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1.
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8 p, 3.1 MB |
Mycobacterium detection method combining filtration, immunomagnetic separation, and electrochemical readout in a portable biosensing device
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Mesas Gómez, Melania (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Molina-Moya, Barbara (Institut Germans Trias i Pujol) ;
de Araújo, Bárbara Camila (Universidade Estadual Paulista. Instituto de Química) ;
Pallarès-Rusiñol, Arnau (BioEclosion S.L.) ;
Ferrer-Dalmau, Jofre (BioEclosion S.L.) ;
Boldrin Zanoni, Maria Valnice (Universidade Estadual Paulista. Instituto de Química) ;
Domínguez, José (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Julián Gómez, Esther (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Pividori, María Isabel (Universitat Autònoma de Barcelona. Departament de Química)
This study addresses a straightforward and highly sensitive approach for detecting Mycobacterium fortuitum. The method involves a combination of filtration and direct immunomagnetic separation to isolate the bacteria retained on filters for further electrochemical magneto immunosensing in a handheld device. [...]
2024 -  10.1016/j.snb.2023.135211
Sensors and actuators. B, Chemical, Vol. 403 (March 2024) , art. 135211
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2.
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13 p, 1.4 MB |
Improved biosensing of Legionella by integrating filtration and immunomagnetic separation of the bacteria retained in filters
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Mesas Gómez, Melania (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Molina-Moya, Barbara (Institut Germans Trias i Pujol) ;
de Araújo, Bárbara Camila (Universidade Estadual Paulista. Department of Analytical Chemistry) ;
Boldrin Zanoni, Maria Valnice (Universidade Estadual Paulista. Department of Analytical Chemistry) ;
Julián Gómez, Esther (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Domínguez, José (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Pividori, María Isabel (Universitat Autònoma de Barcelona. Departament de Química)
A novel approach is presented that combines filtration and the direct immunomagnetic separation of the retained bacteria Legionella in filters, for further electrochemical immunosensing. This strategy allows for the separation and preconcentration of the water-borne pathogen from high-volume samples, up to 1000 mL. [...]
2024 - 10.1007/s00604-023-06122-1
Mikrochimica acta, Vol. 191, Issue 2 (February 2024) , art. 82
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3.
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15 p, 739.8 KB |
Advances in diagnostic tools for respiratory tract infections : from tuberculosis to COVID-19 - changing paradigms?
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Stojanovic, Zoran (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gonçalves-Carvalho, Filipe (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Marín, Alicia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Abad Capa, Jorge (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Domínguez, José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Latorre, Irene (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Lacoma, Alicia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prat i Aymerich, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Respiratory tract infections (RTIs) are one of the most common reasons for seeking healthcare, but are amongst the most challenging diseases in terms of clinical decision-making. Proper and timely diagnosis is critical in order to optimise management and prevent further emergence of antimicrobial resistance by misuse or overuse of antibiotics. [...]
2022 - 10.1183/23120541.00113-2022
ERJ Open Research, Vol. 8 (september 2022)
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4.
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12 p, 984.3 KB |
Pooling samples to increase testing capacity with Xpert Xpress SARS-CoV-2 during the Covid-19 pandemic in Lao People's Democratic Republic
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Iem, Vibol (Liverpool School of Tropical Medicine) ;
Xangsayarath, Phonepadith (National Center for Laboratory and Epidemiology) ;
Chittamany, Phonenaly (National Tuberculosis Control Center) ;
Suthepmany, Sakhone (National Tuberculosis Control Center) ;
Siphanthong, Souvimone (National Tuberculosis Control Center) ;
Paboriboune, Phimpha (Center of Infectiology Lao Christophe Mérieux) ;
Somphavong, Silaphet (Lao Association for Medical Laboratory Sciences) ;
Konstantina, Kontogianni (Liverpool School of Tropical Medicine) ;
Khan, Jahangir A. M. (University of Gothenburg) ;
Edwards, Thomas (Liverpool School of Tropical Medicine) ;
Wingfield, Tom (Liverpool University Hospital NHS Foundation Trust) ;
Creswell, Jacob (Stop TB Partnership) ;
Domínguez, José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Cuevas, Luis E.. (Liverpool School of Tropical Medicine) ;
Universitat Autònoma de Barcelona
The COVID-19 pandemic created the need for large-scale testing of populations. However, most laboratories do not have sufficient testing capacity for mass screening. We evaluated pooled testing of samples, as a strategy to increase testing capacity in Lao PDR. [...]
2022 - 10.1371/journal.pone.0275294
PloS one, Vol. 17 (september 2022)
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5.
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12 p, 1.4 MB |
Study of CD27, CD38, HLA-DR and Ki-67 immune profiles for the characterization of active tuberculosis, latent infection and end of treatment
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Díaz-Fernández, Sergio (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Villar-Hernández, Raquel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Stojanovic, Zoran (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Fernández, Marco A (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
De Souza Galvão, Maria Luiza (Hospital Universitari Vall d'Hebron) ;
Tolosa, Guillermo (Universidad de la Frontera) ;
Sánchez-Montalva, Adrián (Hospital Universitari Vall d'Hebron) ;
Abad Capa, Jorge (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Jiménez-Fuentes, María Ángeles (Hospital Universitari Vall d'Hebron) ;
Safont Gonzalez, Guillem (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Romero i Andrada, Iris (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Sabrià, Josefina (Hospital de Sant Joan Despí Moisès Broggi) ;
Prat i Aymerich, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Domínguez, José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Latorre, Irene (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Current blood-based diagnostic tools for TB are insufficient to properly characterize the distinct stages of TB, from the latent infection (LTBI) to its active form (aTB); nor can they assess treatment efficacy. [...]
2022 - 10.3389/fmicb.2022.885312
Frontiers in microbiology, Vol. 13 (july 2022)
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6.
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14 p, 836.1 KB |
Predictive performance of interferon-gamma release assays and the tuberculin skin test for incident tuberculosis : an individual participant data meta-analysis
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Hamada, Yohhei (University College London) ;
Gupta, Rishi K. (University College London) ;
Quartagno, Matteo (MRC Clinical Trials Unit) ;
Izzard, Abbie (University College London) ;
Acuna-Villaorduna, Carlos (Boston University Medical Center) ;
Altet, Neus (Unitat de TDO de la Tuberculosis 'Servicios Clínicos' (Espanya)) ;
Diel, Roland (Universitätsklinikum Schleswig-Holstein (Alemanya)) ;
Domínguez, José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Floyd, Sian (London School of Hygiene & Tropical Medicine) ;
Gupta, Amita (Johns Hopkins University School of Medicine) ;
Huerga, Helena (Epicentre (França)) ;
Jones-López, Edward C. (University of Southern California) ;
Kinikar, Aarti (Sassoon General Hospital (India)) ;
Lange, Christoph (Tuberculosis Network European Trials Group (Alemanya)) ;
van Leth, Frank (Amsterdam Public Health Research Institute) ;
Liu, Qiao (Center for Disease Control and Prevention of Jiangsu Province) ;
Lu, Wei (Center for Disease Control and Prevention of Jiangsu Province) ;
Lu, Peng (Center for Disease Control and Prevention of Jiangsu Province) ;
Rueda, Irene Latorre (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martinez, Leonardo (Boston University) ;
Mbandi, Stanley Kimbung (South African Tuberculosis Vaccine Initiative) ;
Muñoz, Laura (Universitat de Barcelona) ;
Padilla, Elisabeth Sánchez (Epicentre (França)) ;
Paradkar, Mandar (Johns Hopkins India (India)) ;
Scriba, Thomas (South African Tuberculosis Vaccine Initiative) ;
Sester, Martina (Saarland University) ;
Shanaube, Kwame (Zambart, Zambia) ;
Sharma, Surendra K. (Datta Meghe Institute of Medical Sciences (India)) ;
Sloot, Rosa (Stellenbosch University (Sud Àfrica)) ;
Sotgiu, Giovanni (University of Sassari) ;
Thiruvengadam, Kannan (Indian Council of Medical Research) ;
Vashishtha, Richa (All India Institute of Medical Sciences (Nova Delhi, Índia)) ;
Abubakar, Ibrahim (University College London) ;
Rangaka, Molebogeng X. (University of Cape Town) ;
Universitat Autònoma de Barcelona
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Evidence on the comparative performance of purified protein derivative tuberculin skin tests (TST) and interferon-gamma release assays (IGRA) for predicting incident active tuberculosis (TB) remains conflicting. [...]
2023 - 10.1016/j.eclinm.2022.101815
EClinicalMedicine, Vol. 56 (january 2023)
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7.
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11 p, 1.7 MB |
Pooling sputum testing to diagnose tuberculosis using xpert MTB/RIF and xpert ultra : a cost-effectiveness analysis
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Iem, Vibol (Liverpool School of Tropical Medicine) ;
Bimba, John (Bingham University) ;
Santos, Victor S. (Universidade Federal de Sergipe) ;
Domínguez, José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Creswell, Jacob (Stop TB Partnership) ;
Somphavong, Silaphet (Lao Association for Medical Laboratory Sciences) ;
Wingfield, Tom (Karolinska Institutet (Estocolm, Suècia)) ;
Khan, Jahangir A. M. (University of Gothenburg) ;
Cuevas, Luis E.. (Liverpool School of Tropical Medicine) ;
Universitat Autònoma de Barcelona
The World Health Organization (WHO) recommends the diagnosis of tuberculosis (TB) using molecular tests, such as Xpert MTB/RIF (MTB/RIF) or Xpert Ultra (Ultra). These tests are expensive and resource-consuming, and cost-effective approaches are needed for greater coverage. [...]
2023 - 10.1186/s12879-023-08330-9
BMC Infectious diseases, Vol. 23 (may 2023)
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9.
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22 p, 6.8 MB |
Peripheral myeloid-derived suppressor cells are good biomarkers of the efficacy of fingolimod in multiple sclerosis
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Camacho-Toledano, Celia (Hospital Nacional de Parapléjicos-SESCAM) ;
Machín-Díaz, Isabel (Hospital Nacional de Parapléjicos-SESCAM) ;
Calahorra, Leticia (Hospital Nacional de Parapléjicos-SESCAM) ;
Cabañas-Cotillas, María (Hospital Nacional de Parapléjicos-SESCAM) ;
Otaegui, David (Biodonostia Osasun Ikerketako Institutura (País Basc)) ;
Castillo-Triviño, Tamara (Hospital de Donostia (Sant Sebastià, País Basc)) ;
Villar, Luisa M (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ;
Costa-Frossard, Lucienne (Hospital Universitario Ramón y Cajal (Madrid)) ;
Comabella, Manuel (Hospital Universitari Vall d'Hebron) ;
Midaglia, Luciana (Hospital Universitari Vall d'Hebron) ;
García-Domínguez, José Manuel (Hospital General Universitario Gregorio Marañón) ;
García-Arocha, Jennifer (Hospital Nacional de Parapléjicos-SESCAM) ;
Ortega, María Cristina (Hospital Nacional de Parapléjicos-SESCAM) ;
Clemente, Diego (Hospital Nacional de Parapléjicos-SESCAM) ;
Universitat Autònoma de Barcelona
The increasing number of treatments that are now available to manage patients with multiple sclerosis (MS) highlights the need to develop biomarkers that can be used within the framework of individualized medicine. [...]
2022 - 10.1186/s12974-022-02635-3
Journal of neuroinflammation, Vol. 19 (november 2022)
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10.
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14 p, 899.9 KB |
Measuring T-Cell Responses against SARS-CoV-2 Is of Utility for Disease and Vaccination Management
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Safont, G. (Universitat Autònoma de Barcelona) ;
Latorre, Irene (Universitat Autònoma de Barcelona) ;
Villar-Hernández, Raquel (Universitat Autònoma de Barcelona) ;
Stojanovic, Zorac (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Marín, Alicia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pérez-Cano, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Lacoma, Alicia (Universitat Autònoma de Barcelona) ;
Molina-Moya, Bárbara (Universitat Autònoma de Barcelona) ;
Solis, Alan Jhurior (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Arméstar, Fernando (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Matllo, Joan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Díaz-Fernández, Sergio (Universitat Autònoma de Barcelona) ;
Cendón Esteve, Arnau (Universitat Autònoma de Barcelona) ;
Sokalchuk, Liliya (Universitat Autònoma de Barcelona) ;
Tolosa, Guillermo (Diagnostic and Research in Immunodeficiencies Jeffrey Modell Center. Cytometry and Cellular Culture Area. La Frontera University) ;
Casas, Irma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rosell, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Domínguez, José (Universitat Autònoma de Barcelona)
The measurement of specific T-cell responses can be a useful tool for COVID-19 diagnostics and clinical management. In this study, we evaluated the IFN-γ T-cell response against the main SARS-CoV-2 antigens (spike, nucleocapsid and membrane) in acute and convalescent individuals classified according to severity, and in vaccinated and unvaccinated controls. [...]
2022 - 10.3390/jcm11175103
Journal of clinical medicine, Vol. 11 Núm. 17 (september 2022) , p. 5103
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