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Articles, 2 records found
Articles 2 records found  
1.
11 p, 1.7 MB In silico validation of RNA-Seq results can identify gene fusions with oncogenic potential in glioblastoma / Hernández, Ainhoa (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Muñoz-Mármol, Ana Maria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Esteve-Codina, Anna (Universitat Pompeu Fabra) ; Alameda, Francesc (Institut Hospital del Mar d'Investigacions Mèdiques) ; Carrato, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Pineda, Estela (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Arpí Lluciá, Oriol (Institut Hospital del Mar d'Investigacions Mèdiques) ; Martinez-García, Maria (Hospital del Mar (Barcelona, Catalunya)) ; Mallo, Maria del Mar (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Gut, Marta (Universitat Pompeu Fabra) ; Del Barco Berrón, Sonia (Hospital Universitari de Girona Doctor Josep Trueta) ; Gallego Rubio, Oscar (Institut d'Investigació Biomèdica Sant Pau) ; Dabad, Marc (Universitat Pompeu Fabra) ; Mesia, Carlos (Institut d'Investigació Biomèdica de Bellvitge) ; Bellosillo Paricio, Beatriz (Institut Hospital del Mar d'Investigacions Mèdiques) ; Domènech Viñolas, Marta (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Vidal, Noemí (Hospital Universitari de Bellvitge) ; Aldecoa, Iban (Universitat de Barcelona) ; de la Iglesia, Nuria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Balañá, Carmen (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Universitat Autònoma de Barcelona
RNA-Sequencing (RNA-Seq) can identify gene fusions in tumors, but not all these fusions have functional consequences. Using multiple data bases, we have performed an in silico analysis of fusions detected by RNA-Seq in tumor samples from 139 newly diagnosed glioblastoma patients to identify in-frame fusions with predictable oncogenic potential. [...]
2022 - 10.1038/s41598-022-18608-8
Scientific reports, Vol. 12 Núm. 1 (december 2022) , p. 14439  
Detailed record - Creative Commons
2.
17 p, 936.9 KB Hypoxia : the cornerstone of glioblastoma / Domènech Viñolas, Marta (Institut Català d'Oncologia) ; Hernández, Ainhoa (Institut Català d'Oncologia) ; Plaja, Andrea (Institut Català d'Oncologia) ; Martínez Balibrea, Eva (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Balañá, Carmen (Institut Català d'Oncologia)
Glioblastoma is the most aggressive form of brain tumor in adults and is characterized by the presence of hypervascularization and necrosis, both caused by a hypoxic microenvironment. In this review, we highlight that hypoxia-induced factor 1 (HIF-1), the main factor activated by hypoxia, is an important driver of tumor progression in GB patients. [...]
2021 - 10.3390/ijms222212608
International journal of molecular sciences, Vol. 22 Núm. 22 (november 2021) , p. 12608  
Detailed record - Creative Commons

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