia)) ;
Solis, Juan Rodriguez (Hospital Universitario de Guadalajara) ;
Suau, Oscar Torregrosa (Hospital General Universitari d'Elx. Bone Metabolism Unit, Internal Medicine Unit) ;
Nogués Solán, Xavier (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Herrera, Antonio (University of Zaragoza. Department of Surgery, Aragón Health Research Institute) ;
Díez Pérez, Adolfo (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Universitat Autònoma de Barcelona
We have characterised 997 hip fracture patients from a representative 45 Spanish hospitals, and followed them up prospectively for up to 4 months. Despite suboptimal surgical delays (average 59. 1 hours), in-hospital mortality was lower than in Northern European cohorts. [...]
2018 - 10.1007/s11657-018-0515-8
Archives of Osteoporosis, Vol. 13 (september 2018)
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5.
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15 p, 1.0 MB |
Radiofrequency echographic multi-spectrometry for the in-vivo assessment of bone strength : state of the art-outcomes of an expert consensus meeting organized by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO)
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Díez Pérez, Adolfo (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Brandi, Maria Luisa (University of Florence. Department of Biological, Experimental and Clinical Science) ;
Al-Daghri, Nasser (King Saud University. Chair for Biomarkers of Chronic Diseases, Biochemistry Department, College of Science) ;
Branco, Jaime (Universidade Nova de Lisboa. NOVA Medical School) ;
Bruyère, Olivier (Université de Liège) ;
Cavalli, Loredana (University of Florence. Department of Biological, Experimental and Clinical Science) ;
Cooper, Cyrus (University Hospital Southampton NHS Foundation Trust (Regne Unit)) ;
Cortet, Bernard (University Hospital of Lille (França)) ;
Dawson-Hughes, Bess (Tufts University. Bone Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging) ;
Dimai, Hans Peter (Medical University of Graz. Department of Internal Medicine, Division of Endocrinology and Diabetology) ;
Gonnelli, Stefano (University of Siena. Department of Medicine, Surgery and Neurosciences) ;
Hadji, Peyman (Frankfurter Hormon und Osteoporose Zentrum, Frankfurt, Germany) ;
Halbout, Philippe (International Osteoporosis Foundation, Nyon, Switzerland) ;
Kaufman, Jean-Marc (Universitair Ziekenhuis Gent) ;
Kurth, Andreas (Mayor Teaching Hospital, Charite Medical School) ;
Locquet, Medea (University of Liège. Department of Public Health, Epidemiology and Health Economics) ;
Maggi, Stefania (Institute of Neuroscience. National Research Council, Aging Program) ;
Matijevic, Radmila (Clinical Center of Vojvodina, Clinic for Orthopedic Surgery) ;
Reginster, Jean-Yves (Université de Liège) ;
Rizzoli, René (Geneva University Hospitals (Suïssa)) ;
Thierry, Thomas (University of Lyon. INSERM 1059)
The purpose of this paper was to review the available approaches for bone strength assessment, osteoporosis diagnosis and fracture risk prediction, and to provide insights into radiofrequency echographic multi spectrometry (REMS), a non-ionizing axial skeleton technique. [...]
2019 - 10.1007/s40520-019-01294-4
Aging Clinical and Experimental Research, Vol. 31 (august 2019) , p. 1375-1389
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11 p, 530.5 KB |
Circulating miR-103a-3p and miR-660-5p are associated with bone parameters in patients with controlled acromegaly
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Valassi, Elena (Institut d'Investigació Biomèdica Sant Pau) ;
Garcia-Giralt, Natalia (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Malouf, Jorge (Institut d'Investigació Biomèdica Sant Pau) ;
Crespo, Iris (Institut d'Investigació Biomèdica Sant Pau) ;
Llauger, Jaume (Radiology Department) ;
Díez Pérez, Adolfo (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Webb, S. M.. 1952- (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
Biochemical control of GH/IGF-I excess in acromegaly (ACRO) is associated with persistent impairment of trabecular microstructure leading to increased risk of vertebral fractures. Circulating miRNAs modulate the activity of osteoblasts and osteoclasts, and may be potential biomarkers of osteoporosis. [...]
2018 - 10.1530/EC-18-0482
Endocrine Connections, Vol. 8 (december 2018) , p. 39-49
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5 p, 349.3 KB |
The impact of hip fracture on health-related quality of life and activities of daily living : the SPARE-HIP prospective cohort study
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Prieto-Alhambra, Daniel (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) ;
Moral-Cuesta, D. (Hospital Universitario La Paz (Madrid)) ;
Palmer, A. (Traumatology and Orthopaedics Unit. Nuffield Orthopedic Centre) ;
Aguado-Maestro, Ignacio (Hospital Universitario Río Hortega (Valladolid)) ;
Bardaji, Manuel Francisco Bravo (Hospital Regional Universitario de Málaga) ;
Brañas, F. (Hospital Universitario Infanta Leonor) ;
Bueno, G. A. (Internal Medicine Unit. Hospital Infanta Cristina) ;
Caeiro Rey, José Ramón (Complejo Hospitalario Universitario de Santiago de Compostela) ;
Cano, Ignacio Andrés (Hospital Universitario Puerta del Mar (Cadis, Andalusia)) ;
Barres-Carsi, M. (Hospital Universitari i Politècnic La Fe de València) ;
Delgado, Luis Gracia (Hospital Universitario Reina Sofía (Córdoba, Espanya)) ;
Salomó-Domènech, M. (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Etxebarria-Foronda, I. (Department of Orthopaedic. Alto Deba Hospital) ;
Ferrer, B. L. (Hospital Universitari Son Llàtzer (Palma de Mallorca, Balears)) ;
Mills, S. (Hospital Universitario La Paz (Madrid)) ;
Ezquerra, Laura (Hospital Clínico Universitario "Lozano Blesa" de Zaragoza) ;
Mifsut, D. (Hospital Clínic Universitari (València)) ;
Evangelista, L. D. R. (Hospital Universitario Severo Ochoa) ;
Nogués Solán, Xavier (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Perez-Coto, Ivan (Hospital Universitario San Agustín (Avilés)) ;
Blasco, J. M. I. (Hospital San Pedro de Alcántara) ;
Martín-Hernández, C. (Instituto de Investigación Sanitaria de Aragón) ;
Kessel, H. (Complejo Hospitalario Torrecárdenas (Almeria)) ;
Teixidor Serra, Jordi (Hospital Universitari Vall d'Hebron) ;
Solis, J. R. (Hospital Universitario de Guadalajara) ;
Suau, O. T. (Bone Metabolism Unit. Internal Medicine Unit. Hospital General Universitari d'Elx) ;
Vaquero-Cervino, E. (Complejo Hospitalario Universitario de Pontevedra) ;
Pablos Hernández, Carmen (Hospital Universitario de Salamanca) ;
Mañas, L. R. (Hospital Universitario de Getafe (Madrid)) ;
Herrera, Antonio. (Department of Surgery. Aragón Health Research Institute. University of Zaragoza) ;
Díez Pérez, Adolfo. (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Universitat Autònoma de Barcelona
Purpose: The medical morbidity and mortality associated with neck of femur fractures is well-documented, whereas there is limited data for patient-reported outcomes. The aim of this study was to characterize the impact of neck of femur fractures on activities of daily living and patient-reported health-related quality of life. [...]
2019 - 10.1007/s11657-019-0607-0
Archives of Osteoporosis, Vol. 14 Núm. 1 (january 2019) , p. 56
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8 p, 1.2 MB |
Effects of teriparatide on hip and upper limb fractures in patients with osteoporosis : A systematic review and meta-analysis
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Díez Pérez, Adolfo (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Marin, Fernando (Lilly Research Center, Windlesham, United Kingdom) ;
Eriksen, Erik F. (Oslo University Hospital (Oslo, Noruega)) ;
Kendler, David L. (University of British Columbia, Vancouver, Canada) ;
Krege, John H. (Lilly Research Laboratories, Indianapolis, USA) ;
Delgado-Rodríguez, Miguel (Universidad de Jaén) ;
Universitat Autònoma de Barcelona
In randomized clinical trials (RCTs) with teriparatide, the number of patients with incident hip fractures was small and insufficiently powered to show statistically significant differences between groups. [...]
2019 - 10.1016/j.bone.2018.09.020
Bone, Vol. 120 (march 2019) , p. 1-8
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11 p, 318.1 KB |
Determinants, consequences and potential solutions to poor adherence to anti-osteoporosis treatment : results of an expert group meeting organized by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) and the International Osteoporosis Foundation (IOF)
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Hiligsmann, M. (CAPHRI Care and Public Health Research Institute) ;
Cornelissen, D. (CAPHRI Care and Public Health Research Institute) ;
Vrijens, B. (Université de Liège) ;
Abrahamsen, Bo (University of Southern Denmark) ;
Al-Daghri, Nasser (King Saud University) ;
Biver, E. (Hôpitaux Universitaires de Genève) ;
Brandi, Maria Luisa (Università di Firenze) ;
Bruyère, Olivier (Université de Liège) ;
Burlet, N. (Sanofy Lyon) ;
Cooper, Cyrus (University Hospital Southampton NHS Foundation Trust (Regne Unit)) ;
Cortet, Bernard (Centre Hospitalier Universitaire de Lille) ;
Dennison, E. M. (University Hospital Southampton NHS Foundation Trust (Regne Unit)) ;
Díez Pérez, Adolfo (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Gasparik, A. (University of Medicine, Pharmacy, Science and Technology of Targu Mures) ;
Grosso, A. (Hôpitaux Universitaires de Genève) ;
Hadji, Peyman (Frankfurt Centre of Bone Health) ;
Halbout, P. (International Osteoporosis Foundation) ;
Kanis, J. A. (University of Sheffield Medical School) ;
Kaufman, J. M. (Universitair Ziekenhuis Gent) ;
Laslop, A. (Austrian Federal Office for Safety in Health Care) ;
Maggi, Stefania (CNR Aging Branch - Institute of Neuroscience, Padova) ;
Rizzoli, R. (Hôpitaux Universitaires de Genève) ;
Thomas, T. (CHU Saint-Etienne) ;
Tuzun, S. (İstanbul University Cerrahpaşa) ;
Vlaskovska, M. (Medical University Sofia) ;
Reginster, Jean-Yves (King Saud University) ;
Universitat Autònoma de Barcelona
Summary: Many patients at increased risk of fractures do not take their medication appropriately, resulting in a substantial decrease in the benefits of drug therapy. Improving medication adherence is urgently needed but remains laborious, given the numerous and multidimensional reasons for non-adherence, suggesting the need for measurement-guided, multifactorial and individualized solutions. [...]
2019 - 10.1007/s00198-019-05104-5
Osteoporosis International, Vol. 30 Núm. 11 (january 2019) , p. 2155-2165
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14 p, 433.6 KB |
Algorithm for the Use of Biochemical Markers of Bone Turnover in the Diagnosis, Assessment and Follow-Up of Treatment for Osteoporosis
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Lorentzon, M. (University of Gothenburg) ;
Branco, Jaime (NOVA University of Lisbon) ;
Brandi, Maria Luisa (University of Florence) ;
Bruyère, Olivier (University of Liège) ;
Chapurlat, Roland (Université de Lyon) ;
Cooper, Cyrus (University of Southampton) ;
Cortet, Bernard (CHU Lille) ;
Díez Pérez, Adolfo (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Ferrari, S. (Geneva University Hospitals (Suïssa)) ;
Gasparik, A. (University of Medicine, Pharmacy, Science and Technology of Targu Mures) ;
Herrmann, M. (Medical University of Graz) ;
Jorgensen, N. R. (Copenhagen University Hospital Rigshospitalet) ;
Kanis, J. (Mary MacKillop Institute for Health Research) ;
Kaufman, J. M. (Universitair Ziekenhuis Gent) ;
Laslop, A. (Austrian Agency for Health and Food Safety) ;
Locquet, Medea (University of Liège) ;
Matijevic, Radmila (University of Novi Sad) ;
McCloskey, E. (University of Sheffield) ;
Minisola, S. (Sapienza Università di Roma) ;
Pikner, R. (Klatovska Hospital, Klatovy, Czech Republic) ;
Reginster, Jean-Yves (University of Liège) ;
Rizzoli, R. (Geneva University Hospitals (Suïssa)) ;
Szulc, P. (Université de Lyon) ;
Vlaskovska, M. (Medical University Sofia) ;
Cavalier, E. (University of Liège) ;
Universitat Autònoma de Barcelona
Introduction: Increased biochemical bone turnover markers (BTMs) measured in serum are associated with bone loss, increased fracture risk and poor treatment adherence, but their role in clinical practice is presently unclear. [...]
2019 - 10.1007/s12325-019-01063-9
Advances in Therapy, Vol. 36 Núm. 10 (january 2019) , p. 2811-2824
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